Macarron is a workflow to systematically annotate and prioritize potentially bioactive (and often unannotated) small molecules in microbial community metabolomic datasets. Macarron prioritizes metabolic features as potentially bioactive in a phenotype/condition of interest using a combination of (a) covariance with annotated metabolites, (b) ecological properties such as abundance with respect to covarying annotated compounds, and (c) differential abundance in the phenotype/condition of interest.
If you have questions, please direct it to: Macarron Forum
Macarron requires R version 4.2.0 or higher. Install Bioconductor and then install Macarron:
if(!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("Macarron")
Macarron can be run from the command line or as an R function. Both methods require the same
arguments, have the same options, and use the same default settings. The package includes the
wrapper Macarron()
as well as functions which perform different steps in the Macarron
framework.
Macarron requires 4 comma-separated, appropriately formatted input files. The files and their formatting constraints are described below.
If you do not have the chemical taxonomy file, you can generate this file using the annotation dataframe and Macarron utility decorate_ID
(see Advanced Topics).
By default, all files will be stored in a folder named Macarron_output inside the current working directory. The main prioritization results are stored in prioritized_metabolites_all.csv
. Another file, prioritized_metabolites_characterizable.csv
is a subset of prioritized_metabolites_all.csv
and only contains metabolic features which covary with at least one annotated metabolite.
The columns in these output files are:
Maaslin2
.Example (demo) input files can be found under inst/extdata
folder of the Macarron
source. These files were generated from the PRISM study of stool metabolomes of individuals with inflammatory bowel disease (IBD) and healthy “Control” individuals. Control and IBD are the two phenotypes in this example. Macarron will be applied to prioritize metabolic features with respect to their bioactivity in IBD. Therefore, in this example, the phenotype of interest is “IBD” and the reference phenotype is “Control”. The four input files are demo_abundances.csv
, demo_annotations.csv
, demo_metadata.csv
, and demo_taxonomy.csv
.
library(Macarron)
## Loading required package: SummarizedExperiment
## Loading required package: MatrixGenerics
## Loading required package: matrixStats
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## Attaching package: 'MatrixGenerics'
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prism_abundances <- system.file(
'extdata','demo_abundances.csv', package="Macarron")
prism_annotations <-system.file(
'extdata','demo_annotations.csv', package="Macarron")
prism_metadata <-system.file(
'extdata','demo_metadata.csv', package="Macarron")
mets_taxonomy <-system.file(
'extdata','demo_taxonomy.csv', package="Macarron")
prism_prioritized <- Macarron::Macarron(input_abundances = prism_abundances,
input_annotations = prism_annotations,
input_metadata = prism_metadata,
input_taxonomy = mets_taxonomy)
## 2024-12-19 19:25:15.7901 INFO::Creating output folder.
## 2024-12-19 19:25:15.804639 INFO::Writing function arguments to log file
## Samples with both abundances and metadata: 102
## 2024-12-19 19:25:15.877958 INFO::Summarized Experiment created.
## 2024-12-19 19:25:15.880372 INFO::Metadata chosen for prevalence filtering: diagnosis
## 869 features pass chosen minimum prevalence threshold of 0.7.
## Calculating pairwise correlations in phenotype: IBD
##
## Calculating pairwise correlations in phenotype: Control
## Distance matrix with 869 features created.
## 2024-12-19 19:25:21.251514 INFO::Distance matrix with 869 metabolic features created.
## Initiating module detection
## 2024-12-19 19:25:21.255032 INFO::Minimum module size used for this dataset: 10
## Tree constructed
## Evaluating measures of success
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## ..cutHeight not given, setting it to 0.99 ===> 99% of the (truncated) height range in dendro.
## ..done.
## 2024-12-19 19:25:23.623557 INFO::Total number of modules detected: 30
## Initiating AVA calculations
## Finding anchors
## Calculating AVA
## Initiating q-value calculations
## [1] "Creating output folder"
## [1] "Creating output feature tables folder"
## [1] "Creating output fits folder"
## [1] "Creating output figures folder"
## 2024-12-19 19:25:26.066103 INFO::Writing function arguments to log file
## 2024-12-19 19:25:26.089183 INFO::Verifying options selected are valid
## 2024-12-19 19:25:26.145366 INFO::Determining format of input files
## 2024-12-19 19:25:26.147251 INFO::Input format is data samples as columns and metadata samples as rows
## 2024-12-19 19:25:26.166316 INFO::Formula for fixed effects: expr ~ diagnosis + age + antibiotics
## 2024-12-19 19:25:26.168657 INFO::Filter data based on min abundance and min prevalence
## 2024-12-19 19:25:26.170118 INFO::Total samples in data: 102
## 2024-12-19 19:25:26.171499 INFO::Min samples required with min abundance for a feature not to be filtered: 0.000000
## 2024-12-19 19:25:26.183198 INFO::Total filtered features: 0
## 2024-12-19 19:25:26.185261 INFO::Filtered feature names from abundance and prevalence filtering:
## 2024-12-19 19:25:26.208461 INFO::Total filtered features with variance filtering: 0
## 2024-12-19 19:25:26.210445 INFO::Filtered feature names from variance filtering:
## 2024-12-19 19:25:26.211973 INFO::Running selected normalization method: NONE
## 2024-12-19 19:25:26.213504 INFO::Applying z-score to standardize continuous metadata
## 2024-12-19 19:25:26.236445 INFO::Running selected transform method: NONE
## 2024-12-19 19:25:26.238116 INFO::Running selected analysis method: LM
## 2024-12-19 19:25:26.246751 INFO::Fitting model to feature number 1, F1
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## 2024-12-19 19:25:27.370209 INFO::Fitting model to feature number 184, F190
## 2024-12-19 19:25:27.374702 INFO::Fitting model to feature number 185, F191
## 2024-12-19 19:25:27.379072 INFO::Fitting model to feature number 186, F192
## 2024-12-19 19:25:27.38349 INFO::Fitting model to feature number 187, F193
## 2024-12-19 19:25:27.387947 INFO::Fitting model to feature number 188, F194
## 2024-12-19 19:25:27.393896 INFO::Fitting model to feature number 189, F195
## 2024-12-19 19:25:27.400552 INFO::Fitting model to feature number 190, F196
## 2024-12-19 19:25:27.405285 INFO::Fitting model to feature number 191, F197
## 2024-12-19 19:25:27.409957 INFO::Fitting model to feature number 192, F198
## 2024-12-19 19:25:27.414486 INFO::Fitting model to feature number 193, F199
## 2024-12-19 19:25:27.418979 INFO::Fitting model to feature number 194, F200
## 2024-12-19 19:25:27.423493 INFO::Fitting model to feature number 195, F201
## 2024-12-19 19:25:27.428032 INFO::Fitting model to feature number 196, F202
## 2024-12-19 19:25:27.432577 INFO::Fitting model to feature number 197, F203
## 2024-12-19 19:25:27.437189 INFO::Fitting model to feature number 198, F204
## 2024-12-19 19:25:27.441691 INFO::Fitting model to feature number 199, F206
## 2024-12-19 19:25:27.446213 INFO::Fitting model to feature number 200, F207
## 2024-12-19 19:25:27.450694 INFO::Fitting model to feature number 201, F208
## 2024-12-19 19:25:27.455152 INFO::Fitting model to feature number 202, F209
## 2024-12-19 19:25:27.459626 INFO::Fitting model to feature number 203, F210
## 2024-12-19 19:25:27.464086 INFO::Fitting model to feature number 204, F211
## 2024-12-19 19:25:27.468602 INFO::Fitting model to feature number 205, F212
## 2024-12-19 19:25:27.473046 INFO::Fitting model to feature number 206, F213
## 2024-12-19 19:25:27.477579 INFO::Fitting model to feature number 207, F214
## 2024-12-19 19:25:27.48202 INFO::Fitting model to feature number 208, F215
## 2024-12-19 19:25:27.486576 INFO::Fitting model to feature number 209, F216
## 2024-12-19 19:25:27.491026 INFO::Fitting model to feature number 210, F217
## 2024-12-19 19:25:27.495535 INFO::Fitting model to feature number 211, F218
## 2024-12-19 19:25:27.500027 INFO::Fitting model to feature number 212, F219
## 2024-12-19 19:25:27.504482 INFO::Fitting model to feature number 213, F220
## 2024-12-19 19:25:27.508992 INFO::Fitting model to feature number 214, F221
## 2024-12-19 19:25:27.51356 INFO::Fitting model to feature number 215, F222
## 2024-12-19 19:25:27.518396 INFO::Fitting model to feature number 216, F223
## 2024-12-19 19:25:27.523157 INFO::Fitting model to feature number 217, F224
## 2024-12-19 19:25:27.527753 INFO::Fitting model to feature number 218, F225
## 2024-12-19 19:25:27.532602 INFO::Fitting model to feature number 219, F226
## 2024-12-19 19:25:27.537477 INFO::Fitting model to feature number 220, F227
## 2024-12-19 19:25:27.542135 INFO::Fitting model to feature number 221, F228
## 2024-12-19 19:25:27.547198 INFO::Fitting model to feature number 222, F229
## 2024-12-19 19:25:27.551967 INFO::Fitting model to feature number 223, F230
## 2024-12-19 19:25:27.556639 INFO::Fitting model to feature number 224, F231
## 2024-12-19 19:25:27.56116 INFO::Fitting model to feature number 225, F232
## 2024-12-19 19:25:27.565581 INFO::Fitting model to feature number 226, F233
## 2024-12-19 19:25:27.570039 INFO::Fitting model to feature number 227, F234
## 2024-12-19 19:25:27.574602 INFO::Fitting model to feature number 228, F235
## 2024-12-19 19:25:27.57897 INFO::Fitting model to feature number 229, F236
## 2024-12-19 19:25:27.583272 INFO::Fitting model to feature number 230, F237
## 2024-12-19 19:25:27.587556 INFO::Fitting model to feature number 231, F238
## 2024-12-19 19:25:27.591925 INFO::Fitting model to feature number 232, F239
## 2024-12-19 19:25:27.596262 INFO::Fitting model to feature number 233, F240
## 2024-12-19 19:25:27.600554 INFO::Fitting model to feature number 234, F241
## 2024-12-19 19:25:27.60488 INFO::Fitting model to feature number 235, F242
## 2024-12-19 19:25:27.609267 INFO::Fitting model to feature number 236, F243
## 2024-12-19 19:25:27.613645 INFO::Fitting model to feature number 237, F244
## 2024-12-19 19:25:27.618035 INFO::Fitting model to feature number 238, F245
## 2024-12-19 19:25:27.622467 INFO::Fitting model to feature number 239, F246
## 2024-12-19 19:25:27.626922 INFO::Fitting model to feature number 240, F247
## 2024-12-19 19:25:27.631321 INFO::Fitting model to feature number 241, F248
## 2024-12-19 19:25:27.664688 INFO::Fitting model to feature number 242, F249
## 2024-12-19 19:25:27.669445 INFO::Fitting model to feature