* checking for file ‘predictionet/DESCRIPTION’ ... OK
* preparing ‘predictionet’:
* checking DESCRIPTION meta-information ... OK
* cleaning src
* installing the package to process help pages
* building the PDF package manual
Hmm ... looks like a package
Converting Rd files to LaTeX .
Creating pdf output from LaTeX ...
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LaTeX2e <2011/06/27>
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rman-x-2012-05-30, ngerman-x-2012-05-30, afrikaans, ancientgreek, ibycus, arabi
c, armenian, basque, bulgarian, catalan, pinyin, coptic, croatian, czech, danis
h, dutch, ukenglish, usenglishmax, esperanto, estonian, ethiopic, farsi, finnis
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[]\T1/fi4/m/n/9 mytopo <- matrix(sample(0:1, 100, replace=TRUE, prob=c(0.7,0.3
)), nrow=10, dimnames=list(LETTERS[1:10], LETTERS[1:10]))[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 cuts.discr <- lapply(apply(rbind("nbcat"=categories, data.ras)
, 2, function(x) { y <- x[1]; x <- x[-1]; return(list(quantile(x=x, probs=seq(0
, 1, length.out=y+1), na.rm=TRUE)[-c(1, y+1)])) }), function(x) { return(x[[1]]
) })[]
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[]\T1/ptm/m/n/10 Inferred topol-ogy, an edge be-tween to vari-ables X and Y cor
-re-sponds to net[X,Y]=1.
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[]\T1/fi4/m/n/10 net2pred(net, data, categories, predn, perturbations, method
= c("linear", "linear.penalized", "cpt"), seed)[]
[8]
Overfull \hbox (25.18864pt too wide) in paragraph at lines 403--404
[]\T1/ptm/m/n/10 type of pre-dic-tive model to fit; \T1/fi4/m/n/10 linear \T1/p
tm/m/n/10 for lin-ear re-gres-sion model, \T1/fi4/m/n/10 linear.penalized
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
Overfull \hbox (68.28088pt too wide) in paragraph at lines 426--426
[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
Overfull \hbox (248.28088pt too wide) in paragraph at lines 437--437
[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, perturbations=mypert, priors=mypr
iors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", see
d)[]
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[]\T1/fi4/m/n/10 netinf(data, categories, perturbations, priors, predn, priors
.count = TRUE, priors.weight = 0.5, maxparents = 3, subset, method = c("regrnet
", "bayesnet"), ensemble = FALSE, ensemble.model = c("full","best"), ensemble.m
axnsol = 3, causal=TRUE, seed, bayesnet.maxcomplexity=0, bayesnet.maxiter=100,
verbose = FALSE)[]
[9]
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\T1/ptm/m/n/10 iden-tify all the sta-tis-ti-cally equiv-a-lent net-works, it \T
1/fi4/m/n/10 best \T1/ptm/m/n/10 only the top \T1/fi4/m/n/10 ensemble.maxnsol
[10]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
Overfull \hbox (68.28088pt too wide) in paragraph at lines 509--509
[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, perturbations=mypert, priors=mypr
iors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", see
d=54321)[]
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[]\T1/fi4/m/n/9 xnet <- network(x=mytopo, matrix.type="adjacency", directed=TR
UE, loops=FALSE, vertex.attrnames=dimnames(mytopo)[[1]])[]
Overfull \hbox (383.28088pt too wide) in paragraph at lines 526--526
[]\T1/fi4/m/n/9 plot.network(x=xnet, displayisolates=TRUE, displaylabels=TRUE,
boxed.labels=FALSE, label.pos=0, arrowhead.cex=2, vertex.cex=4, vertex.col="ro
yalblue", jitter=FALSE, pad=0.5)[]
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Overfull \hbox (603.78088pt too wide) in paragraph at lines 537--537
[]\T1/fi4/m/n/9 cuts.discr <- lapply(apply(rbind("nbcat"=categories, mydata),
2, function(x) { y <- x[1]; x <- x[-1]; return(list(quantile(x=x, probs=seq(0,
1, length.out=y+1), na.rm=TRUE)[-c(1, y+1)])) }), function(x) { return(x[[1]])
})[]
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[]\T1/fi4/m/n/9 ## Not run: mynet <- netinf(data=mydata, perturbations=mypert,
priors=mypriors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="b
