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This page was generated on 2025-11-18 11:39 -0500 (Tue, 18 Nov 2025).

HostnameOSArch (*)R versionInstalled pkgs
nebbiolo1Linux (Ubuntu 24.04.3 LTS)x86_64R Under development (unstable) (2025-10-20 r88955) -- "Unsuffered Consequences" 4826
lconwaymacOS 12.7.6 Montereyx86_64R Under development (unstable) (2025-10-21 r88958) -- "Unsuffered Consequences" 4561
kjohnson3macOS 13.7.7 Venturaarm64R Under development (unstable) (2025-11-04 r88984) -- "Unsuffered Consequences" 4562
Click on any hostname to see more info about the system (e.g. compilers)      (*) as reported by 'uname -p', except on Windows and Mac OS X

Package 1108/2325HostnameOS / ArchINSTALLBUILDCHECKBUILD BIN
LACHESIS 0.99.4  (landing page)
Verena Körber
Snapshot Date: 2025-11-17 13:40 -0500 (Mon, 17 Nov 2025)
git_url: https://git.bioconductor.org/packages/LACHESIS
git_branch: devel
git_last_commit: 0cbd1e4
git_last_commit_date: 2025-11-03 10:21:55 -0500 (Mon, 03 Nov 2025)
nebbiolo1Linux (Ubuntu 24.04.3 LTS) / x86_64  OK    OK    OK  UNNEEDED, same version is already published
lconwaymacOS 12.7.6 Monterey / x86_64  OK    OK    OK    OK  YES
kjohnson3macOS 13.7.7 Ventura / arm64  OK    OK    OK    OK  UNNEEDED, same version is already published


CHECK results for LACHESIS on lconway

To the developers/maintainers of the LACHESIS package:
- Allow up to 24 hours (and sometimes 48 hours) for your latest push to git@git.bioconductor.org:packages/LACHESIS.git to reflect on this report. See Troubleshooting Build Report for more information.
- Use the following Renviron settings to reproduce errors and warnings.
- If 'R CMD check' started to fail recently on the Linux builder(s) over a missing dependency, add the missing dependency to 'Suggests:' in your DESCRIPTION file. See Renviron.bioc for more information.

raw results


Summary

Package: LACHESIS
Version: 0.99.4
Command: /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:LACHESIS.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings LACHESIS_0.99.4.tar.gz
StartedAt: 2025-11-18 03:10:09 -0500 (Tue, 18 Nov 2025)
EndedAt: 2025-11-18 03:20:09 -0500 (Tue, 18 Nov 2025)
EllapsedTime: 599.9 seconds
RetCode: 0
Status:   OK  
CheckDir: LACHESIS.Rcheck
Warnings: 0

Command output

##############################################################################
##############################################################################
###
### Running command:
###
###   /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:LACHESIS.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings LACHESIS_0.99.4.tar.gz
###
##############################################################################
##############################################################################


* using log directory ‘/Users/biocbuild/bbs-3.23-bioc/meat/LACHESIS.Rcheck’
* using R Under development (unstable) (2025-10-21 r88958)
* using platform: x86_64-apple-darwin20
* R was compiled by
    Apple clang version 14.0.0 (clang-1400.0.29.202)
    GNU Fortran (GCC) 14.2.0
* running under: macOS Ventura 13.7.8
* using session charset: UTF-8
* using option ‘--no-vignettes’
* checking for file ‘LACHESIS/DESCRIPTION’ ... OK
* this is package ‘LACHESIS’ version ‘0.99.4’
* package encoding: UTF-8
* checking package namespace information ... OK
* checking package dependencies ... OK
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking for sufficient/correct file permissions ... OK
* checking whether package ‘LACHESIS’ can be installed ... OK
* checking installed package size ... INFO
  installed size is  8.8Mb
  sub-directories of 1Mb or more:
    extdata   8.5Mb
* checking package directory ... OK
* checking ‘build’ directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking code files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... OK
* checking whether the package can be loaded with stated dependencies ... OK
* checking whether the package can be unloaded cleanly ... OK
* checking whether the namespace can be loaded with stated dependencies ... OK
* checking whether the namespace can be unloaded cleanly ... OK
* checking dependencies in R code ... OK
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... OK
* checking Rd files ... OK
* checking Rd metadata ... OK
* checking Rd cross-references ... OK
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking files in ‘vignettes’ ... OK
* checking examples ... OK
Examples with CPU (user + system) or elapsed time > 5s
                           user system elapsed
LACHESIS                 30.614  0.456  31.397
plotNB                   16.772  0.300  17.135
plotLachesis             14.874  0.225  15.202
plotClinicalCorrelations 13.867  0.280  14.180
plotSurvival             13.725  0.138  13.947
estimateClonality        13.416  0.389  13.865
classifyLACHESIS         13.328  0.203  13.621
plotClonality            13.013  0.241  13.330
nbImport                  6.772  0.317   7.108
* checking for unstated dependencies in ‘tests’ ... OK
* checking tests ...
  Running ‘tinytest.R’
 OK
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE

