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R Under development (unstable) (2022-12-25 r83502 ucrt) -- "Unsuffered Consequences"
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> library(testthat)
> library(netZooR)
Loading required package: igraph
Attaching package: 'igraph'
The following object is masked from 'package:testthat':
compare
The following objects are masked from 'package:stats':
decompose, spectrum
The following object is masked from 'package:base':
union
Loading required package: reticulate
Loading required package: pandaR
Loading required package: Biobase
Loading required package: BiocGenerics
Attaching package: 'BiocGenerics'
The following objects are masked from 'package:igraph':
normalize, path, union
The following objects are masked from 'package:stats':
IQR, mad, sd, var, xtabs
The following objects are masked from 'package:base':
Filter, Find, Map, Position, Reduce, anyDuplicated, aperm, append,
as.data.frame, basename, cbind, colnames, dirname, do.call,
duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table,
tapply, union, unique, unsplit, which.max, which.min
Welcome to Bioconductor
Vignettes contain introductory material; view with
'browseVignettes()'. To cite Bioconductor, see
'citation("Biobase")', and for packages 'citation("pkgname")'.
Loading required package: yarn
Setting options('download.file.method.GEOquery'='auto')
Setting options('GEOquery.inmemory.gpl'=FALSE)
>
> #download test data
> download.file('https://netzoo.s3.us-east-2.amazonaws.com/netZooR/example_datasets/ppi_medium.txt','testthat/ppi_medium.txt')
trying URL 'https://netzoo.s3.us-east-2.amazonaws.com/netZooR/example_datasets/ppi_medium.txt'
Content type 'text/plain' length 3674311 bytes (3.5 MB)
==================================================
downloaded 3.5 MB
> download.file('https://netzoo.s3.us-east-2.amazonaws.com/netZooR/unittest_datasets/testDataset.RData','testthat/testDataset.RData')
trying URL 'https://netzoo.s3.us-east-2.amazonaws.com/netZooR/unittest_datasets/testDataset.RData'
Content type 'binary/octet-stream' length 15200389 bytes (14.5 MB)
==================================================
downloaded 14.5 MB
>
> test_check("netZooR")
[1] "Detecting communities in control network..."
[1] "modularity of projected graph 0.0210526315789477"
[1] "Q = 0.0263157894736842"
[1] "Q = 0.0263157894736842"
[1] "Computing differential modularity matrix..."
[1] "Computing differential modules..."
[1] "Merging 100 communities"
[1] 1
[1] 2
[1] 3
[1] "Merging 2 communities"
[1] 1
[1] "Computing node scores..."
[1] 1
[1] 2
[1] "modularity of projected graph 0.144628099173554"
[1] "Q = 0.198347107438017"
[1] "Q = 0.231404958677686"
[1] "Q = 0.231404958677686"
[1] "modularity of projected graph 0"
[1] "Q = 0"
[1] "Q = 0.15702479338843"
[1] "Q = 0.231404958677686"
[1] "Q = 0.231404958677686"
[1] 0.1983471 0.2314050 0.2314050
[1] "Q = 0.198347107438017"
[1] "Q = 0.231404958677686"
[1] "Q = 0.231404958677686"
[1] "Q = 0.140495867768595"
[1] "Q = 0.140495867768595"
[1] "modularity of projected graph 0.227272727272727"
[1] "Q = 0.231404958677686"
[1] "Q = 0.231404958677686"
[1] "modularity of projected graph 0.525346928655047"
[1] "Q = 0.52666696475026"
[1] "Q = 0.52666696475026"
% Total % Received % Xferd Average Speed Time Time Time Current
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[1] "Initializing and validating"
[1] "Verified sufficient samples"
[1] "Normalizing networks..."
[1] "Learning Network..."
[1] "Using tanimoto similarity"
[1] "Initializing and validating"
[1] "Verified sufficient samples"
[1] "Normalizing networks..."
[1] "Learning Network..."
[1] "Using tanimoto similarity"
% Total % Received % Xferd Average Speed Time Time Time Current
Dload Upload Total Spent Left Speed
0 0 0 0 0 0 0 0 --:--:-- --:--:-- --:--:-- 0
100 27822 100 27822 0 0 205k 0 --:--:-- --:--:-- --:--:-- 207k
Loading expression data ...
Elapsed time: 0.00 sec.
No PPI data given: ppi matrix will be an identity matrix of size 0
Calculating coexpression network ...
Elapsed time: 0.02 sec.
Returning the correlation matrix of expression data in <Panda_obj>.correlation_matrix
union None ./expr4_200_L.txt None False False True
Loading input data ...
Elapsed time: 0.00 sec.
Number of total samples: 11
Number of computed samples: 1
Number of parallel cores: 1
Running LIONESS for sample 1:
Computing coexpression network:
Elapsed time: 0.00 sec.
Normalizing networks:
Elapsed time: 0.00 sec.
Inferring LIONESS network:
Elapsed time: 0.00 sec.
Saving LIONESS network 1 to lioness_output using no format:
Unknown format no! File will not be saved.
Elapsed time: 0.00 sec.
C:\Python39\lib\site-packages\numpy\lib\function_base.py:2691: RuntimeWarning: invalid value encountered in true_divide
c /= stddev[:, None]
C:\Python39\lib\site-packages\numpy\lib\function_base.py:2692: RuntimeWarning: invalid value encountered in true_divide
c /= stddev[None, :]
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.02 sec.
No PPI data given: ppi matrix will be an identity matrix of size 5
Calculating coexpression network ...