number 243, F250
## 2024-12-19 19:25:27.673973 INFO::Fitting model to feature number 244, F252
## 2024-12-19 19:25:27.678414 INFO::Fitting model to feature number 245, F253
## 2024-12-19 19:25:27.68275 INFO::Fitting model to feature number 246, F254
## 2024-12-19 19:25:27.687193 INFO::Fitting model to feature number 247, F255
## 2024-12-19 19:25:27.691599 INFO::Fitting model to feature number 248, F256
## 2024-12-19 19:25:27.695823 INFO::Fitting model to feature number 249, F257
## 2024-12-19 19:25:27.700006 INFO::Fitting model to feature number 250, F259
## 2024-12-19 19:25:27.704604 INFO::Fitting model to feature number 251, F260
## 2024-12-19 19:25:27.708881 INFO::Fitting model to feature number 252, F261
## 2024-12-19 19:25:27.713132 INFO::Fitting model to feature number 253, F262
## 2024-12-19 19:25:27.717256 INFO::Fitting model to feature number 254, F263
## 2024-12-19 19:25:27.721491 INFO::Fitting model to feature number 255, F264
## 2024-12-19 19:25:27.725751 INFO::Fitting model to feature number 256, F265
## 2024-12-19 19:25:27.730157 INFO::Fitting model to feature number 257, F266
## 2024-12-19 19:25:27.73473 INFO::Fitting model to feature number 258, F267
## 2024-12-19 19:25:27.738923 INFO::Fitting model to feature number 259, F269
## 2024-12-19 19:25:27.743218 INFO::Fitting model to feature number 260, F270
## 2024-12-19 19:25:27.747527 INFO::Fitting model to feature number 261, F271
## 2024-12-19 19:25:27.751917 INFO::Fitting model to feature number 262, F272
## 2024-12-19 19:25:27.756243 INFO::Fitting model to feature number 263, F273
## 2024-12-19 19:25:27.760527 INFO::Fitting model to feature number 264, F274
## 2024-12-19 19:25:27.764927 INFO::Fitting model to feature number 265, F276
## 2024-12-19 19:25:27.769213 INFO::Fitting model to feature number 266, F277
## 2024-12-19 19:25:27.773469 INFO::Fitting model to feature number 267, F278
## 2024-12-19 19:25:27.777685 INFO::Fitting model to feature number 268, F279
## 2024-12-19 19:25:27.781946 INFO::Fitting model to feature number 269, F280
## 2024-12-19 19:25:27.786136 INFO::Fitting model to feature number 270, F281
## 2024-12-19 19:25:27.790355 INFO::Fitting model to feature number 271, F282
## 2024-12-19 19:25:27.79451 INFO::Fitting model to feature number 272, F283
## 2024-12-19 19:25:27.798584 INFO::Fitting model to feature number 273, F284
## 2024-12-19 19:25:27.802673 INFO::Fitting model to feature number 274, F285
## 2024-12-19 19:25:27.806843 INFO::Fitting model to feature number 275, F286
## 2024-12-19 19:25:27.810969 INFO::Fitting model to feature number 276, F287
## 2024-12-19 19:25:27.815167 INFO::Fitting model to feature number 277, F288
## 2024-12-19 19:25:27.821478 INFO::Fitting model to feature number 278, F289
## 2024-12-19 19:25:27.828556 INFO::Fitting model to feature number 279, F290
## 2024-12-19 19:25:27.835626 INFO::Fitting model to feature number 280, F292
## 2024-12-19 19:25:27.84309 INFO::Fitting model to feature number 281, F293
## 2024-12-19 19:25:27.84831 INFO::Fitting model to feature number 282, F294
## 2024-12-19 19:25:27.852653 INFO::Fitting model to feature number 283, F295
## 2024-12-19 19:25:27.857061 INFO::Fitting model to feature number 284, F296
## 2024-12-19 19:25:27.861544 INFO::Fitting model to feature number 285, F297
## 2024-12-19 19:25:27.865878 INFO::Fitting model to feature number 286, F298
## 2024-12-19 19:25:27.870142 INFO::Fitting model to feature number 287, F299
## 2024-12-19 19:25:27.874362 INFO::Fitting model to feature number 288, F300
## 2024-12-19 19:25:27.878587 INFO::Fitting model to feature number 289, F301
## 2024-12-19 19:25:27.882784 INFO::Fitting model to feature number 290, F302
## 2024-12-19 19:25:27.88695 INFO::Fitting model to feature number 291, F303
## 2024-12-19 19:25:27.891139 INFO::Fitting model to feature number 292, F304
## 2024-12-19 19:25:27.895405 INFO::Fitting model to feature number 293, F305
## 2024-12-19 19:25:27.899649 INFO::Fitting model to feature number 294, F306
## 2024-12-19 19:25:27.903813 INFO::Fitting model to feature number 295, F307
## 2024-12-19 19:25:27.907995 INFO::Fitting model to feature number 296, F308
## 2024-12-19 19:25:27.912255 INFO::Fitting model to feature number 297, F309
## 2024-12-19 19:25:28.199774 INFO::Fitting model to feature number 298, F310
## 2024-12-19 19:25:28.204509 INFO::Fitting model to feature number 299, F311
## 2024-12-19 19:25:28.210788 INFO::Fitting model to feature number 300, F312
## 2024-12-19 19:25:28.217334 INFO::Fitting model to feature number 301, F313
## 2024-12-19 19:25:28.224065 INFO::Fitting model to feature number 302, F315
## 2024-12-19 19:25:28.230562 INFO::Fitting model to feature number 303, F316
## 2024-12-19 19:25:28.237753 INFO::Fitting model to feature number 304, F317
## 2024-12-19 19:25:28.244915 INFO::Fitting model to feature number 305, F318
## 2024-12-19 19:25:28.252282 INFO::Fitting model to feature number 306, F319
## 2024-12-19 19:25:28.259128 INFO::Fitting model to feature number 307, F320
## 2024-12-19 19:25:28.26636 INFO::Fitting model to feature number 308, F321
## 2024-12-19 19:25:28.273356 INFO::Fitting model to feature number 309, F322
## 2024-12-19 19:25:28.280483 INFO::Fitting model to feature number 310, F323
## 2024-12-19 19:25:28.287381 INFO::Fitting model to feature number 311, F324
## 2024-12-19 19:25:28.294457 INFO::Fitting model to feature number 312, F325
## 2024-12-19 19:25:28.299058 INFO::Fitting model to feature number 313, F326
## 2024-12-19 19:25:28.303474 INFO::Fitting model to feature number 314, F327
## 2024-12-19 19:25:28.307846 INFO::Fitting model to feature number 315, F328
## 2024-12-19 19:25:28.312227 INFO::Fitting model to feature number 316, F329
## 2024-12-19 19:25:28.31661 INFO::Fitting model to feature number 317, F330
## 2024-12-19 19:25:28.320985 INFO::Fitting model to feature number 318, F331
## 2024-12-19 19:25:28.325339 INFO::Fitting model to feature number 319, F332
## 2024-12-19 19:25:28.329727 INFO::Fitting model to feature number 320, F333
## 2024-12-19 19:25:28.334003 INFO::Fitting model to feature number 321, F334
## 2024-12-19 19:25:28.338367 INFO::Fitting model to feature number 322, F335
## 2024-12-19 19:25:28.342887 INFO::Fitting model to feature number 323, F336
## 2024-12-19 19:25:28.347249 INFO::Fitting model to feature number 324, F337
## 2024-12-19 19:25:28.351488 INFO::Fitting model to feature number 325, F338
## 2024-12-19 19:25:28.355815 INFO::Fitting model to feature number 326, F339
## 2024-12-19 19:25:28.360176 INFO::Fitting model to feature number 327, F340
## 2024-12-19 19:25:28.364487 INFO::Fitting model to feature number 328, F342
## 2024-12-19 19:25:28.368716 INFO::Fitting model to feature number 329, F343
## 2024-12-19 19:25:28.373037 INFO::Fitting model to feature number 330, F344
## 2024-12-19 19:25:28.377376 INFO::Fitting model to feature number 331, F345
## 2024-12-19 19:25:28.381743 INFO::Fitting model to feature number 332, F346
## 2024-12-19 19:25:28.386652 INFO::Fitting model to feature number 333, F347
## 2024-12-19 19:25:28.391194 INFO::Fitting model to feature number 334, F348
## 2024-12-19 19:25:28.395731 INFO::Fitting model to feature number 335, F350
## 2024-12-19 19:25:28.400998 INFO::Fitting model to feature number 336, F351
## 2024-12-19 19:25:28.405723 INFO::Fitting model to feature number 337, F352
## 2024-12-19 19:25:28.410313 INFO::Fitting model to feature number 338, F353
## 2024-12-19 19:25:28.414847 INFO::Fitting model to feature number 339, F355
## 2024-12-19 19:25:28.41931 INFO::Fitting model to feature number 340, F356
## 2024-12-19 19:25:28.423726 INFO::Fitting model to feature number 341, F357
## 2024-12-19 19:25:28.428092 INFO::Fitting model to feature number 342, F358
## 2024-12-19 19:25:28.43238 INFO::Fitting model to feature number 343, F359
## 2024-12-19 19:25:28.436656 INFO::Fitting model to feature number 344, F360
## 2024-12-19 19:25:28.440912 INFO::Fitting model to feature number 345, F361
## 2024-12-19 19:25:28.445208 INFO::Fitting model to feature number 346, F362
## 2024-12-19 19:25:28.449521 INFO::Fitting model to feature number 347, F363
## 2024-12-19 19:25:28.453779 INFO::Fitting model to feature number 348, F364
## 2024-12-19 19:25:28.458102 INFO::Fitting model to feature number 349, F365
## 2024-12-19 19:25:28.462379 INFO::Fitting model to feature number 350, F366
## 2024-12-19 19:25:28.466643 INFO::Fitting model to feature number 351, F367
## 2024-12-19 19:25:28.470972 INFO::Fitting model to feature number 352, F368
## 2024-12-19 19:25:28.475273 INFO::Fitting model to feature number 353, F369
## 2024-12-19 19:25:28.479539 INFO::Fitting model to feature number 354, F370
## 2024-12-19 19:25:28.4839 INFO::Fitting model to feature number 355, F371
## 2024-12-19 19:25:28.488145 INFO::Fitting model to feature number 356, F372
## 2024-12-19 19:25:28.492446 INFO::Fitting model to feature number 357, F373
## 2024-12-19 19:25:28.496768 INFO::Fitting model to feature number 358, F374
## 2024-12-19 19:25:28.501181 INFO::Fitting model to feature number 359, F375
## 2024-12-19 19:25:28.505456 INFO::Fitting model to feature number 360, F376
## 2024-12-19 19:25:28.509663 INFO::Fitting model to feature number 361, F377
## 2024-12-19 19:25:28.515847 INFO::Fitting model to feature number 362, F378
## 2024-12-19 19:25:28.52246 INFO::Fitting model to feature number 363, F379
## 2024-12-19 19:25:28.527656 INFO::Fitting model to feature number 364, F380
## 2024-12-19 19:25:28.532441 INFO::Fitting model to feature number 365, F381
## 2024-12-19 19:25:28.537617 INFO::Fitting model to feature number 366, F382
## 2024-12-19 19:25:28.54248 INFO::Fitting model to feature number 367, F383
## 2024-12-19 19:25:28.549201 INFO::Fitting model to feature number 368, F384
## 2024-12-19 19:25:28.556109 INFO::Fitting model to feature number 369, F386
## 2024-12-19 19:25:28.562883 INFO::Fitting model to feature number 370, F387
## 2024-12-19 19:25:28.569788 INFO::Fitting model to feature number 371, F388
## 2024-12-19 19:25:28.575908 INFO::Fitting model to feature number 372, F389
## 2024-12-19 19:25:28.580316 INFO::Fitting model to feature number 373, F390
## 2024-12-19 19:25:28.584638 INFO::Fitting model to feature number 374, F391
## 2024-12-19 19:25:28.589025 INFO::Fitting model to feature number 375, F392
## 2024-12-19 19:25:28.593587 INFO::Fitting model to feature number 376, F393
## 2024-12-19 19:25:28.597815 INFO::Fitting model to feature number 377, F394
## 2024-12-19 19:25:28.602049 INFO::Fitting model to feature number 378, F395
## 2024-12-19 19:25:28.606281 INFO::Fitting model to feature number 379, F396
## 2024-12-19 