Coverage for biochemistry/michaelis

1"""

2Michaelis-Menten Kinetics

3=========================

5Define the *Michaelis-Menten* kinetics model for enzyme-catalyzed reactions,

6describing the relationship between reaction rate and substrate concentration:

8- :func:`colour.biochemistry.reaction_rate_MichaelisMenten_Michaelis1913`

9- :func:`colour.biochemistry.reaction_rate_MichaelisMenten_Abebe2017`

10- :func:`colour.biochemistry.REACTION_RATE_MICHAELISMENTEN_METHODS`

11- :func:`colour.biochemistry.reaction_rate_MichaelisMenten`

12- :func:`colour.biochemistry.\

13substrate_concentration_MichaelisMenten_Michaelis1913`

14- :func:`colour.biochemistry.\

15substrate_concentration_MichaelisMenten_Abebe2017`

16- :func:`colour.biochemistry.SUBSTRATE_CONCENTRATION_MICHAELISMENTEN_METHODS`

17- :func:`colour.biochemistry.substrate_concentration_MichaelisMenten`

19References

20----------

21- :cite:`Abebe2017` : Abebe, M. A., Pouli, T., Larabi, M.-C., & Reinhard,

22 E. (2017). Perceptual Lightness Modeling for High-Dynamic-Range Imaging.

23 ACM Transactions on Applied Perception, 15(1), 1-19. doi:10.1145/3086577

24- :cite:`Wikipedia2003d` : Wikipedia. (2003). Michaelis-Menten kinetics.

25 Retrieved April 29, 2017, from

26 https://en.wikipedia.org/wiki/Michaelis%E2%80%93Menten_kinetics

27"""

29from __future__ import annotations

31import typing

33if typing.TYPE_CHECKING:

34 from colour.hints import Any, ArrayLike, Literal, NDArrayFloat

36from colour.utilities import (

37 CanonicalMapping,

38 as_float,

39 as_float_array,

40 filter_kwargs,

41 validate_method,

42)

44__author__ = "Colour Developers"

46__license__ = "BSD-3-Clause - https://opensource.org/licenses/BSD-3-Clause"

47__maintainer__ = "Colour Developers"

48__email__ = "colour-developers@colour-science.org"

49__status__ = "Production"

51__all__ = [

52 "reaction_rate_MichaelisMenten_Michaelis1913",

53 "reaction_rate_MichaelisMenten_Abebe2017",

54 "REACTION_RATE_MICHAELISMENTEN_METHODS",

55 "reaction_rate_MichaelisMenten",

56 "substrate_concentration_MichaelisMenten_Michaelis1913",

57 "substrate_concentration_MichaelisMenten_Abebe2017",

58 "SUBSTRATE_CONCENTRATION_MICHAELISMENTEN_METHODS",

59 "substrate_concentration_MichaelisMenten",

60]

63def reaction_rate_MichaelisMenten_Michaelis1913(

64 S: ArrayLike,

65 V_max: ArrayLike,

66 K_m: ArrayLike,

67) -> NDArrayFloat:

68 """

69 Compute the rate of enzymatic reactions by relating reaction rate

70 :math:`v` to substrate concentration :math:`S` using the

71 *Michaelis-Menten* kinetics equation.

73 Parameters

74 ----------

75 S

76 Substrate concentration :math:`S`.

77 V_max

78 Maximum reaction rate :math:`V_{max}` achieved by the system at

79 saturating substrate concentration.

80 K_m

81 Michaelis constant :math:`K_m` representing the substrate

82 concentration at which the reaction rate is half of

83 :math:`V_{max}`.

85 Returns

86 -------

87 :class:`numpy.ndarray`

88 Reaction rate :math:`v`.

90 References

91 ----------

92 :cite:`Wikipedia2003d`

94 Examples

95 --------

96 >>> reaction_rate_MichaelisMenten(0.5, 2.5, 0.8) # doctest: +ELLIPSIS

97 0.9615384...

98 """

100 S = as_float_array(S)

101 V_max = as_float_array(V_max)

102 K_m = as_float_array(K_m)

103

104 v = (V_max * S) / (K_m + S)

105

106 return as_float(v)

107

108

109def reaction_rate_MichaelisMenten_Abebe2017(

110 S: ArrayLike,

111 V_max: ArrayLike,

112 K_m: ArrayLike,

113 b_m: ArrayLike,

114) -> NDArrayFloat:

115 """

116 Compute the rate of enzymatic reactions by relating reaction rate

117 :math:`v` to the concentration of a substrate :math:`S` using the

118 modified *Michaelis-Menten* kinetics equation as specified by *Abebe,

119 Pouli, Larabi and Reinhard (2017)*.

120

121 Parameters

122 ----------

123 S

124 Concentration of a substrate :math:`S` (or

125 :math:`(\\cfrac{Y}{Y_n})^{\\epsilon}`).

