| Back to Multiple platform build/check report for BioC 3.22: simplified long | 
 | 
This page was generated on 2025-10-31 12:05 -0400 (Fri, 31 Oct 2025).
| Hostname | OS | Arch (*) | R version | Installed pkgs | 
|---|---|---|---|---|
| nebbiolo2 | Linux (Ubuntu 24.04.3 LTS) | x86_64 | 4.5.1 Patched (2025-08-23 r88802) -- "Great Square Root" | 4901 | 
| lconway | macOS 12.7.6 Monterey | x86_64 | 4.5.1 Patched (2025-09-10 r88807) -- "Great Square Root" | 4691 | 
| kjohnson3 | macOS 13.7.7 Ventura | arm64 | 4.5.1 Patched (2025-09-10 r88807) -- "Great Square Root" | 4637 | 
| Click on any hostname to see more info about the system (e.g. compilers) (*) as reported by 'uname -p', except on Windows and Mac OS X | ||||
| Package 541/2361 | Hostname | OS / Arch | INSTALL | BUILD | CHECK | BUILD BIN | ||||||||
| decoupleR 2.16.0  (landing page) Pau Badia-i-Mompel 
 | nebbiolo2 | Linux (Ubuntu 24.04.3 LTS) / x86_64 | OK | OK | WARNINGS |  | ||||||||
| lconway | macOS 12.7.6 Monterey / x86_64 | OK | OK | WARNINGS | OK |  | ||||||||
| kjohnson3 | macOS 13.7.7 Ventura / arm64 | OK | OK | ERROR | OK | |||||||||
| To the developers/maintainers of the decoupleR package: - Allow up to 24 hours (and sometimes 48 hours) for your latest push to git@git.bioconductor.org:packages/decoupleR.git to reflect on this report. See Troubleshooting Build Report for more information. - Use the following Renviron settings to reproduce errors and warnings. - If 'R CMD check' started to fail recently on the Linux builder(s) over a missing dependency, add the missing dependency to 'Suggests:' in your DESCRIPTION file. See Renviron.bioc for more information. | 
| Package: decoupleR | 
| Version: 2.16.0 | 
| Command: /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:decoupleR.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings decoupleR_2.16.0.tar.gz | 
| StartedAt: 2025-10-30 19:21:17 -0400 (Thu, 30 Oct 2025) | 
| EndedAt: 2025-10-30 19:26:05 -0400 (Thu, 30 Oct 2025) | 
| EllapsedTime: 287.4 seconds | 
| RetCode: 1 | 
| Status: ERROR | 
| CheckDir: decoupleR.Rcheck | 
| Warnings: NA | 
##############################################################################
##############################################################################
###
### Running command:
###
###   /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:decoupleR.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings decoupleR_2.16.0.tar.gz
###
##############################################################################
##############################################################################
* using log directory ‘/Users/biocbuild/bbs-3.22-bioc/meat/decoupleR.Rcheck’
* using R version 4.5.1 Patched (2025-09-10 r88807)
* using platform: aarch64-apple-darwin20
* R was compiled by
    Apple clang version 16.0.0 (clang-1600.0.26.6)
    GNU Fortran (GCC) 14.2.0
* running under: macOS Ventura 13.7.7
* using session charset: UTF-8
* using option ‘--no-vignettes’
* checking for file ‘decoupleR/DESCRIPTION’ ... OK
* checking extension type ... Package
* this is package ‘decoupleR’ version ‘2.16.0’
* package encoding: UTF-8
* checking package namespace information ... OK
* checking package dependencies ... OK
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking for sufficient/correct file permissions ... OK
* checking whether package ‘decoupleR’ can be installed ... OK
* checking installed package size ... OK
* checking package directory ... OK
* checking ‘build’ directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking code files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... OK
* checking whether the package can be loaded with stated dependencies ... OK
* checking whether the package can be unloaded cleanly ... OK
* checking whether the namespace can be loaded with stated dependencies ... OK
* checking whether the namespace can be unloaded cleanly ... OK
* checking dependencies in R code ... NOTE
[2025-10-30 19:21:31] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:21:31] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:21:31] [INFO]    [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-10-30 19:21:31] [INFO]    [OmnipathR] Package `OmnipathR` packaged: NA
[2025-10-30 19:21:31] [INFO]    [OmnipathR] Package `OmnipathR` date/publication: 2025-10-30
[2025-10-30 19:21:31] [INFO]    [OmnipathR] Package `OmnipathR` built: R 4.5.1; ; 2025-10-30 19:04:55 UTC; unix
[2025-10-30 19:21:31] [INFO]    [OmnipathR] Package `OmnipathR` version: 3.18.0
[2025-10-30 19:21:31] [INFO]    [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.22
[2025-10-30 19:21:32] [INFO]    [OmnipathR] Session info: [version=R version 4.5.1 Patched (2025-09-10 r88807); os=macOS Ventura 13.7.7; system=aarch64, darwin20; ui=X11; language=(EN); collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-10-30; pandoc=3.1.12.3 @ /opt/homebrew/bin/ (via rmarkdown); quarto=1.7.32 @ /usr/local/bin/quarto]
[2025-10-30 19:21:32] [INFO]    [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6.13; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; lapack_version=3.12.1]
[2025-10-30 19:21:32] [INFO]    [OmnipathR] Loaded packages: abind 1.4-8(2024-09-12); annotate 1.88.0(2025-10-30); AnnotationDbi 1.72.0(2025-10-30); AUCell 1.32.0(2025-10-30); backports 1.5.0(2024-05-23); beachmat 2.26.0(2025-10-30); Biobase 2.70.0(2025-10-30); BiocGenerics 0.56.0(2025-10-30); BiocParallel 1.44.0(2025-10-30); BiocSingular 1.26.0(2025-10-30); Biostrings 2.78.0(2025-10-30); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.3(2025-08-18); chromote 0.5.1(2025-04-24); cli 3.6.5(2025-04-23); codetools 0.2-20(2024-03-31); crayon 1.5.3(2024-06-20); curl 7.0.0(2025-08-19); data.table 1.17.8(2025-07-10); DBI 1.2.3(2024-06-02); decoupleR 2.16.0(2025-10-30); DelayedArray 0.36.0(2025-10-30); DelayedMatrixStats 1.32.0(2025-10-30); digest 0.6.37(2024-08-19); dplyr 1.1.4(2023-11-17); evaluate 1.0.5(2025-08-27); fastmap 1.2.0(2024-05-15); fs 1.6.6(2025-04-12); generics 0.1.4(2025-05-09); GenomicRanges 1.62.0(2025-10-30); glue 1.8.0(2024-09-30); graph 1.88.0(2025-10-30); GSEABase 1.72.0(2025-10-30); GSVA 2.4.0(2025-10-30); h5mread 1.2.0(2025-10-30); HDF5Array 1.38.0(2025-10-30); hms 1.1.4(2025-10-17); htmltools 0.5.8.1(2024-04-04); httr 1.4.7(2023-08-15); httr2 1.2.1(2025-07-22); igraph 2.2.1(2025-10-27); IRanges 2.44.0(2025-10-30); irlba 2.3.5.1(2022-10-03); jsonlite 2.0.0(2025-03-27); KEGGREST 1.50.0(2025-10-30); knitr 1.50(2025-03-16); later 1.4.4(2025-08-27); lattice 0.22-7(2025-04-02); lifecycle 1.0.4(2023-11-07); logger 0.4.1(2025-09-11); lubridate 1.9.4(2024-12-08); magick 2.9.0(2025-09-08); magrittr 2.0.4(2025-09-12); Matrix 1.7-4(2025-08-28); MatrixGenerics 1.22.0(2025-10-30); matrixStats 1.5.0(2025-01-07); memoise 2.0.1(2021-11-26); OmnipathR 3.18.0(2025-10-30); otel 0.2.0(2025-08-29); parallelly 1.45.1(2025-07-24); pillar 1.11.1(2025-09-17); pkgconfig 2.0.3(2019-09-22); png 0.1-8(2022-11-29); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.4.0(2025-10-22); ps 1.9.1(2025-04-12); purrr 1.1.0(2025-07-10); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.1(2025-05-02); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); rappdirs 0.3.3(2021-01-31); Rcpp 1.1.0(2025-07-02); readr 2.1.5(2024-01-10); readxl 1.4.5(2025-03-07); rhdf5 2.54.0(2025-10-30); rhdf5filters 1.22.0(2025-10-30); Rhdf5lib 1.32.0(2025-10-30); rjson 0.2.23(2024-09-16); rlang 1.1.6(2025-04-11); rmarkdown 2.30(2025-09-28); RSQLite 2.4.3(2025-08-20); rsvd 1.0.5(2021-04-16); rvest 1.0.5(2025-08-29); S4Arrays 1.10.0(2025-10-30); S4Vectors 0.48.0(2025-10-30); ScaledMatrix 1.18.0(2025-10-30); Seqinfo 1.0.0(2025-10-30); sessioninfo 1.2.3(2025-02-05); SingleCellExperiment 1.32.0(2025-10-30); SparseArray 1.10.0(2025-10-30); sparseMatrixStats 1.22.0(2025-10-30); SpatialExperiment 1.20.0(2025-10-30); stringi 1.8.7(2025-03-27); stringr 1.5.2(2025-09-08); SummarizedExperiment 1.40.0(2025-10-30); tibble 3.3.0(2025-06-08); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); vctrs 0.6.5(2023-12-01); websocket 1.4.4(2025-04-10); withr 3.0.2(2024-10-28); xfun 0.54(2025-10-30); XML 3.99-0.19(2025-08-22); xml2 1.4.1(2025-10-27); xtable 1.8-4(2019-04-21); XVector 0.50.0(2025-10-30); yaml 2.3.10(2024-07-26); zip 2.3.3(2025-05-13)
[2025-10-30 19:21:32] [INFO]    [OmnipathR] CURL: version: 8.14.1; headers: 8.14.1; ssl_version: LibreSSL/3.3.6 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: aarch64-apple-darwin23.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Running on a build server, wiping cache.
