Changes in version 2.16.0                        

    o   Add option "Score.SPA" to assocTestSingle. This option for
	binary outcomes uses the saddlepoint approximation to compute
	p-values and is recommended for unbalanced case/control ratios.

    o   "Wald" is no longer a test option in assocTestSingle. Instead,
	the Score test is always run, and "Est" (an estimation of the
	Wald test beta) is always returned also. The values in the
	"Est" are identical to what was previously returned by
	test="Wald".

    o   Since the only single-variant test option is "Score",
	"burden.test" is no longer an option in assocTestAggregate.
	Output returned is now identical to that described above for
	assocTestSingle.

                       Changes in version 2.15.3                        

    o   Add option "fastSKAT" to assocTestAggregate. Some other
	arguments and names of output columns for SKAT tests have also
	changed. This update includes code from the bigQF package
	(https://github.com/tslumley/bigQF). With the addition of C
	code, GENESIS now requires compilation.

                       Changes in version 2.13.7                        

    o   Remove all monomorphic variants (including all heterozygotes)
	from association test results.

                       Changes in version 2.13.3                        

    o   Restore option to run pcair without kinship matrix.

                       Changes in version 2.13.2                        

    o   Add option to use imputed dosage in association tests.

                       Changes in version 2.12.0                        

    o   pcair and pcrelate have been completely rewritten for better
	consistency with other methods. Some argument names have
	changed; see the documentation. The output of pcrelate is now a
	list of data.frames instead of a list of matrices.

    o   pcrelateReadKinship and pcrelateReadInbreed are deprecated, as
	these tables are now returned by pcrelate.

    o   pcrelateMakeGRM is deprecated; use pcrelateToMatrix with new
	pcrelate output format.

    o   king2mat is deprecated; use kingToMatrix instead.

    o   fitNullMM, fitNullReg, assocTestMM, and admixMapMM are
	deprecated. assocTestSeq and assocTestSeqWindow are defunct.
	Use fitNullModel, assocTestSingle, assocTestAggregate, and
	admixMap instead.

                       Changes in version 2.11.15                       

    o   Refactor pcrelate.

                       Changes in version 2.11.14                       

    o   Added assocTestAggregate method for GenotypeData objects.

                       Changes in version 2.11.11                       

    o   Refactor pcair.

                       Changes in version 2.11.8                        

    o   Added admixMap function to replace admixMapMM.

                       Changes in version 2.11.4                        

    o   Added assocTestSingle and fitNullModel methods for GenotypeData
	objects.

                        Changes in version 2.9.3                        

    o   New methods assocTestSingle and assocTestAggregate are
	refactors of assocTestMM and assocTestSeq/assocTestSeqWindow,
	respectively. assocTestSeq and assocTestSeqWindow are
	deprecated. assocTestMM is still used for GenotypeData objects,
	but will be deprecated in a future release. fitNullModel is a
	refactor of fitNullMM/fitNullReg and should be used with the
	new association test methods.

                        Changes in version 2.7.4                        

    o   In fitNullMM, for Binomial and Poisson GLM families, the
	variance of the fixed effects will not be multiplied by the
	dispersion parameter RSS.

                        Changes in version 2.7.3                        

    o   Change defaults in assocTestSeq*: Davies method for SKAT
	p-values, flat weights.

                        Changes in version 2.6.0                        

    o   Major bug fix: assocTestSeq no longer drops some variants from
	aggregate tests in the case where the same variants are
	included in more than one aggregate unit.

    o   Added function for analysis of admixture mapping data.

                        Changes in version 2.2.0                        

    o   Added support for sequence data files created with the SeqArray
	package.

    o   Added functions for Burden and SKAT tests of sequence data.

                        Changes in version 2.0.0                        

    o   Added functions for PC-Relate.  PC-Relate provides model-free
	estimation of recent genetic relatedness in general samples.
	It can be used to estimate kinship coefficients, IBD sharing
	probabilities, and inbreeding coefficients using genome-wide
	SNP data.  PC-Relate accounts for population structure
	(ancestry) among sample individuals through the use of ancestry
	representative principal components (PCs) to provide accurate
	relatedness estimates due only to recent family (pedigree)
	structure.

    o   GENESIS now imports the package gdsfmt.

                        Changes in version 1.1.1                        

    o   Changed a few default values: MAF filter from 0.05 to 0.01;
	kin.thresh from 0.025 to 2^(-11/2) ~ 0.022; div.thresh from
	-0.025 to -2^(-11/2) ~ -0.022; v (the number of PCs returned)
	from 10 to 20

    o   Changed the argument 'block.size' to 'snp.block.size'

    o   Slightly altered the command line reporting when verbose = TRUE

                       Changes in version 0.99.4                        

    o   Fixed a minor bug to zero out diagonal of divMat in
	pcairPartition()

                       Changes in version 0.99.0                        

    o   Initial version of GENESIS.  Contains functionality to perform
	PC-AiR.