Elapsed time: 0.03 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
union F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt None False False True
Normalizing networks ...
Elapsed time: 0.03 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 0.00 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.3008717441926665
step: 1, hamming: 0.32577840239393485
step: 2, hamming: 0.36046547993298506
step: 3, hamming: 0.36058526850894806
step: 4, hamming: 0.3466240823512552
step: 5, hamming: 0.32456269443005153
step: 6, hamming: 0.2989434598421862
step: 7, hamming: 0.2706019093508666
step: 8, hamming: 0.24146225569326246
step: 9, hamming: 0.21301541796450382
step: 10, hamming: 0.18618747428128857
step: 11, hamming: 0.16147381450104786
step: 12, hamming: 0.13913324895882415
step: 13, hamming: 0.11926159237252416
step: 14, hamming: 0.1018524648128548
step: 15, hamming: 0.08669455519421927
step: 16, hamming: 0.07353017763220226
step: 17, hamming: 0.06215000422873393
step: 18, hamming: 0.05239618178480344
step: 19, hamming: 0.04409487478206072
step: 20, hamming: 0.037011961055401506
step: 21, hamming: 0.03099423061137592
step: 22, hamming: 0.025900515663656126
step: 23, hamming: 0.02160297573646609
step: 24, hamming: 0.017987639137724463
step: 25, hamming: 0.01495414717402849
step: 26, hamming: 0.01241474935607542
step: 27, hamming: 0.010293476645032267
step: 28, hamming: 0.008524772832534408
step: 29, hamming: 0.007052536065331644
step: 30, hamming: 0.005828962967549391
step: 31, hamming: 0.004813469251228287
step: 32, hamming: 0.003971733841541358
step: 33, hamming: 0.003274823735478184
step: 34, hamming: 0.002698421842219443
step: 35, hamming: 0.002222141197914948
step: 36, hamming: 0.0018289290757055085
step: 37, hamming: 0.0015045517890993699
step: 38, hamming: 0.001237148633830058
step: 39, hamming: 0.0010168547681778833
step: 40, hamming: 0.0008354772054776418
Running panda took: 0.58 seconds!
Loading input data ...
Elapsed time: 0.00 sec.
Number of total samples: 11
Number of computed samples: 1
Number of parallel cores: 1
Running LIONESS for sample 1:
Computing coexpression network:
Elapsed time: 0.02 sec.
Normalizing networks:
Elapsed time: 0.02 sec.
Inferring LIONESS network:
step: 0, hamming: 0.3015932422799911
step: 1, hamming: 0.32674478239840066
step: 2, hamming: 0.36109248186970144
step: 3, hamming: 0.36080894284507337
step: 4, hamming: 0.34665241776678835
step: 5, hamming: 0.3245939713292134
step: 6, hamming: 0.2989655066138038
step: 7, hamming: 0.27062058204102246
step: 8, hamming: 0.24148327279879642
step: 9, hamming: 0.21304028351555665
step: 10, hamming: 0.18620484129483603
step: 11, hamming: 0.1614836666882501
step: 12, hamming: 0.13913925776650915
step: 13, hamming: 0.1192705526210247
step: 14, hamming: 0.10186083999388719
step: 15, hamming: 0.0867061558174197
step: 16, hamming: 0.0735398859822866
step: 17, hamming: 0.06215811356512186
step: 18, hamming: 0.05241372809810256
step: 19, hamming: 0.04410977556767985
step: 20, hamming: 0.03702457033326145
step: 21, hamming: 0.031005003311004847
step: 22, hamming: 0.02590957296357105
step: 23, hamming: 0.021610559908641202
step: 24, hamming: 0.01799395112713222
step: 25, hamming: 0.014959350583484143
step: 26, hamming: 0.012419036091497034
step: 27, hamming: 0.010296989659986456
step: 28, hamming: 0.00852768414504873
step: 29, hamming: 0.007054962882501573
step: 30, hamming: 0.005830983737417465
step: 31, hamming: 0.004815151202585597
step: 32, hamming: 0.003973130484197424
step: 33, hamming: 0.0032759823203917893
step: 34, hamming: 0.0026993820286105494
step: 35, hamming: 0.0022229362315468095
step: 36, hamming: 0.0018295867892865773
step: 37, hamming: 0.0015050947585658215
step: 38, hamming: 0.0012375965038720221
step: 39, hamming: 0.001017223969926159
step: 40, hamming: 0.0008357813833837506
Elapsed time: 0.56 sec.
Saving LIONESS network 1 to lioness_output using no format:
Unknown format no! File will not be saved.
Elapsed time: 0.00 sec.
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.00 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.08 sec.
Calculating coexpression network ...
Elapsed time: 0.02 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.08 sec.
union F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt False False True
Normalizing networks ...
Elapsed time: 0.87 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 1.09 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.08748661874955622
step: 1, hamming: 0.06888714365861337
step: 2, hamming: 0.062114312778413824
step: 3, hamming: 0.05713353090446696
step: 4, hamming: 0.05304016922455829
step: 5, hamming: 0.049101138022894876
step: 6, hamming: 0.045074438192725504
step: 7, hamming: 0.04095526634659027
step: 8, hamming: 0.036830333937534133
step: 9, hamming: 0.03280131999197774
step: 10, hamming: 0.02895800229188848
step: 11, hamming: 0.025365652761878358
step: 12, hamming: 0.022066636023677574
step: 13, hamming: 0.019078836711277743
step: 14, hamming: 0.016405313028879685
step: 15, hamming: 0.014037779400693116
step: 16, hamming: 0.01195982841838061
step: 17, hamming: 0.01015009070774131
step: 18, hamming: 0.008584499851559681
step: 19, hamming: 0.007238007589517707
step: 20, hamming: 0.00608586224867506
step: 21, hamming: 0.005104411138700386
step: 22, hamming: 0.004271661591718609
step: 23, hamming: 0.003567561174685126
step: 24, hamming: 0.002974084885079086
step: 25, hamming: 0.002475243890114065
step: 26, hamming: 0.002056989100113543
step: 27, hamming: 0.0017070859535523232
step: 28, hamming: 0.0014149533300699651
step: 29, hamming: 0.0011714963862095031
step: 30, hamming: 0.000968936912293422
Running panda took: 24.25 seconds!
