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### Running command:
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### /home/biocbuild/bbs-3.20-bioc/R/bin/R CMD build --keep-empty-dirs --no-resave-data --md5 pairkat
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* checking for file ‘pairkat/DESCRIPTION’ ... OK
* preparing ‘pairkat’:
* checking DESCRIPTION meta-information ... OK
* installing the package to build vignettes
* creating vignettes ... ERROR
--- re-building ‘using-pairkat.Rmd’ using rmarkdown
Quitting from using-pairkat.Rmd:236-243 [unnamed-chunk-8]
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<error/rlang_error>
Error in `if (.self$lastField == "REFERENCE") ...`:
! missing value where TRUE/FALSE needed
---
Backtrace:
▆
1. └─pairkat::GatherNetworks(...)
2. └─pairkat:::pathList(...)
3. └─KEGGREST::keggGet(getPaths)
4. └─KEGGREST:::.getUrl(url, .flatFileParser)
5. ├─base::do.call(parser, list(content, ...))
6. └─KEGGREST (local) `<fn>`("ENTRY hsa00010 Pathway\nNAME Glycolysis / Gluconeogenesis - Homo sapiens (human)\nDESCRIPTION Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].\nCLASS Metabolism; Carbohydrate metabolism\nPATHWAY_MAP hsa00010 Glycolysis / Gluconeogenesis\nMODULE hsa_M00001 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate [PATH:hsa00010]\n hsa_M00002 Glycolysis, core module involving three-carbon compounds [PATH:hsa00010]\n hsa_M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:hsa00010]\n hsa_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00010]\nNETWORK nt06017 Glycogen metabolism\n ELEMENT N00731 Glycolysis\nDRUG D00123 Cyanamide (JP18)\n D00131 Disulfiram (JP18/USP/INN)\n D07257 Lonidamine (INN)\n D08970 Piragliatin (USAN)\n D11342 Dorzagliatin (USAN)\n D11408 Mitapivat sulfate (USAN)\n D12320 Cadisegliatin (USAN)\n D12362 Etavopivat (USAN/INN)\n D13032 Tebapivat (USAN/INN)\nDBLINKS GO: 0006096 0006094\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 10327 AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]\n 124 ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]\n 125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]\n 126 ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]\n 127 ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]\n 128 ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]\n 130 ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]\n 130589 GALM; galactose mutarotase [KO:K01785] [EC:5.1.3.3]\n 131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]\n 160287 LDHAL6A; lactate dehydrogenase A like 6A [KO:K00016] [EC:1.1.1.27]\n 1737 DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]\n 1738 DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]\n 2023 ENO1; enolase 1 [KO:K01689] [EC:4.2.1.11]\n 2026 ENO2; enolase 2 [KO:K01689] [EC:4.2.1.11]\n 2027 ENO3; enolase 3 [KO:K01689] [EC:4.2.1.11]\n 217 ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]\n 218 ALDH3A1; aldehyde dehydrogenase 3 family member A1 [KO:K00129] [EC:1.2.1.5]\n 219 ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]\n 2203 FBP1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]\n 221 ALDH3B1; aldehyde dehydrogenase 3 family member B1 [KO:K00129] [EC:1.2.1.5]\n 222 ALDH3B2; aldehyde dehydrogenase 3 family member B2 [KO:K00129] [EC:1.2.1.5]\n 223 ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]\n 224 ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]\n 226 ALDOA; aldolase, fructose-bisphosphate A [KO:K01623] [EC:4.1.2.13]\n 229 ALDOB; aldolase, fructose-bisphosphate B [KO:K01623] [EC:4.1.2.13]\n 230 ALDOC; aldolase, fructose-bisphosphate C [KO:K01623] [EC:4.1.2.13]\n 2538 G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]\n 2597 GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]\n 26330 GAPDHS; glyceraldehyde-3-phosphate dehydrogenase, spermatogenic [KO:K10705] [EC:1.2.1.12]\n 2645 GCK; glucokinase [KO:K12407] [EC:2.7.1.2]\n 2821 GPI; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]\n 3098 HK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]\n 3099 HK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]\n 3101 HK3; hexokinase 3 [KO:K00844] [EC:2.7.1.1]\n 387712 ENO4; enolase 4 [KO:K27394]\n 3939 LDHA; lactate dehydrogenase A [KO:K00016] [EC:1.1.1.27]\n 3945 LDHB; lactate dehydrogenase B [KO:K00016] [EC:1.1.1.27]\n 3948 LDHC; lactate dehydrogenase C [KO:K00016] [EC:1.1.1.27]\n 441531 PGAM4; phosphoglycerate mutase family member 4 [KO:K01834] [EC:5.4.2.11]\n 501 ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]\n 5105 PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]\n 5106 PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]\n 5160 PDHA1; pyruvate dehydrogenase E1 subunit alpha 1 [KO:K00161] [EC:1.2.4.1]\n 5161 PDHA2; pyruvate dehydrogenase E1 subunit alpha 2 [KO:K00161] [EC:1.2.4.1]\n 5162 PDHB; pyruvate dehydrogenase E1 subunit beta [KO:K00162] [EC:1.2.4.1]\n 5211 PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]\n 5213 PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]\n 5214 PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]\n 5223 PGAM1; phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]\n 5224 PGAM2; phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]\n 5230 PGK1; phosphoglycerate kinase 1 [KO:K00927] [EC:2.7.2.3]\n 5232 PGK2; phosphoglycerate kinase 2 [KO:K00927] [EC:2.7.2.3]\n 5236 PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]\n 5313 PKLR; pyruvate kinase L/R [KO:K12406] [EC:2.7.1.40]\n 5315 PKM; pyruvate kinase M1/2 [KO:K00873] [EC:2.7.1.40]\n 55276 PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]\n 55902 ACSS2; acyl-CoA synthetase short chain family member 2 [KO:K01895] [EC:6.2.1.1]\n 57818 G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]\n 669 BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]\n 7167 TPI1; triosephosphate isomerase 1 [KO:K01803] [EC:5.3.1.1]\n 80201 HKDC1; hexokinase domain containing 1 [KO:K00844] [EC:2.7.1.1]\n 83440 ADPGK; ADP dependent glucokinase [KO:K08074] [EC:2.7.1.147]\n 84532 ACSS1; acyl-CoA synthetase short chain family member 1 [KO:K01895] [EC:6.2.1.1]\n 8789 FBP2; fructose-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]\n 92483 LDHAL6B; lactate dehydrogenase A like 6B [KO:K00016] [EC:1.1.1.27]\n 92579 G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]\n 9562 MINPP1; multiple inositol-polyphosphate phosphatase 1 [KO:K03103] [EC:3.1.3.62 3.1.3.80]\nCOMPOUND C00022 Pyruvate\n C00024 Acetyl-CoA\n C00031 D-Glucose\n C00033 Acetate\n C00036 Oxaloacetate\n C00068 Thiamin diphosphate\n C00074 Phosphoenolpyruvate\n C00084 Acetaldehyde\n C00085 D-Fructose 6-phosphate\n C00103 D-Glucose 1-phosphate\n C00111 Glycerone phosphate\n C00118 D-Glyceraldehyde 3-phosphate\n C00186 (S)-Lactate\n C00197 3-Phospho-D-glycerate\n C00221 beta-D-Glucose\n C00236 3-Phospho-D-glyceroyl phosphate\n C00267 alpha-D-Glucose\n C00354 D-Fructose 1,6-bisphosphate\n C00469 Ethanol\n C00631 2-Phospho-D-glycerate\n C00668 alpha-D-Glucose 6-phosphate\n C01159 2,3-Bisphospho-D-glycerate\n C01172 beta-D-Glucose 6-phosphate\n C01451 Salicin\n C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate\n C06186 Arbutin\n C06187 Arbutin 6-phosphate\n C06188 Salicin 6-phosphate\n C15972 Enzyme N6-(lipoyl)lysine\n C15973 Enzyme N6-(dihydrolipoyl)lysine\n C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine\nREFERENCE \n AUTHORS Nishizuka Y (ed).