Changes in version 0.99.0 Initial Submission to Bioconductor - Initial submission of MeLSI (Metric Learning for Statistical Inference) to Bioconductor - Novel machine learning method for microbiome beta diversity analysis - Learns optimal distance metrics to improve statistical power in detecting group differences - Comprehensive validation against standard methods (Bray-Curtis, Euclidean, Jaccard) - Robust ensemble learning approach with conservative pre-filtering - Validated on real microbiome datasets with proper Type I error control - Provides feature importance weights for biological interpretability - Includes helper functions for CLR transformation and visualization (VIP plots, PCoA) - Full integration with Bioconductor ecosystem (phyloseq, microbiome packages)