Loading input data ...
Elapsed time: 0.00 sec.
Number of total samples: 11
Number of computed samples: 1
Number of parallel cores: 1
Running LIONESS for sample 1:
Computing coexpression network:
Elapsed time: 0.02 sec.
Normalizing networks:
Elapsed time: 0.02 sec.
Inferring LIONESS network:
step: 0, hamming: 0.0874818573175637
step: 1, hamming: 0.06891282897076391
step: 2, hamming: 0.06213058734815114
step: 3, hamming: 0.05714118386838519
step: 4, hamming: 0.053045294463774983
step: 5, hamming: 0.04910525549313264
step: 6, hamming: 0.045077507937550505
step: 7, hamming: 0.040957168253354534
step: 8, hamming: 0.036831755781812706
step: 9, hamming: 0.032802826977823524
step: 10, hamming: 0.028959920494437665
step: 11, hamming: 0.02536789474365321
step: 12, hamming: 0.022069009727623188
step: 13, hamming: 0.019081318203819215
step: 14, hamming: 0.016407788201894247
step: 15, hamming: 0.014040090736288896
step: 16, hamming: 0.011961875397219707
step: 17, hamming: 0.010151865216875243
step: 18, hamming: 0.008586011382256611
step: 19, hamming: 0.007239278751699701
step: 20, hamming: 0.006086920160262565
step: 21, hamming: 0.005105283470150481
step: 22, hamming: 0.004272377006570679
step: 23, hamming: 0.0035681447767932513
step: 24, hamming: 0.002974559350795157
step: 25, hamming: 0.002475628259651009
step: 26, hamming: 0.0020572999963523056
step: 27, hamming: 0.0017073373347909835
step: 28, hamming: 0.00141515656139142
step: 29, hamming: 0.0011716607762849165
step: 30, hamming: 0.0009690701447933722
Elapsed time: 24.55 sec.
Saving LIONESS network 1 to lioness_output using no format:
Unknown format no! File will not be saved.
Elapsed time: 0.00 sec.
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.02 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.06 sec.
Calculating coexpression network ...
Elapsed time: 0.00 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.06 sec.
intersection F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt False False True
Normalizing networks ...
Elapsed time: 0.00 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.6788049340248108
step: 1, hamming: 0.4237635135650635
step: 2, hamming: 0.3794232904911041
step: 3, hamming: 0.3818596303462982
step: 4, hamming: 0.38526612520217896
step: 5, hamming: 0.3832989037036896
step: 6, hamming: 0.36915773153305054
step: 7, hamming: 0.34574782848358154
step: 8, hamming: 0.31520816683769226
step: 9, hamming: 0.2818054258823395
step: 10, hamming: 0.24849660694599152
step: 11, hamming: 0.21666744351387024
step: 12, hamming: 0.18729539215564728
step: 13, hamming: 0.16079427301883698
step: 14, hamming: 0.13726864755153656
step: 15, hamming: 0.11666569113731384
step: 16, hamming: 0.09877120703458786
step: 17, hamming: 0.08336563408374786
step: 18, hamming: 0.07016085088253021
step: 19, hamming: 0.058891184628009796
step: 20, hamming: 0.04931585118174553
step: 21, hamming: 0.041211165487766266
step: 22, hamming: 0.03437766060233116
step: 23, hamming: 0.02863147109746933
step: 24, hamming: 0.0238089170306921
step: 25, hamming: 0.019770871847867966
step: 26, hamming: 0.016396749764680862
step: 27, hamming: 0.01358273159712553
step: 28, hamming: 0.011239762417972088
step: 29, hamming: 0.009291956201195717
step: 30, hamming: 0.0076749688014388084
step: 31, hamming: 0.0063342684879899025
step: 32, hamming: 0.005223971791565418
step: 33, hamming: 0.004305408801883459
step: 34, hamming: 0.0035461909137666225
step: 35, hamming: 0.002919200574979186
step: 36, hamming: 0.0024018811527639627
step: 37, hamming: 0.0019753146916627884
step: 38, hamming: 0.0016238073585554957
step: 39, hamming: 0.001334344851784408
step: 40, hamming: 0.0010961124207824469
step: 41, hamming: 0.0009001471335068345
Running panda took: 0.00 seconds!
Loading input data ...
Elapsed time: 0.00 sec.
Number of total samples: 11
Number of computed samples: 1
Number of parallel cores: 1
Running LIONESS for sample 1:
Computing coexpression network:
Elapsed time: 0.00 sec.
Normalizing networks:
Elapsed time: 0.00 sec.