19:25:28.610581 INFO::Fitting model to feature number 380, F397
## 2024-12-19 19:25:28.614793 INFO::Fitting model to feature number 381, F398
## 2024-12-19 19:25:28.619012 INFO::Fitting model to feature number 382, F399
## 2024-12-19 19:25:28.623166 INFO::Fitting model to feature number 383, F400
## 2024-12-19 19:25:28.62736 INFO::Fitting model to feature number 384, F401
## 2024-12-19 19:25:28.631568 INFO::Fitting model to feature number 385, F402
## 2024-12-19 19:25:28.635773 INFO::Fitting model to feature number 386, F403
## 2024-12-19 19:25:28.640071 INFO::Fitting model to feature number 387, F404
## 2024-12-19 19:25:28.645003 INFO::Fitting model to feature number 388, F406
## 2024-12-19 19:25:28.649565 INFO::Fitting model to feature number 389, F407
## 2024-12-19 19:25:28.654049 INFO::Fitting model to feature number 390, F408
## 2024-12-19 19:25:28.658538 INFO::Fitting model to feature number 391, F409
## 2024-12-19 19:25:28.663104 INFO::Fitting model to feature number 392, F410
## 2024-12-19 19:25:28.667636 INFO::Fitting model to feature number 393, F411
## 2024-12-19 19:25:28.672175 INFO::Fitting model to feature number 394, F412
## 2024-12-19 19:25:28.676724 INFO::Fitting model to feature number 395, F413
## 2024-12-19 19:25:28.68138 INFO::Fitting model to feature number 396, F414
## 2024-12-19 19:25:28.68631 INFO::Fitting model to feature number 397, F415
## 2024-12-19 19:25:28.691284 INFO::Fitting model to feature number 398, F416
## 2024-12-19 19:25:28.696026 INFO::Fitting model to feature number 399, F417
## 2024-12-19 19:25:28.700667 INFO::Fitting model to feature number 400, F418
## 2024-12-19 19:25:28.705436 INFO::Fitting model to feature number 401, F419
## 2024-12-19 19:25:28.710198 INFO::Fitting model to feature number 402, F420
## 2024-12-19 19:25:28.714803 INFO::Fitting model to feature number 403, F421
## 2024-12-19 19:25:28.719386 INFO::Fitting model to feature number 404, F422
## 2024-12-19 19:25:28.723959 INFO::Fitting model to feature number 405, F423
## 2024-12-19 19:25:28.728623 INFO::Fitting model to feature number 406, F425
## 2024-12-19 19:25:28.733171 INFO::Fitting model to feature number 407, F426
## 2024-12-19 19:25:28.73779 INFO::Fitting model to feature number 408, F428
## 2024-12-19 19:25:28.742589 INFO::Fitting model to feature number 409, F429
## 2024-12-19 19:25:28.747147 INFO::Fitting model to feature number 410, F430
## 2024-12-19 19:25:28.751665 INFO::Fitting model to feature number 411, F431
## 2024-12-19 19:25:28.756162 INFO::Fitting model to feature number 412, F432
## 2024-12-19 19:25:28.760615 INFO::Fitting model to feature number 413, F433
## 2024-12-19 19:25:28.765104 INFO::Fitting model to feature number 414, F434
## 2024-12-19 19:25:28.769615 INFO::Fitting model to feature number 415, F435
## 2024-12-19 19:25:28.774155 INFO::Fitting model to feature number 416, F436
## 2024-12-19 19:25:28.778738 INFO::Fitting model to feature number 417, F437
## 2024-12-19 19:25:28.783218 INFO::Fitting model to feature number 418, F438
## 2024-12-19 19:25:28.787647 INFO::Fitting model to feature number 419, F439
## 2024-12-19 19:25:28.792083 INFO::Fitting model to feature number 420, F440
## 2024-12-19 19:25:28.796572 INFO::Fitting model to feature number 421, F441
## 2024-12-19 19:25:28.801024 INFO::Fitting model to feature number 422, F442
## 2024-12-19 19:25:28.805528 INFO::Fitting model to feature number 423, F443
## 2024-12-19 19:25:28.810056 INFO::Fitting model to feature number 424, F444
## 2024-12-19 19:25:28.814646 INFO::Fitting model to feature number 425, F445
## 2024-12-19 19:25:28.819162 INFO::Fitting model to feature number 426, F446
## 2024-12-19 19:25:28.823628 INFO::Fitting model to feature number 427, F447
## 2024-12-19 19:25:28.828231 INFO::Fitting model to feature number 428, F448
## 2024-12-19 19:25:28.832749 INFO::Fitting model to feature number 429, F449
## 2024-12-19 19:25:28.837253 INFO::Fitting model to feature number 430, F450
## 2024-12-19 19:25:28.841744 INFO::Fitting model to feature number 431, F451
## 2024-12-19 19:25:28.846252 INFO::Fitting model to feature number 432, F452
## 2024-12-19 19:25:28.850701 INFO::Fitting model to feature number 433, F454
## 2024-12-19 19:25:28.855144 INFO::Fitting model to feature number 434, F455
## 2024-12-19 19:25:28.85967 INFO::Fitting model to feature number 435, F456
## 2024-12-19 19:25:28.864186 INFO::Fitting model to feature number 436, F457
## 2024-12-19 19:25:28.868699 INFO::Fitting model to feature number 437, F458
## 2024-12-19 19:25:28.87318 INFO::Fitting model to feature number 438, F459
## 2024-12-19 19:25:28.877696 INFO::Fitting model to feature number 439, F461
## 2024-12-19 19:25:28.882124 INFO::Fitting model to feature number 440, F462
## 2024-12-19 19:25:28.886565 INFO::Fitting model to feature number 441, F463
## 2024-12-19 19:25:28.891088 INFO::Fitting model to feature number 442, F464
## 2024-12-19 19:25:28.895732 INFO::Fitting model to feature number 443, F465
## 2024-12-19 19:25:28.900277 INFO::Fitting model to feature number 444, F466
## 2024-12-19 19:25:28.904845 INFO::Fitting model to feature number 445, F467
## 2024-12-19 19:25:28.909373 INFO::Fitting model to feature number 446, F468
## 2024-12-19 19:25:28.914071 INFO::Fitting model to feature number 447, F469
## 2024-12-19 19:25:28.918772 INFO::Fitting model to feature number 448, F470
## 2024-12-19 19:25:28.92379 INFO::Fitting model to feature number 449, F471
## 2024-12-19 19:25:28.929296 INFO::Fitting model to feature number 450, F474
## 2024-12-19 19:25:28.934297 INFO::Fitting model to feature number 451, F475
## 2024-12-19 19:25:28.939353 INFO::Fitting model to feature number 452, F476
## 2024-12-19 19:25:28.944148 INFO::Fitting model to feature number 453, F477
## 2024-12-19 19:25:28.949061 INFO::Fitting model to feature number 454, F478
## 2024-12-19 19:25:28.95405 INFO::Fitting model to feature number 455, F479
## 2024-12-19 19:25:28.958895 INFO::Fitting model to feature number 456, F480
## 2024-12-19 19:25:28.963655 INFO::Fitting model to feature number 457, F481
## 2024-12-19 19:25:28.968425 INFO::Fitting model to feature number 458, F482
## 2024-12-19 19:25:28.973067 INFO::Fitting model to feature number 459, F483
## 2024-12-19 19:25:28.9777 INFO::Fitting model to feature number 460, F484
## 2024-12-19 19:25:28.982358 INFO::Fitting model to feature number 461, F485
## 2024-12-19 19:25:28.986907 INFO::Fitting model to feature number 462, F486
## 2024-12-19 19:25:28.99142 INFO::Fitting model to feature number 463, F487
## 2024-12-19 19:25:28.995968 INFO::Fitting model to feature number 464, F488
## 2024-12-19 19:25:29.000456 INFO::Fitting model to feature number 465, F489
## 2024-12-19 19:25:29.004946 INFO::Fitting model to feature number 466, F490
## 2024-12-19 19:25:29.009428 INFO::Fitting model to feature number 467, F491
## 2024-12-19 19:25:29.013949 INFO::Fitting model to feature number 468, F492
## 2024-12-19 19:25:29.018454 INFO::Fitting model to feature number 469, F493
## 2024-12-19 19:25:29.022917 INFO::Fitting model to feature number 470, F494
## 2024-12-19 19:25:29.027383 INFO::Fitting model to feature number 471, F495
## 2024-12-19 19:25:29.031878 INFO::Fitting model to feature number 472, F496
## 2024-12-19 19:25:29.036349 INFO::Fitting model to feature number 473, F497
## 2024-12-19 19:25:29.040771 INFO::Fitting model to feature number 474, F498
## 2024-12-19 19:25:29.045167 INFO::Fitting model to feature number 475, F499
## 2024-12-19 19:25:29.049622 INFO::Fitting model to feature number 476, F500
## 2024-12-19 19:25:29.054038 INFO::Fitting model to feature number 477, F501
## 2024-12-19 19:25:29.058539 INFO::Fitting model to feature number 478, F502
## 2024-12-19 19:25:29.063091 INFO::Fitting model to feature number 479, F503
## 2024-12-19 19:25:29.067625 INFO::Fitting model to feature number 480, F504
## 2024-12-19 19:25:29.072137 INFO::Fitting model to feature number 481, F505
## 2024-12-19 19:25:29.076667 INFO::Fitting model to feature number 482, F506
## 2024-12-19 19:25:29.081198 INFO::Fitting model to feature number 483, F507
## 2024-12-19 19:25:29.085724 INFO::Fitting model to feature number 484, F508
## 2024-12-19 19:25:29.090272 INFO::Fitting model to feature number 485, F509
## 2024-12-19 19:25:29.094772 INFO::Fitting model to feature number 486, F510
## 2024-12-19 19:25:29.099265 INFO::Fitting model to feature number 487, F511
## 2024-12-19 19:25:29.103755 INFO::Fitting model to feature number 488, F512
## 2024-12-19 19:25:29.108208 INFO::Fitting model to feature number 489, F513
## 2024-12-19 19:25:29.112632 INFO::Fitting model to feature number 490, F514
## 2024-12-19 19:25:29.117089 INFO::Fitting model to feature number 491, F515
## 2024-12-19 19:25:29.121539 INFO::Fitting model to feature number 492, F516
## 2024-12-19 19:25:29.125962 INFO::Fitting model to feature number 493, F517
## 2024-12-19 19:25:29.130342 INFO::Fitting model to feature number 494, F518
## 2024-12-19 19:25:29.13475 INFO::Fitting model to feature number 495, F519
## 2024-12-19 19:25:29.139167 INFO::Fitting model to feature number 496, F520
## 2024-12-19 19:25:29.143947 INFO::Fitting model to feature number 497, F521
## 2024-12-19 19:25:29.148609 INFO::Fitting model to feature number 498, F522
## 2024-12-19 19:25:29.153168 INFO::Fitting model to feature number 499, F523
## 2024-12-19 19:25:29.1578 INFO::Fitting model to feature number 500, F524
## 2024-12-19 19:25:29.16235 INFO::Fitting model to feature number 501, F525
## 2024-12-19 19:25:29.16696 INFO::Fitting model to feature number 502, F526
## 2024-12-19 19:25:29.171745 INFO::Fitting model to feature number 503, F527
## 2024-12-19 19:25:29.176442 INFO::Fitting model to feature number 504, F528
## 2024-12-19 19:25:29.181049 INFO::Fitting model to feature number 505, F529
## 2024-12-19 19:25:29.185554 INFO::Fitting model to feature number 506, F530
## 2024-12-19 19:25:29.190022 INFO::Fitting model to feature number 507, F531
## 2024-12-19 19:25:29.194475 INFO::Fitting model to feature number 508, F532
## 2024-12-19 19:25:29.198947 INFO::Fitting model to feature number 509, F533
## 2024-12-19 19:25:29.203401 INFO::Fitting model to feature number 510, F534
## 2024-12-19 19:25:29.207939 INFO::Fitting model to feature number 511, F535
## 2024-12-19 19:25:29.212402 INFO::Fitting model to feature number 512, F536
## 2024-12-19 19:25:29.216842 INFO::Fitting model to feature number 513, F537
## 2024-12-19 19:25:29.22132 INFO::Fitting model to feature number 514, F539
## 2024-12-19 19:25:29.225748 INFO::Fitting model to feature number 515, F540
## 2024-12-19 19:25:29.230154 INFO::Fitting model