## ----lkfimo16----------------------------------------------------------------- suppressPackageStartupMessages({ library(TFutils) library(GenomicRanges) }) fimo16 ## ----lkimp-------------------------------------------------------------------- if (.Platform$OS.type != "windows") { si = TFutils::seqinfo_hg19_chr17 myg = GRanges("chr17", IRanges(38.07e6,38.09e6), seqinfo=si) colnames(fimo16) = fimo16$HGNC lk2 = GenomicFiles::reduceByRange(fimo16[, c("POU2F1", "VDR")], MAP=function(r,f) scanTabix(f, param=r)) str(lk2) } ## ----domult------------------------------------------------------------------- #fimo_ranges = function(gf, query) { # prototypical code # rowRanges(gf) = query # ans = GenomicFiles::reduceByRange(gf, MAP=function(r,f) scanTabix(f, param=r)) # ans = unlist(ans, recursive=FALSE) # drop top list structure # tabs = lapply(ans, lapply, function(x) { # con = textConnection(x) # on.exit(close(con)) # dtf = read.delim(con, h=FALSE, stringsAsFactors=FALSE, sep="\t") # colnames(dtf) = c("chr", "start", "end", "rname", "score", "dir", "pval") # ans = with(dtf, GRanges(seqnames=chr, IRanges(start, end), # rname=rname, score=score, dir=dir, pval=pval)) # ans # }) # GRangesList(unlist(tabs, recursive=FALSE)) #} if (.Platform$OS.type != "windows") { rr = fimo_granges(fimo16[, c("POU2F1", "VDR")], myg) rr } ## ----sesss-------------------------------------------------------------------- sessionInfo()