Inferring LIONESS network:
step: 0, hamming: 0.6829624252643024
step: 1, hamming: 0.43097386969737467
step: 2, hamming: 0.3855310332972826
step: 3, hamming: 0.38637191344546506
step: 4, hamming: 0.39001820267044696
step: 5, hamming: 0.38601884753426646
step: 6, hamming: 0.37083627595496715
step: 7, hamming: 0.3469023721010731
step: 8, hamming: 0.31596767563237377
step: 9, hamming: 0.2823677724041992
step: 10, hamming: 0.24886232875703243
step: 11, hamming: 0.21693733016217834
step: 12, hamming: 0.1875129193175416
step: 13, hamming: 0.1609701836223114
step: 14, hamming: 0.13743834351937564
step: 15, hamming: 0.11682177402185094
step: 16, hamming: 0.0989602327792078
step: 17, hamming: 0.08353838996370484
step: 18, hamming: 0.07031459662912222
step: 19, hamming: 0.05903107230891116
step: 20, hamming: 0.049447848936208585
step: 21, hamming: 0.041332665358096286
step: 22, hamming: 0.03448368388232095
step: 23, hamming: 0.028720375548938075
step: 24, hamming: 0.02388327219797364
step: 25, hamming: 0.019832958716462273
step: 26, hamming: 0.016448511057472182
step: 27, hamming: 0.013625773339477069
step: 28, hamming: 0.011275503429549753
step: 29, hamming: 0.009321615661804542
step: 30, hamming: 0.007699524683027151
step: 31, hamming: 0.006354585216875863
step: 32, hamming: 0.00524073243580051
step: 33, hamming: 0.00431923098127344
step: 34, hamming: 0.003557580755210537
step: 35, hamming: 0.002928611407776382
step: 36, hamming: 0.0024096126806938843
step: 37, hamming: 0.001981682374285388
step: 38, hamming: 0.0016290920553380466
step: 39, hamming: 0.001338728463991543
step: 40, hamming: 0.0010997294054595165
step: 41, hamming: 0.0009031298195247417
Elapsed time: 0.02 sec.
Saving LIONESS network 1 to lioness_output using no format:
Unknown format no! File will not be saved.
Elapsed time: 0.00 sec.
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.00 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.06 sec.
Calculating coexpression network ...
Elapsed time: 0.02 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.09 sec.
legacy F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt False False True
Normalizing networks ...
Elapsed time: 0.00 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 0.03 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.5867745269558597
step: 1, hamming: 0.4770948069617154
step: 2, hamming: 0.4695616866661462
step: 3, hamming: 0.45425003629838684
step: 4, hamming: 0.4187427725151872
step: 5, hamming: 0.3679724124423835
step: 6, hamming: 0.31337190961143313
step: 7, hamming: 0.2640386174641925
step: 8, hamming: 0.22399992327898238
step: 9, hamming: 0.19253176059893798
step: 10, hamming: 0.1676553667649102
step: 11, hamming: 0.14730006142326466
step: 12, hamming: 0.1298215908983933
step: 13, hamming: 0.11459157116297605
step: 14, hamming: 0.10108821391424126
step: 15, hamming: 0.08890364507467007
step: 16, hamming: 0.07787244456478047
step: 17, hamming: 0.06785464923123904
step: 18, hamming: 0.05878796471238135
step: 19, hamming: 0.05062155744809771
step: 20, hamming: 0.04333239380925903
step: 21, hamming: 0.036892574940160516
step: 22, hamming: 0.03126206012121671
step: 23, hamming: 0.02638428040392175
step: 24, hamming: 0.022190961740915574
step: 25, hamming: 0.01860922988517212
step: 26, hamming: 0.015566652188260111
step: 27, hamming: 0.012993283312056424
step: 28, hamming: 0.010824919177296213
step: 29, hamming: 0.009003507268894196
step: 30, hamming: 0.00747755291088981
step: 31, hamming: 0.0062020628941105065
step: 32, hamming: 0.005138069423501644
step: 33, hamming: 0.004252085993537948
step: 34, hamming: 0.0035154788596479672
step: 35, hamming: 0.00290392674390587
step: 36, hamming: 0.0023968521367998454
step: 37, hamming: 0.0019768786344578015
step: 38, hamming: 0.0016294013136896744
step: 39, hamming: 0.0013421799963357426
step: 40, hamming: 0.0011049738470584863
step: 41, hamming: 0.000909227997318053
Running panda took: 0.05 seconds!
Loading input data ...
Elapsed time: 0.00 sec.
Number of total samples: 11
Number of computed samples: 1
Number of parallel cores: 1
Running LIONESS for sample 1:
Computing coexpression network:
Elapsed time: 0.00 sec.
Normalizing networks:
Elapsed time: 0.00 sec.