to feature number 516, F541
## 2024-12-19 19:25:29.234551 INFO::Fitting model to feature number 517, F543
## 2024-12-19 19:25:29.238985 INFO::Fitting model to feature number 518, F544
## 2024-12-19 19:25:29.243387 INFO::Fitting model to feature number 519, F545
## 2024-12-19 19:25:29.247778 INFO::Fitting model to feature number 520, F546
## 2024-12-19 19:25:29.252266 INFO::Fitting model to feature number 521, F547
## 2024-12-19 19:25:29.256784 INFO::Fitting model to feature number 522, F548
## 2024-12-19 19:25:29.261346 INFO::Fitting model to feature number 523, F549
## 2024-12-19 19:25:29.265898 INFO::Fitting model to feature number 524, F550
## 2024-12-19 19:25:29.270536 INFO::Fitting model to feature number 525, F551
## 2024-12-19 19:25:29.277217 INFO::Fitting model to feature number 526, F552
## 2024-12-19 19:25:29.284389 INFO::Fitting model to feature number 527, F553
## 2024-12-19 19:25:29.291485 INFO::Fitting model to feature number 528, F554
## 2024-12-19 19:25:29.298796 INFO::Fitting model to feature number 529, F555
## 2024-12-19 19:25:29.306445 INFO::Fitting model to feature number 530, F556
## 2024-12-19 19:25:29.314668 INFO::Fitting model to feature number 531, F557
## 2024-12-19 19:25:29.321814 INFO::Fitting model to feature number 532, F558
## 2024-12-19 19:25:29.328938 INFO::Fitting model to feature number 533, F559
## 2024-12-19 19:25:29.33619 INFO::Fitting model to feature number 534, F560
## 2024-12-19 19:25:29.343371 INFO::Fitting model to feature number 535, F561
## 2024-12-19 19:25:29.350568 INFO::Fitting model to feature number 536, F562
## 2024-12-19 19:25:29.357764 INFO::Fitting model to feature number 537, F563
## 2024-12-19 19:25:29.364864 INFO::Fitting model to feature number 538, F564
## 2024-12-19 19:25:29.371948 INFO::Fitting model to feature number 539, F566
## 2024-12-19 19:25:29.379089 INFO::Fitting model to feature number 540, F567
## 2024-12-19 19:25:29.386209 INFO::Fitting model to feature number 541, F568
## 2024-12-19 19:25:29.391836 INFO::Fitting model to feature number 542, F569
## 2024-12-19 19:25:29.396589 INFO::Fitting model to feature number 543, F570
## 2024-12-19 19:25:29.40367 INFO::Fitting model to feature number 544, F571
## 2024-12-19 19:25:29.408473 INFO::Fitting model to feature number 545, F572
## 2024-12-19 19:25:29.414653 INFO::Fitting model to feature number 546, F573
## 2024-12-19 19:25:29.419973 INFO::Fitting model to feature number 547, F574
## 2024-12-19 19:25:29.42473 INFO::Fitting model to feature number 548, F575
## 2024-12-19 19:25:29.429376 INFO::Fitting model to feature number 549, F576
## 2024-12-19 19:25:29.433964 INFO::Fitting model to feature number 550, F577
## 2024-12-19 19:25:29.438562 INFO::Fitting model to feature number 551, F578
## 2024-12-19 19:25:29.443164 INFO::Fitting model to feature number 552, F579
## 2024-12-19 19:25:29.447706 INFO::Fitting model to feature number 553, F580
## 2024-12-19 19:25:29.452219 INFO::Fitting model to feature number 554, F581
## 2024-12-19 19:25:29.456795 INFO::Fitting model to feature number 555, F582
## 2024-12-19 19:25:29.461181 INFO::Fitting model to feature number 556, F583
## 2024-12-19 19:25:29.465617 INFO::Fitting model to feature number 557, F584
## 2024-12-19 19:25:29.47067 INFO::Fitting model to feature number 558, F585
## 2024-12-19 19:25:29.475352 INFO::Fitting model to feature number 559, F586
## 2024-12-19 19:25:29.479814 INFO::Fitting model to feature number 560, F587
## 2024-12-19 19:25:29.484297 INFO::Fitting model to feature number 561, F588
## 2024-12-19 19:25:29.488783 INFO::Fitting model to feature number 562, F589
## 2024-12-19 19:25:29.493269 INFO::Fitting model to feature number 563, F590
## 2024-12-19 19:25:29.497785 INFO::Fitting model to feature number 564, F591
## 2024-12-19 19:25:29.525099 INFO::Fitting model to feature number 565, F592
## 2024-12-19 19:25:29.529824 INFO::Fitting model to feature number 566, F593
## 2024-12-19 19:25:29.534359 INFO::Fitting model to feature number 567, F594
## 2024-12-19 19:25:29.538766 INFO::Fitting model to feature number 568, F595
## 2024-12-19 19:25:29.543101 INFO::Fitting model to feature number 569, F596
## 2024-12-19 19:25:29.547476 INFO::Fitting model to feature number 570, F597
## 2024-12-19 19:25:29.551731 INFO::Fitting model to feature number 571, F598
## 2024-12-19 19:25:29.556106 INFO::Fitting model to feature number 572, F599
## 2024-12-19 19:25:29.560349 INFO::Fitting model to feature number 573, F600
## 2024-12-19 19:25:29.564602 INFO::Fitting model to feature number 574, F601
## 2024-12-19 19:25:29.568776 INFO::Fitting model to feature number 575, F602
## 2024-12-19 19:25:29.572992 INFO::Fitting model to feature number 576, F603
## 2024-12-19 19:25:29.577203 INFO::Fitting model to feature number 577, F605
## 2024-12-19 19:25:29.581472 INFO::Fitting model to feature number 578, F606
## 2024-12-19 19:25:29.585648 INFO::Fitting model to feature number 579, F607
## 2024-12-19 19:25:29.589843 INFO::Fitting model to feature number 580, F608
## 2024-12-19 19:25:29.594026 INFO::Fitting model to feature number 581, F609
## 2024-12-19 19:25:29.598248 INFO::Fitting model to feature number 582, F610
## 2024-12-19 19:25:29.602411 INFO::Fitting model to feature number 583, F611
## 2024-12-19 19:25:29.606612 INFO::Fitting model to feature number 584, F612
## 2024-12-19 19:25:29.610754 INFO::Fitting model to feature number 585, F613
## 2024-12-19 19:25:29.614884 INFO::Fitting model to feature number 586, F614
## 2024-12-19 19:25:29.619081 INFO::Fitting model to feature number 587, F615
## 2024-12-19 19:25:29.623488 INFO::Fitting model to feature number 588, F616
## 2024-12-19 19:25:29.627816 INFO::Fitting model to feature number 589, F617
## 2024-12-19 19:25:29.632548 INFO::Fitting model to feature number 590, F618
## 2024-12-19 19:25:29.637219 INFO::Fitting model to feature number 591, F619
## 2024-12-19 19:25:29.64292 INFO::Fitting model to feature number 592, F620
## 2024-12-19 19:25:29.64871 INFO::Fitting model to feature number 593, F621
## 2024-12-19 19:25:29.653719 INFO::Fitting model to feature number 594, F622
## 2024-12-19 19:25:29.660777 INFO::Fitting model to feature number 595, F623
## 2024-12-19 19:25:29.667806 INFO::Fitting model to feature number 596, F624
## 2024-12-19 19:25:29.674376 INFO::Fitting model to feature number 597, F625
## 2024-12-19 19:25:29.681038 INFO::Fitting model to feature number 598, F626
## 2024-12-19 19:25:29.687696 INFO::Fitting model to feature number 599, F627
## 2024-12-19 19:25:29.694608 INFO::Fitting model to feature number 600, F628
## 2024-12-19 19:25:29.70153 INFO::Fitting model to feature number 601, F629
## 2024-12-19 19:25:29.708324 INFO::Fitting model to feature number 602, F630
## 2024-12-19 19:25:29.714934 INFO::Fitting model to feature number 603, F631
## 2024-12-19 19:25:29.720491 INFO::Fitting model to feature number 604, F632
## 2024-12-19 19:25:29.725102 INFO::Fitting model to feature number 605, F633
## 2024-12-19 19:25:29.729624 INFO::Fitting model to feature number 606, F634
## 2024-12-19 19:25:29.734075 INFO::Fitting model to feature number 607, F635
## 2024-12-19 19:25:29.738474 INFO::Fitting model to feature number 608, F636
## 2024-12-19 19:25:29.742854 INFO::Fitting model to feature number 609, F637
## 2024-12-19 19:25:29.747606 INFO::Fitting model to feature number 610, F638
## 2024-12-19 19:25:29.752103 INFO::Fitting model to feature number 611, F639
## 2024-12-19 19:25:29.756569 INFO::Fitting model to feature number 612, F640
## 2024-12-19 19:25:29.760952 INFO::Fitting model to feature number 613, F641
## 2024-12-19 19:25:29.765193 INFO::Fitting model to feature number 614, F642
## 2024-12-19 19:25:29.769446 INFO::Fitting model to feature number 615, F643
## 2024-12-19 19:25:29.773709 INFO::Fitting model to feature number 616, F644
## 2024-12-19 19:25:29.778012 INFO::Fitting model to feature number 617, F645
## 2024-12-19 19:25:29.782383 INFO::Fitting model to feature number 618, F646
## 2024-12-19 19:25:29.786691 INFO::Fitting model to feature number 619, F647
## 2024-12-19 19:25:29.790935 INFO::Fitting model to feature number 620, F648
## 2024-12-19 19:25:29.795216 INFO::Fitting model to feature number 621, F649
## 2024-12-19 19:25:29.799589 INFO::Fitting model to feature number 622, F650
## 2024-12-19 19:25:29.80395 INFO::Fitting model to feature number 623, F651
## 2024-12-19 19:25:29.808628 INFO::Fitting model to feature number 624, F652
## 2024-12-19 19:25:29.813113 INFO::Fitting model to feature number 625, F653
## 2024-12-19 19:25:29.817398 INFO::Fitting model to feature number 626, F654
## 2024-12-19 19:25:29.822064 INFO::Fitting model to feature number 627, F655
## 2024-12-19 19:25:29.826309 INFO::Fitting model to feature number 628, F656
## 2024-12-19 19:25:29.830497 INFO::Fitting model to feature number 629, F657
## 2024-12-19 19:25:29.834669 INFO::Fitting model to feature number 630, F658
## 2024-12-19 19:25:29.838859 INFO::Fitting model to feature number 631, F659
## 2024-12-19 19:25:29.843058 INFO::Fitting model to feature number 632, F660
## 2024-12-19 19:25:29.847931 INFO::Fitting model to feature number 633, F661
## 2024-12-19 19:25:29.85224 INFO::Fitting model to feature number 634, F662
## 2024-12-19 19:25:29.856502 INFO::Fitting model to feature number 635, F663
## 2024-12-19 19:25:29.860865 INFO::Fitting model to feature number 636, F664
## 2024-12-19 19:25:29.865144 INFO::Fitting model to feature number 637, F665
## 2024-12-19 19:25:29.869451 INFO::Fitting model to feature number 638, F666
## 2024-12-19 19:25:29.873777 INFO::Fitting model to feature number 639, F667
## 2024-12-19 19:25:29.878041 INFO::Fitting model to feature number 640, F668
## 2024-12-19 19:25:29.882524 INFO::Fitting model to feature number 641, F669
## 2024-12-19 19:25:29.886918 INFO::Fitting model to feature number 642, F670
## 2024-12-19 19:25:29.891328 INFO::Fitting model to feature number 643, F671
## 2024-12-19 19:25:29.895537 INFO::Fitting model to feature number 644, F672
## 2024-12-19 19:25:29.899725 INFO::Fitting model to feature number 645, F673
## 2024-12-19 19:25:29.903948 INFO::Fitting model to feature number 646, F674
## 2024-12-19 19:25:29.908252 INFO::Fitting model to feature number 647, F675
## 2024-12-19 19:25:29.913601 INFO::Fitting model to feature number 648, F676
## 2024-12-19 19:25:29.918671 INFO::Fitting model to feature number 649, F677
## 2024-12-19 19:25:29.9231 INFO::Fitting model to feature number 650, F678
## 2024-12-19 19:25:29.927539 INFO::Fitting model to feature number 651, F679
## 2024-12-19 19:25:29.931911 INFO::Fitting model to feature number 652, F680