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Contains 9 files.
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Cache is locked: FALSE.
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:21:32] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Pandoc version: `3.1.12.3`.
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8).
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8).
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8).
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8).
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:21:32] [TRACE]   [OmnipathR] Cache locked: FALSE
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... OK
* checking Rd files ... OK
* checking Rd metadata ... OK
* checking Rd cross-references ... WARNING
Missing link(s) in Rd file 'run_gsva.Rd':
  ‘GSVA::gsva’ ‘GeneSetCollection’
Non-topic package-anchored link(s) in Rd file 'pipe.Rd':
  ‘[magrittr:pipe]{%>%}’
See section 'Cross-references' in the 'Writing R Extensions' manual.
Found the following Rd file(s) with Rd \link{} targets missing package
anchors:
  run_gsva.Rd: GSVA::gsva, GeneSetCollection
Please provide package anchors for all Rd \link{} targets not in the
package itself and the base packages.
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking files in ‘vignettes’ ... OK
* checking examples ... OK
Examples with CPU (user + system) or elapsed time > 5s
                user system elapsed
run_fgsea     10.717  0.601  14.359
get_collectri  9.396  1.263  19.231
get_dorothea   7.924  0.560  13.867
run_aucell     3.905  1.715   7.980
get_progeny    3.048  0.220  10.910
run_gsva       0.890  0.447   6.022
* checking for unstated dependencies in ‘tests’ ... OK
* checking tests ...
  Running ‘testthat.R’
 ERROR
Running the tests in ‘tests/testthat.R’ failed.
Last 13 lines of output:
  [120] 0.112          | 0.112            [120]
  [121] 0.991          - 1.000            [121]
  [122] 0.991          - 1.000            [122]
  [123] 0.123          - 0.126            [123]
  [124] 0.123          - 0.126            [124]
  [125] 0.156          | 0.156            [125]
  [126] 0.156          | 0.156            [126]
  [127] 0.592          | 0.592            [127]
  
    `actual$p_value[132:139]`: 0.125 0.592 0.592 0.175 0.175 0.198 0.198 0.592
  `expected$p_value[132:139]`: 0.125 0.592 0.592 0.184 0.184 0.198 0.198 0.592
  
  [ FAIL 1 | WARN 18 | SKIP 0 | PASS 34 ]
  Error: Test failures
  Execution halted
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE
Status: 1 ERROR, 1 WARNING, 1 NOTE
See
  ‘/Users/biocbuild/bbs-3.22-bioc/meat/decoupleR.Rcheck/00check.log’
for details.
decoupleR.Rcheck/00install.out
############################################################################## ############################################################################## ### ### Running command: ### ### /Library/Frameworks/R.framework/Resources/bin/R CMD INSTALL decoupleR ### ############################################################################## ############################################################################## * installing to library ‘/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library’ * installing *source* package ‘decoupleR’ ... ** this is package ‘decoupleR’ version ‘2.16.0’ ** using staged installation ** R ** inst ** byte-compile and prepare package for lazy loading ** help *** installing help indices *** copying figures ** building package indices ** installing vignettes ** testing if installed package can be loaded from temporary location ** testing if installed package can be loaded from final location ** testing if installed package keeps a record of temporary installation path * DONE (decoupleR)
decoupleR.Rcheck/tests/testthat.Rout.fail
R version 4.5.1 Patched (2025-09-10 r88807) -- "Great Square Root"
Copyright (C) 2025 The R Foundation for Statistical Computing
Platform: aarch64-apple-darwin20
R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.
R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.
Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.
> library(testthat)
> library(decoupleR)
> 
> test_check("decoupleR")
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Initialized cache: `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Package `OmnipathR` packaged: NA
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Package `OmnipathR` date/publication: 2025-10-30
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Package `OmnipathR` built: R 4.5.1; ; 2025-10-30 19:04:55 UTC; unix
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Package `OmnipathR` version: 3.18.0
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Package `OmnipathR` repository: Bioconductor 3.22
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Session info: [version=R version 4.5.1 Patched (2025-09-10 r88807); os=macOS Ventura 13.7.7; system=aarch64, darwin20; ui=X11; language=C; collate=C; ctype=en_US.UTF-8; tz=America/New_York; date=2025-10-30; pandoc=3.1.12.3 @ /opt/homebrew/bin/ (via rmarkdown); quarto=1.7.32 @ /usr/local/bin/quarto]
[2025-10-30 19:23:27] [INFO]    [OmnipathR] External libraries: [cairo=1.17.6; cairoFT=; pango=1.50.14; png=1.6.44; jpeg=9.5; tiff=LIBTIFF, Version 4.5.0; tcl=8.6.13; curl=8.7.1; zlib=1.2.11; bzlib=1.0.8, 13-Jul-2019; xz=5.6.3; deflate=1.23; PCRE=10.44 2024-06-07; ICU=70.2; TRE=TRE 0.8.0 R_fixes (BSD); iconv=Apple or GNU libiconv 1.11 /Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libR.dylib; readline=5.2; BLAS=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRblas.0.dylib; lapack=/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/lib/libRlapack.dylib; lapack_version=3.12.1]