Inferring LIONESS network:
step: 0, hamming: 0.5875614098660666
step: 1, hamming: 0.48294668487646625
step: 2, hamming: 0.4810579089105837
step: 3, hamming: 0.46847113464020446
step: 4, hamming: 0.4337012115522554
step: 5, hamming: 0.38094873330102347
step: 6, hamming: 0.32310742082399213
step: 7, hamming: 0.27060297935454153
step: 8, hamming: 0.22871223602816745
step: 9, hamming: 0.19638081399100335
step: 10, hamming: 0.17127585718635555
step: 11, hamming: 0.15034152043301924
step: 12, hamming: 0.1323105478668466
step: 13, hamming: 0.11649711485539004
step: 14, hamming: 0.1023563092541029
step: 15, hamming: 0.08963435266941024
step: 16, hamming: 0.07811460526211582
step: 17, hamming: 0.06770343603846223
step: 18, hamming: 0.058342983115191926
step: 19, hamming: 0.04999398523930742
step: 20, hamming: 0.04261616820807743
step: 21, hamming: 0.036160346966779874
step: 22, hamming: 0.03055914202736641
step: 23, hamming: 0.02573700902927474
step: 24, hamming: 0.021610772222598034
step: 25, hamming: 0.018099099845240618
step: 26, hamming: 0.01512391162922807
step: 27, hamming: 0.012613019715219047
step: 28, hamming: 0.010500738712116988
step: 29, hamming: 0.008728774744404807
step: 30, hamming: 0.007245746309115974
step: 31, hamming: 0.0060071587779357664
step: 32, hamming: 0.004974647163777003
step: 33, hamming: 0.004115358386600001
step: 34, hamming: 0.003401306327536735
step: 35, hamming: 0.002808749172176155
step: 36, hamming: 0.002317621564663277
step: 37, hamming: 0.0019110115327221292
step: 38, hamming: 0.0015747162820157854
step: 39, hamming: 0.0012968334760169568
step: 40, hamming: 0.0010674133797636278
step: 41, hamming: 0.0008781471581459396
Elapsed time: 0.05 sec.
Saving LIONESS network 1 to lioness_output using no format:
Unknown format no! File will not be saved.
Elapsed time: 0.00 sec.
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.00 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.08 sec.
Remove expression not in motif:
166 rows removed from the initial 200
Remove motif not in expression data:
467 rows removed from the initial 506
Remove ppi not in motif:
100017 rows removed from the initial 100019
new case
Calculating coexpression network ...
Elapsed time: 0.00 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.00 sec.
legacy F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt False True True
Normalizing networks ...
Elapsed time: 0.00 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 0.00 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.6201117836163109
step: 1, hamming: 0.48938385169250487
step: 2, hamming: 0.49937220814370314
step: 3, hamming: 0.5234998024292964
step: 4, hamming: 0.5316279091580729
step: 5, hamming: 0.5196461826284899
step: 6, hamming: 0.49096615680840516
step: 7, hamming: 0.45136867762995053
step: 8, hamming: 0.4081852233215105
step: 9, hamming: 0.363060630725845
step: 10, hamming: 0.3189123247409479
step: 11, hamming: 0.27733895854371826
step: 12, hamming: 0.23925292481822666
step: 13, hamming: 0.20518316158337402
step: 14, hamming: 0.17501658473943316
step: 15, hamming: 0.14854288648840214
step: 16, hamming: 0.12553582999076404
step: 17, hamming: 0.10573284427875865
step: 18, hamming: 0.08878386418920353
step: 19, hamming: 0.07436882705115158
step: 20, hamming: 0.062172412390917475
step: 21, hamming: 0.051880715413709574
step: 22, hamming: 0.043220322319520395
step: 23, hamming: 0.03594946787636906
step: 24, hamming: 0.029859895475909407
step: 25, hamming: 0.0247709383962932
step: 26, hamming: 0.02052575604899425
step: 27, hamming: 0.016990787588434916
step: 28, hamming: 0.014051171275167215
step: 29, hamming: 0.011609873894851033
step: 30, hamming: 0.009584973156032758
step: 31, hamming: 0.007907374279360044
step: 32, hamming: 0.006518966440957067
step: 33, hamming: 0.00537099915686947
step: 34, hamming: 0.004422666090211263
step: 35, hamming: 0.003639879247818417
step: 36, hamming: 0.002994214649903011
step: 37, hamming: 0.002462010284380626
step: 38, hamming: 0.0020235978467206613
step: 39, hamming: 0.001662650998788406
step: 40, hamming: 0.0013656343876712778
step: 41, hamming: 0.001121339276182217
step: 42, hamming: 0.0009204932425645662
Running panda took: 0.02 seconds!
Loading input data ...
Elapsed time: 0.00 sec.
Number of total samples: 11
Number of computed samples: 1
Number of parallel cores: 1
Running LIONESS for sample 1:
Computing coexpression network:
Elapsed time: 0.00 sec.
Normalizing networks:
Elapsed time: 0.00 sec.
Inferring LIONESS network:
step: 0, hamming: 0.6267664063560152
step: 1, hamming: 0.49929052211545427
step: 2, hamming: 0.5091133020260827
step: 3, hamming: 0.5347173973757746
step: 4, hamming: 0.5397805120478006
step: 5, hamming: 0.5249527732389625
step: 6, hamming: 0.4945006816241802
step: 7, hamming: 0.45361576992526725
step: 8, hamming: 0.40948805442896147
step: 9, hamming: 0.364314775944606
step: 10, hamming: 0.3202827156746967
step: 11, hamming: 0.27889575055839505
step: 12, hamming: 0.240869786159727
step: 13, hamming: 0.2065830558514754
step: 14, hamming: 0.17608500470506336
step: 15, hamming: 0.14929860299983969
step: 16, hamming: 0.1260432183021211
step: 17, hamming: 0.10605108373830612
step: 18, hamming: 0.08898835303868327
step: 19, hamming: 0.07448950012171325
step: 20, hamming: 0.06222491628833415
step: 21, hamming: 0.05188708455543115
step: 22, hamming: 0.04319809393977557
step: 23, hamming: 0.03591255015730086
step: 24, hamming: 0.02981582036436827
step: 25, hamming: 0.024724122666490836
step: 26, hamming: 0.020479690684899493
step: 27, hamming: 0.016946966247749058
step: 28, hamming: 0.014010645315880806
step: 29, hamming: 0.011573255021910579
step: 30, hamming: 0.009552447322836884
step: 31, hamming: 0.00787886102785467
step: 32, hamming: 0.006494227871820657
step: 33, hamming: 0.00534971327882381
step: 34, hamming: 0.004404475166617579
step: 35, hamming: 0.0036244207432898318
step: 36, hamming: 0.0029811401934302546
step: 37, hamming: 0.002450996487900658
step: 38, hamming: 0.002014351683946002
step: 39, hamming: 0.0016549116365250542
step: 40, hamming: 0.0013591727817255587
step: 41, hamming: 0.0011159564314784573
step: 42, hamming: 0.0009160177452470277
Elapsed time: 0.00 sec.