## 2024-12-19 19:25:29.936268 INFO::Fitting model to feature number 653, F681
## 2024-12-19 19:25:29.940677 INFO::Fitting model to feature number 654, F682
## 2024-12-19 19:25:29.945079 INFO::Fitting model to feature number 655, F683
## 2024-12-19 19:25:29.949425 INFO::Fitting model to feature number 656, F684
## 2024-12-19 19:25:29.953736 INFO::Fitting model to feature number 657, F685
## 2024-12-19 19:25:29.957983 INFO::Fitting model to feature number 658, F686
## 2024-12-19 19:25:29.962288 INFO::Fitting model to feature number 659, F687
## 2024-12-19 19:25:29.966532 INFO::Fitting model to feature number 660, F688
## 2024-12-19 19:25:29.970793 INFO::Fitting model to feature number 661, F689
## 2024-12-19 19:25:29.975023 INFO::Fitting model to feature number 662, F690
## 2024-12-19 19:25:29.979313 INFO::Fitting model to feature number 663, F691
## 2024-12-19 19:25:29.983545 INFO::Fitting model to feature number 664, F692
## 2024-12-19 19:25:29.987937 INFO::Fitting model to feature number 665, F693
## 2024-12-19 19:25:29.992273 INFO::Fitting model to feature number 666, F694
## 2024-12-19 19:25:29.996554 INFO::Fitting model to feature number 667, F695
## 2024-12-19 19:25:30.000918 INFO::Fitting model to feature number 668, F696
## 2024-12-19 19:25:30.005314 INFO::Fitting model to feature number 669, F697
## 2024-12-19 19:25:30.00973 INFO::Fitting model to feature number 670, F698
## 2024-12-19 19:25:30.014095 INFO::Fitting model to feature number 671, F699
## 2024-12-19 19:25:30.018457 INFO::Fitting model to feature number 672, F700
## 2024-12-19 19:25:30.022844 INFO::Fitting model to feature number 673, F701
## 2024-12-19 19:25:30.027205 INFO::Fitting model to feature number 674, F702
## 2024-12-19 19:25:30.031704 INFO::Fitting model to feature number 675, F704
## 2024-12-19 19:25:30.036308 INFO::Fitting model to feature number 676, F705
## 2024-12-19 19:25:30.040733 INFO::Fitting model to feature number 677, F706
## 2024-12-19 19:25:30.04533 INFO::Fitting model to feature number 678, F707
## 2024-12-19 19:25:30.049794 INFO::Fitting model to feature number 679, F708
## 2024-12-19 19:25:30.054173 INFO::Fitting model to feature number 680, F709
## 2024-12-19 19:25:30.058704 INFO::Fitting model to feature number 681, F710
## 2024-12-19 19:25:30.063305 INFO::Fitting model to feature number 682, F711
## 2024-12-19 19:25:30.06781 INFO::Fitting model to feature number 683, F712
## 2024-12-19 19:25:30.072365 INFO::Fitting model to feature number 684, F713
## 2024-12-19 19:25:30.076841 INFO::Fitting model to feature number 685, F714
## 2024-12-19 19:25:30.081298 INFO::Fitting model to feature number 686, F715
## 2024-12-19 19:25:30.085791 INFO::Fitting model to feature number 687, F716
## 2024-12-19 19:25:30.090193 INFO::Fitting model to feature number 688, F717
## 2024-12-19 19:25:30.094639 INFO::Fitting model to feature number 689, F718
## 2024-12-19 19:25:30.098937 INFO::Fitting model to feature number 690, F719
## 2024-12-19 19:25:30.103223 INFO::Fitting model to feature number 691, F720
## 2024-12-19 19:25:30.1075 INFO::Fitting model to feature number 692, F721
## 2024-12-19 19:25:30.111953 INFO::Fitting model to feature number 693, F722
## 2024-12-19 19:25:30.116694 INFO::Fitting model to feature number 694, F723
## 2024-12-19 19:25:30.121167 INFO::Fitting model to feature number 695, F724
## 2024-12-19 19:25:30.125742 INFO::Fitting model to feature number 696, F725
## 2024-12-19 19:25:30.130187 INFO::Fitting model to feature number 697, F726
## 2024-12-19 19:25:30.134604 INFO::Fitting model to feature number 698, F727
## 2024-12-19 19:25:30.139041 INFO::Fitting model to feature number 699, F728
## 2024-12-19 19:25:30.143479 INFO::Fitting model to feature number 700, F729
## 2024-12-19 19:25:30.147857 INFO::Fitting model to feature number 701, F730
## 2024-12-19 19:25:30.152261 INFO::Fitting model to feature number 702, F731
## 2024-12-19 19:25:30.156703 INFO::Fitting model to feature number 703, F732
## 2024-12-19 19:25:30.161161 INFO::Fitting model to feature number 704, F733
## 2024-12-19 19:25:30.165582 INFO::Fitting model to feature number 705, F734
## 2024-12-19 19:25:30.170252 INFO::Fitting model to feature number 706, F735
## 2024-12-19 19:25:30.174654 INFO::Fitting model to feature number 707, F736
## 2024-12-19 19:25:30.179015 INFO::Fitting model to feature number 708, F737
## 2024-12-19 19:25:30.183348 INFO::Fitting model to feature number 709, F739
## 2024-12-19 19:25:30.189703 INFO::Fitting model to feature number 710, F740
## 2024-12-19 19:25:30.197529 INFO::Fitting model to feature number 711, F741
## 2024-12-19 19:25:30.204105 INFO::Fitting model to feature number 712, F742
## 2024-12-19 19:25:30.208996 INFO::Fitting model to feature number 713, F743
## 2024-12-19 19:25:30.21414 INFO::Fitting model to feature number 714, F744
## 2024-12-19 19:25:30.218904 INFO::Fitting model to feature number 715, F745
## 2024-12-19 19:25:30.22355 INFO::Fitting model to feature number 716, F746
## 2024-12-19 19:25:30.228172 INFO::Fitting model to feature number 717, F747
## 2024-12-19 19:25:30.232861 INFO::Fitting model to feature number 718, F748
## 2024-12-19 19:25:30.23754 INFO::Fitting model to feature number 719, F749
## 2024-12-19 19:25:30.242076 INFO::Fitting model to feature number 720, F750
## 2024-12-19 19:25:30.246545 INFO::Fitting model to feature number 721, F751
## 2024-12-19 19:25:30.250975 INFO::Fitting model to feature number 722, F752
## 2024-12-19 19:25:30.255382 INFO::Fitting model to feature number 723, F753
## 2024-12-19 19:25:30.259826 INFO::Fitting model to feature number 724, F754
## 2024-12-19 19:25:30.264318 INFO::Fitting model to feature number 725, F755
## 2024-12-19 19:25:30.268743 INFO::Fitting model to feature number 726, F756
## 2024-12-19 19:25:30.273196 INFO::Fitting model to feature number 727, F757
## 2024-12-19 19:25:30.277609 INFO::Fitting model to feature number 728, F758
## 2024-12-19 19:25:30.282127 INFO::Fitting model to feature number 729, F759
## 2024-12-19 19:25:30.286613 INFO::Fitting model to feature number 730, F760
## 2024-12-19 19:25:30.291315 INFO::Fitting model to feature number 731, F761
## 2024-12-19 19:25:30.296175 INFO::Fitting model to feature number 732, F762
## 2024-12-19 19:25:30.300893 INFO::Fitting model to feature number 733, F763
## 2024-12-19 19:25:30.305398 INFO::Fitting model to feature number 734, F764
## 2024-12-19 19:25:30.310036 INFO::Fitting model to feature number 735, F765
## 2024-12-19 19:25:30.314657 INFO::Fitting model to feature number 736, F766
## 2024-12-19 19:25:30.319082 INFO::Fitting model to feature number 737, F767
## 2024-12-19 19:25:30.323652 INFO::Fitting model to feature number 738, F768
## 2024-12-19 19:25:30.328657 INFO::Fitting model to feature number 739, F769
## 2024-12-19 19:25:30.333307 INFO::Fitting model to feature number 740, F770
## 2024-12-19 19:25:30.337959 INFO::Fitting model to feature number 741, F771
## 2024-12-19 19:25:30.342429 INFO::Fitting model to feature number 742, F772
## 2024-12-19 19:25:30.347515 INFO::Fitting model to feature number 743, F773
## 2024-12-19 19:25:30.352071 INFO::Fitting model to feature number 744, F774
## 2024-12-19 19:25:30.356733 INFO::Fitting model to feature number 745, F775
## 2024-12-19 19:25:30.361534 INFO::Fitting model to feature number 746, F776
## 2024-12-19 19:25:30.366438 INFO::Fitting model to feature number 747, F777
## 2024-12-19 19:25:30.371404 INFO::Fitting model to feature number 748, F778
## 2024-12-19 19:25:30.376549 INFO::Fitting model to feature number 749, F779
## 2024-12-19 19:25:30.381244 INFO::Fitting model to feature number 750, F780
## 2024-12-19 19:25:30.38584 INFO::Fitting model to feature number 751, F781
## 2024-12-19 19:25:30.390354 INFO::Fitting model to feature number 752, F782
## 2024-12-19 19:25:30.394939 INFO::Fitting model to feature number 753, F783
## 2024-12-19 19:25:30.399429 INFO::Fitting model to feature number 754, F784
## 2024-12-19 19:25:30.404074 INFO::Fitting model to feature number 755, F785
## 2024-12-19 19:25:30.408782 INFO::Fitting model to feature number 756, F786
## 2024-12-19 19:25:30.413323 INFO::Fitting model to feature number 757, F787
## 2024-12-19 19:25:30.417891 INFO::Fitting model to feature number 758, F788
## 2024-12-19 19:25:30.422325 INFO::Fitting model to feature number 759, F789
## 2024-12-19 19:25:30.426787 INFO::Fitting model to feature number 760, F790
## 2024-12-19 19:25:30.4312 INFO::Fitting model to feature number 761, F791
## 2024-12-19 19:25:30.436315 INFO::Fitting model to feature number 762, F792
## 2024-12-19 19:25:30.440885 INFO::Fitting model to feature number 763, F793
## 2024-12-19 19:25:30.445354 INFO::Fitting model to feature number 764, F794
## 2024-12-19 19:25:30.449928 INFO::Fitting model to feature number 765, F795
## 2024-12-19 19:25:30.454922 INFO::Fitting model to feature number 766, F796
## 2024-12-19 19:25:30.459468 INFO::Fitting model to feature number 767, F797
## 2024-12-19 19:25:30.464023 INFO::Fitting model to feature number 768, F798
## 2024-12-19 19:25:30.468598 INFO::Fitting model to feature number 769, F799
## 2024-12-19 19:25:30.473316 INFO::Fitting model to feature number 770, F800
## 2024-12-19 19:25:30.478553 INFO::Fitting model to feature number 771, F801
## 2024-12-19 19:25:30.484089 INFO::Fitting model to feature number 772, F802
## 2024-12-19 19:25:30.491305 INFO::Fitting model to feature number 773, F803
## 2024-12-19 19:25:30.49832 INFO::Fitting model to feature number 774, F804
## 2024-12-19 19:25:30.506411 INFO::Fitting model to feature number 775, F805
## 2024-12-19 19:25:30.513969 INFO::Fitting model to feature number 776, F806
## 2024-12-19 19:25:30.52163 INFO::Fitting model to feature number 777, F808
## 2024-12-19 19:25:30.529343 INFO::Fitting model to feature number 778, F809
## 2024-12-19 19:25:30.537072 INFO::Fitting model to feature number 779, F810
## 2024-12-19 19:25:30.544912 INFO::Fitting model to feature number 780, F811
## 2024-12-19 19:25:30.550118 INFO::Fitting model to feature number 781, F812
## 2024-12-19 19:25:30.55522 INFO::Fitting model to feature number 782, F813
## 2024-12-19 19:25:30.560282 INFO::Fitting model to feature number 783, F814
## 2024-12-19 19:25:30.567453 INFO::Fitting model to feature number 784, F815
## 2024-12-19 19:25:30.575289 INFO::Fitting model to feature number 785, F816
## 2024-12-19 19:25:30.583349 INFO::Fitting model to feature number 786, F817
## 2024-12-19 19:25:30.591252 INFO::Fitting model to feature number 787, F818
## 2024-12-19 19:25:30.599484 INFO::Fitting model to feature number 788, F819
## 2024-12-19 19:25:30.607474 