[2025-10-30 19:23:27] [INFO]    [OmnipathR] Loaded packages: abind 1.4-8(2024-09-12); annotate 1.88.0(2025-10-30); AnnotationDbi 1.72.0(2025-10-30); AUCell 1.32.0(2025-10-30); backports 1.5.0(2024-05-23); beachmat 2.26.0(2025-10-30); Biobase 2.70.0(2025-10-30); BiocGenerics 0.56.0(2025-10-30); BiocParallel 1.44.0(2025-10-30); BiocSingular 1.26.0(2025-10-30); Biostrings 2.78.0(2025-10-30); bit 4.6.0(2025-03-06); bit64 4.6.0-1(2025-01-16); blob 1.2.4(2023-03-17); brio 1.1.5(2024-04-24); broom 1.0.10(2025-09-13); cachem 1.1.0(2024-05-16); cellranger 1.1.0(2016-07-27); checkmate 2.3.3(2025-08-18); chromote 0.5.1(2025-04-24); class 7.3-23(2025-01-01); cli 3.6.5(2025-04-23); codetools 0.2-20(2024-03-31); cowplot 1.2.0(2025-07-07); crayon 1.5.3(2024-06-20); curl 7.0.0(2025-08-19); data.table 1.17.8(2025-07-10); DBI 1.2.3(2024-06-02); decoupleR 2.16.0(2025-10-30); DelayedArray 0.36.0(2025-10-30); DelayedMatrixStats 1.32.0(2025-10-30); desc 1.4.3(2023-12-10); dichromat 2.0-0.1(2022-05-02); digest 0.6.37(2024-08-19); dplyr 1.1.4(2023-11-17); e1071 1.7-16(2024-09-16); evaluate 1.0.5(2025-08-27); farver 2.1.2(2024-05-13); fastmap 1.2.0(2024-05-15); fastmatch 1.1-6(2024-12-23); fgsea 1.36.0(2025-10-30); fs 1.6.6(2025-04-12); generics 0.1.4(2025-05-09); GenomicRanges 1.62.0(2025-10-30); ggplot2 4.0.0(2025-09-11); glue 1.8.0(2024-09-30); graph 1.88.0(2025-10-30); GSEABase 1.72.0(2025-10-30); GSVA 2.4.0(2025-10-30); gtable 0.3.6(2024-10-25); h5mread 1.2.0(2025-10-30); HDF5Array 1.38.0(2025-10-30); hms 1.1.4(2025-10-17); htmltools 0.5.8.1(2024-04-04); htmlwidgets 1.6.4(2023-12-06); httr 1.4.7(2023-08-15); httr2 1.2.1(2025-07-22); igraph 2.2.1(2025-10-27); IRanges 2.44.0(2025-10-30); irlba 2.3.5.1(2022-10-03); jsonlite 2.0.0(2025-03-27); KEGGREST 1.50.0(2025-10-30); kernlab 0.9-33(2024-08-13); KernSmooth 2.23-26(2025-01-01); knitr 1.50(2025-03-16); later 1.4.4(2025-08-27); lattice 0.22-7(2025-04-02); lazyeval 0.2.2(2019-03-15); lifecycle 1.0.4(2023-11-07); logger 0.4.1(2025-09-11); lubridate 1.9.4(2024-12-08); magick 2.9.0(2025-09-08); magrittr 2.0.4(2025-09-12); MASS 7.3-65(2025-02-28); Matrix 1.7-4(2025-08-28); MatrixGenerics 1.22.0(2025-10-30); matrixStats 1.5.0(2025-01-07); memoise 2.0.1(2021-11-26); mixtools 2.0.0.1(2025-03-08); nlme 3.1-168(2025-03-31); OmnipathR 3.18.0(2025-10-30); otel 0.2.0(2025-08-29); parallelly 1.45.1(2025-07-24); pillar 1.11.1(2025-09-17); pkgconfig 2.0.3(2019-09-22); plotly 4.11.0(2025-06-19); png 0.1-8(2022-11-29); prettyunits 1.2.0(2023-09-24); processx 3.8.6(2025-02-21); progress 1.2.3(2023-12-06); promises 1.4.0(2025-10-22); proxy 0.4-27(2022-06-09); ps 1.9.1(2025-04-12); purrr 1.1.0(2025-07-10); R.methodsS3 1.8.2(2022-06-13); R.oo 1.27.1(2025-05-02); R.utils 2.13.0(2025-02-24); R6 2.6.1(2025-02-15); ranger 0.17.0(2024-11-08); rappdirs 0.3.3(2021-01-31); RColorBrewer 1.1-3(2022-04-03); Rcpp 1.1.0(2025-07-02); readr 2.1.5(2024-01-10); readxl 1.4.5(2025-03-07); rhdf5 2.54.0(2025-10-30); rhdf5filters 1.22.0(2025-10-30); Rhdf5lib 1.32.0(2025-10-30); rjson 0.2.23(2024-09-16); rlang 1.1.6(2025-04-11); rmarkdown 2.30(2025-09-28); rpart 4.1.24(2025-01-07); RSQLite 2.4.3(2025-08-20); rsvd 1.0.5(2021-04-16); rvest 1.0.5(2025-08-29); S4Arrays 1.10.0(2025-10-30); S4Vectors 0.48.0(2025-10-30); S7 0.2.0(2024-11-07); ScaledMatrix 1.18.0(2025-10-30); scales 1.4.0(2025-04-24); segmented 2.1-4(2025-02-28); Seqinfo 1.0.0(2025-10-30); sessioninfo 1.2.3(2025-02-05); SingleCellExperiment 1.32.0(2025-10-30); SparseArray 1.10.0(2025-10-30); sparseMatrixStats 1.22.0(2025-10-30); SpatialExperiment 1.20.0(2025-10-30); stringi 1.8.7(2025-03-27); stringr 1.5.2(2025-09-08); SummarizedExperiment 1.40.0(2025-10-30); survival 3.8-3(2024-12-17); testthat 3.2.3(2025-01-13); tibble 3.3.0(2025-06-08); tidyr 1.3.1(2024-01-24); tidyselect 1.2.1(2024-03-11); timechange 0.3.0(2024-01-18); tzdb 0.5.0(2025-03-15); vctrs 0.6.5(2023-12-01); viper 1.44.0(2025-10-30); viridisLite 0.4.2(2023-05-02); waldo 0.6.2(2025-07-11); websocket 1.4.4(2025-04-10); withr 3.0.2(2024-10-28); xfun 0.54(2025-10-30); XML 3.99-0.19(2025-08-22); xml2 1.4.1(2025-10-27); xtable 1.8-4(2019-04-21); XVector 0.50.0(2025-10-30); yaml 2.3.10(2024-07-26); zip 2.3.3(2025-05-13)
[2025-10-30 19:23:27] [INFO]    [OmnipathR] CURL: version: 8.14.1; headers: 8.14.1; ssl_version: LibreSSL/3.3.6 (SecureTransport); libz_version: 1.2.11; libssh_version: NA; libidn_version: NA; host: aarch64-apple-darwin23.6.0; protocols: dict, file, ftp, ftps, gopher, gophers, http, https, imap, imaps, ldap, ldaps, mqtt, pop3, pop3s, rtsp, smb, smbs, smtp, smtps, telnet, tftp, ws, wss; ipv6: TRUE; http2: TRUE; idn: FALSE; url_parser: TRUE
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Running on a build server, wiping cache.
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Cache is at `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Contains 9 files.
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Cache is locked: FALSE.
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:27] [SUCCESS] [OmnipathR] Removing all cache contents from `/Users/biocbuild/Library/Caches/OmnipathR`.
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Pandoc version: `3.1.12.3`.
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/db/db_def.json` (encoding: UTF-8).
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/magic_bytes.json` (encoding: UTF-8).
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/urls.json` (encoding: UTF-8).
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Reading JSON from `/Library/Frameworks/R.framework/Versions/4.5-arm64/Resources/library/OmnipathR/internal/id_types.json` (encoding: UTF-8).
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Cache locked: FALSE
[2025-10-30 19:23:27] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:28] [INFO]    [OmnipathR] Loading database `Ensembl and OMA organism names`.
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:28] [INFO]    [OmnipathR] Looking up in cache `https://www.ensembl.org/info/about/species.html`: key=7332486db7400730697234bad76ca0c8e4d00799, no version available.
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:28] [INFO]    [OmnipathR] Created new version for cache record 7332486db7400730697234bad76ca0c8e4d00799: version 1.
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Cache file path: /Users/biocbuild/Library/Caches/OmnipathR/7332486db7400730697234bad76ca0c8e4d00799-1.html
[2025-10-30 19:23:28] [INFO]    [OmnipathR] Retrieving URL: `https://www.ensembl.org/info/about/species.html`
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Downloading by `httr2` in `download_base`.
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Attempt 1/3: `https://www.ensembl.org/info/about/species.html`
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Preparing httr2 request to URL `https://www.ensembl.org/info/about/species.html`.
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0]
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] HTTP headers: [User-Agent=Mozilla/5.0 (X11; Linux x86_64; rv:134.0) Gecko/20100101 Firefox/134.0]
[2025-10-30 19:23:28] [TRACE]   [OmnipathR] Sending HTTP request.
[2025-10-30 19:23:29] [TRACE]   [OmnipathR] HTTP 200 (OK)
[2025-10-30 19:23:29] [TRACE]   [OmnipathR] HTTP v2 GET: status 200.