\n TITLE [Metabolic Maps] (In Japanese)\n JOURNAL Tokyo Kagaku Dojin (1980)\nREFERENCE \n AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).\n TITLE [Cellular Functions and Metabolic Maps] (In Japanese)\n JOURNAL Tokyo Kagaku Dojin (1997)\nREFERENCE \n AUTHORS Michal G.\n TITLE Biochemical Pathways\n JOURNAL Wiley (1999)\nREL_PATHWAY hsa00020 Citrate cycle (TCA cycle)\n hsa00030 Pentose phosphate pathway\n hsa00500 Starch and sucrose metabolism\n hsa00620 Pyruvate metabolism\n hsa00640 Propanoate metabolism\nKO_PATHWAY ko00010\n///\n\nENTRY hsa00020 Pathway\nNAME Citrate cycle (TCA cycle) - Homo sapiens (human)\nDESCRIPTION The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].\nCLASS Metabolism; Carbohydrate metabolism\nPATHWAY_MAP hsa00020 Citrate cycle (TCA cycle)\nMODULE hsa_M00003 Gluconeogenesis, oxaloacetate => fructose-6P [PATH:hsa00020]\n hsa_M00009 Citrate cycle (TCA cycle, Krebs cycle) [PATH:hsa00020]\n hsa_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:hsa00020]\n hsa_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:hsa00020]\n hsa_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:hsa00020]\nNETWORK nt06024 Valine, leucine and isoleucine degradation\n nt06031 Citrate cycle and pyruvate metabolism\n nt06032 Lipoic acid metabolism\n ELEMENT N01603 Pyruvate oxidation\n N01604 Citrate cycle, first carbon oxidation\n N01609 Citrate cycle, second carbon oxidation 1\n N01616 Dihydrolipoamide dehydrogenase\n N01617 Citrate cycle, second carbon oxidation 2\nDRUG D10691 Bempedoic acid (JAN/USAN/INN)\n D11090 Ivosidenib (JAN/USAN/INN)\n D11834 Vorasidenib (USAN/INN)\n D11835 Vorasidenib citrate (USAN)\n D12483 Olutasidenib (USAN/INN)\n D12708 Crelosidenib (USAN)\n D12717 Crelosidenib gentisate (USAN)\nDBLINKS GO: 0006099\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 1431 CS; citrate synthase [KO:K01647] [EC:2.3.3.1]\n 1737 DLAT; dihydrolipoamide S-acetyltransferase [KO:K00627] [EC:2.3.1.12]\n 1738 DLD; dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]\n 1743 DLST; dihydrolipoamide S-succinyltransferase [KO:K00658] [EC:2.3.1.61]\n 2271 FH; fumarate hydratase [KO:K01679] [EC:4.2.1.2]\n 3417 IDH1; isocitrate dehydrogenase (NADP(+)) 1 [KO:K00031] [EC:1.1.1.42]\n 3418 IDH2; isocitrate dehydrogenase (NADP(+)) 2 [KO:K00031] [EC:1.1.1.42]\n 3419 IDH3A; isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha [KO:K00030] [EC:1.1.1.41]\n 3420 IDH3B; isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta [KO:K00030] [EC:1.1.1.41]\n 3421 IDH3G; isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma [KO:K00030] [EC:1.1.1.41]\n 4190 MDH1; malate dehydrogenase 1 [KO:K00025] [EC:1.1.1.37]\n 4191 MDH2; malate dehydrogenase 2 [KO:K00026] [EC:1.1.1.37]\n 47 ACLY; ATP citrate lyase [KO:K01648] [EC:2.3.3.8]\n 48 ACO1; aconitase 1 [KO:K01681] [EC:4.2.1.3]\n 4967 OGDH; oxoglutarate dehydrogenase [KO:K00164] [EC:1.2.4.2]\n 50 ACO2; aconitase 2 [KO:K01681] [EC:4.2.1.3]\n 5091 PC; pyruvate carboxylase [KO:K01958] [EC:6.4.1.1]\n 5105 PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]\n 5106 PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]\n 5160 PDHA1; pyruvate dehydrogenase E1 subunit alpha 1 [KO:K00161] [EC:1.2.4.1]\n 5161 PDHA2; pyruvate dehydrogenase E1 subunit alpha 2 [KO:K00161] [EC:1.2.4.1]\n 5162 PDHB; pyruvate dehydrogenase E1 subunit beta [KO:K00162] [EC:1.2.4.1]\n 55753 OGDHL; oxoglutarate dehydrogenase L [KO:K00164] [EC:1.2.4.2]\n 6389 SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]\n 6390 SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]\n 6391 SDHC; succinate dehydrogenase complex subunit C [KO:K00236]\n 6392 SDHD; succinate dehydrogenase complex subunit D [KO:K00237]\n 8801 SUCLG2; succinate-CoA ligase GDP-forming subunit beta [KO:K01900] [EC:6.2.1.4 6.2.1.5]\n 8802 SUCLG1; succinate-CoA ligase GDP/ADP-forming subunit alpha [KO:K01899] [EC:6.2.1.4 6.2.1.5]\n 8803 SUCLA2; succinate-CoA ligase ADP-forming subunit beta [KO:K01900] [EC:6.2.1.4 6.2.1.5]\nCOMPOUND C00022 Pyruvate\n C00024 Acetyl-CoA\n C00026 2-Oxoglutarate\n C00036 Oxaloacetate\n C00042 Succinate\n C00068 Thiamin diphosphate\n C00074 Phosphoenolpyruvate\n C00091 Succinyl-CoA\n C00122 Fumarate\n C00149 (S)-Malate\n C00158 Citrate\n C00311 Isocitrate\n C00417 cis-Aconitate\n C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate\n C05379 Oxalosuccinate\n C05381 3-Carboxy-1-hydroxypropyl-ThPP\n C15972 Enzyme N6-(lipoyl)lysine\n C15973 Enzyme N6-(dihydrolipoyl)lysine\n C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine\n C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine\nREFERENCE \n AUTHORS Nishizuka Y (ed).\n TITLE [Metabolic Maps] (In Japanese)\n JOURNAL Tokyo Kagaku Dojin (1980)\nREFERENCE \n AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).\n TITLE [Cellular Functions and Metabolic Maps] (In Japanese)\n JOURNAL Tokyo Kagaku Dojin (1997)\nREFERENCE \n AUTHORS Michal G.\n TITLE Biochemical Pathways\n JOURNAL Wiley (1999)\nREL_PATHWAY hsa00010 Glycolysis / Gluconeogenesis\n hsa00053 Ascorbate and aldarate metabolism\n hsa00061 Fatty acid biosynthesis\n hsa00062 Fatty acid elongation\n hsa00071 Fatty acid degradation\n hsa00190 Oxidative phosphorylation\n hsa00220 Arginine biosynthesis\n hsa00250 Alanine, aspartate and glutamate metabolism\n hsa00280 Valine, leucine and isoleucine degradation\n hsa00350 Tyrosine metabolism\n hsa00470 D-Amino acid metabolism\n hsa00630 Glyoxylate and dicarboxylate metabolism\nKO_PATHWAY ko00020\n///\n\nENTRY hsa00030 Pathway\nNAME Pentose phosphate pathway - Homo sapiens (human)\nDESCRIPTION The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].\nCLASS Metabolism; Carbohydrate metabolism\nPATHWAY_MAP hsa00030 Pentose phosphate pathway\nMODULE hsa_M00004 Pentose phosphate pathway (Pentose phosphate cycle) [PATH:hsa00030]\n hsa_M00005 PRPP biosynthesis, ribose 5P => PRPP [PATH:hsa00030]\n hsa_M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:hsa00030]\n hsa_M00007 Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:hsa00030]\nDBLINKS GO: 0006098\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 132158 GLYCTK; glycerate kinase [KO:K11529] [EC:2.7.1.165]\n 2203 FBP1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]\n 221823 PRPS1L1; phosphoribosyl pyrophosphate synthetase 1 like 1 [KO:K00948] [EC:2.7.6.1]\n 226 ALDOA; aldolase, fructose-bisphosphate A [KO:K01623] [EC:4.1.2.13]\n 229 ALDOB; aldolase, fructose-bisphosphate B [KO:K01623] [EC:4.1.2.13]\n 22934 RPIA; ribose 5-phosphate isomerase A [KO:K01807] [EC:5.3.1.6]\n 230 ALDOC; aldolase, fructose-bisphosphate C [KO:K01623] [EC:4.1.2.13]\n 23729 SHPK; sedoheptulokinase [KO:K11214] [EC:2.7.1.14]\n 2539 G6PD; glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]\n 25796 PGLS; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]\n 2821 GPI; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]\n 414328 IDNK; IDNK gluconokinase [KO:K00851] [EC:2.7.1.12]\n 51071 DERA; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]\n 5211 PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]\n 5213 PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]\n 5214 PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]\n 5226 PGD; phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44 1.1.1.343]\n 5236 PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]\n 55276 PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]\n 5631 PRPS1; phosphoribosyl pyrophosphate synthetase 1 [KO:K00948] [EC:2.7.6.1]\n 5634 PRPS2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]\n 6120 RPE; ribulose-5-phosphate-3-epimerase [KO:K01783] [EC:5.1.3.1]\n 64080 RBKS; ribokinase [KO:K00852] [EC:2.7.1.15]\n 6888 TALDO1; transaldolase 1 [KO:K00616] [EC:2.2.1.2]\n 7086 TKT; transketolase [KO:K00615] [EC:2.2.1.1]\n 729020 RPEL1; ribulose-5-phosphate-3-epimerase like 1 [KO:K01783] [EC:5.1.3.1]\n 8277 TKTL1; transketolase like 1 [KO:K00615] [EC:2.2.1.1]\n 84076 TKTL2; transketolase like 2 [KO:K00615] [EC:2.2.1.1]\n 8789 FBP2; fructose-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]\n 9104 RGN; regucalcin [KO:K01053] [EC:3.1.1.17]\n 9563 H6PD; hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase [KO:K13937] [EC:1.1.1.47 3.1.1.31]\nCOMPOUND C00022 Pyruvate\n C00031 D-Glucose\n C00085 D-Fructose 6-phosphate\n C00117 D-Ribose 5-phosphate\n C00118 D-Glyceraldehyde 3-phosphate\n C00119 5-Phospho-alpha-D-ribose 1-diphosphate\n C00121 D-Ribose\n C00197 3-Phospho-D-glycerate\n C00198 D-Glucono-1,5-lactone\n C00199 D-Ribulose 5-phosphate\n C00204 2-Dehydro-3-deoxy-D-gluconate\n C00221 beta-D-Glucose\n C00231 D-Xylulose 5-phosphate\n C00257 D-Gluconic acid\n C00258 D-Glycerate\n C00279 D-Erythrose 4-phosphate\n C00345 6-Phospho-D-gluconate\n C00354 D-Fructose 1,6-bisphosphate\n C00577 D-Glyceraldehyde\n C00620 alpha-D-Ribose 1-phosphate\n C00631 2-Phospho-D-glycerate\n C00668 alpha-D-Glucose 6-phosphate\n C00672 2-Deoxy-D-ribose 1-phosphate\n C00673 2-Deoxy-D-ribose 5-phosphate\n C01151 D-Ribose 1,5-bisphosphate\n C01172 beta-D-Glucose 6-phosphate\n C01182 D-Ribulose 1,5-bisphosphate\n C01218 6-Phospho-2-dehydro-D-gluconate\n C01236 D-Glucono-1,5-lactone 6-phosphate\n C01801 Deoxyribose\n C02076 Sedoheptulose\n C03752 2-Amino-2-deoxy-D-gluconate\n C04442 2-Dehydro-3-deoxy-6-phospho-D-gluconate\n C05382 Sedoheptulose 7-phosphate\n C06019 D-arabino-Hex-3-ulose 6-phosphate\n C06473 2-Keto-D-gluconic acid\n C20589 D-Glucosaminate-6-phosphate\nREFERENCE \n AUTHORS Nishizuka Y (ed).\n TITLE [Metabolic Maps] (In Japanese)\n JOURNAL Tokyo Kagaku Dojin (1980)\nREFERENCE \n AUTHORS Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).\n TITLE [Cellular Functions and Metabolic Maps] (In Japanese)\n JOURNAL Tokyo Kagaku Dojin (1997)\nREFERENCE \n AUTHORS Michal G.\n TITLE Biochemical Pathways\n JOURNAL Wiley (1999)\nREFERENCE PMID:12700258\n AUTHORS Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.\n TITLE Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.\n JOURNAL J Bacteriol 185:2793-801 (2003)\n DOI:10.1128/JB.185.9.2793-2801.2003\nREFERENCE PMID:16788179\n AUTHORS Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y\n TITLE The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.\n JOURNAL J Bacteriol 188:4698-704 (2006)\n DOI:10.1128/JB.00492-06\nREFERENCE PMID:16428816\n AUTHORS Kato N, Yurimoto H, Thauer RK\n TITLE The physiological role of the ribulose monophosphate pathway in bacteria and archaea.\n JOURNAL Biosci Biotechnol Biochem 70:10-21 (2006)\n DOI:10.1271/bbb.70.10\nREFERENCE PMID:23279921\n AUTHORS Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B\n TITLE Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.\n JOURNAL FEBS J 280:1126-38 (2013)\n DOI:10.1111/febs.12106\nREFERENCE PMID:16458304\n AUTHORS Reher M, Schonheit P\n TITLE Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.\n JOURNAL FEBS Lett 580:1198-204 (2006)\n DOI:10.1016/j.febslet.2006.01.029\nREFERENCE PMID:20023024\n AUTHORS Reher M, Fuhrer T, Bott M, Schonheit P\n TITLE The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.\n JOURNAL J Bacteriol 192:964-74 (2010)\n DOI:10.1128/JB.01281-09\nREL_PATHWAY hsa00010 Glycolysis / Gluconeogenesis\n hsa00040 Pentose and glucuronate interconversions\n hsa00052 Galactose metabolism\n hsa00230 Purine metabolism\n hsa00240 Pyrimidine metabolism\n hsa00340 Histidine metabolism\n hsa00630 Glyoxylate and dicarboxylate metabolism\n hsa00750 Vitamin B6 metabolism\nKO_PATHWAY ko00030\n///\n\nENTRY hsa00040 Pathway\nNAME Pentose and glucuronate interconversions - Homo sapiens (human)\nCLASS Metabolism; Carbohydrate metabolism\nPATHWAY_MAP hsa00040 Pentose and glucuronate interconversions\nMODULE hsa_M00014 Glucuronate pathway (uronate pathway) [PATH:hsa00040]\nDRUG D01805 Aceglatone (JAN/INN)\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 10327 AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]\n 10720 UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]\n 10941 UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]\n 231 AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]\n 27294 DHDH; dihydrodiol dehydrogenase [KO:K00078] [EC:1.3.1.20 1.1.1.179]\n 2990 GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]\n 441282 AKR1B15; aldo-keto reductase family 1 member B15 [KO:K00011] [EC:1.1.1.21]\n 51084 CRYL1; crystallin lambda 1 [KO:K13247] [EC:1.1.1.45]\n 51181 DCXR; dicarbonyl and L-xylulose reductase [KO:K03331] [EC:1.1.1.10]\n 54490 UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]\n 54575 UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]\n 54576 UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]\n 54577 UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]\n 54578 UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]\n 54579 UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]\n 54600 UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]\n 54657 UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]\n 54658 UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]\n 54659 UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]\n 55277 FGGY; FGGY carbohydrate kinase domain containing [KO:K00875] [EC:2.7.1.47]\n 57016 AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]\n 574537 UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]\n 6120 RPE; ribulose-5-phosphate-3-epimerase [KO:K01783] [EC:5.1.3.1]\n 6652 SORD; sorbitol dehydrogenase [KO:K00008] [EC:1.1.1.14]\n 729020 RPEL1; ribulose-5-phosphate-3-epimerase like 1 [KO:K01783] [EC:5.1.3.1]\n 729920 CRPPA; CDP-L-ribitol pyrophosphorylase A [KO:K21031] [EC:2.7.7.40]\n 7358 UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]\n 7360 UGP2; UDP-glucose pyrophosphorylase 2 [KO:K00963] [EC:2.7.7.9]\n 7363 UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]\n 7364 UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]\n 7365 UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]\n 7366 UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]\n 7367 UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]\n 79799 UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]\n 9365 KL; klotho [KO:K14756] [EC:3.2.1.31]\n 9942 XYLB; xylulokinase [KO:K00854] [EC:2.7.1.17]\nCOMPOUND C00022 Pyruvate\n C00026 2-Oxoglutarate\n C00029 UDP-glucose\n C00103 D-Glucose 1-phosphate\n C00111 Glycerone phosphate\n C00116 Glycerol\n C00167 UDP-glucuronate\n C00181 D-Xylose\n C00191 D-Glucuronate\n C00199 D-Ribulose 5-phosphate\n C00204 2-Dehydro-3-deoxy-D-gluconate\n C00216 D-Arabinose\n C00231 D-Xylulose 5-phosphate\n C00259 L-Arabinose\n C00266 Glycolaldehyde\n C00309 D-Ribulose\n C00310 D-Xylulose\n C00312 L-Xylulose\n C00333 D-Galacturonate\n C00379 