ayesnet", seed=54321)[]
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[]\T1/fi4/m/n/9 ## Not run: xnet <- network(x=mytopo, matrix.type="adjacency",
directed=TRUE, loops=FALSE, vertex.attrnames=dimnames(mytopo)[[1]])[]
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[]\T1/fi4/m/n/9 ## Not run: plot.network(x=xnet, displayisolates=TRUE, display
labels=TRUE, boxed.labels=FALSE, label.pos=0, arrowhead.cex=2, vertex.cex=4, ve
rtex.col="royalblue", jitter=FALSE, pad=0.5)[]
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[]\T1/fi4/m/n/10 netinf.cv(data, categories, perturbations, priors, predn, pri
ors.count = TRUE, priors.weight = 0.5, maxparents = 3, subset, method = c("regr
net", "bayesnet"), ensemble = FALSE, ensemble.maxnsol=3, predmodel = c("linear"
, "linear.penalized", "cpt"), nfold = 10, causal = TRUE, seed, bayesnet.maxcomp
lexity = 0, bayesnet.maxiter = 100, verbose = FALSE)[]
[12]
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[]\T1/ptm/m/n/10 type of pre-dic-tive model to fit; \T1/fi4/m/n/10 linear \T1/p
tm/m/n/10 for lin-ear re-gres-sion model, \T1/fi4/m/n/10 linear.penalized
[13]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 res <- netinf.cv(data=mydata, categories=3, perturbations=mype
rt, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[
]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/10 netinf.predict(net, data, categories, perturbations, subset,
predn, method=c("linear", "linear.penalized", "cpt"))[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, priors=mypriors, priors.count=TRU
E, priors.weight=0.5, maxparents=3, method="regrnet", seed=54321)[]
[15]
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[]\T1/fi4/m/n/9 plot(mydata[ ,goi[1]], mypreds, xlab="Observed gene expression
", ylab="Predicted gene expression")[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
[16]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf.cv(data=mydata, categories=3, priors=mypriors,
priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", nfold=3,
seed=54321)[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
[18]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 res <- netinf.cv(data=mydata, categories=3, perturbations=mype
rt, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[
]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/10 predictionet.stability.cv(data, categories, perturbations, pr
iors, predn, priors.count = TRUE, priors.weight = 0.5, maxparents = 3, subset,
method = c("regrnet", "bayesnet"), ensemble = FALSE, ensemble.maxnsol = 3, nfol
d = 10, causal = TRUE, seed, bayesnet.maxcomplexity = 0, bayesnet.maxiter = 100
)[]
[19]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
[20]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 res <-netinf.cv(data=mydata, categories=3, perturbations=myper
t, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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live/2012/texmf-dist/fonts/enc/dvips/inconsolata/fi4-ec.enc}</usr/local/texlive
/2012/texmf-dist/fonts/type1/public/inconsolata/Inconsolata.pfb></usr/local/tex
live/2012/texmf-dist/fonts/type1/urw/helvetic/uhvr8a.pfb></usr/local/texlive/20
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LaTeX2e <2011/06/27>
Babel <v3.8m> and hyphenation patterns for english, dumylang, nohyphenation, ge
rman-x-2012-05-30, ngerman-x-2012-05-30, afrikaans, ancientgreek, ibycus, arabi
c, armenian, basque, bulgarian, catalan, pinyin, coptic, croatian, czech, danis
h, dutch, ukenglish, usenglishmax, esperanto, estonian, ethiopic, farsi, finnis
h, french, friulan, galician, german, ngerman, swissgerman, monogreek, greek, h
ungarian, icelandic, assamese, bengali, gujarati, hindi, kannada, malayalam, ma
rathi, oriya, panjabi, tamil, telugu, indonesian, interlingua, irish, italian,
kurmanji, latin, latvian, lithuanian, mongolian, mongolianlmc, bokmal, nynorsk,
polish, portuguese, romanian, romansh, russian, sanskrit, serbian, serbianc, s
lovak, slovenian, spanish, swedish, turkish, turkmen, ukrainian, uppersorbian,
welsh, loaded.