[2025-10-30 19:23:29] [TRACE]   [OmnipathR] Downloaded 31.1 Kb in 0.724742s from www.ensembl.org (43 Kb/s); Redirect: 0.530503s, DNS look up: 0.006383s, Connection: 0.010392s, Pretransfer: 0.412835s, First byte at: 0.699893s
[2025-10-30 19:23:29] [TRACE]   [OmnipathR] HTTP headers: HTTP/1.1 302 Found; Date: Thu, 30 Oct 2025 23:23:29 GMT; Content-Type: text/html; charset=iso-8859-1; Content-Length: 288; Connection: keep-alive; Server: Apache; Set-cookie: redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT; Location: //useast.ensembl.org/info/about/species.html?redirectsrc=//www.ensembl.org%2Finfo%2Fabout%2Fspecies.html; X-NGINX-MACHINE: wp-p1m2-35.ebi.ac.uk; HTTP/2 302 ; date: Thu, 30 Oct 2025 23:23:29 GMT; content-type: text/html; charset=iso-8859-1; content-length: 208; server: Apache; set-cookie: redirected_from_url=%2F%2Fwww.ensembl.org%252Finfo%252Fabout%252Fspecies.html; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; location: /info/about/species.html; x-nginx-machine: ip-10-25-25-90.us-east-2.compute.internal; HTTP/2 200 ; date: Thu, 30 Oct 2025 23:23:29 GMT; content-type: text/html; charset=utf-8; content-length: 31875; server: Apache; set-cookie: redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT; set-cookie: redirect_mirror=no; path=/; expires=Fri, 31 Oct 2025 23:19:34 GMT; set-cookie: ENSEMBL_WWW_SESSION=361aebea6896b9510cef503d69530c8603d7d20ad6af8848bbd15d7a; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly; set-cookie: redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT; set-cookie: redirect_mirror=no; path=/; expires=Fri, 31 Oct 2025 23:19:34 GMT; set-cookie: ENSEMBL_WWW_SESSION=361aebea6896b9510cef503d69530c8603d7d20ad6af8848bbd15d7a; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly; vary: Accept-Encoding; content-encoding: gzip; x-frame-options: SAMEORIGIN; content-security-policy: frame-ancestors 'self'; x-nginx-machine: ip-10-25-25-94.us-east-2.compute.internal
[2025-10-30 19:23:29] [TRACE]   [OmnipathR] Response headers: [date=Thu, 30 Oct 2025 23:23:29 GMT,content-type=text/html; charset=utf-8,content-length=31875,server=Apache,set-cookie=redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT,set-cookie=redirect_mirror=no; path=/; expires=Fri, 31 Oct 2025 23:19:34 GMT,set-cookie=ENSEMBL_WWW_SESSION=361aebea6896b9510cef503d69530c8603d7d20ad6af8848bbd15d7a; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly,set-cookie=redirect_mirror=; path=/; expires=Mon, 01-Jan-2001 00:00:01 GMT,set-cookie=redirect_mirror=no; path=/; expires=Fri, 31 Oct 2025 23:19:34 GMT,set-cookie=ENSEMBL_WWW_SESSION=361aebea6896b9510cef503d69530c8603d7d20ad6af8848bbd15d7a; path=/; expires=Thu, 31-Dec-2037 23:59:59 GMT; HttpOnly,vary=Accept-Encoding,content-encoding=gzip,x-frame-options=SAMEORIGIN,content-security-policy=frame-ancestors 'self',x-nginx-machine=ip-10-25-25-94.us-east-2.compute.internal]
[2025-10-30 19:23:30] [INFO]    [OmnipathR] Download ready [key=7332486db7400730697234bad76ca0c8e4d00799, version=1]
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:30] [INFO]    [OmnipathR] Cache item `7332486db7400730697234bad76ca0c8e4d00799` version 1: status changed from `unknown` to `ready`.
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-10-30 19:23:30] [INFO]    [OmnipathR] Cache record does not exist: `https://omabrowser.org/All/oma-species.txt`
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://omabrowser.org/All/oma-species.txt`.
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:30] [INFO]    [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-10-30 19:23:30] [INFO]    [OmnipathR] Retrieving URL: `https://omabrowser.org/All/oma-species.txt`
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Attempt 1/3: `https://omabrowser.org/All/oma-species.txt`
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] HTTP v2 GET: status 200.
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] Downloaded 8.7 Kb in 0.255551s from omabrowser.org (34 Kb/s); Redirect: 0s, DNS look up: 0.001114s, Connection: 0.006397s, Pretransfer: 0.170787s, First byte at: 0.255389s
[2025-10-30 19:23:30] [TRACE]   [OmnipathR] HTTP headers: HTTP/2 200 ; date: Thu, 30 Oct 2025 23:23:30 GMT; server: nginx; strict-transport-security: max-age=31536000; includeSubDomains; content-type: text/plain; charset=UTF-8; last-modified: Wed, 20 Nov 2024 10:20:02 GMT; etag: W/"673db7d2-6517f"; access-control-allow-origin: *; content-encoding: gzip
[2025-10-30 19:23:31] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-10-30 19:23:31] [INFO]    [OmnipathR] Download ready [key=30e690cbb55dfc63b5903ab337f34ffc2f4be397, version=1]
[2025-10-30 19:23:31] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:31] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:31] [INFO]    [OmnipathR] Cache item `30e690cbb55dfc63b5903ab337f34ffc2f4be397` version 1: status changed from `started` to `ready`.
[2025-10-30 19:23:31] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:23:31] [TRACE]   [OmnipathR] Looking up in cache: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`.
[2025-10-30 19:23:31] [INFO]    [OmnipathR] Cache record does not exist: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`
[2025-10-30 19:23:31] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`.
[2025-10-30 19:23:32] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:32] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:32] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:32] [INFO]    [OmnipathR] Cache item `56ad6544dc07a2222fa6013d8d83e6e5a35fdf33` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:23:32] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/56ad6544dc07a2222fa6013d8d83e6e5a35fdf33-1.rds`.
[2025-10-30 19:23:32] [INFO]    [OmnipathR] Retrieving URL: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`
[2025-10-30 19:23:32] [TRACE]   [OmnipathR] Attempt 1/3: `https://ftp.expasy.org/databases/uniprot/current_release/knowledgebase/complete/docs/speclist.txt`
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/56ad6544dc07a2222fa6013d8d83e6e5a35fdf33-1.rds`.
[2025-10-30 19:23:48] [INFO]    [OmnipathR] Download ready [key=56ad6544dc07a2222fa6013d8d83e6e5a35fdf33, version=1]
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:48] [INFO]    [OmnipathR] Cache item `56ad6544dc07a2222fa6013d8d83e6e5a35fdf33` version 1: status changed from `started` to `ready`.
[2025-10-30 19:23:48] [INFO]    [OmnipathR] Loaded database `Ensembl and OMA organism names`.
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=TFcensus,query_type=annotations]
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:23:48] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:49] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:49] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:49] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] HTTP v1 GET: status 200.
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] Downloaded 15.7 Kb in 0.285234s from omnipathdb.org (54.9 Kb/s); Redirect: 0s, DNS look up: 0.001065s, Connection: 0.009389s, Pretransfer: 0.147229s, First byte at: 0.285021s
[2025-10-30 19:23:49] [TRACE]   [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Thu, 30 Oct 2025 23:23:49 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 31 Oct 2025 00:23:49 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-10-30 19:23:50] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=TFcensus&license=academic`
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:50] [INFO]    [OmnipathR] Cache item `6f000d9b5edd9832b1c28754d1c3d9449c1c7490` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/6f000d9b5edd9832b1c28754d1c3d9449c1c7490-1.rds`.
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/6f000d9b5edd9832b1c28754d1c3d9449c1c7490-1.rds`.
[2025-10-30 19:23:50] [INFO]    [OmnipathR] Download ready [key=6f000d9b5edd9832b1c28754d1c3d9449c1c7490, version=1]
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:50] [INFO]    [OmnipathR] Cache item `6f000d9b5edd9832b1c28754d1c3d9449c1c7490` version 1: status changed from `started` to `ready`.
[2025-10-30 19:23:50] [SUCCESS] [OmnipathR] Downloaded 3497 annotation records.
[2025-10-30 19:23:50] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=PROGENy,query_type=annotations]
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:51] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:51] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:51] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:23:51] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:23:52] [TRACE]   [OmnipathR] HTTP v1 GET: status 200.
[2025-10-30 19:23:52] [TRACE]   [OmnipathR] Downloaded 15.7 Kb in 0.306605s from omnipathdb.org (51.1 Kb/s); Redirect: 0s, DNS look up: 0.000847s, Connection: 0.001667s, Pretransfer: 0.153009s, First byte at: 0.306396s
[2025-10-30 19:23:52] [TRACE]   [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Thu, 30 Oct 2025 23:23:52 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 31 Oct 2025 00:23:52 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-10-30 19:23:59] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:23:59] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:59] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:59] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:23:59] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:23:59] [INFO]    [OmnipathR] Cache item `3492392585ba05414edfae46801492076437d7e7` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:23:59] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-10-30 19:24:00] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-10-30 19:24:00] [INFO]    [OmnipathR] Download ready [key=3492392585ba05414edfae46801492076437d7e7, version=1]
[2025-10-30 19:24:00] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:00] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:00] [INFO]    [OmnipathR] Cache item `3492392585ba05414edfae46801492076437d7e7` version 1: status changed from `started` to `ready`.