Xylitol\n C00433 2,5-Dioxopentanoate\n C00470 Pectate\n C00474 Ribitol\n C00476 D-Lyxose\n C00502 D-Xylonate\n C00508 L-Ribulose\n C00514 D-Mannonate\n C00532 L-Arabitol\n C00558 D-Tagaturonate\n C00618 3-Dehydro-L-gulonate\n C00714 Pectin\n C00789 CDP-ribitol\n C00800 L-Gulonate\n C00817 D-Altronate\n C00905 D-Fructuronate\n C01068 D-Ribitol 5-phosphate\n C01101 L-Ribulose 5-phosphate\n C01508 L-Lyxose\n C01904 D-Arabitol\n C02266 D-Xylonolactone\n C02273 Digalacturonate\n C02426 L-Glyceraldehyde\n C02753 D-Xylono-1,4-lactone\n C03033 beta-D-Glucuronoside\n C03291 L-Xylulose 5-phosphate\n C03826 2-Dehydro-3-deoxy-D-xylonate\n C04053 5-Dehydro-4-deoxy-D-glucuronate\n C04349 (4S)-4,6-Dihydroxy-2,5-dioxohexanoate\n C04575 (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate\n C05385 D-Glucuronate 1-phosphate\n C05411 L-Xylonate\n C05412 L-Lyxonate\n C06118 4-(4-Deoxy-alpha-D-gluc-4-enuronosyl)-D-galacturonate\n C06441 L-Xylulose 1-phosphate\n C14899 3-Dehydro-L-gulonate 6-phosphate\n C15930 L-Galactonate\n C20680 2-Dehydro-3-deoxy-L-galactonate\n C22337 D-Ribulose 1-phosphate\n C22712 4-Deoxy-L-threo-hex-4-enopyranuronate\nREFERENCE PMID:11741871\n AUTHORS Yew WS, Gerlt JA.\n TITLE Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons.\n JOURNAL J Bacteriol 184:302-6 (2002)\n DOI:10.1128/JB.184.1.302-306.2002\nREFERENCE PMID:15697206\n AUTHORS Yew WS, Akana J, Wise EL, Rayment I, Gerlt JA\n TITLE Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase.\n JOURNAL Biochemistry 44:1807-15 (2005)\n DOI:10.1021/bi047815v\nREFERENCE PMID:10572115\n AUTHORS Yasueda H, Kawahara Y, Sugimoto S.\n TITLE Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.\n JOURNAL J Bacteriol 181:7154-60 (1999)\n DOI:10.1128/JB.181.23.7154-7160.1999\nREFERENCE PMID:10913097\n AUTHORS Ibanez E, Gimenez R, Pedraza T, Baldoma L, Aguilar J, Badia J\n TITLE Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose.\n JOURNAL J Bacteriol 182:4625-7 (2000)\n DOI:10.1128/JB.182.16.4625-4627.2000\nREFERENCE PMID:15901685\n AUTHORS Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N\n TITLE The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.\n JOURNAL J Bacteriol 187:3636-42 (2005)\n DOI:10.1128/JB.187.11.3636-3642.2005\nREL_PATHWAY hsa00010 Glycolysis / Gluconeogenesis\n hsa00020 Citrate cycle (TCA cycle)\n hsa00030 Pentose phosphate pathway\n hsa00052 Galactose metabolism\n hsa00053 Ascorbate and aldarate metabolism\n hsa00520 Amino sugar and nucleotide sugar metabolism\n hsa00561 Glycerolipid metabolism\n hsa00562 Inositol phosphate metabolism\n hsa00740 Riboflavin metabolism\nKO_PATHWAY ko00040\n///\n\nENTRY hsa00051 Pathway\nNAME Fructose and mannose metabolism - Homo sapiens (human)\nCLASS Metabolism; Carbohydrate metabolism\nPATHWAY_MAP hsa00051 Fructose and mannose metabolism\nDRUG D01688 Epalrestat (JP18/INN)\n D01715 Risarestat (INN)\n D01842 Fidarestat (JAN/INN)\n D02323 Tolrestat (USAN/INN)\n D02328 Zopolrestat (USAN/INN)\n D02835 Alrestatin sodium (USAN)\n D03803 Lidorestat (USAN)\n D03805 Minalrestat (USAN/INN)\n D03806 Ponalrestat (USAN/INN)\n D03807 Zenarestat (USAN/INN)\n D05893 Sorbinil (USAN/INN)\n D06403 Ranirestat (JAN/INN)\n D12384 Govorestat (USAN/INN)\n D12390 Caficrestat (USAN/INN)\nDBLINKS GO: 0006000 0006013\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 197258 FCSK; fucose kinase [KO:K05305] [EC:2.7.1.52]\n 2203 FBP1; fructose-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]\n 226 ALDOA; aldolase, fructose-bisphosphate A [KO:K01623] [EC:4.1.2.13]\n 229 ALDOB; aldolase, fructose-bisphosphate B [KO:K01623] [EC:4.1.2.13]\n 230 ALDOC; aldolase, fructose-bisphosphate C [KO:K01623] [EC:4.1.2.13]\n 231 AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]\n 26007 TKFC; triokinase and FMN cyclase [KO:K00863] [EC:2.7.1.28 2.7.1.29 4.6.1.15]\n 2762 GMDS; GDP-mannose 4,6-dehydratase [KO:K01711] [EC:4.2.1.47]\n 29925 GMPPB; GDP-mannose pyrophosphorylase B [KO:K00966] [EC:2.7.7.13]\n 29926 GMPPA; GDP-mannose pyrophosphorylase A [KO:K00966] [EC:2.7.7.13]\n 3098 HK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]\n 3099 HK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]\n 3101 HK3; hexokinase 3 [KO:K00844] [EC:2.7.1.1]\n 3795 KHK; ketohexokinase [KO:K00846] [EC:2.7.1.3]\n 4351 MPI; mannose phosphate isomerase [KO:K01809] [EC:5.3.1.8]\n 441282 AKR1B15; aldo-keto reductase family 1 member B15 [KO:K00011] [EC:1.1.1.21]\n 5207 PFKFB1; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 [KO:K19028] [EC:2.7.1.105 3.1.3.46]\n 5208 PFKFB2; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [KO:K19029] [EC:2.7.1.105 3.1.3.46]\n 5209 PFKFB3; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [KO:K01103] [EC:2.7.1.105 3.1.3.46]\n 5210 PFKFB4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 [KO:K19030] [EC:2.7.1.105 3.1.3.46]\n 5211 PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]\n 5213 PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]\n 5214 PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]\n 5372 PMM1; phosphomannomutase 1 [KO:K17497] [EC:5.4.2.8]\n 5373 PMM2; phosphomannomutase 2 [KO:K17497] [EC:5.4.2.8]\n 55556 ENOSF1; enolase superfamily member 1 [KO:K18334] [EC:4.2.1.68]\n 57016 AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]\n 57103 TIGAR; TP53 induced glycolysis regulatory phosphatase [KO:K14634] [EC:3.1.3.46]\n 6652 SORD; sorbitol dehydrogenase [KO:K00008] [EC:1.1.1.14]\n 7167 TPI1; triosephosphate isomerase 1 [KO:K01803] [EC:5.3.1.1]\n 7264 GFUS; GDP-L-fucose synthase [KO:K02377] [EC:1.1.1.271]\n 80201 HKDC1; hexokinase domain containing 1 [KO:K00844] [EC:2.7.1.1]\n 8789 FBP2; fructose-bisphosphatase 2 [KO:K03841] [EC:3.1.3.11]\n 8790 FPGT; fucose-1-phosphate guanylyltransferase [KO:K00976] [EC:2.7.7.30]\nCOMPOUND C00085 D-Fructose 6-phosphate\n C00095 D-Fructose\n C00096 GDP-mannose\n C00111 Glycerone phosphate\n C00118 D-Glyceraldehyde 3-phosphate\n C00159 D-Mannose\n C00186 (S)-Lactate\n C00247 L-Sorbose\n C00267 alpha-D-Glucose\n C00275 D-Mannose 6-phosphate\n C00325 GDP-L-fucose\n C00354 D-Fructose 1,6-bisphosphate\n C00392 Mannitol\n C00424 (S)-Lactaldehyde\n C00464 Mannan\n C00507 L-Rhamnose\n C00577 D-Glyceraldehyde\n C00636 D-Mannose 1-phosphate\n C00644 D-Mannitol 1-phosphate\n C00665 beta-D-Fructose 2,6-bisphosphate\n C00794 D-Sorbitol\n C00861 L-Rhamnulose\n C00976 GDP-D-mannuronate\n C01019 L-Fucose\n C01094 D-Fructose 1-phosphate\n C01096 Sorbitol 6-phosphate\n C01099 L-Fuculose 1-phosphate\n C01131 L-Rhamnulose 1-phosphate\n C01222 GDP-4-dehydro-6-deoxy-D-mannose\n C01355 Fructan\n C01487 D-Allose\n C01720 L-Fuconate\n C01721 L-Fuculose\n C01768 (Alginate)n\n C01934 L-Rhamnonate\n C02431 L-Rhamnofuranose\n C02492 1,4-beta-D-Mannan\n C02888 Sorbose 1-phosphate\n C02962 D-Allose 6-phosphate\n C02977 GDP-6-deoxy-D-talose\n C02985 L-Fucose 1-phosphate\n C02991 L-Rhamnono-1,4-lactone\n C03117 GDP-6-deoxy-D-mannose\n C03267 beta-D-Fructose 2-phosphate\n C03827 2-Dehydro-3-deoxy-L-fuconate\n C03979 2-Dehydro-3-deoxy-L-rhamnonate\n C05144 (beta-D-Mannuronate)n\n C05392 Oligouronide with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl group\n C06192 ADP-mannose\n C11516 2-(alpha-D-Mannosyl)-3-phosphoglycerate\n C11544 2-O-(alpha-D-Mannosyl)-D-glycerate\n C18028 L-Fucono-1,5-lactone\n C18096 D-Allulose 6-phosphate\n C20781 2,4-Diketo-3-deoxy-L-fuconate\n