Contents

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1 Introduction

The DAPAR and Prostar packages are a series of software dedicated to the processing of proteomics data. More precisely, they are devoted to the analysis of quantitative datasets produced by bottom-up discovery proteomics experiments with a LC-MS/MS pipeline (Liquid Chromatography and Tandem Mass spectrometry). DAPAR (Differential Analysis of Protein Abundance with R) is an R package that contains all the necessary functions to process the data in command lines. It can be used on its own; or as a complement to the numerous Bioconductor packages () it is compliant with; or through the Prostar interface. Prostar (Proteomics statistical analysis with R) is a web interface based on Shiny technology () that provides GUI (Graphical User Interfaces) to all the DAPAR functionalities, so as to guide any practitioner that is not comfortable with R programming through the complete quantitative analysis process. The experiment package DAPARdata contains many datasets that can be used as examples.

sessionInfo()
## R version 4.6.0 RC (2026-04-17 r89917)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.4 LTS
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## Matrix products: default
## BLAS:   /home/biocbuild/bbs-3.23-bioc/R/lib/libRblas.so 
## LAPACK: /usr/lib/x86_64-linux-gnu/lapack/liblapack.so.3.12.0  LAPACK version 3.12.0
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## time zone: America/New_York
## tzcode source: system (glibc)
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## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
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## other attached packages:
## [1] BiocStyle_2.39.0
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##  [4] fastmap_1.2.0       xfun_0.57           cachem_1.1.0       
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## [10] lifecycle_1.0.5     cli_3.6.6           sass_0.4.10        
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## [16] evaluate_1.0.5      bslib_0.10.0        yaml_2.3.12        
## [19] otel_0.2.0          BiocManager_1.30.27 jsonlite_2.0.0     
## [22] rlang_1.2.0