[2025-10-30 19:24:00] [SUCCESS] [OmnipathR] Downloaded 699831 annotation records.
[2025-10-30 19:24:01] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:24:01] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:01] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:24:01] [TRACE]   [OmnipathR] Arguments for OmniPath query: [wide=TRUE,resources=PROGENy,query_type=annotations]
[2025-10-30 19:24:01] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:24:01] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:24:01] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:24:02] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:02] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:24:03] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/3492392585ba05414edfae46801492076437d7e7-1.rds`.
[2025-10-30 19:24:03] [INFO]    [OmnipathR] Loaded from cache: `https://omnipathdb.org/annotations?resources=PROGENy&license=academic`
[2025-10-30 19:24:03] [SUCCESS] [OmnipathR] Loaded 699831 annotation records from cache.
[2025-10-30 19:24:04] [INFO]    [OmnipathR] Loading database `Orthologous Matrix (OMA) gene pairs`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/All/oma-species.txt`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/30e690cbb55dfc63b5903ab337f34ffc2f4be397-1.rds`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Looking up in cache: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`.
[2025-10-30 19:24:04] [INFO]    [OmnipathR] Cache record does not exist: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:04] [INFO]    [OmnipathR] Cache item `8f45b25c384d814c7de210e7ca40b7e35894e4f1` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/8f45b25c384d814c7de210e7ca40b7e35894e4f1-1.rds`.
[2025-10-30 19:24:04] [INFO]    [OmnipathR] Retrieving URL: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Attempt 1/3: `https://omabrowser.org/api/pairs/HUMAN/MOUSE/?format=tsv&xrefs=UniProtKB%2FSwissProt&per_page=2000000`
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:24:04] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:24:36] [TRACE]   [OmnipathR] HTTP v2 GET: status 200.
[2025-10-30 19:24:36] [TRACE]   [OmnipathR] Downloaded 9.5 Kb in 32.103298s from omabrowser.org (302 bytes/s); Redirect: 0s, DNS look up: 0.001232s, Connection: 0.002108s, Pretransfer: 0.331107s, First byte at: 32.103161s
[2025-10-30 19:24:36] [TRACE]   [OmnipathR] HTTP headers: HTTP/2 200 ; date: Thu, 30 Oct 2025 23:24:36 GMT; server: nginx; strict-transport-security: max-age=31536000; includeSubDomains; content-type: text/tsv; charset=utf-8; content-length: 1187278; x-total-count: 22374; vary: Accept,Origin,Cookie; allow: GET, HEAD, OPTIONS; content-disposition: attachment; filename=OMA-Pairs_HUMAN-MOUSE_2025-10-30_232434.tsv; x-frame-options: SAMEORIGIN; set-cookie: __matomo=1a5495fd28391a38; expires=Sat, 30-Oct-2027 23:24:36 UTC; Path=/
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/8f45b25c384d814c7de210e7ca40b7e35894e4f1-1.rds`.
[2025-10-30 19:24:38] [INFO]    [OmnipathR] Download ready [key=8f45b25c384d814c7de210e7ca40b7e35894e4f1, version=1]
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:38] [INFO]    [OmnipathR] Cache item `8f45b25c384d814c7de210e7ca40b7e35894e4f1` version 1: status changed from `started` to `ready`.
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] ID translation table: from `uniprot_entry` to `uniprot`, using `uniprot`.
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Creating ID mapping table from `id` to `accession`, for organism 9606 (only reviewed: TRUE)
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Loading all UniProt records for organism 9606 (only reviewed: TRUE); fields: id,accession
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`.
[2025-10-30 19:24:38] [INFO]    [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`.
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:38] [INFO]    [OmnipathR] Cache item `6558a1824894a625b8e3f80538cd3aa6e8a44379` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/6558a1824894a625b8e3f80538cd3aa6e8a44379-1.rds`.
[2025-10-30 19:24:38] [INFO]    [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:9606%20AND%20reviewed:true`
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:24:38] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:24:39] [TRACE]   [OmnipathR] HTTP v2 GET: status 200.
[2025-10-30 19:24:39] [TRACE]   [OmnipathR] Downloaded 31 bytes in 0.860037s from rest.uniprot.org (36 bytes/s); Redirect: 0s, DNS look up: 0.003795s, Connection: 0.005455s, Pretransfer: 0.520221s, First byte at: 0.859942s
[2025-10-30 19:24:39] [TRACE]   [OmnipathR] HTTP headers: HTTP/2 200 ; vary: accept,accept-encoding,x-uniprot-release,x-api-deployment-date, User-Agent, Accept-Encoding; cache-control: public, max-age=43200; content-type: text/plain;format=tsv; content-encoding: gzip; access-control-allow-credentials: true; access-control-expose-headers: Link, X-Total-Results, X-UniProt-Release, X-UniProt-Release-Date, X-API-Deployment-Date; x-api-deployment-date: 15-October-2025; strict-transport-security: max-age=31536000; includeSubDomains; date: Thu, 30 Oct 2025 23:24:39 GMT; access-control-max-age: 1728000; x-uniprot-release: 2025_04; access-control-allow-origin: *; accept-ranges: bytes; access-control-allow-methods: GET, PUT, POST, DELETE, PATCH, OPTIONS; access-control-allow-headers: DNT,Keep-Alive,User-Agent,X-Requested-With,If-Modified-Since,Cache-Control,Content-Type,Range,Authorization; x-uniprot-release-date: 15-October-2025
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/6558a1824894a625b8e3f80538cd3aa6e8a44379-1.rds`.
[2025-10-30 19:24:48] [INFO]    [OmnipathR] Download ready [key=6558a1824894a625b8e3f80538cd3aa6e8a44379, version=1]
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:48] [INFO]    [OmnipathR] Cache item `6558a1824894a625b8e3f80538cd3aa6e8a44379` version 1: status changed from `started` to `ready`.
[2025-10-30 19:24:48] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 20420 records
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] Translating complexes: 0 complexes in data.
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] Translated 0 complexes to 0.
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] 13774 rows before translation, 13774 uniprot_entry IDs in column `id_organism_a`.
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] 13774 rows after translation; translated 13550 `uniprot_entry` IDs in column `id_organism_a` to 13550 `uniprot` IDs in column `id_organism_a`.
[2025-10-30 19:24:48] [TRACE]   [OmnipathR] ID translation table: from `uniprot_entry` to `uniprot`, using `uniprot`.
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Creating ID mapping table from `id` to `accession`, for organism 10090 (only reviewed: TRUE)
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Loading all UniProt records for organism 10090 (only reviewed: TRUE); fields: id,accession
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`.
[2025-10-30 19:24:49] [INFO]    [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`.
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:49] [INFO]    [OmnipathR] Cache item `43ea5f2cdaa9ac7e0e114371af97235cdddd776f` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/43ea5f2cdaa9ac7e0e114371af97235cdddd776f-1.rds`.
[2025-10-30 19:24:49] [INFO]    [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=id,accession&query=organism_id:10090%20AND%20reviewed:true`
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] HTTP v2 GET: status 200.
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] Downloaded 31 bytes in 0.764888s from rest.uniprot.org (40 bytes/s); Redirect: 0s, DNS look up: 0.000851s, Connection: 0.001544s, Pretransfer: 0.484922s, First byte at: 0.764792s
[2025-10-30 19:24:49] [TRACE]   [OmnipathR] HTTP headers: HTTP/2 200 ; vary: accept,accept-encoding,x-uniprot-release,x-api-deployment-date, User-Agent, Accept-Encoding; cache-control: public, max-age=43200; content-type: text/plain;format=tsv; content-encoding: gzip; access-control-allow-credentials: true; access-control-expose-headers: Link, X-Total-Results, X-UniProt-Release, X-UniProt-Release-Date, X-API-Deployment-Date; x-api-deployment-date: 15-October-2025; strict-transport-security: max-age=31536000; includeSubDomains; date: Thu, 30 Oct 2025 23:24:49 GMT; access-control-max-age: 1728000; x-uniprot-release: 2025_04; access-control-allow-origin: *; accept-ranges: bytes; access-control-allow-methods: GET, PUT, POST, DELETE, PATCH, OPTIONS; access-control-allow-headers: DNT,Keep-Alive,User-Agent,X-Requested-With,If-Modified-Since,Cache-Control,Content-Type,Range,Authorization; x-uniprot-release-date: 15-October-2025
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/43ea5f2cdaa9ac7e0e114371af97235cdddd776f-1.rds`.
