Roleswitch

This package is for version 3.11 of Bioconductor. This package has been removed from Bioconductor. For the last stable, up-to-date release version, see Roleswitch.

Infer miRNA-mRNA interactions using paired expression data from a single sample

Bioconductor version: 3.11

Infer Probabilities of MiRNA-mRNA Interaction Signature (ProMISe) using paired expression data from a single sample. Roleswitch operates in two phases by inferring the probability of mRNA (miRNA) being the targets ("targets") of miRNA (mRNA), taking into account the expression of all of the mRNAs (miRNAs) due to their potential competition for the same miRNA (mRNA). Due to dynamic miRNA repression in the cell, Roleswitch assumes that the total transcribed mRNA levels are higher than the observed (equilibrium) mRNA levels and iteratively updates the total transcription of each mRNA targets based on the above inference. NB: in the paper, we used ProMISe as both the model name and inferred score name.

Author: Yue Li

Maintainer: Yue Li <yueli at cs.toronto.edu>

Citation (from within R, enter citation("Roleswitch")):

Installation

To install this package, start R (version "4.0") and enter:


if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")

BiocManager::install("Roleswitch")

For older versions of R, please refer to the appropriate Bioconductor release.

Documentation

To view documentation for the version of this package installed in your system, start R and enter:

browseVignettes("Roleswitch")

Roleswitch	PDF	R Script
Reference Manual	PDF
NEWS	Text

Need some help? Ask on the Bioconductor Support site!

Details

biocViews	Software, miRNA
Version	1.25.0
In Bioconductor since	BioC 2.13 (R-3.0) (10.5 years)
License	GPL-2
Depends	R (>= 2.10), pracma, reshape, plotrix, microRNA, biomaRt, Biostrings, Biobase, DBI
Imports
System Requirements
URL	http://www.cs.utoronto.ca/~yueli/roleswitch.html

Suggests	ggplot2
Linking To
Enhances
Depends On Me
Imports Me	miRLAB
Suggests Me
Links To Me
Build Report	Build Report

Package Archives

Follow Installation instructions to use this package in your R session.

Source Package	Roleswitch_1.25.0.tar.gz
Windows Binary	Roleswitch_1.25.0.zip
macOS 10.13 (High Sierra)
Source Repository	git clone https://git.bioconductor.org/packages/Roleswitch
Source Repository (Developer Access)	git clone git@git.bioconductor.org:packages/Roleswitch
Bioc Package Browser	https://code.bioconductor.org/browse/Roleswitch/
Package Short Url	https://bioconductor.org/packages/Roleswitch/
Package Downloads Report	Download Stats
Old Source Packages for BioC 3.11	Source Archive