Saving LIONESS network 1 to lioness_output using no format:
Unknown format no! File will not be saved.
Elapsed time: 0.00 sec.
[1] "Computing network for sample 1"
[1] "Computing network for sample 2"
[1] "Computing network for sample 3"
[1] "Computing network for sample 4"
[1] "Computing network for sample 1"
[1] "Computing network for sample 2"
[1] "Computing network for sample 3"
[1] "Computing network for sample 4"
% Total % Received % Xferd Average Speed Time Time Time Current
Dload Upload Total Spent Left Speed
0 0 0 0 0 0 0 0 --:--:-- --:--:-- --:--:-- 0
100 1079k 100 1079k 0 0 4660k 0 --:--:-- --:--:-- --:--:-- 4693k
[1] "1 network transitions to be estimated"
[1] "Running iteration 1"
[1] "Initializing and validating"
[1] "Verified adequate samples, calculating correlation matrix"
Time difference of 0.0001039505 secs
[1] "More data cleaning"
[1] "Main calculation"
.....................................................[1] "Initializing and validating"
[1] "Verified adequate samples, calculating correlation matrix"
Time difference of 0.0001471043 secs
[1] "More data cleaning"
[1] "Main calculation"
.....................................................[1] "Using OLS method"
[1] "Finished running iteration 1"
Time difference of 3.261539 secs
Time difference of 0.07651687 secs
Time difference of 0.09346604 secs
Time difference of 0.07651711 secs
Time difference of 0.09316683 secs
[1] "Using OLS method"
Time difference of 1.40667e-05 secs
Time difference of 1.390055 secs
Time difference of 0.5945771 secs
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MONSTER object
2555 genes
20 baseline samples
20 final samples
Transition driven by 53 transcription factors
Run with 10 randomized permutations.
% Total % Received % Xferd Average Speed Time Time Time Current
Dload Upload Total Spent Left Speed
0 0 0 0 0 0 0 0 --:--:-- --:--:-- --:--:-- 0
100 27822 100 27822 0 0 146k 0 --:--:-- --:--:-- --:--:-- 147k
Loading expression data ...
Elapsed time: 0.02 sec.
No PPI data given: ppi matrix will be an identity matrix of size 0
Calculating coexpression network ...
Elapsed time: 0.00 sec.
Returning the correlation matrix of expression data in <Panda_obj>.correlation_matrix
union None ./expr4_200_L.txt None False False False
Loading motif data ...
Elapsed time: 0.02 sec.
Loading expression data ...
Elapsed time: 0.00 sec.
No PPI data given: ppi matrix will be an identity matrix of size 5
Calculating coexpression network ...
Elapsed time: 0.02 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
union F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt None False False False
Normalizing networks ...
Elapsed time: 0.00 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 0.02 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.3008717441926665
step: 1, hamming: 0.32577840239393485
step: 2, hamming: 0.36046547993298506
step: 3, hamming: 0.36058526850894806
step: 4, hamming: 0.3466240823512552
step: 5, hamming: 0.32456269443005153
step: 6, hamming: 0.2989434598421862
step: 7, hamming: 0.2706019093508666
step: 8, hamming: 0.24146225569326246
step: 9, hamming: 0.21301541796450382
step: 10, hamming: 0.18618747428128857
step: 11, hamming: 0.16147381450104786
step: 12, hamming: 0.13913324895882415
step: 13, hamming: 0.11926159237252416
step: 14, hamming: 0.1018524648128548
step: 15, hamming: 0.08669455519421927
step: 16, hamming: 0.07353017763220226
step: 17, hamming: 0.06215000422873393
step: 18, hamming: 0.05239618178480344
step: 19, hamming: 0.04409487478206072
step: 20, hamming: 0.037011961055401506
step: 21, hamming: 0.03099423061137592
step: 22, hamming: 0.025900515663656126
step: 23, hamming: 0.02160297573646609
step: 24, hamming: 0.017987639137724463
step: 25, hamming: 0.01495414717402849
step: 26, hamming: 0.01241474935607542
step: 27, hamming: 0.010293476645032267
step: 28, hamming: 0.008524772832534408
step: 29, hamming: 0.007052536065331644
step: 30, hamming: 0.005828962967549391
step: 31, hamming: 0.004813469251228287
step: 32, hamming: 0.003971733841541358
step: 33, hamming: 0.003274823735478184
step: 34, hamming: 0.002698421842219443
step: 35, hamming: 0.002222141197914948
step: 36, hamming: 0.0018289290757055085
step: 37, hamming: 0.0015045517890993699
step: 38, hamming: 0.001237148633830058
step: 39, hamming: 0.0010168547681778833
step: 40, hamming: 0.0008354772054776418
Running panda took: 0.58 seconds!
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.02 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.06 sec.
Calculating coexpression network ...
Elapsed time: 0.02 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.08 sec.
union F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt False False False
Normalizing networks ...