126 V_max

127 Maximum rate :math:`V_{max}` (or :math:`a_m`) achieved by the system

128 at saturating substrate concentration.

129 K_m

130 Substrate concentration :math:`K_m` (or :math:`c_m`) at which the

131 reaction rate is half of :math:`V_{max}`.

132 b_m

133 Bias factor :math:`b_m`.

134

135 Returns

136 -------

137 :class:`numpy.ndarray`

138 Reaction rate :math:`v`.

139

140 References

141 ----------

142 :cite:`Abebe2017`

143

144 Examples

145 --------

146 >>> reaction_rate_MichaelisMenten_Abebe2017(0.5, 1.448, 0.635, 0.813)

147 ... # doctest: +ELLIPSIS

148 0.6951512...

149 """

150

151 S = as_float_array(S)

152 V_max = as_float_array(V_max)

153 K_m = as_float_array(K_m)

154 b_m = as_float_array(b_m)

155

156 v = (V_max * S) / (b_m * S + K_m)

157

158 return as_float(v)

159

160

161REACTION_RATE_MICHAELISMENTEN_METHODS: CanonicalMapping = CanonicalMapping(

162 {

163 "Michaelis 1913": reaction_rate_MichaelisMenten_Michaelis1913,

164 "Abebe 2017": reaction_rate_MichaelisMenten_Abebe2017,

165 }

166)

167REACTION_RATE_MICHAELISMENTEN_METHODS.__doc__ = """

168Supported *Michaelis-Menten* kinetics reaction rate equation computation

169methods.

170

171References

172----------

173:cite:`Wikipedia2003d`, :cite:`Abebe2017`

174"""

175

176

177def reaction_rate_MichaelisMenten(

178 S: ArrayLike,

179 V_max: ArrayLike,

180 K_m: ArrayLike,

181 method: Literal["Michaelis 1913", "Abebe 2017"] | str = "Michaelis 1913",

182 **kwargs: Any,

183) -> NDArrayFloat:

184 """

185 Compute the rate of enzymatic reactions by relating reaction rate

186 :math:`v` to substrate concentration :math:`S` using the

187 *Michaelis-Menten* kinetics equation using the specified method.

188

189 Parameters

190 ----------

191 S

192 Concentration of substrate :math:`S`.

193 V_max

194 Maximum reaction rate :math:`V_{max}` achieved at saturating substrate

195 concentration.

196 K_m

197 Michaelis constant :math:`K_m` representing substrate concentration at

198 which reaction rate equals half of :math:`V_{max}`.

199 method

200 Computation method.

201

202 Other Parameters

203 ----------------

204 b_m

205 {:func:`colour.biochemistry.reaction_rate_MichaelisMenten_Abebe2017`},

206 Bias factor :math:`b_m`.

207

208 Returns

209 -------

210 :class:`numpy.ndarray`

211 Reaction rate :math:`v`.

212

213 References

214 ----------

215 :cite:`Wikipedia2003d`, :cite:`Abebe2017`

216

217 Examples

218 --------

219 >>> reaction_rate_MichaelisMenten(0.5, 2.5, 0.8) # doctest: +ELLIPSIS

220 0.9615384...

221 >>> reaction_rate_MichaelisMenten(

222 ... 0.5, 2.5, 0.8, method="Abebe 2017", b_m=0.813

223 ... ) # doctest: +ELLIPSIS

224 1.0360547...

225 """

226

227 method = validate_method(method, tuple(REACTION_RATE_MICHAELISMENTEN_METHODS))

228

229 function = REACTION_RATE_MICHAELISMENTEN_METHODS[method]

230

231 return function(S, V_max, K_m, **filter_kwargs(function, **kwargs))

232

233

234def substrate_concentration_MichaelisMenten_Michaelis1913(

235 v: ArrayLike,

236 V_max: ArrayLike,

237 K_m: ArrayLike,

238) -> NDArrayFloat:

239 """

240 Compute substrate concentration by relating the concentration of a

241 substrate :math:`S` to the reaction rate :math:`v` using the

242 *Michaelis-Menten* kinetics equation..

243

244 Parameters

245 ----------

246 v

247 Reaction rate :math:`v`.

248 V_max

249 Maximum rate :math:`V_{max}` achieved by the system at saturating

250 substrate concentration.

251 K_m

252 Substrate concentration :math:`K_m` at which the reaction rate is

253 half of :math:`V_{max}`.

254

255 Returns

256 -------

257 :class:`numpy.ndarray`

258 Concentration of a substrate :math:`S`.

259

260 References

261 ----------

262 :cite:`Wikipedia2003d`

263

264 Examples

265 --------

266 >>> substrate_concentration_MichaelisMenten(0.961538461538461, 2.5, 0.8)

267 ... # doctest: +ELLIPSIS

268 0.4999999...

