Changes in version 1.9.1 o Added Csm complex RNA-targeting nuclease. Changes in version 1.7.1 o Updated weights in the SaCas9 nuclease. Changes in version 1.3.3 o Added BiocStyle to Suggests. Changes in version 1.3.2 o Added nuclease MAD. Changes in version 1.0.0 o New package crisprBase, Base functions and classes for CRISPR gRNA design.