Elapsed time: 0.86 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 1.37 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.08748661874955622
step: 1, hamming: 0.06888714365861337
step: 2, hamming: 0.062114312778413824
step: 3, hamming: 0.05713353090446696
step: 4, hamming: 0.05304016922455829
step: 5, hamming: 0.049101138022894876
step: 6, hamming: 0.045074438192725504
step: 7, hamming: 0.04095526634659027
step: 8, hamming: 0.036830333937534133
step: 9, hamming: 0.03280131999197774
step: 10, hamming: 0.02895800229188848
step: 11, hamming: 0.025365652761878358
step: 12, hamming: 0.022066636023677574
step: 13, hamming: 0.019078836711277743
step: 14, hamming: 0.016405313028879685
step: 15, hamming: 0.014037779400693116
step: 16, hamming: 0.01195982841838061
step: 17, hamming: 0.01015009070774131
step: 18, hamming: 0.008584499851559681
step: 19, hamming: 0.007238007589517707
step: 20, hamming: 0.00608586224867506
step: 21, hamming: 0.005104411138700386
step: 22, hamming: 0.004271661591718609
step: 23, hamming: 0.003567561174685126
step: 24, hamming: 0.002974084885079086
step: 25, hamming: 0.002475243890114065
step: 26, hamming: 0.002056989100113543
step: 27, hamming: 0.0017070859535523232
step: 28, hamming: 0.0014149533300699651
step: 29, hamming: 0.0011714963862095031
step: 30, hamming: 0.000968936912293422
Running panda took: 23.05 seconds!
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.00 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.06 sec.
Calculating coexpression network ...
Elapsed time: 0.00 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.05 sec.
intersection F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt True False True
Normalizing networks ...
Elapsed time: 0.00 sec.
Clearing motif and ppi data, unique tfs, and gene names for speed
Running PANDA algorithm ...
step: 0, hamming: 0.6788049340248108
step: 1, hamming: 0.4237635135650635
step: 2, hamming: 0.3794232904911041
step: 3, hamming: 0.3818596303462982
step: 4, hamming: 0.38526612520217896
step: 5, hamming: 0.3832989037036896
step: 6, hamming: 0.36915773153305054
step: 7, hamming: 0.34574782848358154
step: 8, hamming: 0.31520816683769226
step: 9, hamming: 0.2818054258823395
step: 10, hamming: 0.24849660694599152
step: 11, hamming: 0.21666744351387024
step: 12, hamming: 0.18729539215564728
step: 13, hamming: 0.16079427301883698
step: 14, hamming: 0.13726864755153656
step: 15, hamming: 0.11666569113731384
step: 16, hamming: 0.09877120703458786
step: 17, hamming: 0.08336563408374786
step: 18, hamming: 0.07016085088253021
step: 19, hamming: 0.058891184628009796
step: 20, hamming: 0.04931585118174553
step: 21, hamming: 0.041211165487766266
step: 22, hamming: 0.03437766060233116
step: 23, hamming: 0.02863147109746933
step: 24, hamming: 0.0238089170306921
step: 25, hamming: 0.019770871847867966
step: 26, hamming: 0.016396749764680862
step: 27, hamming: 0.01358273159712553
step: 28, hamming: 0.011239762417972088
step: 29, hamming: 0.009291956201195717
step: 30, hamming: 0.0076749688014388084
step: 31, hamming: 0.0063342684879899025
step: 32, hamming: 0.005223971791565418
step: 33, hamming: 0.004305408801883459
step: 34, hamming: 0.0035461909137666225
step: 35, hamming: 0.002919200574979186
step: 36, hamming: 0.0024018811527639627
step: 37, hamming: 0.0019753146916627884
step: 38, hamming: 0.0016238073585554957
step: 39, hamming: 0.001334344851784408
step: 40, hamming: 0.0010961124207824469
step: 41, hamming: 0.0009001471335068345
Running panda took: 0.02 seconds!
Loading motif data ...
Elapsed time: 0.00 sec.
Loading expression data ...
Elapsed time: 0.00 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.08 sec.
Calculating coexpression network ...
Elapsed time: 0.00 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.05 sec.
legacy F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt False False False
Normalizing networks ...
Elapsed time: 0.00 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 0.02 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.5867745269558597
step: 1, hamming: 0.4770948069617154
step: 2, hamming: 0.4695616866661462
step: 3, hamming: 0.45425003629838684
step: 4, hamming: 0.4187427725151872
step: 5, hamming: 0.3679724124423835
step: 6, hamming: 0.31337190961143313
step: 7, hamming: 0.2640386174641925
step: 8, hamming: 0.22399992327898238
step: 9, hamming: 0.19253176059893798
step: 10, hamming: 0.1676553667649102
step: 11, hamming: 0.14730006142326466
step: 12, hamming: 0.1298215908983933
step: 13, hamming: 0.11459157116297605
step: 14, hamming: 0.10108821391424126
step: 15, hamming: 0.08890364507467007
step: 16, hamming: 0.07787244456478047
step: 17, hamming: 0.06785464923123904
step: 18, hamming: 0.05878796471238135
step: 19, hamming: 0.05062155744809771
step: 20, hamming: 0.04333239380925903
step: 21, hamming: 0.036892574940160516
step: 22, hamming: 0.03126206012121671
step: 23, hamming: 0.02638428040392175
step: 24, hamming: 0.022190961740915574
step: 25, hamming: 0.01860922988517212
step: 26, hamming: 0.015566652188260111
step: 27, hamming: 0.012993283312056424
step: 28, hamming: 0.010824919177296213
step: 29, hamming: 0.009003507268894196
step: 30, hamming: 0.00747755291088981
step: 31, hamming: 0.0062020628941105065
step: 32, hamming: 0.005138069423501644
step: 33, hamming: 0.004252085993537948
step: 34, hamming: 0.0035154788596479672
step: 35, hamming: 0.00290392674390587
step: 36, hamming: 0.0023968521367998454
step: 37, hamming: 0.0019768786344578015
step: 38, hamming: 0.0016294013136896744
step: 39, hamming: 0.0013421799963357426
step: 40, hamming: 0.0011049738470584863
step: 41, hamming: 0.000909227997318053
Running panda took: 0.05 seconds!