Status: OK


Installation output

LACHESIS.Rcheck/00install.out

##############################################################################
##############################################################################
###
### Running command:
###
###   /Library/Frameworks/R.framework/Resources/bin/R CMD INSTALL LACHESIS
###
##############################################################################
##############################################################################


* installing to library ‘/Library/Frameworks/R.framework/Versions/4.6-x86_64/Resources/library’
* installing *source* package ‘LACHESIS’ ...
** this is package ‘LACHESIS’ version ‘0.99.4’
** using staged installation
** R
** inst
** byte-compile and prepare package for lazy loading
** help
*** installing help indices
*** copying figures
** building package indices
** installing vignettes
** testing if installed package can be loaded from temporary location
** testing if installed package can be loaded from final location
** testing if installed package keeps a record of temporary installation path
* DONE (LACHESIS)

Tests output

LACHESIS.Rcheck/tests/tinytest.Rout


R Under development (unstable) (2025-10-21 r88958) -- "Unsuffered Consequences"
Copyright (C) 2025 The R Foundation for Statistical Computing
Platform: x86_64-apple-darwin20

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> if (requireNamespace("tinytest", quietly = TRUE)) {
+     tinytest::test_package("LACHESIS")
+ }

test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    
test_examples.R...............    0 tests    Computing SNV density for sample NBE11
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Filtering 3 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 25 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 1 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 24 segments with copy number information on 22 chromosomes.
Total copy number computed as A + B.
Read in 690 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 254 segments with copy number > 4...
Change chromosome names to 1, 2, 3, ...
Removing 4 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 44 segments with copy number information on 21 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Assuming sample_tumor_XI003_10023 as tumor
Importing VCF..
Total variants         : 167
Variants passing filter: 167
Bi-allelic variants    : 142
single nucl. variants  : 47
Primary contig vars.   : 47
Autosomal variants     : 11
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..

test_examples.R...............   30 tests OK 30.7s

test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    
test_integration.R............    0 tests    Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 25 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 1 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 24 segments with copy number information on 22 chromosomes.
Total copy number computed as A + B.
Read in 690 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 254 segments with copy number > 4...
Change chromosome names to 1, 2, 3, ...
Removing 4 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 44 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming sample_tumor_XI003_10023 as tumor
Importing VCF..
Total variants         : 167
Variants passing filter: 167
Bi-allelic variants    : 142
single nucl. variants  : 47
Primary contig vars.   : 47
Autosomal variants     : 11
Filtering for min.depth and VAF..
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Assuming NBE11 as tumor
Primary contig vars.   : 4827
Autosomal variants     : 4718
Filtering for min.depth and VAF..
Filtering 5 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Total copy number computed as A + B.
Read in 160 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 69 segments with copy number information on 22 chromosomes.
Assuming NBE26 as tumor
Primary contig vars.   : 308
Autosomal variants     : 298
Filtering for min.depth and VAF..
Filtering 0 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Filtering 1 segments below the minimal segment size and 0 segments on excluded chromosomes.
Computing mutation density at MRCA...
Computing mutation densities at ECA...
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Signature methods test skipped due to: some columns are not in the data.table: [chrom, TCN, A, B]

test_integration.R............   34 tests OK 1.2s

test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    
test_nbImport.R...............    0 tests    Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Assuming NBE11 as tumor
Primary contig vars.   : 4827
Autosomal variants     : 4718
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..