C20836 beta-L-Fucopyranose\nREL_PATHWAY hsa00010 Glycolysis / Gluconeogenesis\n hsa00052 Galactose metabolism\n hsa00053 Ascorbate and aldarate metabolism\n hsa00510 N-Glycan biosynthesis\n hsa00520 Amino sugar and nucleotide sugar metabolism\n hsa00620 Pyruvate metabolism\nKO_PATHWAY ko00051\n///\n\nENTRY hsa00052 Pathway\nNAME Galactose metabolism - Homo sapiens (human)\nCLASS Metabolism; Carbohydrate metabolism\nPATHWAY_MAP hsa00052 Galactose metabolism\nMODULE hsa_M00554 Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:hsa00052]\n hsa_M00632 Galactose degradation, Leloir pathway, galactose => alpha-D-glucose-1P [PATH:hsa00052]\nNETWORK nt06023 Galactose degradation\n ELEMENT N00847 Galactose degradation\nDRUG D00216 Acarbose (JAN/USAN/INN)\n D00625 Miglitol (JP18/USAN/INN)\n D01665 Voglibose (JP18/USAN/INN)\n D01688 Epalrestat (JP18/INN)\n D01715 Risarestat (INN)\n D01842 Fidarestat (JAN/INN)\n D02323 Tolrestat (USAN/INN)\n D02328 Zopolrestat (USAN/INN)\n D02835 Alrestatin sodium (USAN)\n D03207 Alglucosidase alfa (USAN/INN)\n D03342 Camiglibose (USAN)\n D03803 Lidorestat (USAN)\n D03805 Minalrestat (USAN/INN)\n D03806 Ponalrestat (USAN/INN)\n D03807 Zenarestat (USAN/INN)\n D05782 Sacrosidase (USAN)\n D05893 Sorbinil (USAN/INN)\n D06403 Ranirestat (JAN/INN)\n D09605 Duvoglustat (USAN/INN)\n D09606 Duvoglustat hydrochloride (USAN)\n D09779 Emiglitate (JAN/INN)\n D11744 Avalglucosidase alfa (USAN/INN)\n D11798 Cipaglucosidase alfa (USAN)\n D11828 Clervonafusp alfa (USAN/INN)\n D12384 Govorestat (USAN/INN)\n D12390 Caficrestat (USAN/INN)\nDBLINKS GO: 0006012\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 130589 GALM; galactose mutarotase [KO:K01785] [EC:5.1.3.3]\n 231 AKR1B1; aldo-keto reductase family 1 member B [KO:K00011] [EC:1.1.1.21]\n 2538 G6PC1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]\n 2548 GAA; alpha glucosidase [KO:K12316] [EC:3.2.1.20]\n 2582 GALE; UDP-galactose-4-epimerase [KO:K01784] [EC:5.1.3.2]\n 2584 GALK1; galactokinase 1 [KO:K00849] [EC:2.7.1.6]\n 2592 GALT; galactose-1-phosphate uridylyltransferase [KO:K00965] [EC:2.7.7.12]\n 2595 GANC; glucosidase alpha, neutral C [KO:K12317] [EC:3.2.1.20]\n 2645 GCK; glucokinase [KO:K12407] [EC:2.7.1.2]\n 2683 B4GALT1; beta-1,4-galactosyltransferase 1 [KO:K07966] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]\n 2717 GLA; galactosidase alpha [KO:K01189] [EC:3.2.1.22]\n 2720 GLB1; galactosidase beta 1 [KO:K12309] [EC:3.2.1.23]\n 3098 HK1; hexokinase 1 [KO:K00844] [EC:2.7.1.1]\n 3099 HK2; hexokinase 2 [KO:K00844] [EC:2.7.1.1]\n 3101 HK3; hexokinase 3 [KO:K00844] [EC:2.7.1.1]\n 3906 LALBA; lactalbumin alpha [KO:K00704] [EC:2.4.1.22]\n 3938 LCT; lactase [KO:K01229] [EC:3.2.1.108 3.2.1.62]\n 441282 AKR1B15; aldo-keto reductase family 1 member B15 [KO:K00011] [EC:1.1.1.21]\n 5211 PFKL; phosphofructokinase, liver type [KO:K00850] [EC:2.7.1.11]\n 5213 PFKM; phosphofructokinase, muscle [KO:K00850] [EC:2.7.1.11]\n 5214 PFKP; phosphofructokinase, platelet [KO:K00850] [EC:2.7.1.11]\n 5236 PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]\n 55276 PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]\n 57016 AKR1B10; aldo-keto reductase family 1 member B10 [KO:K00011] [EC:1.1.1.21]\n 57818 G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]\n 6476 SI; sucrase-isomaltase [KO:K01203] [EC:3.2.1.48 3.2.1.10]\n 7360 UGP2; UDP-glucose pyrophosphorylase 2 [KO:K00963] [EC:2.7.7.9]\n 80201 HKDC1; hexokinase domain containing 1 [KO:K00844] [EC:2.7.1.1]\n 8704 B4GALT2; beta-1,4-galactosyltransferase 2 [KO:K07967] [EC:2.4.1.22 2.4.1.90 2.4.1.38 2.4.1.-]\n 8972 MGAM; maltase-glucoamylase [KO:K12047] [EC:3.2.1.20 3.2.1.3]\n 92579 G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]\n 93432 MGAM2; maltase-glucoamylase 2 (putative) [KO:K12047] [EC:3.2.1.20 3.2.1.3]\nCOMPOUND C00029 UDP-glucose\n C00031 D-Glucose\n C00052 UDP-alpha-D-galactose\n C00085 D-Fructose 6-phosphate\n C00089 Sucrose\n C00095 D-Fructose\n C00103 D-Glucose 1-phosphate\n C00111 Glycerone phosphate\n C00116 Glycerol\n C00118 D-Glyceraldehyde 3-phosphate\n C00124 D-Galactose\n C00137 myo-Inositol\n C00159 D-Mannose\n C00243 Lactose\n C00267 alpha-D-Glucose\n C00446 alpha-D-Galactose 1-phosphate\n C00492 Raffinose\n C00577 D-Glyceraldehyde\n C00668 alpha-D-Glucose 6-phosphate\n C00794 D-Sorbitol\n C00795 D-Tagatose\n C00880 D-Galactonate\n C00984 alpha-D-Galactose\n C01097 D-Tagatose 6-phosphate\n C01113 D-Galactose 6-phosphate\n C01132 N-Acetyl-D-galactosamine\n C01216 2-Dehydro-3-deoxy-D-galactonate\n C01235 alpha-D-Galactosyl-(1->3)-1D-myo-inositol\n C01286 2-Dehydro-3-deoxy-6-phospho-D-galactonate\n C01613 Stachyose\n C01697 Galactitol\n C02262 D-Galactosamine\n C02669 D-Galactono-1,5-lactone\n C03383 D-Galactono-1,4-lactone\n C03733 UDP-alpha-D-galactofuranose\n C03785 D-Tagatose 1,6-bisphosphate\n C05396 Lactose 6'-phosphate\n C05399 Melibiitol\n C05400 Epimelibiose\n C05401 3-beta-D-Galactosyl-sn-glycerol\n C05402 Melibiose\n C05404 D-Gal alpha 1->6D-Gal alpha 1->6D-Glucose\n C05796 Galactan\n C06311 Galactitol 1-phosphate\n C06376 N-Acetyl-D-galactosamine 6-phosphate\n C06377 D-Galactosamine 6-phosphate\nREL_PATHWAY hsa00010 Glycolysis / Gluconeogenesis\n hsa00030 Pentose phosphate pathway\n hsa00040 Pentose and glucuronate interconversions\n hsa00051 Fructose and mannose metabolism\n hsa00520 Amino sugar and nucleotide sugar metabolism\nKO_PATHWAY ko00052\n///\n\nENTRY hsa00053 Pathway\nNAME Ascorbate and aldarate metabolism - Homo sapiens (human)\nCLASS Metabolism; Carbohydrate metabolism\nPATHWAY_MAP hsa00053 Ascorbate and aldarate metabolism\nDBLINKS GO: 0019852 0019577 0019572\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 10327 AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]\n 10720 UGT2B11; UDP glucuronosyltransferase family 2 member B11 [KO:K00699] [EC:2.4.1.17]\n 10941 UGT2A1; UDP glucuronosyltransferase family 2 member A1 complex locus [KO:K00699] [EC:2.4.1.17]\n 217 ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]\n 219 ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]\n 223 ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]\n 224 ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]\n 2990 GUSB; glucuronidase beta [KO:K01195] [EC:3.2.1.31]\n 501 ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]\n 54490 UGT2B28; UDP glucuronosyltransferase family 2 member B28 [KO:K00699] [EC:2.4.1.17]\n 54575 UGT1A10; UDP glucuronosyltransferase family 1 member A10 [KO:K00699] [EC:2.4.1.17]\n 54576 UGT1A8; UDP glucuronosyltransferase family 1 member A8 [KO:K00699] [EC:2.4.1.17]\n 54577 UGT1A7; UDP glucuronosyltransferase family 1 member A7 [KO:K00699] [EC:2.4.1.17]\n 54578 UGT1A6; UDP glucuronosyltransferase family 1 member A6 [KO:K00699] [EC:2.4.1.17]\n 54579 UGT1A5; UDP glucuronosyltransferase family 1 member A5 [KO:K00699] [EC:2.4.1.17]\n 54600 UGT1A9; UDP glucuronosyltransferase family 1 member A9 [KO:K00699] [EC:2.4.1.17]\n 54657 UGT1A4; UDP glucuronosyltransferase family 1 member A4 [KO:K00699] [EC:2.4.1.17]\n 54658 UGT1A1; UDP glucuronosyltransferase family 1 member A1 [KO:K00699] [EC:2.4.1.17]\n 54659 UGT1A3; UDP glucuronosyltransferase family 1 member A3 [KO:K00699] [EC:2.4.1.17]\n 55586 MIOX; myo-inositol oxygenase [KO:K00469] [EC:1.13.99.1]\n 574537 UGT2A2; UDP glucuronosyltransferase family 2 member A2 [KO:K00699] [EC:2.4.1.17]\n 7358 UGDH; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]\n 7363 UGT2B4; UDP glucuronosyltransferase family 2 member B4 [KO:K00699] [EC:2.4.1.17]\n 7364 UGT2B7; UDP glucuronosyltransferase family 2 member B7 [KO:K00699] [EC:2.4.1.17]\n 7365 UGT2B10; UDP glucuronosyltransferase family 2 member B10 [KO:K00699] [EC:2.4.1.17]\n 7366 UGT2B15; UDP glucuronosyltransferase family 2 member B15 [KO:K00699] [EC:2.4.1.17]\n 7367 UGT2B17; UDP glucuronosyltransferase family 2 member B17 [KO:K00699] [EC:2.4.1.17]\n 79799 UGT2A3; UDP glucuronosyltransferase family 2 member A3 [KO:K00699] [EC:2.4.1.17]\n 9104 RGN; regucalcin [KO:K01053] [EC:3.1.1.17]\n 9365 KL; klotho [KO:K14756] [EC:3.2.1.31]\nCOMPOUND C00022 Pyruvate\n C00026 2-Oxoglutarate\n C00029 UDP-glucose\n C00072 Ascorbate\n C00096 GDP-mannose\n C00137 myo-Inositol\n C00167 UDP-glucuronate\n C00191 D-Glucuronate\n C00216 D-Arabinose\n C00231 D-Xylulose 5-phosphate\n C00259 L-Arabinose\n C00333 D-Galacturonate\n C00433 2,5-Dioxopentanoate\n C00545 L-Arabinonate\n C00558 D-Tagaturonate\n C00617 UDP-D-galacturonate\n C00618 3-Dehydro-L-gulonate\n C00652 D-Arabinono-1,4-lactone\n C00679 5-Dehydro-4-deoxy-D-glucarate\n C00684 2-Dehydro-3-deoxy-L-arabinonate\n C00800 L-Gulonate\n C00818 D-Glucarate\n C00878 D-Arabinonate\n C00879 D-Galactarate\n C01040 L-Gulono-1,4-lactone\n C01041 Monodehydroascorbate\n C01101 L-Ribulose 5-phosphate\n C01114 L-Arabinono-1,4-lactone\n C01115 L-Galactono-1,4-lactone\n C01146 2-Hydroxy-3-oxopropanoate\n C01620 Threonate\n C01825 L-Galactose\n C02280 GDP-L-galactose\n C02670 D-Glucuronolactone\n C03033 beta-D-Glucuronoside\n C03064 3-Dehydro-L-threonate\n C03289 L-xylo-Hexulonolactone\n C03291 L-Xylulose 5-phosphate\n C03826 2-Dehydro-3-deoxy-D-xylonate\n C03921 2-Dehydro-3-deoxy-D-glucarate\n C04037 1-Phospho-alpha-D-galacturonate\n C04575 (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate\n C05385 D-Glucuronate 1-phosphate\n C05411 L-Xylonate\n C05412 L-Lyxonate\n C05422 Dehydroascorbate\n C06316 Dehydro-D-arabinono-1,4-lactone\n C14899 3-Dehydro-L-gulonate 6-phosphate\n C15923 L-Gulose\n C15924 L-Gulose 1-phosphate\n C15925 GDP-L-gulose\n C15926 beta-L-Galactose 1-phosphate\n C15930 L-Galactonate\n C16186 L-Ascorbate 6-phosphate\n C20889 D-Galactaro-1,5-lactone\n C20896 D-Galactaro-1,4-lactone\n C21955 L-Galactono-1,5-lactone\nREFERENCE PMID:17222174\n AUTHORS Linster CL, Van Schaftingen E\n TITLE Vitamin C. Biosynthesis, recycling and degradation in mammals.\n JOURNAL FEBS J 274:1-22 (2007)\n DOI:10.1111/j.1742-4658.2006.05607.x\nREFERENCE PMID:15564123\n AUTHORS Valpuesta V, Botella MA.\n TITLE Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.\n JOURNAL Trends Plant Sci 9:573-7 (2004)\n DOI:10.1016/j.tplants.2004.10.002\nREFERENCE PMID:10517845\n AUTHORS Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.\n TITLE Ascorbate biosynthesis in Arabidopsis cell suspension culture.\n JOURNAL Plant Physiol 121:535-43 (1999)\n DOI:10.1104/pp.121.2.535\nREFERENCE PMID:16595667\n AUTHORS Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.\n TITLE Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.\n JOURNAL J Biol Chem 281:15662-70 (2006)\n DOI:10.1074/jbc.M601409200\nREFERENCE PMID:17462988\n AUTHORS Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.\n TITLE Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.\n JOURNAL J Biol Chem 282:18879-85 (2007)\n DOI:10.1074/jbc.M702094200\nREFERENCE PMID:14996803\n AUTHORS Campos E, Baldoma L, Aguilar J, Badia J.\n TITLE Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.\n JOURNAL J Bacteriol 186:1720-8 (2004)\n DOI:10.1128/JB.186.6.1720-1728.2004\nREFERENCE PMID:12644495\n AUTHORS Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.\n TITLE The ascorbate transporter of Escherichia coli.\n JOURNAL J Bacteriol 185:2243-50 (2003)\n DOI:10.1128/JB.185.7.2243-2250.2003\nREL_PATHWAY hsa00020 Citrate cycle (TCA cycle)\n hsa00040 Pentose and glucuronate interconversions\n hsa00051 Fructose and mannose metabolism\n hsa00520 Amino sugar and nucleotide sugar metabolism\n hsa00630 Glyoxylate and dicarboxylate metabolism\nKO_PATHWAY ko00053\n///\n\nENTRY hsa00061 Pathway\nNAME Fatty acid biosynthesis - Homo sapiens (human)\nCLASS Metabolism; Lipid metabolism\nPATHWAY_MAP hsa00061 Fatty acid biosynthesis\nMODULE hsa_M00082 Fatty acid biosynthesis, initiation [PATH:hsa00061]\n hsa_M00083 Fatty acid biosynthesis, elongation [PATH:hsa00061]\n hsa_M00086 beta-Oxidation, acyl-CoA synthesis [PATH:hsa00061]\n hsa_M00873 Fatty acid biosynthesis in mitochondria, animals [PATH:hsa00061]\nDRUG D11186 Olumacostat glasaretil (USAN/INN)\n D11640 Firsocostat (USAN/INN)\n D11902 Clesacostat (USAN)\n D11903 Clesacostat tromethamine (USAN)\n D12391 Denifanstat (USAN/INN)\nDBLINKS GO: 0006633\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 109703458 HTD2; hydroxyacyl-thioester dehydratase type 2 [KO:K22540] [EC:4.2.1.-]\n 197322 ACSF3; acyl-CoA synthetase family member 3 [KO:K18660] [EC:6.2.1.76 6.2.1.-]\n 2180 ACSL1; acyl-CoA synthetase long chain family member 1 [KO:K01897] [EC:6.2.1.3]\n 2181 ACSL3; acyl-CoA synthetase long chain family member 3 [KO:K01897] [EC:6.2.1.3]\n 2182 ACSL4; acyl-CoA synthetase long chain family member 4 [KO:K01897] [EC:6.2.1.3]\n 2194 FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]\n 23205 ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]\n 23305 ACSL6; acyl-CoA synthetase long chain family member 6 [KO:K01897] [EC:6.2.1.3]\n 27349 MCAT; malonyl-CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]\n 31 ACACA; acetyl-CoA carboxylase alpha [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]\n 32 ACACB; acetyl-CoA carboxylase beta [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]\n 51102 MECR; mitochondrial trans-2-enoyl-CoA reductase [KO:K07512] [EC:1.3.1.- 1.3.1.38]\n 51703 ACSL5; acyl-CoA synthetase long chain family member 5 [KO:K01897] [EC:6.2.1.3]\n 54995 OXSM; 3-oxoacyl-ACP synthase, mitochondrial [KO:K09458] [EC:2.3.1.179]\n 55301 OLAH; oleoyl-ACP hydrolase [KO:K01071] [EC:3.1.2.21]\n 7923 HSD17B8; hydroxysteroid 17-beta dehydrogenase 8 [KO:K13370] [EC:1.1.1.62 1.1.1.239]\n 81616 ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]\n 84869 CBR4; carbonyl reductase 4 [KO:K11539] [EC:1.1.1.