INFO::Fitting model to feature number 789, F820
## 2024-12-19 19:25:30.615214 INFO::Fitting model to feature number 790, F821
## 2024-12-19 19:25:30.623136 INFO::Fitting model to feature number 791, F822
## 2024-12-19 19:25:30.630883 INFO::Fitting model to feature number 792, F823
## 2024-12-19 19:25:30.638658 INFO::Fitting model to feature number 793, F824
## 2024-12-19 19:25:30.646465 INFO::Fitting model to feature number 794, F825
## 2024-12-19 19:25:30.65407 INFO::Fitting model to feature number 795, F826
## 2024-12-19 19:25:30.661742 INFO::Fitting model to feature number 796, F827
## 2024-12-19 19:25:30.674729 INFO::Fitting model to feature number 797, F828
## 2024-12-19 19:25:30.682463 INFO::Fitting model to feature number 798, F829
## 2024-12-19 19:25:30.690222 INFO::Fitting model to feature number 799, F830
## 2024-12-19 19:25:30.698014 INFO::Fitting model to feature number 800, F831
## 2024-12-19 19:25:30.705911 INFO::Fitting model to feature number 801, F832
## 2024-12-19 19:25:30.713743 INFO::Fitting model to feature number 802, F833
## 2024-12-19 19:25:30.721699 INFO::Fitting model to feature number 803, F834
## 2024-12-19 19:25:30.729541 INFO::Fitting model to feature number 804, F835
## 2024-12-19 19:25:30.737313 INFO::Fitting model to feature number 805, F836
## 2024-12-19 19:25:30.745107 INFO::Fitting model to feature number 806, F837
## 2024-12-19 19:25:30.752965 INFO::Fitting model to feature number 807, F838
## 2024-12-19 19:25:30.760792 INFO::Fitting model to feature number 808, F839
## 2024-12-19 19:25:30.768608 INFO::Fitting model to feature number 809, F840
## 2024-12-19 19:25:30.774729 INFO::Fitting model to feature number 810, F841
## 2024-12-19 19:25:30.780087 INFO::Fitting model to feature number 811, F842
## 2024-12-19 19:25:30.784992 INFO::Fitting model to feature number 812, F843
## 2024-12-19 19:25:30.789932 INFO::Fitting model to feature number 813, F844
## 2024-12-19 19:25:30.794647 INFO::Fitting model to feature number 814, F845
## 2024-12-19 19:25:30.799548 INFO::Fitting model to feature number 815, F846
## 2024-12-19 19:25:30.805204 INFO::Fitting model to feature number 816, F847
## 2024-12-19 19:25:30.810279 INFO::Fitting model to feature number 817, F848
## 2024-12-19 19:25:30.815194 INFO::Fitting model to feature number 818, F849
## 2024-12-19 19:25:30.820041 INFO::Fitting model to feature number 819, F850
## 2024-12-19 19:25:30.824768 INFO::Fitting model to feature number 820, F851
## 2024-12-19 19:25:30.829795 INFO::Fitting model to feature number 821, F852
## 2024-12-19 19:25:30.836912 INFO::Fitting model to feature number 822, F853
## 2024-12-19 19:25:30.844642 INFO::Fitting model to feature number 823, F854
## 2024-12-19 19:25:30.852352 INFO::Fitting model to feature number 824, F855
## 2024-12-19 19:25:30.860254 INFO::Fitting model to feature number 825, F856
## 2024-12-19 19:25:30.868038 INFO::Fitting model to feature number 826, F857
## 2024-12-19 19:25:30.874598 INFO::Fitting model to feature number 827, F858
## 2024-12-19 19:25:30.880213 INFO::Fitting model to feature number 828, F859
## 2024-12-19 19:25:30.886358 INFO::Fitting model to feature number 829, F860
## 2024-12-19 19:25:30.892534 INFO::Fitting model to feature number 830, F861
## 2024-12-19 19:25:30.897468 INFO::Fitting model to feature number 831, F862
## 2024-12-19 19:25:30.905271 INFO::Fitting model to feature number 832, F863
## 2024-12-19 19:25:30.910051 INFO::Fitting model to feature number 833, F864
## 2024-12-19 19:25:30.915922 INFO::Fitting model to feature number 834, F865
## 2024-12-19 19:25:30.921089 INFO::Fitting model to feature number 835, F866
## 2024-12-19 19:25:30.926378 INFO::Fitting model to feature number 836, F867
## 2024-12-19 19:25:30.932581 INFO::Fitting model to feature number 837, F868
## 2024-12-19 19:25:30.939954 INFO::Fitting model to feature number 838, F869
## 2024-12-19 19:25:30.9475 INFO::Fitting model to feature number 839, F870
## 2024-12-19 19:25:30.955167 INFO::Fitting model to feature number 840, F871
## 2024-12-19 19:25:30.962736 INFO::Fitting model to feature number 841, F872
## 2024-12-19 19:25:30.97009 INFO::Fitting model to feature number 842, F873
## 2024-12-19 19:25:30.977853 INFO::Fitting model to feature number 843, F874
## 2024-12-19 19:25:30.985821 INFO::Fitting model to feature number 844, F875
## 2024-12-19 19:25:30.993599 INFO::Fitting model to feature number 845, F876
## 2024-12-19 19:25:31.001127 INFO::Fitting model to feature number 846, F877
## 2024-12-19 19:25:31.008934 INFO::Fitting model to feature number 847, F878
## 2024-12-19 19:25:31.017044 INFO::Fitting model to feature number 848, F879
## 2024-12-19 19:25:31.025265 INFO::Fitting model to feature number 849, F880
## 2024-12-19 19:25:31.031337 INFO::Fitting model to feature number 850, F881
## 2024-12-19 19:25:31.036326 INFO::Fitting model to feature number 851, F882
## 2024-12-19 19:25:31.041442 INFO::Fitting model to feature number 852, F883
## 2024-12-19 19:25:31.046388 INFO::Fitting model to feature number 853, F884
## 2024-12-19 19:25:31.051273 INFO::Fitting model to feature number 854, F885
## 2024-12-19 19:25:31.056098 INFO::Fitting model to feature number 855, F886
## 2024-12-19 19:25:31.063194 INFO::Fitting model to feature number 856, F887
## 2024-12-19 19:25:31.070493 INFO::Fitting model to feature number 857, F888
## 2024-12-19 19:25:31.078534 INFO::Fitting model to feature number 858, F889
## 2024-12-19 19:25:31.083688 INFO::Fitting model to feature number 859, F890
## 2024-12-19 19:25:31.088547 INFO::Fitting model to feature number 860, F891
## 2024-12-19 19:25:31.093231 INFO::Fitting model to feature number 861, F892
## 2024-12-19 19:25:31.098581 INFO::Fitting model to feature number 862, F893
## 2024-12-19 19:25:31.103536 INFO::Fitting model to feature number 863, F894
## 2024-12-19 19:25:31.10865 INFO::Fitting model to feature number 864, F895
## 2024-12-19 19:25:31.114032 INFO::Fitting model to feature number 865, F896
## 2024-12-19 19:25:31.11893 INFO::Fitting model to feature number 866, F897
## 2024-12-19 19:25:31.123872 INFO::Fitting model to feature number 867, F898
## 2024-12-19 19:25:31.128867 INFO::Fitting model to feature number 868, F899
## 2024-12-19 19:25:31.136694 INFO::Fitting model to feature number 869, F900
## 2024-12-19 19:25:31.329831 INFO::Counting total values for each feature
## 2024-12-19 19:25:31.437707 INFO::Writing filtered data to file Macarron_output/maaslin2_results/features/filtered_data.tsv
## 2024-12-19 19:25:31.676893 INFO::Writing filtered, normalized data to file Macarron_output/maaslin2_results/features/filtered_data_norm.tsv
## 2024-12-19 19:25:31.915051 INFO::Writing filtered, normalized, transformed data to file Macarron_output/maaslin2_results/features/filtered_data_norm_transformed.tsv
## 2024-12-19 19:25:32.166623 INFO::Writing residuals to file Macarron_output/maaslin2_results/fits/residuals.rds
## 2024-12-19 19:25:32.217564 INFO::Writing fitted values to file Macarron_output/maaslin2_results/fits/fitted.rds
## 2024-12-19 19:25:32.260258 INFO::Writing all results to file (ordered by increasing q-values): Macarron_output/maaslin2_results/all_results.tsv
## 2024-12-19 19:25:32.344515 INFO::Writing the significant results (those which are less than or equal to the threshold of 0.250000 ) to file (ordered by increasing q-values): Macarron_output/maaslin2_results/significant_results.tsv
## 2024-12-19 19:25:32.383182 INFO::Writing association plots (one for each significant association) to output folder: Macarron_output/maaslin2_results
## 2024-12-19 19:25:33.151394 INFO::Plotting associations from most to least significant, grouped by metadata
## 2024-12-19 19:25:33.153294 INFO::Plotting data for metadata number 1, diagnosis
## 2024-12-19 19:25:33.215459 INFO::Creating boxplot for categorical data, diagnosis vs F504
## 2024-12-19 19:25:33.562821 INFO::Creating boxplot for categorical data, diagnosis vs F859
## 2024-12-19 19:25:33.78183 INFO::Creating boxplot for categorical data, diagnosis vs F533
## 2024-12-19 19:25:34.022353 INFO::Creating boxplot for categorical data, diagnosis vs F587
## 2024-12-19 19:25:34.195757 INFO::Creating boxplot for categorical data, diagnosis vs F584
## 2024-12-19 19:25:34.371744 INFO::Creating boxplot for categorical data, diagnosis vs F197
## 2024-12-19 19:25:34.613217 INFO::Creating boxplot for categorical data, diagnosis vs F380
## 2024-12-19 19:25:34.788016 INFO::Creating boxplot for categorical data, diagnosis vs F829
## 2024-12-19 19:25:35.010359 INFO::Creating boxplot for categorical data, diagnosis vs F664
## 2024-12-19 19:25:35.316131 INFO::Creating boxplot for categorical data, diagnosis vs F93
## 2024-12-19 19:25:35.520362 INFO::Creating boxplot for categorical data, diagnosis vs F15
## 2024-12-19 19:25:35.688725 INFO::Creating boxplot for categorical data, diagnosis vs F881
## 2024-12-19 19:25:35.940237 INFO::Creating boxplot for categorical data, diagnosis vs F806
## 2024-12-19 19:25:36.148327 INFO::Creating boxplot for categorical data, diagnosis vs F78
## 2024-12-19 19:25:36.476856 INFO::Creating boxplot for categorical data, diagnosis vs F189
## 2024-12-19 19:25:36.651266 INFO::Creating boxplot for categorical data, diagnosis vs F369
## 2024-12-19 19:25:36.835721 INFO::Creating boxplot for categorical data, diagnosis vs F623
## 2024-12-19 19:25:37.071316 INFO::Creating boxplot for categorical data, diagnosis vs F710
## 2024-12-19 19:25:37.33644 INFO::Creating boxplot for categorical data, diagnosis vs F851
## 2024-12-19 19:25:37.588707 INFO::Creating boxplot for categorical data, diagnosis vs F257
## 2024-12-19 19:25:37.761357 INFO::Creating boxplot for categorical data, diagnosis vs F330
## 2024-12-19 19:25:37.930029 INFO::Creating boxplot for categorical data, diagnosis vs F344
## 2024-12-19 19:25:38.108845 INFO::Creating boxplot for categorical data, diagnosis vs F696
## 2024-12-19 19:25:38.281539 INFO::Creating boxplot for categorical data, diagnosis vs F741
## 2024-12-19 19:25:38.469876 INFO::Creating boxplot for categorical data, diagnosis vs F509
## 2024-12-19 19:25:38.651435 INFO::Creating boxplot for categorical data, diagnosis vs F479
## 2024-12-19 19:25:38.821343 INFO::Creating boxplot for categorical data, diagnosis vs F550
## 2024-12-19 19:25:38.998799 INFO::Creating boxplot for categorical data, diagnosis vs F640
## 2024-12-19 19:25:39.170499 INFO::Creating boxplot for categorical data, diagnosis vs F281
## 2024-12-19 19:25:39.362327 INFO::Creating boxplot for categorical data, diagnosis vs F80
## 2024-12-19 19:25:39.561021 INFO::Creating boxplot for categorical data, diagnosis