269 """

270

271 v = as_float_array(v)

272 V_max = as_float_array(V_max)

273 K_m = as_float_array(K_m)

274

275 S = (v * K_m) / (V_max - v)

276

277 return as_float(S)

278

279

280def substrate_concentration_MichaelisMenten_Abebe2017(

281 v: ArrayLike,

282 V_max: ArrayLike,

283 K_m: ArrayLike,

284 b_m: ArrayLike,

285) -> NDArrayFloat:

286 """

287 Compute substrate concentration by relating the concentration of a

288 substrate :math:`S` to the reaction rate :math:`v` using the

289 *Michaelis-Menten* kinetics equation as specified by *Abebe, Pouli, Larabi

290 and Reinhard (2017)*.

291

292 Parameters

293 ----------

294 v

295 Reaction rate :math:`v`.

296 V_max

297 Maximum rate :math:`V_{max}` (or :math:`a_m`) achieved by the system

298 at saturating substrate concentration.

299 K_m

300 Substrate concentration :math:`K_m` (or :math:`c_m`) at which the

301 reaction rate is half of :math:`V_{max}`.

302 b_m

303 Bias factor :math:`b_m`.

304

305 Returns

306 -------

307 :class:`numpy.ndarray`

308 Concentration of a substrate :math:`S`.

309

310 References

311 ----------

312 :cite:`Abebe2017`

313

314 Examples

315 --------

316 >>> substrate_concentration_MichaelisMenten_Abebe2017(

317 ... 0.695151224195871, 1.448, 0.635, 0.813

318 ... ) # doctest: +ELLIPSIS

319 0.4999999...

320 """

321

322 v = as_float_array(v)

323 V_max = as_float_array(V_max)

324 K_m = as_float_array(K_m)

325 b_m = as_float_array(b_m)

326

327 S = (v * K_m) / (V_max - b_m * v)

328

329 return as_float(S)

330

331

332SUBSTRATE_CONCENTRATION_MICHAELISMENTEN_METHODS: CanonicalMapping = CanonicalMapping(

333 {

334 "Michaelis 1913": substrate_concentration_MichaelisMenten_Michaelis1913,

335 "Abebe 2017": substrate_concentration_MichaelisMenten_Abebe2017,

336 }

337)

338SUBSTRATE_CONCENTRATION_MICHAELISMENTEN_METHODS.__doc__ = """

339Supported *Michaelis-Menten* kinetics substrate concentration equation

340computation methods.

341

342References

343----------

344:cite:`Wikipedia2003d`, :cite:`Abebe2017`

345"""

346

347

348def substrate_concentration_MichaelisMenten(

349 v: ArrayLike,

350 V_max: ArrayLike,

351 K_m: ArrayLike,

352 method: Literal["Michaelis 1913", "Abebe 2017"] | str = "Michaelis 1913",

353 **kwargs: Any,

354) -> NDArrayFloat:

355 """

356 Compute substrate concentration by relating the concentration of a

357 substrate :math:`S` to the reaction rate :math:`v` using the

358 *Michaelis-Menten* kinetics equation using the specified method.

359

360 Parameters

361 ----------

362 v

363 Reaction rate :math:`v`.

364 V_max

365 Maximum rate :math:`V_{max}` achieved by the system at saturating

366 substrate concentration.

367 K_m

368 Substrate concentration :math:`K_m` at which the reaction rate is

369 half of :math:`V_{max}`.

370 method

371 Computation method.

372

373 Other Parameters

374 ----------------

375 b_m

376 {:func:`colour.biochemistry.\

377substrate_concentration_MichaelisMenten_Abebe2017`},

378 Bias factor :math:`b_m`.

379

380 Returns

381 -------

382 :class:`numpy.ndarray`

383 Concentration of a substrate :math:`S`.

384

385 References

386 ----------

387 :cite:`Wikipedia2003d`, :cite:`Abebe2017`

388

389 Examples

390 --------

391 >>> substrate_concentration_MichaelisMenten(0.961538461538461, 2.5, 0.8)

392 ... # doctest: +ELLIPSIS

393 0.4999999...

394 >>> substrate_concentration_MichaelisMenten(

395 ... 1.036054703688355, 2.5, 0.8, method="Abebe 2017", b_m=0.813

396 ... )

397 ... # doctest: +ELLIPSIS

398 0.5000000...

399 """

400

401 method = validate_method(

402 method, tuple(SUBSTRATE_CONCENTRATION_MICHAELISMENTEN_METHODS)

403 )

404

405 function = SUBSTRATE_CONCENTRATION_MICHAELISMENTEN_METHODS[method]

406

407 return function(v, V_max, K_m, **filter_kwargs(function, **kwargs))

Coverage for biochemistry/michaelis_menten.py: 58%

48 statements