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[]\T1/fi4/m/n/9 mytopo <- matrix(sample(0:1, 100, replace=TRUE, prob=c(0.7,0.3
)), nrow=10, dimnames=list(LETTERS[1:10], LETTERS[1:10]))[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 cuts.discr <- lapply(apply(rbind("nbcat"=categories, data.ras)
, 2, function(x) { y <- x[1]; x <- x[-1]; return(list(quantile(x=x, probs=seq(0
, 1, length.out=y+1), na.rm=TRUE)[-c(1, y+1)])) }), function(x) { return(x[[1]]
) })[]
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[]\T1/ptm/m/n/10 Inferred topol-ogy, an edge be-tween to vari-ables X and Y cor
-re-sponds to net[X,Y]=1.
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[]\T1/fi4/m/n/10 net2pred(net, data, categories, predn, perturbations, method
= c("linear", "linear.penalized", "cpt"), seed)[]
[8]
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[]\T1/ptm/m/n/10 type of pre-dic-tive model to fit; \T1/fi4/m/n/10 linear \T1/p
tm/m/n/10 for lin-ear re-gres-sion model, \T1/fi4/m/n/10 linear.penalized
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
Overfull \hbox (68.28088pt too wide) in paragraph at lines 426--426
[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
[9]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, perturbations=mypert, priors=mypr
iors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", see
d)[]
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[]\T1/fi4/m/n/10 netinf(data, categories, perturbations, priors, predn, priors
.count = TRUE, priors.weight = 0.5, maxparents = 3, subset, method = c("regrnet
", "bayesnet"), ensemble = FALSE, ensemble.model = c("full","best"), ensemble.m
axnsol = 3, causal=TRUE, seed, bayesnet.maxcomplexity=0, bayesnet.maxiter=100,
verbose = FALSE)[]
[10]
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\T1/ptm/m/n/10 iden-tify all the sta-tis-ti-cally equiv-a-lent net-works, it \T
1/fi4/m/n/10 best \T1/ptm/m/n/10 only the top \T1/fi4/m/n/10 ensemble.maxnsol
Overfull \hbox (176.28088pt too wide) in paragraph at lines 501--501
[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
[11]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, perturbations=mypert, priors=mypr
iors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", see
d=54321)[]
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[]\T1/fi4/m/n/9 xnet <- network(x=mytopo, matrix.type="adjacency", directed=TR
UE, loops=FALSE, vertex.attrnames=dimnames(mytopo)[[1]])[]
Overfull \hbox (383.28088pt too wide) in paragraph at lines 526--526
[]\T1/fi4/m/n/9 plot.network(x=xnet, displayisolates=TRUE, displaylabels=TRUE,
boxed.labels=FALSE, label.pos=0, arrowhead.cex=2, vertex.cex=4, vertex.col="ro
yalblue", jitter=FALSE, pad=0.5)[]
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[]\T1/fi4/m/n/9 cuts.discr <- lapply(apply(rbind("nbcat"=categories, mydata),
2, function(x) { y <- x[1]; x <- x[-1]; return(list(quantile(x=x, probs=seq(0,
1, length.out=y+1), na.rm=TRUE)[-c(1, y+1)])) }), function(x) { return(x[[1]])
})[]
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[]\T1/fi4/m/n/9 ## Not run: mynet <- netinf(data=mydata, perturbations=mypert,
priors=mypriors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="b
ayesnet", seed=54321)[]
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[]\T1/fi4/m/n/9 ## Not run: xnet <- network(x=mytopo, matrix.type="adjacency",
directed=TRUE, loops=FALSE, vertex.attrnames=dimnames(mytopo)[[1]])[]
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[]\T1/fi4/m/n/9 ## Not run: plot.network(x=xnet, displayisolates=TRUE, display
labels=TRUE, boxed.labels=FALSE, label.pos=0, arrowhead.cex=2, vertex.cex=4, ve
rtex.col="royalblue", jitter=FALSE, pad=0.5)[]
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[]\T1/fi4/m/n/10 netinf.cv(data, categories, perturbations, priors, predn, pri
ors.count = TRUE, priors.weight = 0.5, maxparents = 3, subset, method = c("regr
net", "bayesnet"), ensemble = FALSE, ensemble.maxnsol=3, predmodel = c("linear"
, "linear.penalized", "cpt"), nfold = 10, causal = TRUE, seed, bayesnet.maxcomp
lexity = 0, bayesnet.maxiter = 100, verbose = FALSE)[]
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[]\T1/ptm/m/n/10 type of pre-dic-tive model to fit; \T1/fi4/m/n/10 linear \T1/p