[2025-10-30 19:24:55] [INFO]    [OmnipathR] Download ready [key=43ea5f2cdaa9ac7e0e114371af97235cdddd776f, version=1]
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:55] [INFO]    [OmnipathR] Cache item `43ea5f2cdaa9ac7e0e114371af97235cdddd776f` version 1: status changed from `started` to `ready`.
[2025-10-30 19:24:55] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 17240 records
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Translating complexes: 0 complexes in data.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Translated 0 complexes to 0.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] 13774 rows before translation, 13773 uniprot_entry IDs in column `id_organism_b`.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] 13774 rows after translation; translated 13253 `uniprot_entry` IDs in column `id_organism_b` to 13253 `uniprot` IDs in column `id_organism_b`.
[2025-10-30 19:24:55] [INFO]    [OmnipathR] Loaded database `Orthologous Matrix (OMA) gene pairs`.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] ID translation table: from `uniprot` to `genesymbol`, using `uniprot`.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Creating ID mapping table from `accession` to `gene_primary`, for organism 10090 (only reviewed: TRUE)
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Loading all UniProt records for organism 10090 (only reviewed: TRUE); fields: accession,gene_primary
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Downloading by `generic_downloader`.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Looking up in cache: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`.
[2025-10-30 19:24:55] [INFO]    [OmnipathR] Cache record does not exist: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Could not find in cache, initiating download: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:24:55] [INFO]    [OmnipathR] Cache item `3ec84ba713c02573704adb50f1a94dab684df34b` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/3ec84ba713c02573704adb50f1a94dab684df34b-1.rds`.
[2025-10-30 19:24:55] [INFO]    [OmnipathR] Retrieving URL: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Attempt 1/3: `https://rest.uniprot.org/uniprotkb/stream?format=tsv&fields=accession,gene_primary&query=organism_id:10090%20AND%20reviewed:true`
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:24:55] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:24:56] [TRACE]   [OmnipathR] HTTP v2 GET: status 200.
[2025-10-30 19:24:56] [TRACE]   [OmnipathR] Downloaded 43 bytes in 0.526853s from rest.uniprot.org (81 bytes/s); Redirect: 0s, DNS look up: 0.000846s, Connection: 0.009466s, Pretransfer: 0.250355s, First byte at: 0.526764s
[2025-10-30 19:24:56] [TRACE]   [OmnipathR] HTTP headers: HTTP/2 200 ; vary: accept,accept-encoding,x-uniprot-release,x-api-deployment-date, User-Agent, Accept-Encoding; cache-control: public, max-age=43200; content-type: text/plain;format=tsv; content-encoding: gzip; access-control-allow-credentials: true; access-control-expose-headers: Link, X-Total-Results, X-UniProt-Release, X-UniProt-Release-Date, X-API-Deployment-Date; x-api-deployment-date: 15-October-2025; strict-transport-security: max-age=31536000; includeSubDomains; date: Thu, 30 Oct 2025 23:24:56 GMT; access-control-max-age: 1728000; x-uniprot-release: 2025_04; access-control-allow-origin: *; accept-ranges: bytes; access-control-allow-methods: GET, PUT, POST, DELETE, PATCH, OPTIONS; access-control-allow-headers: DNT,Keep-Alive,User-Agent,X-Requested-With,If-Modified-Since,Cache-Control,Content-Type,Range,Authorization; x-uniprot-release-date: 15-October-2025
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/3ec84ba713c02573704adb50f1a94dab684df34b-1.rds`.
[2025-10-30 19:25:01] [INFO]    [OmnipathR] Download ready [key=3ec84ba713c02573704adb50f1a94dab684df34b, version=1]
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:01] [INFO]    [OmnipathR] Cache item `3ec84ba713c02573704adb50f1a94dab684df34b` version 1: status changed from `started` to `ready`.
[2025-10-30 19:25:01] [SUCCESS] [OmnipathR] UniProt (rest.uniprot.org): downloaded 17240 records
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Translating complexes: 0 complexes in data.
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] 0 complexes after removing the ones mapping to more than 1 items in target identifier space.
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Translated 0 complexes to 0.
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] 163908 rows before translation, 12855 uniprot IDs in column `uniprot`.
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] 163908 rows after translation; translated 12855 `uniprot` IDs in column `uniprot` to 12769 `genesymbol` IDs in column `genesymbol`.
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B,C,D],genesymbols=TRUE,organisms=9606,query_type=interactions,datasets=dorothea]
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:01] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:01] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:01] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:25:01] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:25:02] [TRACE]   [OmnipathR] HTTP v1 GET: status 200.
[2025-10-30 19:25:02] [TRACE]   [OmnipathR] Downloaded 15.7 Kb in 0.296346s from omnipathdb.org (52.9 Kb/s); Redirect: 0s, DNS look up: 0.000816s, Connection: 0.001745s, Pretransfer: 0.146467s, First byte at: 0.296132s
[2025-10-30 19:25:02] [TRACE]   [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Thu, 30 Oct 2025 23:25:02 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 31 Oct 2025 00:25:02 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-10-30 19:25:05] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=9606&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:05] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:05] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:05] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:05] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:05] [INFO]    [OmnipathR] Cache item `46d37339bbc3f9a05bb89ccb79278cf1233f5cdf` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:25:05] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/46d37339bbc3f9a05bb89ccb79278cf1233f5cdf-1.rds`.
[2025-10-30 19:25:06] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/46d37339bbc3f9a05bb89ccb79278cf1233f5cdf-1.rds`.
[2025-10-30 19:25:06] [INFO]    [OmnipathR] Download ready [key=46d37339bbc3f9a05bb89ccb79278cf1233f5cdf, version=1]
[2025-10-30 19:25:06] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:06] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:06] [INFO]    [OmnipathR] Cache item `46d37339bbc3f9a05bb89ccb79278cf1233f5cdf` version 1: status changed from `started` to `ready`.
[2025-10-30 19:25:10] [SUCCESS] [OmnipathR] Downloaded 278677 interactions.
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Arguments for OmniPath query: [dorothea_levels=[A,B,C,D],genesymbols=TRUE,organisms=10090,query_type=interactions,datasets=dorothea]
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Organism(s): 10090
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:16] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:16] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:16] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:25:16] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:25:17] [TRACE]   [OmnipathR] HTTP v1 GET: status 200.
[2025-10-30 19:25:17] [TRACE]   [OmnipathR] Downloaded 15.7 Kb in 0.433405s from omnipathdb.org (36.1 Kb/s); Redirect: 0s, DNS look up: 0.000919s, Connection: 0.001699s, Pretransfer: 0.288503s, First byte at: 0.429338s
[2025-10-30 19:25:17] [TRACE]   [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Thu, 30 Oct 2025 23:25:17 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 31 Oct 2025 00:25:17 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-10-30 19:25:20] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=dorothea&organisms=10090&dorothea_levels=A,B,C,D&fields=sources,references,curation_effort,dorothea_level&license=academic`
[2025-10-30 19:25:20] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:20] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:20] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:20] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:20] [INFO]    [OmnipathR] Cache item `ff347dedf78ef5e38c9c6d8eed291fa901aa3791` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:25:20] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/ff347dedf78ef5e38c9c6d8eed291fa901aa3791-1.rds`.
[2025-10-30 19:25:21] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/ff347dedf78ef5e38c9c6d8eed291fa901aa3791-1.rds`.
[2025-10-30 19:25:21] [INFO]    [OmnipathR] Download ready [key=ff347dedf78ef5e38c9c6d8eed291fa901aa3791, version=1]
[2025-10-30 19:25:21] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:21] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:21] [INFO]    [OmnipathR] Cache item `ff347dedf78ef5e38c9c6d8eed291fa901aa3791` version 1: status changed from `started` to `ready`.
[2025-10-30 19:25:27] [SUCCESS] [OmnipathR] Downloaded 249440 interactions.
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Arguments for OmniPath query: [loops=TRUE,organisms=9606,genesymbols=TRUE,query_type=interactions,datasets=collectri]
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:30] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:30] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:30] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] HTTP v1 GET: status 200.