test_nbImport.R...............   33 tests OK 39.9s

test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    
test_parameter_validation.R...    0 tests    Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming sample_tumor_XI003_10023 as tumor
Importing VCF..
Total variants         : 167
Variants passing filter: 167
Bi-allelic variants    : 142
single nucl. variants  : 47
Primary contig vars.   : 47
Autosomal variants     : 11
Filtering for min.depth and VAF..
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..

test_parameter_validation.R...   34 tests OK 29.1s

test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    
test_readCNV.R................    0 tests    Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 25 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 1 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 24 segments with copy number information on 22 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 25 segments with copy number > 3...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 98 segments with copy number information on 20 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 5...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 123 segments with copy number information on 22 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 121 segments with copy number information on 22 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 487 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 81 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 25 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 1 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 24 segments with copy number information on 22 chromosomes.
Total copy number computed as A + B.
Read in 690 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 254 segments with copy number > 4...
Change chromosome names to 1, 2, 3, ...
Removing 4 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 44 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.
Total copy number computed as A + B.
Read in 721 segments with copy number information on 23 chromosomes.
Removing 0 segments without copy number information...
Removing 8 segments with copy number > 4...
Removing 9 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 116 segments with copy number information on 21 chromosomes.

test_readCNV.R................   24 tests OK 0.2s

test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    
test_readVCF.R................    0 tests    Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming sample_tumor_XI003_10023 as tumor
Importing VCF..
Total variants         : 167
Variants passing filter: 167
Bi-allelic variants    : 142
single nucl. variants  : 47
Primary contig vars.   : 47
Autosomal variants     : 11
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..
Assuming TUMOR as tumor
Importing VCF..
Total variants         : 4819
Variants passing filter: 4819
Bi-allelic variants    : 4819
single nucl. variants  : 4819
Primary contig vars.   : 4819
Autosomal variants     : 4819
Filtering for min.depth and VAF..

test_readVCF.R................   20 tests OK 3.5s

test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    
test_signature_assignment.R...    0 tests    Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..
Total copy number computed as A + B.
Read in 1770 segments with copy number information on 24 chromosomes.
Removing 0 segments without copy number information...
Removing 0 segments with copy number > 4...
Removing 0 segments on allosomes...
Removing 0 segments without B allele information...
Merging adjacent segments with equal copy number...
Retaining 241 segments with copy number information on 22 chromosomes.
Assuming NBE15 as tumor
Primary contig vars.   : 2701
Autosomal variants     : 2631
Filtering for min.depth and VAF..

test_signature_assignment.R...   22 tests OK 45.3s
All ok, 197 results (3m 38.3s)
There were 50 or more warnings (use warnings() to see the first 50)
> 
> proc.time()
   user  system elapsed 
216.592   5.207 222.975 

Example timings

LACHESIS.Rcheck/LACHESIS-Ex.timings

nameusersystemelapsed
LACHESIS30.614 0.45631.397
MRCA4.2850.0614.379
classifyLACHESIS13.328 0.20313.621
clonalMutationCounter3.2430.0243.285
estimateClonality13.416 0.38913.865
nbImport6.7720.3177.108
normalizeCounts3.3750.0383.427
plotClinicalCorrelations13.867 0.28014.180
plotClonality13.013 0.24113.330
plotLachesis14.874 0.22515.202
plotMutationDensities3.6590.0173.683
plotNB16.772 0.30017.135
plotSurvival13.725 0.13813.947
plotVAFdistr0.2080.0100.220
readCNV0.0500.0040.056
readVCF2.3840.0442.439