tm/m/n/10 for lin-ear re-gres-sion model, \T1/fi4/m/n/10 linear.penalized
[13]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
[14]
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[]\T1/fi4/m/n/9 res <- netinf.cv(data=mydata, categories=3, perturbations=mype
rt, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[
]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/10 netinf.predict(net, data, categories, perturbations, subset,
predn, method=c("linear", "linear.penalized", "cpt"))[]
[15]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, priors=mypriors, priors.count=TRU
E, priors.weight=0.5, maxparents=3, method="regrnet", seed=54321)[]
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[]\T1/fi4/m/n/9 plot(mydata[ ,goi[1]], mypreds, xlab="Observed gene expression
", ylab="Predicted gene expression")[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf.cv(data=mydata, categories=3, priors=mypriors,
priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", nfold=3,
seed=54321)[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 res <- netinf.cv(data=mydata, categories=3, perturbations=mype
rt, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[
]
[19]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/10 predictionet.stability.cv(data, categories, perturbations, pr
iors, predn, priors.count = TRUE, priors.weight = 0.5, maxparents = 3, subset,
method = c("regrnet", "bayesnet"), ensemble = FALSE, ensemble.maxnsol = 3, nfol
d = 10, causal = TRUE, seed, bayesnet.maxcomplexity = 0, bayesnet.maxiter = 100
)[]
[20]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
[21]
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[]\T1/fi4/m/n/9 res <-netinf.cv(data=mydata, categories=3, perturbations=myper
t, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/9 mytopo <- matrix(sample(0:1, 100, replace=TRUE, prob=c(0.7,0.3
)), nrow=10, dimnames=list(LETTERS[1:10], LETTERS[1:10]))[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 cuts.discr <- lapply(apply(rbind("nbcat"=categories, data.ras)
, 2, function(x) { y <- x[1]; x <- x[-1]; return(list(quantile(x=x, probs=seq(0
, 1, length.out=y+1), na.rm=TRUE)[-c(1, y+1)])) }), function(x) { return(x[[1]]
) })[]
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[]\T1/ptm/m/n/10 Inferred topol-ogy, an edge be-tween to vari-ables X and Y cor
-re-sponds to net[X,Y]=1.
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[]\T1/fi4/m/n/10 net2pred(net, data, categories, predn, perturbations, method
= c("linear", "linear.penalized", "cpt"), seed)[]
[8]
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[]\T1/ptm/m/n/10 type of pre-dic-tive model to fit; \T1/fi4/m/n/10 linear \T1/p
tm/m/n/10 for lin-ear re-gres-sion model, \T1/fi4/m/n/10 linear.penalized
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
[9]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, perturbations=mypert, priors=mypr
iors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", see
d)[]
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[]\T1/fi4/m/n/10 netinf(data, categories, perturbations, priors, predn, priors
.count = TRUE, priors.weight = 0.5, maxparents = 3, subset, method = c("regrnet
", "bayesnet"), ensemble = FALSE, ensemble.model = c("full","best"), ensemble.m
axnsol = 3, causal=TRUE, seed, bayesnet.maxcomplexity=0, bayesnet.maxiter=100,
verbose = FALSE)[]
[10]
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\T1/ptm/m/n/10 iden-tify all the sta-tis-ti-cally equiv-a-lent net-works, it \T
1/fi4/m/n/10 best \T1/ptm/m/n/10 only the top \T1/fi4/m/n/10 ensemble.maxnsol
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
[11]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, perturbations=mypert, priors=mypr
iors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", see
d=54321)[]
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[]\T1/fi4/m/n/9 xnet <- network(x=mytopo, matrix.type="adjacency", directed=TR
UE, loops=FALSE, vertex.attrnames=dimnames(mytopo)[[1]])[]
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[]\T1/fi4/m/n/9 plot.network(x=xnet, displayisolates=TRUE, displaylabels=TRUE,
boxed.labels=FALSE, label.pos=0, arrowhead.cex=2, vertex.cex=4, vertex.col="ro
yalblue", jitter=FALSE, pad=0.5)[]