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] Downloaded 15.7 Kb in 0.298565s from omnipathdb.org (52.5 Kb/s); Redirect: 0s, DNS look up: 0.008119s, Connection: 0.010395s, Pretransfer: 0.154763s, First byte at: 0.297737s
[2025-10-30 19:25:30] [TRACE]   [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Thu, 30 Oct 2025 23:25:30 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 31 Oct 2025 00:25:30 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-10-30 19:25:33] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:33] [INFO]    [OmnipathR] Cache item `b10176737ba43d460b13709623189f3911123779` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-10-30 19:25:33] [INFO]    [OmnipathR] Download ready [key=b10176737ba43d460b13709623189f3911123779, version=1]
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:33] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:33] [INFO]    [OmnipathR] Cache item `b10176737ba43d460b13709623189f3911123779` version 1: status changed from `started` to `ready`.
[2025-10-30 19:25:34] [SUCCESS] [OmnipathR] Downloaded 64979 interactions.
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Arguments for OmniPath query: [genesymbols=TRUE,resources=CollecTRI,strict_evidences=TRUE,query_type=interactions,datasets=tf_mirna]
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:34] [INFO]    [OmnipathR] Cache record does not exist: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Looking up in cache: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:34] [INFO]    [OmnipathR] Cache record does not exist: `http://no-tls.omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Attempting `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:34] [INFO]    [OmnipathR] Retrieving URL: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Attempt 1/3: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] HTTP request by `omnipath_curl`.
[2025-10-30 19:25:34] [TRACE]   [OmnipathR] Curl options: [connecttimeout=10,timeout=300,debugfunction=<function>,verbose=FALSE,tcp_keepalive=TRUE,tcp_keepintvl=10,tcp_keepidle=10,tcp_keepcnt=13,upkeep_interval_ms=30000,ssl_verifypeer=1,ssl_verifyhost=2]
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] HTTP v1 GET: status 200.
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Downloaded 9 Kb in 0.238706s from omnipathdb.org (37.9 Kb/s); Redirect: 0s, DNS look up: 0.000797s, Connection: 0.004711s, Pretransfer: 0.156766s, First byte at: 0.234092s
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] HTTP headers: HTTP/1.1 200 OK; Server: nginx; Date: Thu, 30 Oct 2025 23:25:34 GMT; Content-Type: text/plain; charset=utf-8; Transfer-Encoding: chunked; Connection: keep-alive; Cache-Control: max-age=3600; Access-Control-Allow-Origin: *; Expires: Fri, 31 Oct 2025 00:25:34 GMT; Cache-Control: public; X-Frame-Options: DENY; Content-Encoding: gzip
[2025-10-30 19:25:35] [INFO]    [OmnipathR] Successfully retrieved: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:35] [INFO]    [OmnipathR] Cache item `f7d34500401ba98803b7d2b26c48f64cee1eea1b` version 1: status changed from `unknown` to `started`.
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Exporting object to RDS: `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Exported RDS to `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-10-30 19:25:35] [INFO]    [OmnipathR] Download ready [key=f7d34500401ba98803b7d2b26c48f64cee1eea1b, version=1]
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Reading JSON from `/Users/biocbuild/Library/Caches/OmnipathR/cache.json` (encoding: UTF-8).
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:35] [INFO]    [OmnipathR] Cache item `f7d34500401ba98803b7d2b26c48f64cee1eea1b` version 1: status changed from `started` to `ready`.
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Converting JSON column `evidences` to list.
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Restricting interaction records to datasets: tf_mirna; and resources: CollecTRI
[2025-10-30 19:25:35] [TRACE]   [OmnipathR] Filtering evidence columns: positive, negative, directed, undirected; to datasets: tf_mirna; and resources: CollecTRI; excluding resources: none
[2025-10-30 19:25:36] [SUCCESS] [OmnipathR] Downloaded 207 interactions.
[2025-10-30 19:25:36] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:25:36] [TRACE]   [OmnipathR] Arguments for OmniPath query: [loops=TRUE,organisms=9606,genesymbols=TRUE,query_type=interactions,datasets=collectri]
[2025-10-30 19:25:36] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:25:36] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:25:36] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:36] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/b10176737ba43d460b13709623189f3911123779-1.rds`.
[2025-10-30 19:25:36] [INFO]    [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&datasets=collectri&organisms=9606&fields=sources,references,curation_effort&loops=yes&license=academic`
[2025-10-30 19:25:38] [SUCCESS] [OmnipathR] Loaded 64979 interactions from cache.
[2025-10-30 19:25:38] [TRACE]   [OmnipathR] Processing args for OmniPath query
[2025-10-30 19:25:38] [TRACE]   [OmnipathR] Arguments for OmniPath query: [genesymbols=TRUE,resources=CollecTRI,strict_evidences=TRUE,query_type=interactions,datasets=tf_mirna]
[2025-10-30 19:25:38] [TRACE]   [OmnipathR] Organism(s): 9606
[2025-10-30 19:25:38] [TRACE]   [OmnipathR] Orthology targets: 
[2025-10-30 19:25:38] [TRACE]   [OmnipathR] Reading JSON from `https://omnipathdb.org/resources` (encoding: UTF-8).
[2025-10-30 19:25:39] [TRACE]   [OmnipathR] JSON validation successful: TRUE
[2025-10-30 19:25:39] [TRACE]   [OmnipathR] Looking up in cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:39] [TRACE]   [OmnipathR] Loaded data from RDS `/Users/biocbuild/Library/Caches/OmnipathR/f7d34500401ba98803b7d2b26c48f64cee1eea1b-1.rds`.
[2025-10-30 19:25:39] [INFO]    [OmnipathR] Loaded from cache: `https://omnipathdb.org/interactions?genesymbols=yes&resources=CollecTRI&datasets=tf_mirna&organisms=9606&fields=evidences,sources,references,curation_effort&license=academic`
[2025-10-30 19:25:39] [TRACE]   [OmnipathR] Converting JSON column `evidences` to list.
[2025-10-30 19:25:39] [TRACE]   [OmnipathR] Restricting interaction records to datasets: tf_mirna; and resources: CollecTRI
[2025-10-30 19:25:39] [TRACE]   [OmnipathR] Filtering evidence columns: positive, negative, directed, undirected; to datasets: tf_mirna; and resources: CollecTRI; excluding resources: none
[2025-10-30 19:25:39] [SUCCESS] [OmnipathR] Loaded 207 interactions from cache.
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
  |                                                                            
  |                                                                      |   0%
  |                                                                            
  |===================================                                   |  50%
  |                                                                            
  |======================================================================| 100%
Attaching package: 'dplyr'
The following object is masked from 'package:testthat':
    matches
The following objects are masked from 'package:stats':
    filter, lag
The following objects are masked from 'package:base':
    intersect, setdiff, setequal, union
[ FAIL 1 | WARN 18 | SKIP 0 | PASS 34 ]
══ Failed tests ════════════════════════════════════════════════════════════════
── Failure ('test-statistic-fgsea.R:26:3'): test run_fgsea ─────────────────────
`res_1` (`actual`) not equal to `exp_1` (`expected`).
actual vs expected
                      p_value
  actual[1, ]     0.075479709
  actual[2, ]     0.075479709
- actual[3, ]     0.511687342
+ expected[3, ]   0.548454870
- actual[4, ]     0.511687342
+ expected[4, ]   0.548454870
  actual[5, ]     0.010000000
  actual[6, ]     0.010000000
  actual[7, ]     0.076411558
actual vs expected
                      p_value
  actual[12, ]    0.010000000
  actual[13, ]    0.114238030
  actual[14, ]    0.114238030
- actual[15, ]    0.510665738
+ expected[15, ]  0.522337972
- actual[16, ]    0.510665738
+ expected[16, ]  0.522337972
  actual[17, ]    0.010000000
  actual[18, ]    0.010000000
  actual[19, ]    0.004682543
  actual[20, ]    0.004682543
- actual[21, ]    0.219233595
+ expected[21, ]  0.294730294
and 10 more ...
