Package: CytoGLMM
Type: Package
Title: Conditional Differential Analysis for Flow and Mass Cytometry
        Experiments
Version: 1.20.0
Authors@R: c(
    person("Christof", "Seiler", , "christof.seiler@maastrichtuniversity.nl", 
    role = c("aut", "cre"), 
    comment = c(ORCID = "0000-0001-8802-3642"))
    )
Description: The CytoGLMM R package implements two multiple regression
        strategies: A bootstrapped generalized linear model (GLM) and a
        generalized linear mixed model (GLMM). Most current data
        analysis tools compare expressions across many computationally
        discovered cell types. CytoGLMM focuses on just one cell type.
        Our narrower field of application allows us to define a more
        specific statistical model with easier to control statistical
        guarantees. As a result, CytoGLMM finds differential proteins
        in flow and mass cytometry data while reducing biases arising
        from marker correlations and safeguarding against false
        discoveries induced by patient heterogeneity.
License: LGPL-3
URL: https://christofseiler.github.io/CytoGLMM,
        https://github.com/ChristofSeiler/CytoGLMM
BugReports: https://github.com/ChristofSeiler/CytoGLMM/issues
Encoding: UTF-8
Imports: stats, methods, BiocParallel, RColorBrewer, cowplot,
        doParallel, dplyr, factoextra, flexmix, ggplot2, magrittr,
        mbest, pheatmap, stringr, strucchange, tibble, ggrepel, MASS,
        logging, Matrix, tidyr, caret, rlang, grDevices
Suggests: knitr, rmarkdown, testthat, BiocStyle
VignetteBuilder: knitr
RoxygenNote: 7.3.2
biocViews: FlowCytometry, Proteomics, SingleCell, CellBasedAssays,
        CellBiology, ImmunoOncology, Regression, StatisticalMethod,
        Software
Config/pak/sysreqs: cmake make libicu-dev libuv1-dev
Repository: https://bioc-release.r-universe.dev
Date/Publication: 2026-04-28 12:55:33 UTC
RemoteUrl: https://github.com/bioc/CytoGLMM
RemoteRef: RELEASE_3_23
RemoteSha: e2ce946d5912183a0da1a9ff60a48fd60faf462a
NeedsCompilation: no
Packaged: 2026-04-29 20:53:51 UTC; root
Author: Christof Seiler [aut, cre] (ORCID:
    <https://orcid.org/0000-0001-8802-3642>)
Maintainer: Christof Seiler <christof.seiler@maastrichtuniversity.nl>
Built: R 4.6.0; ; 2026-04-29 20:57:12 UTC; windows