vs F285
## 2024-12-19 19:25:39.761942 INFO::Creating boxplot for categorical data, diagnosis vs F531
## 2024-12-19 19:25:39.944938 INFO::Creating boxplot for categorical data, diagnosis vs F737
## 2024-12-19 19:25:40.135525 INFO::Creating boxplot for categorical data, diagnosis vs F875
## 2024-12-19 19:25:40.358748 INFO::Creating boxplot for categorical data, diagnosis vs F864
## 2024-12-19 19:25:40.600035 INFO::Creating boxplot for categorical data, diagnosis vs F379
## 2024-12-19 19:25:40.770319 INFO::Creating boxplot for categorical data, diagnosis vs F190
## 2024-12-19 19:25:40.94311 INFO::Creating boxplot for categorical data, diagnosis vs F4
## 2024-12-19 19:25:41.12562 INFO::Creating boxplot for categorical data, diagnosis vs F591
## 2024-12-19 19:25:41.371666 INFO::Creating boxplot for categorical data, diagnosis vs F773
## 2024-12-19 19:25:41.564903 INFO::Creating boxplot for categorical data, diagnosis vs F283
## 2024-12-19 19:25:41.728722 INFO::Creating boxplot for categorical data, diagnosis vs F233
## 2024-12-19 19:25:41.893881 INFO::Creating boxplot for categorical data, diagnosis vs F420
## 2024-12-19 19:25:42.059073 INFO::Creating boxplot for categorical data, diagnosis vs F5
## 2024-12-19 19:25:42.225802 INFO::Creating boxplot for categorical data, diagnosis vs F137
## 2024-12-19 19:25:42.40956 INFO::Creating boxplot for categorical data, diagnosis vs F215
## 2024-12-19 19:25:42.576193 INFO::Creating boxplot for categorical data, diagnosis vs F489
## 2024-12-19 19:25:42.767899 INFO::Creating boxplot for categorical data, diagnosis vs F220
## 2024-12-19 19:25:43.04189 INFO::Creating boxplot for categorical data, diagnosis vs F691
## 2024-12-19 19:25:43.220914 INFO::Creating boxplot for categorical data, diagnosis vs F381
## 2024-12-19 19:25:43.426458 INFO::Creating boxplot for categorical data, diagnosis vs F539
## 2024-12-19 19:25:43.600806 INFO::Creating boxplot for categorical data, diagnosis vs F490
## 2024-12-19 19:25:43.764958 INFO::Creating boxplot for categorical data, diagnosis vs F832
## 2024-12-19 19:25:43.937528 INFO::Creating boxplot for categorical data, diagnosis vs F396
## 2024-12-19 19:25:44.109561 INFO::Creating boxplot for categorical data, diagnosis vs F528
## 2024-12-19 19:25:44.283806 INFO::Creating boxplot for categorical data, diagnosis vs F234
## 2024-12-19 19:25:44.466907 INFO::Creating boxplot for categorical data, diagnosis vs F178
## 2024-12-19 19:25:44.631724 INFO::Creating boxplot for categorical data, diagnosis vs F761
## 2024-12-19 19:25:44.807014 INFO::Creating boxplot for categorical data, diagnosis vs F2
## 2024-12-19 19:25:44.972277 INFO::Creating boxplot for categorical data, diagnosis vs F260
## 2024-12-19 19:25:45.140063 INFO::Creating boxplot for categorical data, diagnosis vs F734
## 2024-12-19 19:25:45.333025 INFO::Creating boxplot for categorical data, diagnosis vs F429
## 2024-12-19 19:25:45.52779 INFO::Creating boxplot for categorical data, diagnosis vs F630
## 2024-12-19 19:25:45.706412 INFO::Creating boxplot for categorical data, diagnosis vs F817
## 2024-12-19 19:25:45.902263 INFO::Creating boxplot for categorical data, diagnosis vs F847
## 2024-12-19 19:25:46.087769 INFO::Creating boxplot for categorical data, diagnosis vs F896
## 2024-12-19 19:25:46.290085 INFO::Creating boxplot for categorical data, diagnosis vs F81
## 2024-12-19 19:25:46.562304 INFO::Creating boxplot for categorical data, diagnosis vs F110
## 2024-12-19 19:25:46.783065 INFO::Creating boxplot for categorical data, diagnosis vs F3
## 2024-12-19 19:25:46.954076 INFO::Creating boxplot for categorical data, diagnosis vs F33
## 2024-12-19 19:25:47.170716 INFO::Creating boxplot for categorical data, diagnosis vs F270
## 2024-12-19 19:25:47.35298 INFO::Creating boxplot for categorical data, diagnosis vs F278
## 2024-12-19 19:25:47.518892 INFO::Creating boxplot for categorical data, diagnosis vs F264
## 2024-12-19 19:25:47.683878 INFO::Creating boxplot for categorical data, diagnosis vs F90
## 2024-12-19 19:25:47.849693 INFO::Creating boxplot for categorical data, diagnosis vs F403
## 2024-12-19 19:25:48.018643 INFO::Creating boxplot for categorical data, diagnosis vs F727
## 2024-12-19 19:25:48.209093 INFO::Creating boxplot for categorical data, diagnosis vs F394
## 2024-12-19 19:25:48.373058 INFO::Creating boxplot for categorical data, diagnosis vs F800
## 2024-12-19 19:25:48.578791 INFO::Creating boxplot for categorical data, diagnosis vs F439
## 2024-12-19 19:25:48.756722 INFO::Creating boxplot for categorical data, diagnosis vs F554
## 2024-12-19 19:25:48.939458 INFO::Creating boxplot for categorical data, diagnosis vs F559
## 2024-12-19 19:25:49.141341 INFO::Creating boxplot for categorical data, diagnosis vs F548
## 2024-12-19 19:25:49.34977 INFO::Creating boxplot for categorical data, diagnosis vs F794
## 2024-12-19 19:25:49.525217 INFO::Creating boxplot for categorical data, diagnosis vs F45
## 2024-12-19 19:25:49.751891 INFO::Creating boxplot for categorical data, diagnosis vs F158
## 2024-12-19 19:25:50.029347 INFO::Creating boxplot for categorical data, diagnosis vs F477
## 2024-12-19 19:25:50.342395 INFO::Creating boxplot for categorical data, diagnosis vs F1
## 2024-12-19 19:25:50.513627 INFO::Creating boxplot for categorical data, diagnosis vs F862
## 2024-12-19 19:25:50.714504 INFO::Creating boxplot for categorical data, diagnosis vs F803
## 2024-12-19 19:25:50.915172 INFO::Creating boxplot for categorical data, diagnosis vs F751
## 2024-12-19 19:25:51.113705 INFO::Creating boxplot for categorical data, diagnosis vs F98
## 2024-12-19 19:25:51.318967 INFO::Creating boxplot for categorical data, diagnosis vs F22
## 2024-12-19 19:25:51.565103 INFO::Creating boxplot for categorical data, diagnosis vs F625
## 2024-12-19 19:25:51.828961 INFO::Creating boxplot for categorical data, diagnosis vs F206
## 2024-12-19 19:25:52.005584 INFO::Creating boxplot for categorical data, diagnosis vs F779
## 2024-12-19 19:25:52.188894 INFO::Creating boxplot for categorical data, diagnosis vs F532
## 2024-12-19 19:25:52.376069 INFO::Creating boxplot for categorical data, diagnosis vs F676
## 2024-12-19 19:25:52.564924 INFO::Creating boxplot for categorical data, diagnosis vs F644
## 2024-12-19 19:25:52.764238 INFO::Creating boxplot for categorical data, diagnosis vs F7
## 2024-12-19 19:25:52.968903 INFO::Creating boxplot for categorical data, diagnosis vs F596
## 2024-12-19 19:25:53.205616 INFO::Creating boxplot for categorical data, diagnosis vs F250
## 2024-12-19 19:25:53.395087 INFO::Creating boxplot for categorical data, diagnosis vs F462
## 2024-12-19 19:25:53.57494 INFO::Creating boxplot for categorical data, diagnosis vs F516
## 2024-12-19 19:25:53.745019 INFO::Creating boxplot for categorical data, diagnosis vs F659
## 2024-12-19 19:25:53.914514 INFO::Creating boxplot for categorical data, diagnosis vs F663
## 2024-12-19 19:25:54.082824 INFO::Creating boxplot for categorical data, diagnosis vs F837
## 2024-12-19 19:25:54.252169 INFO::Creating boxplot for categorical data, diagnosis vs F138
## 2024-12-19 19:25:54.448429 INFO::Creating boxplot for categorical data, diagnosis vs F445
## 2024-12-19 19:25:54.644079 INFO::Creating boxplot for categorical data, diagnosis vs F697
## 2024-12-19 19:25:54.812674 INFO::Creating boxplot for categorical data, diagnosis vs F225
## 2024-12-19 19:25:54.981105 INFO::Creating boxplot for categorical data, diagnosis vs F148
## 2024-12-19 19:25:55.151919 INFO::Creating boxplot for categorical data, diagnosis vs F448
## 2024-12-19 19:25:55.331207 INFO::Creating boxplot for categorical data, diagnosis vs F91
## 2024-12-19 19:25:55.496987 INFO::Creating boxplot for categorical data, diagnosis vs F123
## 2024-12-19 19:25:55.669493 INFO::Creating boxplot for categorical data, diagnosis vs F665
## 2024-12-19 19:25:55.837823 INFO::Creating boxplot for categorical data, diagnosis vs F845
## 2024-12-19 19:25:56.014824 INFO::Creating boxplot for categorical data, diagnosis vs F331
## 2024-12-19 19:25:56.200923 INFO::Creating boxplot for categorical data, diagnosis vs F361
## 2024-12-19 19:25:56.363767 INFO::Creating boxplot for categorical data, diagnosis vs F421
## 2024-12-19 19:25:56.529046 INFO::Creating boxplot for categorical data, diagnosis vs F277
## 2024-12-19 19:25:56.699708 INFO::Creating boxplot for categorical data, diagnosis vs F307
## 2024-12-19 19:25:56.890416 INFO::Creating boxplot for categorical data, diagnosis vs F503
## 2024-12-19 19:25:57.133232 INFO::Creating boxplot for categorical data, diagnosis vs F34
## 2024-12-19 19:25:57.334046 INFO::Creating boxplot for categorical data, diagnosis vs F649
## 2024-12-19 19:25:57.508637 INFO::Creating boxplot for categorical data, diagnosis vs F825
## 2024-12-19 19:25:57.672954 INFO::Creating boxplot for categorical data, diagnosis vs F298
## 2024-12-19 19:25:57.849262 INFO::Creating boxplot for categorical data, diagnosis vs F461
## 2024-12-19 19:25:58.055574 INFO::Creating boxplot for categorical data, diagnosis vs F242
## 2024-12-19 19:25:58.251364 INFO::Creating boxplot for categorical data, diagnosis vs F375
## 2024-12-19 19:25:58.426457 INFO::Creating boxplot for categorical data, diagnosis vs F648
## 2024-12-19 19:25:58.618038 INFO::Creating boxplot for categorical data, diagnosis vs F724
## 2024-12-19 19:25:58.795669 INFO::Creating boxplot for categorical data, diagnosis vs F678
## 2024-12-19 19:25:59.00014 INFO::Creating boxplot for categorical data, diagnosis vs F290
## 2024-12-19 19:25:59.17782 INFO::Creating boxplot for categorical data, diagnosis vs F743
## 2024-12-19 19:25:59.424267 INFO::Creating boxplot for categorical data, diagnosis vs F495
## 2024-12-19 19:25:59.607374 INFO::Creating boxplot for categorical data, diagnosis vs F261
## 2024-12-19 19:25:59.829115 INFO::Creating boxplot for categorical data, diagnosis vs F43
## 2024-12-19 19:26:00.022567 INFO::Creating boxplot for categorical data, diagnosis vs F714
## 2024-12-19 19:26:00.199989 INFO::Creating boxplot for categorical data, diagnosis vs F131
## 2024-12-19 19:26:00.376904 INFO::Creating boxplot for categorical data, diagnosis vs F150
## 2024-12-19 19:26:00.559353 INFO::Creating boxplot for categorical data, diagnosis vs F651
## 2024-12-19 19:26:01.174982 INFO::Creating boxplot for categorical data, diagnosis vs F798
## 2024-12-19 19:26:01.374615 INFO::Creating boxplot for categorical data, diagnosis vs F289
## 2024-12-19 19:26:01.651857 INFO::Creating boxplot for categorical data, diagnosis vs F661
## 2024-12-19 19:26:01.93452 INFO::Creating boxplot for categorical data, diagnosis vs F199
## 2024-12-19 19:26:02.177094 INFO::Creating