-]\nCOMPOUND C00024 Acetyl-CoA\n C00083 Malonyl-CoA\n C00154 Palmitoyl-CoA\n C00173 Acyl-[acyl-carrier protein]\n C00229 Acyl-carrier protein\n C00249 Hexadecanoic acid\n C00383 Malonate\n C00638 Long-chain fatty acid\n C00685 3-Oxoacyl-[acyl-carrier protein]\n C00693 trans-2,3-Dehydroacyl-[acyl-carrier protein]\n C00712 (9Z)-Octadecenoic acid\n C01203 Oleoyl-[acyl-carrier protein]\n C01209 Malonyl-[acyl-carrier protein]\n C01271 (3R)-3-Hydroxyacyl-[acyl-carrier protein]\n C01530 Octadecanoic acid\n C01571 Decanoic acid\n C02679 Dodecanoic acid\n C02843 Long-chain acyl-CoA\n C03939 Acetyl-[acyl-carrier protein]\n C04088 Octadecanoyl-[acyl-carrier protein]\n C04180 cis-Dec-3-enoyl-[acp]\n C04246 But-2-enoyl-[acyl-carrier protein]\n C04618 (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]\n C04619 (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]\n C04620 (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]\n C04633 (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]\n C04688 (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]\n C05223 Dodecanoyl-[acyl-carrier protein]\n C05744 Acetoacetyl-[acp]\n C05745 Butyryl-[acp]\n C05746 3-Oxohexanoyl-[acp]\n C05747 (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]\n C05748 trans-Hex-2-enoyl-[acp]\n C05749 Hexanoyl-[acp]\n C05750 3-Oxooctanoyl-[acp]\n C05751 trans-Oct-2-enoyl-[acp]\n C05752 Octanoyl-[acp]\n C05753 3-Oxodecanoyl-[acp]\n C05754 trans-Dec-2-enoyl-[acp]\n C05755 Decanoyl-[acp]\n C05756 3-Oxododecanoyl-[acp]\n C05757 (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]\n C05758 trans-Dodec-2-enoyl-[acp]\n C05759 3-Oxotetradecanoyl-[acp]\n C05760 trans-Tetradec-2-enoyl-[acp]\n C05761 Tetradecanoyl-[acp]\n C05762 3-Oxohexadecanoyl-[acp]\n C05763 trans-Hexadec-2-enoyl-[acp]\n C05764 Hexadecanoyl-[acp]\n C06423 Octanoic acid\n C06424 Tetradecanoic acid\n C08362 (9Z)-Hexadecenoic acid\n C16219 3-Oxostearoyl-[acp]\n C16220 (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]\n C16221 (2E)-Octadecenoyl-[acp]\n C16520 Hexadecenoyl-[acyl-carrier protein]\n C20683 Long-chain acyl-[acyl-carrier protein]\n C20794 n-7 Unsaturated acyl-[acyl-carrier protein]\nREFERENCE PMID:12061798\n AUTHORS Salas JJ, Ohlrogge JB.\n TITLE Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.\n JOURNAL Arch Biochem Biophys 403:25-34 (2002)\n DOI:10.1016/S0003-9861(02)00017-6\nREFERENCE PMID:12518017\n AUTHORS Zhang YM, Marrakchi H, White SW, Rock CO.\n TITLE The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.\n JOURNAL J Lipid Res 44:1-10 (2003)\n DOI:10.1194/jlr.R200016-JLR200\nREFERENCE PMID:11337402\n AUTHORS Voelker T, Kinney AJ.\n TITLE VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.\n JOURNAL Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)\n DOI:10.1146/annurev.arplant.52.1.335\nREFERENCE PMID:17573542\n AUTHORS Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.\n TITLE Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.\n JOURNAL Plant Physiol 144:1827-42 (2007)\n DOI:10.1104/pp.107.096172\nREFERENCE PMID:30201289\n AUTHORS Bowman CE, Wolfgang MJ\n TITLE Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.\n JOURNAL Adv Biol Regul 71:34-40 (2019)\n DOI:10.1016/j.jbior.2018.09.002\nREFERENCE PMID:25203508\n AUTHORS Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z\n TITLE Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.\n JOURNAL Nat Commun 5:4805 (2014)\n DOI:10.1038/ncomms5805\nREFERENCE PMID:19686777\n AUTHORS Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ\n TITLE Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.\n JOURNAL Prog Lipid Res 49:27-45 (2010)\n DOI:10.1016/j.plipres.2009.08.001\nREFERENCE PMID:27553474\n AUTHORS Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK\n TITLE Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.\n JOURNAL Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)\n DOI:10.1016/j.bbalip.2016.08.011\nREL_PATHWAY hsa00020 Citrate cycle (TCA cycle)\n hsa00062 Fatty acid elongation\n hsa00071 Fatty acid degradation\n hsa00410 beta-Alanine metabolism\n hsa00561 Glycerolipid metabolism\n hsa00564 Glycerophospholipid metabolism\n hsa00620 Pyruvate metabolism\n hsa00785 Lipoic acid metabolism\nKO_PATHWAY ko00061\n///\n\nENTRY hsa00062 Pathway\nNAME Fatty acid elongation - Homo sapiens (human)\nCLASS Metabolism; Lipid metabolism\nPATHWAY_MAP hsa00062 Fatty acid elongation\nMODULE hsa_M00085 Fatty acid elongation in mitochondria [PATH:hsa00062]\n hsa_M00415 Fatty acid elongation in endoplasmic reticulum [PATH:hsa00062]\nDBLINKS GO: 0030497\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 10449 ACAA2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]\n 10965 ACOT2; acyl-CoA thioesterase 2 [KO:K01068] [EC:3.1.2.2]\n 11332 ACOT7; acyl-CoA thioesterase 7 [KO:K17360] [EC:3.1.2.2]\n 117145 THEM4; thioesterase superfamily member 4 [KO:K16339] [EC:3.1.2.2]\n 122970 ACOT4; acyl-CoA thioesterase 4 [KO:K01068] [EC:3.1.2.2]\n 153364 MBLAC2; metallo-beta-lactamase domain containing 2 [KO:K28199]\n 1892 ECHS1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]\n 201562 HACD2; 3-hydroxyacyl-CoA dehydratase 2 [KO:K10703] [EC:4.2.1.134]\n 284486 THEM5; thioesterase superfamily member 5 [KO:K22554] [EC:3.1.2.2]\n 3030 HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]\n 3032 HADHB; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [KO:K07509] [EC:2.3.1.16]\n 3033 HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]\n 401494 HACD4; 3-hydroxyacyl-CoA dehydratase 4 [KO:K10703] [EC:4.2.1.134]\n 51102 MECR; mitochondrial trans-2-enoyl-CoA reductase [KO:K07512] [EC:1.3.1.- 1.3.1.38]\n 51144 HSD17B12; hydroxysteroid 17-beta dehydrogenase 12 [KO:K10251] [EC:1.1.1.62 1.1.1.330]\n 51495 HACD3; 3-hydroxyacyl-CoA dehydratase 3 [KO:K10703] [EC:4.2.1.134]\n 54898 ELOVL2; ELOVL fatty acid elongase 2 [KO:K10205] [EC:2.3.1.199]\n 5538 PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]\n 60481 ELOVL5; ELOVL fatty acid elongase 5 [KO:K10244] [EC:2.3.1.199]\n 641371 ACOT1; acyl-CoA thioesterase 1 [KO:K01068] [EC:3.1.2.2]\n 64834 ELOVL1; ELOVL fatty acid elongase 1 [KO:K10247] [EC:2.3.1.199]\n 6785 ELOVL4; ELOVL fatty acid elongase 4 [KO:K10249] [EC:2.3.1.199]\n 79071 ELOVL6; ELOVL fatty acid elongase 6 [KO:K10203] [EC:2.3.1.199]\n 79993 ELOVL7; ELOVL fatty acid elongase 7 [KO:K10250] [EC:2.3.1.199]\n 83401 ELOVL3; ELOVL fatty acid elongase 3 [KO:K10248] [EC:2.3.1.199]\n 9200 HACD1; 3-hydroxyacyl-CoA dehydratase 1 [KO:K10703] [EC:4.2.1.134]\n 9374 PPT2; palmitoyl-protein thioesterase 2 [KO:K01074] [EC:3.1.2.22]\n 9524 TECR; trans-2,3-enoyl-CoA reductase [KO:K10258] [EC:1.3.1.93]\nCOMPOUND C00024 Acetyl-CoA\n C00040 Acyl-CoA\n C00083 Malonyl-CoA\n C00136 Butanoyl-CoA\n C00154 Palmitoyl-CoA\n C00162 Fatty acid\n C00249 Hexadecanoic acid\n C00264 3-Oxoacyl-CoA\n C00605 2,3-Dehydroacyl-CoA\n C00638 Long-chain fatty acid\n C00640 (3S)-3-Hydroxyacyl-CoA\n C00658 trans-2,3-Dehydroacyl-CoA\n C01832 Lauroyl-CoA\n C01944 Octanoyl-CoA\n C02593 Tetradecanoyl-CoA\n C02843 Long-chain acyl-CoA\n C03221 2-trans-Dodecenoyl-CoA\n C05258 (S)-3-Hydroxyhexadecanoyl-CoA\n C05259 3-Oxopalmitoyl-CoA\n C05260 (S)-3-Hydroxytetradecanoyl-CoA\n C05261 3-Oxotetradecanoyl-CoA\n C05262 (S)-3-Hydroxydodecanoyl-CoA\n C05263 3-Oxododecanoyl-CoA\n C05264 (S)-Hydroxydecanoyl-CoA\n C05265 3-Oxodecanoyl-CoA\n C05266 (S)-3-Hydroxyoctanoyl-CoA\n C05267 3-Oxooctanoyl-CoA\n C05268 (S)-Hydroxyhexanoyl-CoA\n C05269 3-Oxohexanoyl-CoA\n C05270 Hexanoyl-CoA\n C05271 trans-Hex-2-enoyl-CoA\n C05272 trans-Hexadec-2-enoyl-CoA\n C05273 trans-Tetradec-2-enoyl-CoA\n C05274 Decanoyl-CoA\n C05275 trans-Dec-2-enoyl-CoA\n C05276 trans-Oct-2-enoyl-CoA\n C20876 Very-long-chain acyl-CoA\n C20877 Very-long-chain 3-oxoacyl-CoA\n C20878 Very-long-chain (3R)-3-hydroxyacyl-CoA\n C20879 Very-long-chain trans-2,3-dehydroacyl-CoA\nREFERENCE PMID:4387390\n AUTHORS Seubert W, Lamberts I, Kramer R, Ohly B\n TITLE On the mechanism of malonyl-CoA-independent fatty acid synthesis. I. The mechanism of elongation of long-chain fatty acids by acetyl-CoA.\n JOURNAL Biochim Biophys Acta 164:498-517 (1968)\n DOI:10.1016/0005-2760(68)90180-X\nREFERENCE PMID:7150615\n AUTHORS El-Fakhri M, Middleton B\n TITLE The existence of an inner-membrane-bound, long acyl-chain-specific 3-hydroxyacyl-CoA dehydrogenase in mammalian mitochondria.