CHANGES IN VERSION 1.2.0 ------------------------ NEW FEATURES o Add support for CpG annotations for hg38, mm10, and rn6 via the UCSC goldenpath URLs. o Add a function to build annotations from AnnotationHub resources, build_ah_annots(). o Add support for chromHMM tracks (chromatin state) from the UCSC Genome Browser. o Users may annotate to chromatin states in multiple cell lines, if desired. o Use rtracklayer::liftOver to lift hg19 and mm9 enhancers into hg38 and mm10. USER-FACING CHANGES o Add minoverlaps parameter to annotate_regions() that is passed to GenomicRanges::findOverlaps(). o Change supported_annotations() and supported_genomes() into builtin_annotations() and builtin_genomes(). This enables more flexibility required for AnnotationHub annotations. o Added documentation for coercing result of annotate_regions() to data.frame and subsetting based on gene symbol to the vignette. BUGFIXES o Fixed a bug in coercion of GRanges to data.frame where row.names could be duplicated. Thanks to @kdkorthauer. o Require GenomeInfoDb >= 1.10.3 because of changes to NCBI servers. o Change scale_fill_brewer() to scale_fill_hue() in plot_categorical() to enable more categories and avoid plotting abnormalities. o Fixed bug that mistakenly displayed some supported annotations. o Fixed a bug in lncRNA annotation building caused by incomplete reference. CHANGES IN VERSION 0.99.13 -------------------------- PKG FEATURES o annotatr is a package to quickly and flexibly annotate genomic regions to genomic annotations. o Genomic annotations include CpG features (island, shore, shelves, and open sea), genic features (1-5kb upstream of TSS, promoters, 5'UTRs, exons, introns, CDS, 3'UTRs, intron/exon boundaries, and exon/ intron boundaries), as well as enhancers from the FANTOM5 consortium for hg19 and mm9. o Annotations are built at runtime using the TxDb.*, AnnotationHub, and rtracklayer packages. Users can select annotations a la carte, or via shortcuts, such as hg19_basicgenes. o Annotations are currently available for hg19, mm9, mm10, dm3, dm6, rn4, rn5, and rn6. Any species is supported through custom annotations. o Genomic regions are read in using the rtracklayer::import() function, and the extraCols argument enables users to include an arbitrary number of categorical or numerical data with the genomic regions. o Annotations are determined via GenomicRanges::findOverlaps(), and all annotations are returned, rather than imposing a prioritization. o annotatr provides several helpful summarization (using dplyr) and plot functions (using ggplot2) to investigate trends in data associated with the genomic regions over annotations.