SPIA

Signaling Pathway Impact Analysis (SPIA) using combined evidence of pathway over-representation and unusual signaling perturbations

This package implements the Signaling Pathway Impact Analysis (SPIA) which uses the information form a list of differentially expressed genes and their log fold changes together with signaling pathways topology, in order to identify the pathways most relevant to the condition under the study.

Author Adi Laurentiu Tarca , Purvesh Kathri and Sorin Draghici
Maintainer Adi Laurentiu Tarca

To install this package, start R and enter:

    source("http://bioconductor.org/biocLite.R")
    biocLite("SPIA")

Documentation

SPIA PDF R Script
Reference Manual

Details

biocViews
Depends
R , graphics , RCurl
Imports
graphics , RCurl
Suggests
System Requirements
License GPL (>=2)
URL http://bioinformatics.oxfordjournals.org/cgi/reprint/btn577v1
Depends On Me
Imports Me
Suggests Me
Development History Bioconductor Changelog

Package Downloads

Package source SPIA_1.0.0.tar.gz
Windows binary SPIA_1.0.0.zip
MacOS X 10.4 (Tiger) binary SPIA_1.0.0.tgz
MacOS X 10.5 (Leopard) binary SPIA_1.0.0.tgz
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