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[]\T1/fi4/m/n/9 cuts.discr <- lapply(apply(rbind("nbcat"=categories, mydata),
2, function(x) { y <- x[1]; x <- x[-1]; return(list(quantile(x=x, probs=seq(0,
1, length.out=y+1), na.rm=TRUE)[-c(1, y+1)])) }), function(x) { return(x[[1]])
})[]
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[]\T1/fi4/m/n/9 ## Not run: mynet <- netinf(data=mydata, perturbations=mypert,
priors=mypriors, priors.count=TRUE, priors.weight=0.5, maxparents=3, method="b
ayesnet", seed=54321)[]
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[]\T1/fi4/m/n/9 ## Not run: xnet <- network(x=mytopo, matrix.type="adjacency",
directed=TRUE, loops=FALSE, vertex.attrnames=dimnames(mytopo)[[1]])[]
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[]\T1/fi4/m/n/9 ## Not run: plot.network(x=xnet, displayisolates=TRUE, display
labels=TRUE, boxed.labels=FALSE, label.pos=0, arrowhead.cex=2, vertex.cex=4, ve
rtex.col="royalblue", jitter=FALSE, pad=0.5)[]
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[]\T1/fi4/m/n/10 netinf.cv(data, categories, perturbations, priors, predn, pri
ors.count = TRUE, priors.weight = 0.5, maxparents = 3, subset, method = c("regr
net", "bayesnet"), ensemble = FALSE, ensemble.maxnsol=3, predmodel = c("linear"
, "linear.penalized", "cpt"), nfold = 10, causal = TRUE, seed, bayesnet.maxcomp
lexity = 0, bayesnet.maxiter = 100, verbose = FALSE)[]
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[]\T1/ptm/m/n/10 type of pre-dic-tive model to fit; \T1/fi4/m/n/10 linear \T1/p
tm/m/n/10 for lin-ear re-gres-sion model, \T1/fi4/m/n/10 linear.penalized
[13]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
[14]
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[]\T1/fi4/m/n/9 res <- netinf.cv(data=mydata, categories=3, perturbations=mype
rt, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[
]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/10 netinf.predict(net, data, categories, perturbations, subset,
predn, method=c("linear", "linear.penalized", "cpt"))[]
[15]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf(data=mydata, priors=mypriors, priors.count=TRU
E, priors.weight=0.5, maxparents=3, method="regrnet", seed=54321)[]
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[]\T1/fi4/m/n/9 plot(mydata[ ,goi[1]], mypreds, xlab="Observed gene expression
", ylab="Predicted gene expression")[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 mynet <- netinf.cv(data=mydata, categories=3, priors=mypriors,
priors.count=TRUE, priors.weight=0.5, maxparents=3, method="regrnet", nfold=3,
seed=54321)[]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
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[]\T1/fi4/m/n/9 res <- netinf.cv(data=mydata, categories=3, perturbations=mype
rt, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[
]
[19]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/10 predictionet.stability.cv(data, categories, perturbations, pr
iors, predn, priors.count = TRUE, priors.weight = 0.5, maxparents = 3, subset,
method = c("regrnet", "bayesnet"), ensemble = FALSE, ensemble.maxnsol = 3, nfol
d = 10, causal = TRUE, seed, bayesnet.maxcomplexity = 0, bayesnet.maxiter = 100
)[]
[20]
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[]\T1/fi4/m/n/9 ## load gene expression data for colon cancer data, list of ge
nes related to RAS signaling pathway and the corresponding priors[]
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[]\T1/fi4/m/n/9 pert <- matrix(0, nrow=nrow(data.ras), ncol=ncol(data.ras), di
mnames=dimnames(data.ras))[]
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[]\T1/fi4/m/n/9 goi <- dimnames(annot.ras)[[1]][order(abs(log2(annot.ras[ ,"fo
ld.change"])), decreasing=TRUE)[1:genen]][]
[21]
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[]\T1/fi4/m/n/9 res <-netinf.cv(data=mydata, categories=3, perturbations=myper
t, priors=mypriors, priors.weight=0.5, method="regrnet", nfold=3, seed=54321)[]
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[]\T1/fi4/m/n/9 ## Not run: res <- netinf.cv(data=mydata, categories=3, pertur
bations=mypert, priors=mypriors, priors.count=TRUE, priors.weight=0.5, method="
bayesnet", nfold=3, seed=54321)[]
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