actual vs expected
                      p_value
  actual[34, ]    1.000000000
  actual[35, ]    0.010000000
  actual[36, ]    0.010000000
- actual[37, ]    0.091542106
+ expected[37, ]  0.103646587
- actual[38, ]    0.091542106
+ expected[38, ]  0.103646587
  actual[39, ]    0.592371428
  actual[40, ]    0.592371428
  actual[41, ]    0.010000000
actual vs expected
                      p_value
  actual[52, ]    0.976649086
  actual[53, ]    0.010000000
  actual[54, ]    0.010000000
- actual[55, ]    0.066624941
+ expected[55, ]  0.076411558
- actual[56, ]    0.066624941
+ expected[56, ]  0.076411558
  actual[57, ]    0.592371428
  actual[58, ]    0.592371428
  actual[59, ]    0.010000000
  actual[60, ]    0.010000000
- actual[61, ]    0.111211902
+ expected[61, ]  0.108185775
and 4 more ...
actual vs expected
                      p_value
  actual[70, ]    1.000000000
  actual[71, ]    0.010000000
  actual[72, ]    0.010000000
- actual[73, ]    0.256981914
+ expected[73, ]  0.469812943
- actual[74, ]    0.256981914
+ expected[74, ]  0.469812943
- actual[75, ]    0.133907888
+ expected[75, ]  0.132394821
- actual[76, ]    0.133907888
+ expected[76, ]  0.132394821
  actual[77, ]    0.123204721
  actual[78, ]    0.123204721
- actual[79, ]    0.146641013
+ expected[79, ]  0.207618744
and 4 more ...
actual vs expected
                      p_value
  actual[88, ]    0.177906190
  actual[89, ]    0.154281338
  actual[90, ]    0.154281338
- actual[91, ]    0.434796297
+ expected[91, ]  0.487321278
- actual[92, ]    0.434796297
+ expected[92, ]  0.487321278
  actual[93, ]    0.009411332
  actual[94, ]    0.009411332
  actual[95, ]    0.005020222
  actual[96, ]    0.005020222
- actual[97, ]    0.294730294
+ expected[97, ]  0.493157392
and 16 more ...
actual vs expected
                      p_value
  actual[118, ]   0.126342554
  actual[119, ]   0.111593916
  actual[120, ]   0.111593916
- actual[121, ]   0.991185346
+ expected[121, ] 1.000000000
- actual[122, ]   0.991185346
+ expected[122, ] 1.000000000
- actual[123, ]   0.123316421
+ expected[123, ] 0.126342554
- actual[124, ]   0.123316421
+ expected[124, ] 0.126342554
  actual[125, ]   0.155922629
  actual[126, ]   0.155922629
  actual[127, ]   0.592371428
actual vs expected
                      p_value
  actual[132, ]   0.124515409
  actual[133, ]   0.592371428
  actual[134, ]   0.592371428
- actual[135, ]   0.174865133
+ expected[135, ] 0.183988307
- actual[136, ]   0.174865133
+ expected[136, ] 0.183988307
  actual[137, ]   0.198360798
  actual[138, ]   0.198360798
  actual[139, ]   0.592371428
  `actual$p_value[1:7]`: 0.075 0.075 0.512 0.512 0.010 0.010 0.076
`expected$p_value[1:7]`: 0.075 0.075 0.548 0.548 0.010 0.010 0.076
     actual$p_value | expected$p_value                
[12] 0.010          | 0.010            [12]           
[13] 0.114          | 0.114            [13]           
[14] 0.114          | 0.114            [14]           
[15] 0.511          - 0.522            [15]           
[16] 0.511          - 0.522            [16]           
[17] 0.010          | 0.010            [17]           
[18] 0.010          | 0.010            [18]           
[19] 0.005          | 0.005            [19]           
[20] 0.005          | 0.005            [20]           
[21] 0.219          - 0.295            [21]           
 ... ...              ...              and 10 more ...
  `actual$p_value[34:41]`: 1.000 0.010 0.010 0.092 0.092 0.592 0.592 0.010
`expected$p_value[34:41]`: 1.000 0.010 0.010 0.104 0.104 0.592 0.592 0.010
     actual$p_value | expected$p_value               
[52] 0.977          | 0.977            [52]          
[53] 0.010          | 0.010            [53]          
[54] 0.010          | 0.010            [54]          
[55] 0.067          - 0.076            [55]          
[56] 0.067          - 0.076            [56]          
[57] 0.592          | 0.592            [57]          
[58] 0.592          | 0.592            [58]          
[59] 0.010          | 0.010            [59]          
[60] 0.010          | 0.010            [60]          
[61] 0.111          - 0.108            [61]          
 ... ...              ...              and 4 more ...
     actual$p_value | expected$p_value               
[70] 1.000          | 1.000            [70]          
[71] 0.010          | 0.010            [71]          
[72] 0.010          | 0.010            [72]          
[73] 0.257          - 0.470            [73]          
[74] 0.257          - 0.470            [74]          
[75] 0.134          - 0.132            [75]          
[76] 0.134          - 0.132            [76]          
[77] 0.123          | 0.123            [77]          
[78] 0.123          | 0.123            [78]          
[79] 0.147          - 0.208            [79]          
 ... ...              ...              and 4 more ...
     actual$p_value | expected$p_value                
[88] 0.178          | 0.178            [88]           
[89] 0.154          | 0.154            [89]           
[90] 0.154          | 0.154            [90]           
[91] 0.435          - 0.487            [91]           
[92] 0.435          - 0.487            [92]           
[93] 0.009          | 0.009            [93]           
[94] 0.009          | 0.009            [94]           
[95] 0.005          | 0.005            [95]           
[96] 0.005          | 0.005            [96]           
[97] 0.295          - 0.493            [97]           
 ... ...              ...              and 16 more ...
      actual$p_value | expected$p_value      
[118] 0.126          | 0.126            [118]
[119] 0.112          | 0.112            [119]
[120] 0.112          | 0.112            [120]
[121] 0.991          - 1.000            [121]
[122] 0.991          - 1.000            [122]
[123] 0.123          - 0.126            [123]
[124] 0.123          - 0.126            [124]
[125] 0.156          | 0.156            [125]
[126] 0.156          | 0.156            [126]
[127] 0.592          | 0.592            [127]
  `actual$p_value[132:139]`: 0.125 0.592 0.592 0.175 0.175 0.198 0.198 0.592
`expected$p_value[132:139]`: 0.125 0.592 0.592 0.184 0.184 0.198 0.198 0.592
[ FAIL 1 | WARN 18 | SKIP 0 | PASS 34 ]
Error: Test failures
Execution halted
decoupleR.Rcheck/decoupleR-Ex.timings
| name | user | system | elapsed | |
| check_corr | 0.031 | 0.004 | 0.035 | |
| convert_f_defaults | 0.009 | 0.001 | 0.011 | |
| decouple | 0 | 0 | 0 | |
| dot-fit_preprocessing | 0.009 | 0.001 | 0.010 | |
| extract_sets | 0.007 | 0.000 | 0.007 | |
| filt_minsize | 0.012 | 0.000 | 0.011 | |
| get_collectri | 9.396 | 1.263 | 19.231 | |
| get_dorothea | 7.924 | 0.560 | 13.867 | |
| get_profile_of | 0.000 | 0.000 | 0.001 | |
| get_progeny | 3.048 | 0.220 | 10.910 | |
| get_resource | 0.393 | 0.043 | 2.141 | |
| get_toy_data | 0.001 | 0.000 | 0.001 | |
| intersect_regulons | 0.009 | 0.004 | 0.033 | |
| pipe | 0.000 | 0.001 | 0.000 | |
| pivot_wider_profile | 0 | 0 | 0 | |
| randomize_matrix | 0 | 0 | 0 | |
| rename_net | 0.013 | 0.004 | 0.026 | |
| run_aucell | 3.905 | 1.715 | 7.980 | |
| run_consensus | 0.641 | 0.224 | 1.146 | |
| run_fgsea | 10.717 | 0.601 | 14.359 | |
| run_gsva | 0.890 | 0.447 | 6.022 | |
| run_mdt | 0.058 | 0.021 | 0.230 | |
| run_mlm | 0.034 | 0.007 | 0.084 | |
| run_ora | 0.162 | 0.042 | 0.253 | |
| run_udt | 0.091 | 0.024 | 0.129 | |
| run_ulm | 0.026 | 0.009 | 0.047 | |
| run_viper | 0.332 | 0.206 | 0.816 | |
| run_wmean | 0.217 | 0.035 | 0.282 | |
| run_wsum | 0.256 | 0.040 | 0.505 | |
| show_methods | 0.019 | 0.005 | 0.046 | |
| show_resources | 0.024 | 0.004 | 0.553 | |
| tidyeval | 0 | 0 | 0 | |