Loading motif data ...
Elapsed time: 0.02 sec.
Loading expression data ...
Elapsed time: 0.00 sec.
Loading PPI data ...
Number of PPIs: 100019
Elapsed time: 0.06 sec.
Remove expression not in motif:
166 rows removed from the initial 200
Remove motif not in expression data:
467 rows removed from the initial 506
Remove ppi not in motif:
100017 rows removed from the initial 100019
new case
Calculating coexpression network ...
Elapsed time: 0.00 sec.
Creating motif network ...
Elapsed time: 0.00 sec.
Creating PPI network ...
Elapsed time: 0.00 sec.
legacy F:/biocbuild/bbs-3.17-bioc/R/library/netZooR/extdata/chip_medium.txt ./expr4_200_L.txt ./ppi_medium.txt False True False
Normalizing networks ...
Elapsed time: 0.00 sec.
Saving expression matrix and normalized networks ...
Elapsed time: 0.00 sec.
Running PANDA algorithm ...
step: 0, hamming: 0.6201117836163109
step: 1, hamming: 0.48938385169250487
step: 2, hamming: 0.49937220814370314
step: 3, hamming: 0.5234998024292964
step: 4, hamming: 0.5316279091580729
step: 5, hamming: 0.5196461826284899
step: 6, hamming: 0.49096615680840516
step: 7, hamming: 0.45136867762995053
step: 8, hamming: 0.4081852233215105
step: 9, hamming: 0.363060630725845
step: 10, hamming: 0.3189123247409479
step: 11, hamming: 0.27733895854371826
step: 12, hamming: 0.23925292481822666
step: 13, hamming: 0.20518316158337402
step: 14, hamming: 0.17501658473943316
step: 15, hamming: 0.14854288648840214
step: 16, hamming: 0.12553582999076404
step: 17, hamming: 0.10573284427875865
step: 18, hamming: 0.08878386418920353
step: 19, hamming: 0.07436882705115158
step: 20, hamming: 0.062172412390917475
step: 21, hamming: 0.051880715413709574
step: 22, hamming: 0.043220322319520395
step: 23, hamming: 0.03594946787636906
step: 24, hamming: 0.029859895475909407
step: 25, hamming: 0.0247709383962932
step: 26, hamming: 0.02052575604899425
step: 27, hamming: 0.016990787588434916
step: 28, hamming: 0.014051171275167215
step: 29, hamming: 0.011609873894851033
step: 30, hamming: 0.009584973156032758
step: 31, hamming: 0.007907374279360044
step: 32, hamming: 0.006518966440957067
step: 33, hamming: 0.00537099915686947
step: 34, hamming: 0.004422666090211263
step: 35, hamming: 0.003639879247818417
step: 36, hamming: 0.002994214649903011
step: 37, hamming: 0.002462010284380626
step: 38, hamming: 0.0020235978467206613
step: 39, hamming: 0.001662650998788406
step: 40, hamming: 0.0013656343876712778
step: 41, hamming: 0.001121339276182217
step: 42, hamming: 0.0009204932425645662
Running panda took: 0.02 seconds!
[1] "Detecting communities in control network..."
[1] "modularity of projected graph 0.471004488691679"
[1] "Q = 0.471024100010188"
[1] "Q = 0.471024100010188"
[1] "Computing differential modularity matrix..."
[1] "Computing differential modules..."
[1] "Merging 386 communities"
[1] 1
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[1] "Merging 201 communities"
[1] 1
[1] "Computing node scores..."
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Read 7424 items
WARNING: Score threshold is not specified. We will be using medium stringency cut-off of 400.
trying URL 'https://stringdb-static.org/download/protein.aliases.v11.0/83332.protein.aliases.v11.0.txt.gz'
Content type 'application/octet-stream' length 614783 bytes (600 KB)
==================================================
downloaded 600 KB
trying URL 'https://stringdb-static.org/download/protein.info.v11.0/83332.protein.info.v11.0.txt.gz'
Content type 'application/octet-stream' length 442274 bytes (431 KB)
==================================================
downloaded 431 KB
trying URL 'https://stringdb-static.org/download/protein.links.v11.0/83332.protein.links.v11.0.txt.gz'
Content type 'application/octet-stream' length 7455726 bytes (7.1 MB)
==================================================
downloaded 7.1 MB
[ FAIL 1 | WARN 1 | SKIP 0 | PASS 60 ]
══ Failed tests ════════════════════════════════════════════════════════════════
── Failure ('test-monster.R:19'): MONSTER function works ───────────────────────
monsterTransformationMatrix(cc.net.1, cc.net.2, method = "kabsch") not equal to `monsterTM_kabsch`.
2/2809 mismatches (average diff: 1)
[393] -0.00086 - 0.999 == -1
[1121] -0.00086 - 0.999 == -1
[ FAIL 1 | WARN 1 | SKIP 0 | PASS 60 ]
Error: Test failures
Execution halted