TCGAbiolinks 1.0.9 --------------------------------------------------------------- * Bug fix: logFC result from TCGAanalyze_DEA for method "glmLRT" was considerent the alphabetical order of groups, which migth induce the user to error TCGAbiolinks 1.0.8 ---------------------------------------------------------------- * Improvement: TCGADownload checks for data integrity. TCGAbiolinks 1.0.7 ---------------------------------------------------------------- * Bugfix in TCGAanalyze_Preprocessing: if there were outliers it was subseeting wrongly. TCGAbiolinks 1.0.6 ---------------------------------------------------------------- * Bug fix: preparing the data for "IlluminaGA_DNASeq" platform and TCGAquery_maf had a problem for some files. * Added batch information to summarizedExperiment object * Update lgg and gbm subtype information. Source: http://dx.doi.org/10.1016/j.cell.2015.12.028 TCGAbiolinks 1.0.5 ---------------------------------------------------------------- * Bugfix: updated ggplot2 code to work with version 2.0 TCGAbiolinks 1.0.4 ---------------------------------------------------------------- * Improving TCGAquery_clinical to use barcodes. * Bug fix in TCGAquery_MatchedCoupledSampleTypes * Bug fix in TCGAPrepare: bt.exon_quantification files from IlluminaHiseq_RNASeqV2 platform was not ok. TCGAbiolinks 1.0.2-1.0.3 ---------------------------------------------------------------- * Updating Database * Updating citation TCGAbiolinks 0.99.2 ---------------------------------------------------------------- FIRST VERSION - FEATURES * TCGAanalyze_DEA Differentially expression analysis (DEA) using edgeR package. * TCGAanalyze_DMR Differentially methylated regions Analysis * TCGAanalyze_EA Enrichment analysis of a gene-set with GO [BP,MF,CC] and pathways. * TCGAanalyze_EAcomplete Enrichment analysis for Gene Ontology (GO) [BP,MF,CC] and Pathways * TCGAanalyze_Filtering Filtering mRNA transcripts and miRNA selecting a threshold. * TCGAanalyze_LevelTab Adding information related to DEGs genes from DEA as mean values in two conditions. * TCGAanalyze_Normalization normalization mRNA transcripts and miRNA using EDASeq package. * TCGAanalyze_Preprocessing Array Array Intensity correlation (AAIC) and correlation boxplot to define outlier * TCGAanalyze_survival Creates survival analysis * TCGAanalyze_SurvivalKM survival analysis (SA) univariate with Kaplan-Meier (KM) method. * TCGAbiolinks Download data of samples from * TCGA * TCGAdownload Download the data from * TCGA using as reference the output from * TCGAquery * TCGAintegrate Filtering common samples among platforms from * TCGAquery for the same tumor * TCGAinvestigate Find most studied TF in pubmed related to a specific cancer, disease, or tissue * TCGAprepare Read the data from level 3 the experiments and prepare it for downstream analysis into a SummarizedExperiment object. * TCGAquery Searches * TCGA open-access data providing also latest version of the files. * TCGAquery_clinic Get the clinical information * TCGAquery_clinicFilt Filter samples using clinical data * TCGAquery_MatchedCoupledSampleTypes Retrieve multiple tissue types from the same patients. * TCGAquery_samplesfilter Filtering sample output from * TCGAquery * TCGAquery_SampleTypes Retrieve multiple tissue types not from the same patients. * TCGAquery_Version Shows a summary (version, date, number of samples, size of the data) of all versions of data for a given tumor and platform. * TCGAsocial Finds the number of downloads of a package on CRAN or BIOC and find questions in website ("bioconductor.org", "biostars.org", "stackoverflow). * TCGAvisualize_EAbarplot barPlot for a complete Enrichment Analysis * TCGAvisualize_meanMethylation Mean methylation boxplot * TCGAvisualize_PCA Principal components analysis (PCA) plot * TCGAvisualize_starburst Create starburst plot * TCGAvisualize_SurvivalCoxNET Survival analysis with univariate Cox regression package (dnet)