\n JOURNAL Biochim Biophys Acta 713:270-9 (1982)\n DOI:10.1016/0005-2760(82)90244-2\nREFERENCE PMID:8190743\n AUTHORS Cassagne C, Lessire R, Bessoule JJ, Moreau P, Creach A, Schneider F, Sturbois B\n TITLE Biosynthesis of very long chain fatty acids in higher plants.\n JOURNAL Prog Lipid Res 33:55-69 (1994)\n DOI:10.1016/0163-7827(94)90009-4\nREFERENCE PMID:16564093\n AUTHORS Jakobsson A, Westerberg R, Jacobsson A.\n TITLE Fatty acid elongases in mammals: their regulation and roles in metabolism.\n JOURNAL Prog Lipid Res 45:237-49 (2006)\n DOI:10.1016/j.plipres.2006.01.004\nREFERENCE PMID:16765910\n AUTHORS Blacklock BJ, Jaworski JG\n TITLE Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases.\n JOURNAL Biochem Biophys Res Commun 346:583-90 (2006)\n DOI:10.1016/j.bbrc.2006.05.162\nREFERENCE PMID:16866954\n AUTHORS Shepherd T, Wynne Griffiths D\n TITLE The effects of stress on plant cuticular waxes.\n JOURNAL New Phytol 171:469-99 (2006)\n DOI:10.1111/j.1469-8137.2006.01826.x\nREFERENCE PMID:17719534\n AUTHORS Riezman H\n TITLE The long and short of fatty acid synthesis.\n JOURNAL Cell 130:587-8 (2007)\n DOI:10.1016/j.cell.2007.08.008\nREFERENCE PMID:19649180\n AUTHORS Raffaele S, Leger A, Roby D\n TITLE Very long chain fatty acid and lipid signaling in the response of plants to pathogens.\n JOURNAL Plant Signal Behav 4:94-9 (2009)\n DOI:10.4161/psb.4.2.7580\nREL_PATHWAY hsa00071 Fatty acid degradation\nKO_PATHWAY ko00062\n///\n\nENTRY hsa00071 Pathway\nNAME Fatty acid degradation - Homo sapiens (human)\nCLASS Metabolism; Lipid metabolism\nPATHWAY_MAP hsa00071 Fatty acid degradation\nMODULE hsa_M00086 beta-Oxidation, acyl-CoA synthesis [PATH:hsa00071]\n hsa_M00087 beta-Oxidation [PATH:hsa00071]\nNETWORK nt06020 beta-Oxidation in mitochondria\n ELEMENT N00765 beta-Oxidation, acyl-CoA synthesis\n N00804 beta-Oxidation\nDRUG D00123 Cyanamide (JP18)\n D00131 Disulfiram (JP18/USP/INN)\n D05292 Oxfenicine (USAN/INN)\nDBLINKS GO: 0009062\nORGANISM Homo sapiens (human) [GN:hsa]\nGENE 10449 ACAA2; acetyl-CoA acyltransferase 2 [KO:K07508] [EC:2.3.1.16]\n 10455 ECI2; enoyl-CoA delta isomerase 2 [KO:K13239] [EC:5.3.3.8]\n 113612 CYP2U1; cytochrome P450 family 2 subfamily U member 1 [KO:K07422] [EC:1.14.14.80]\n 124 ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide [KO:K13951] [EC:1.1.1.1]\n 125 ADH1B; alcohol dehydrogenase 1B (class I), beta polypeptide [KO:K13951] [EC:1.1.1.1]\n 126 ADH1C; alcohol dehydrogenase 1C (class I), gamma polypeptide [KO:K13951] [EC:1.1.1.1]\n 126129 CPT1C; carnitine palmitoyltransferase 1C [KO:K19524] [EC:2.3.1.21]\n 127 ADH4; alcohol dehydrogenase 4 (class II), pi polypeptide [KO:K13980] [EC:1.1.1.1]\n 128 ADH5; alcohol dehydrogenase 5 (class III), chi polypeptide [KO:K00121] [EC:1.1.1.284 1.1.1.1]\n 130 ADH6; alcohol dehydrogenase 6 (class V) [KO:K13952] [EC:1.1.1.1]\n 131 ADH7; alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide [KO:K13951] [EC:1.1.1.1]\n 1374 CPT1A; carnitine palmitoyltransferase 1A [KO:K08765] [EC:2.3.1.21]\n 1375 CPT1B; carnitine palmitoyltransferase 1B [KO:K19523] [EC:2.3.1.21]\n 1376 CPT2; carnitine palmitoyltransferase 2 [KO:K08766] [EC:2.3.1.21]\n 1632 ECI1; enoyl-CoA delta isomerase 1 [KO:K13238] [EC:5.3.3.8]\n 1892 ECHS1; enoyl-CoA hydratase, short chain 1 [KO:K07511] [EC:4.2.1.17]\n 1962 EHHADH; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]\n 217 ALDH2; aldehyde dehydrogenase 2 family member [KO:K00128] [EC:1.2.1.3]\n 2180 ACSL1; acyl-CoA synthetase long chain family member 1 [KO:K01897] [EC:6.2.1.3]\n 2181 ACSL3; acyl-CoA synthetase long chain family member 3 [KO:K01897] [EC:6.2.1.3]\n 2182 ACSL4; acyl-CoA synthetase long chain family member 4 [KO:K01897] [EC:6.2.1.3]\n 219 ALDH1B1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]\n 223 ALDH9A1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]\n 224 ALDH3A2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]\n 23205 ACSBG1; acyl-CoA synthetase bubblegum family member 1 [KO:K15013] [EC:6.2.1.3]\n 23305 ACSL6; acyl-CoA synthetase long chain family member 6 [KO:K01897] [EC:6.2.1.3]\n 2639 GCDH; glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]\n 30 ACAA1; acetyl-CoA acyltransferase 1 [KO:K07513] [EC:2.3.1.16]\n 3030 HADHA; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha [KO:K07515] [EC:4.2.1.17 1.1.1.211]\n 3032 HADHB; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta [KO:K07509] [EC:2.3.1.16]\n 3033 HADH; hydroxyacyl-CoA dehydrogenase [KO:K00022] [EC:1.1.1.35]\n 33 ACADL; acyl-CoA dehydrogenase long chain [KO:K00255] [EC:1.3.8.8]\n 34 ACADM; acyl-CoA dehydrogenase medium chain [KO:K00249] [EC:1.3.8.7]\n 35 ACADS; acyl-CoA dehydrogenase short chain [KO:K00248] [EC:1.3.8.1]\n 36 ACADSB; acyl-CoA dehydrogenase short/branched chain [KO:K09478] [EC:1.3.8.5]\n 37 ACADVL; acyl-CoA dehydrogenase very long chain [KO:K09479] [EC:1.3.8.9]\n 38 ACAT1; acetyl-CoA acetyltransferase 1 [KO:K00626] [EC:2.3.1.9]\n 39 ACAT2; acetyl-CoA acetyltransferase 2 [KO:K00626] [EC:2.3.1.9]\n 501 ALDH7A1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]\n 51 ACOX1; acyl-CoA oxidase 1 [KO:K00232] [EC:1.3.3.6]\n 51703 ACSL5; acyl-CoA synthetase long chain family member 5 [KO:K01897] [EC:6.2.1.3]\n 81616 ACSBG2; acyl-CoA synthetase bubblegum family member 2 [KO:K15013] [EC:6.2.1.3]\n 8310 ACOX3; acyl-CoA oxidase 3, pristanoyl [KO:K00232] [EC:1.3.3.6]\nCOMPOUND C00010 CoA\n C00024 Acetyl-CoA\n C00071 Aldehyde\n C00136 Butanoyl-CoA\n C00154 Palmitoyl-CoA\n C00162 Fatty acid\n C00226 Primary alcohol\n C00229 Acyl-carrier protein\n C00249 Hexadecanoic acid\n C00332 Acetoacetyl-CoA\n C00340 Reduced rubredoxin\n C00435 Oxidized rubredoxin\n C00489 Glutarate\n C00517 Hexadecanal\n C00527 Glutaryl-CoA\n C00638 Long-chain fatty acid\n C00823 1-Hexadecanol\n C00877 Crotonoyl-CoA\n C01144 (S)-3-Hydroxybutanoyl-CoA\n C01371 Alkane\n C01832 Lauroyl-CoA\n C01944 Octanoyl-CoA\n C02593 Tetradecanoyl-CoA\n C02990 L-Palmitoylcarnitine\n C03221 2-trans-Dodecenoyl-CoA\n C03547 omega-Hydroxy fatty acid\n C03561 (R)-3-Hydroxybutanoyl-CoA\n C05102 alpha-Hydroxy fatty acid\n C05258 (S)-3-Hydroxyhexadecanoyl-CoA\n C05259 3-Oxopalmitoyl-CoA\n C05260 (S)-3-Hydroxytetradecanoyl-CoA\n C05261 3-Oxotetradecanoyl-CoA\n C05262 (S)-3-Hydroxydodecanoyl-CoA\n C05263 3-Oxododecanoyl-CoA\n C05264 (S)-Hydroxydecanoyl-CoA\n C05265 3-Oxodecanoyl-CoA\n C05266 (S)-3-Hydroxyoctanoyl-CoA\n C05267 3-Oxooctanoyl-CoA\n C05268 (S)-Hydroxyhexanoyl-CoA\n C05269 3-Oxohexanoyl-CoA\n C05270 Hexanoyl-CoA\n C05271 trans-Hex-2-enoyl-CoA\n C05272 trans-Hexadec-2-enoyl-CoA\n C05273 trans-Tetradec-2-enoyl-CoA\n C05274 Decanoyl-CoA\n C05275 trans-Dec-2-enoyl-CoA\n C05276 trans-Oct-2-enoyl-CoA\n C05279 trans,cis-Lauro-2,6-dienoyl-CoA\n C05280 cis,cis-3,6-Dodecadienoyl-CoA\n C20683 Long-chain acyl-[acyl-carrier protein]\nREFERENCE PMID:869535\n AUTHORS Parekh VR, Traxler RW, Sobek JM\n TITLE N-Alkane oxidation enzymes of a pseudomonad.\n JOURNAL Appl Environ Microbiol 33:881-4 (1977)\n DOI:10.1128/AEM.33.4.881-884.1977\nREL_PATHWAY hsa00020 Citrate cycle (TCA cycle)\n hsa00061 Fatty acid biosynthesis\n hsa00062 Fatty acid elongation\n hsa00561 Glycerolipid metabolism\n hsa00630 Glyoxylate and dicarboxylate metabolism\n hsa00650 Butanoate metabolism\nKO_PATHWAY ko00071\n///")
7. └─ffrec$setBody(value)
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
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