boxplot for categorical data, diagnosis vs F406
## 2024-12-19 19:26:02.346352 INFO::Creating boxplot for categorical data, diagnosis vs F139
## 2024-12-19 19:26:02.516641 INFO::Creating boxplot for categorical data, diagnosis vs F506
## 2024-12-19 19:26:02.713602 INFO::Creating boxplot for categorical data, diagnosis vs F552
## 2024-12-19 19:26:02.899558 INFO::Creating boxplot for categorical data, diagnosis vs F94
## 2024-12-19 19:26:03.105048 INFO::Creating boxplot for categorical data, diagnosis vs F430
## 2024-12-19 19:26:03.279456 INFO::Creating boxplot for categorical data, diagnosis vs F639
## 2024-12-19 19:26:03.470284 INFO::Creating boxplot for categorical data, diagnosis vs F500
## 2024-12-19 19:26:03.722786 INFO::Creating boxplot for categorical data, diagnosis vs F609
## 2024-12-19 19:26:03.925353 INFO::Creating boxplot for categorical data, diagnosis vs F306
## 2024-12-19 19:26:04.151951 INFO::Creating boxplot for categorical data, diagnosis vs F507
## 2024-12-19 19:26:04.326518 INFO::Creating boxplot for categorical data, diagnosis vs F671
## 2024-12-19 19:26:04.518625 INFO::Creating boxplot for categorical data, diagnosis vs F894
## 2024-12-19 19:26:04.724573 INFO::Creating boxplot for categorical data, diagnosis vs F345
## 2024-12-19 19:26:04.912989 INFO::Creating boxplot for categorical data, diagnosis vs F801
## 2024-12-19 19:26:05.08214 INFO::Creating boxplot for categorical data, diagnosis vs F194
## 2024-12-19 19:26:05.25901 INFO::Creating boxplot for categorical data, diagnosis vs F195
## 2024-12-19 19:26:05.449923 INFO::Creating boxplot for categorical data, diagnosis vs F119
## 2024-12-19 19:26:05.644709 INFO::Creating boxplot for categorical data, diagnosis vs F120
## 2024-12-19 19:26:05.843125 INFO::Creating boxplot for categorical data, diagnosis vs F231
## 2024-12-19 19:26:06.08565 INFO::Creating boxplot for categorical data, diagnosis vs F311
## 2024-12-19 19:26:06.368007 INFO::Creating boxplot for categorical data, diagnosis vs F646
## 2024-12-19 19:26:06.635709 INFO::Creating boxplot for categorical data, diagnosis vs F814
## 2024-12-19 19:26:06.835027 INFO::Creating boxplot for categorical data, diagnosis vs F510
## 2024-12-19 19:26:07.06013 INFO::Creating boxplot for categorical data, diagnosis vs F398
## 2024-12-19 19:26:07.291482 INFO::Creating boxplot for categorical data, diagnosis vs F60
## 2024-12-19 19:26:07.527675 INFO::Creating boxplot for categorical data, diagnosis vs F153
## 2024-12-19 19:26:07.735863 INFO::Creating boxplot for categorical data, diagnosis vs F858
## 2024-12-19 19:26:07.912551 INFO::Creating boxplot for categorical data, diagnosis vs F775
## 2024-12-19 19:26:08.14014 INFO::Creating boxplot for categorical data, diagnosis vs F684
## 2024-12-19 19:26:08.317068 INFO::Creating boxplot for categorical data, diagnosis vs F384
## 2024-12-19 19:26:08.487525 INFO::Creating boxplot for categorical data, diagnosis vs F134
## 2024-12-19 19:26:08.66604 INFO::Creating boxplot for categorical data, diagnosis vs F670
## 2024-12-19 19:26:08.856137 INFO::Creating boxplot for categorical data, diagnosis vs F632
## 2024-12-19 19:26:09.054822 INFO::Creating boxplot for categorical data, diagnosis vs F721
## 2024-12-19 19:26:09.236988 INFO::Creating boxplot for categorical data, diagnosis vs F700
## 2024-12-19 19:26:09.419126 INFO::Creating boxplot for categorical data, diagnosis vs F376
## 2024-12-19 19:26:09.591973 INFO::Creating boxplot for categorical data, diagnosis vs F301
## 2024-12-19 19:26:09.772127 INFO::Creating boxplot for categorical data, diagnosis vs F27
## 2024-12-19 19:26:10.038398 INFO::Creating boxplot for categorical data, diagnosis vs F280
## 2024-12-19 19:26:10.224841 INFO::Creating boxplot for categorical data, diagnosis vs F391
## 2024-12-19 19:26:10.408345 INFO::Creating boxplot for categorical data, diagnosis vs F725
## 2024-12-19 19:26:10.579023 INFO::Creating boxplot for categorical data, diagnosis vs F186
## 2024-12-19 19:26:10.776782 INFO::Creating boxplot for categorical data, diagnosis vs F481
## 2024-12-19 19:26:10.992495 INFO::Creating boxplot for categorical data, diagnosis vs F333
## 2024-12-19 19:26:11.20887 INFO::Creating boxplot for categorical data, diagnosis vs F720
## 2024-12-19 19:26:11.421708 INFO::Creating boxplot for categorical data, diagnosis vs F520
## 2024-12-19 19:26:11.635117 INFO::Creating boxplot for categorical data, diagnosis vs F129
## 2024-12-19 19:26:11.81339 INFO::Creating boxplot for categorical data, diagnosis vs F204
## 2024-12-19 19:26:12.015545 INFO::Creating boxplot for categorical data, diagnosis vs F259
## 2024-12-19 19:26:12.190367 INFO::Creating boxplot for categorical data, diagnosis vs F831
## 2024-12-19 19:26:12.361015 INFO::Creating boxplot for categorical data, diagnosis vs F891
## 2024-12-19 19:26:12.546682 INFO::Creating boxplot for categorical data, diagnosis vs F262
## 2024-12-19 19:26:12.733282 INFO::Creating boxplot for categorical data, diagnosis vs F592
## 2024-12-19 19:26:12.929 INFO::Creating boxplot for categorical data, diagnosis vs F343
## 2024-12-19 19:26:13.096867 INFO::Creating boxplot for categorical data, diagnosis vs F505
## 2024-12-19 19:26:13.26447 INFO::Creating boxplot for categorical data, diagnosis vs F622
## 2024-12-19 19:26:13.451403 INFO::Creating boxplot for categorical data, diagnosis vs F348
## 2024-12-19 19:26:13.623203 INFO::Creating boxplot for categorical data, diagnosis vs F133
## 2024-12-19 19:26:13.822611 INFO::Creating boxplot for categorical data, diagnosis vs F371
## 2024-12-19 19:26:13.997021 INFO::Creating boxplot for categorical data, diagnosis vs F113
## 2024-12-19 19:26:14.230478 INFO::Creating boxplot for categorical data, diagnosis vs F336
## 2024-12-19 19:26:14.402986 INFO::Creating boxplot for categorical data, diagnosis vs F399
## 2024-12-19 19:26:14.575581 INFO::Creating boxplot for categorical data, diagnosis vs F416
## 2024-12-19 19:26:14.77479 INFO::Creating boxplot for categorical data, diagnosis vs F657
## 2024-12-19 19:26:14.946964 INFO::Creating boxplot for categorical data, diagnosis vs F241
## 2024-12-19 19:26:15.117512 INFO::Creating boxplot for categorical data, diagnosis vs F95
## 2024-12-19 19:26:15.284567 INFO::Creating boxplot for categorical data, diagnosis vs F128
## 2024-12-19 19:26:15.489779 INFO::Creating boxplot for categorical data, diagnosis vs F595
## 2024-12-19 19:26:15.74041 INFO::Creating boxplot for categorical data, diagnosis vs F428
## 2024-12-19 19:26:16.003711 INFO::Creating boxplot for categorical data, diagnosis vs F796
## 2024-12-19 19:26:16.268885 INFO::Creating boxplot for categorical data, diagnosis vs F709
## 2024-12-19 19:26:16.507419 INFO::Creating boxplot for categorical data, diagnosis vs F602
## 2024-12-19 19:26:16.717325 INFO::Creating boxplot for categorical data, diagnosis vs F293
## 2024-12-19 19:26:17.021687 INFO::Creating boxplot for categorical data, diagnosis vs F867
## 2024-12-19 19:26:17.199135 INFO::Creating boxplot for categorical data, diagnosis vs F108
## 2024-12-19 19:26:17.372652 INFO::Creating boxplot for categorical data, diagnosis vs F846
## 2024-12-19 19:26:17.544003 INFO::Creating boxplot for categorical data, diagnosis vs F633
## 2024-12-19 19:26:17.715549 INFO::Creating boxplot for categorical data, diagnosis vs F564
## 2024-12-19 19:26:17.926966 INFO::Creating boxplot for categorical data, diagnosis vs F183
## 2024-12-19 19:26:18.099706 INFO::Creating boxplot for categorical data, diagnosis vs F647
## 2024-12-19 19:26:18.270772 INFO::Creating boxplot for categorical data, diagnosis vs F288
## 2024-12-19 19:26:18.46251 INFO::Creating boxplot for categorical data, diagnosis vs F159
## 2024-12-19 19:26:18.638337 INFO::Creating boxplot for categorical data, diagnosis vs F638
## 2024-12-19 19:26:18.91785 INFO::Creating boxplot for categorical data, diagnosis vs F484
## 2024-12-19 19:26:19.183478 INFO::Creating boxplot for categorical data, diagnosis vs F20
## 2024-12-19 19:26:19.479964 INFO::Creating boxplot for categorical data, diagnosis vs F19
## 2024-12-19 19:26:19.673977 INFO::Creating boxplot for categorical data, diagnosis vs F897
## 2024-12-19 19:26:19.907235 INFO::Creating boxplot for categorical data, diagnosis vs F442
## 2024-12-19 19:26:20.20478 INFO::Creating boxplot for categorical data, diagnosis vs F372
## 2024-12-19 19:26:20.476612 INFO::Creating boxplot for categorical data, diagnosis vs F771
## 2024-12-19 19:26:20.654707 INFO::Creating boxplot for categorical data, diagnosis vs F370
## 2024-12-19 19:26:20.827777 INFO::Creating boxplot for categorical data, diagnosis vs F620
## 2024-12-19 19:26:21.001927 INFO::Creating boxplot for categorical data, diagnosis vs F753
## 2024-12-19 19:26:21.211817 INFO::Creating boxplot for categorical data, diagnosis vs F568
## 2024-12-19 19:26:21.406501 INFO::Creating boxplot for categorical data, diagnosis vs F312
## 2024-12-19 19:26:21.584427 INFO::Creating boxplot for categorical data, diagnosis vs F485
## 2024-12-19 19:26:21.754609 INFO::Creating boxplot for categorical data, diagnosis vs F627
## 2024-12-19 19:26:21.923728 INFO::Creating boxplot for categorical data, diagnosis vs F72
## 2024-12-19 19:26:22.095162 INFO::Creating boxplot for categorical data, diagnosis vs F575
## 2024-12-19 19:26:22.288879 INFO::Creating boxplot for categorical data, diagnosis vs F332
## 2024-12-19 19:26:22.513523 INFO::Creating boxplot for categorical data, diagnosis vs F674
## 2024-12-19 19:26:22.804279 INFO::Creating boxplot for categorical data, diagnosis vs F537
## 2024-12-19 19:26:23.093592 INFO::Creating boxplot for categorical data, diagnosis vs F839
## 2024-12-19 19:26:23.38087 INFO::Creating boxplot for categorical data, diagnosis vs F715
## 2024-12-19 19:26:23.61564 INFO::Creating boxplot for categorical data, diagnosis vs F768
## 2024-12-19 19:26:23.789814 INFO::Creating boxplot for categorical data, diagnosis vs F202
## 2024-12-19 19:26:23.961661 INFO::Creating boxplot for categorical data, diagnosis vs F756
## 2024-12-19 19:26:24.128903 INFO::Creating boxplot for categorical data, diagnosis vs F536
## 2024-12-19 19:26:24.328916 INFO::Creating boxplot for categorical data, diagnosis vs F677
## 2024-12-19 19:26:24.574688 INFO::Creating boxplot for categorical data, diagnosis vs F435
## 2024-12-19 19:26:24.75155 INFO::Creating boxplot for categorical data, diagnosis vs F574
## 2024-12-19 19:26:24.9225 INFO::Creating boxplot for categorical data, diagnosis vs F70
## 2024-12-19 19:26:25.102676 INFO::Creating boxplot for categorical data, diagnosis vs F146
## 2024-12-19 19:26:25.273749 INFO::Creating boxplot for categorical data, diagnosis vs F236
## 2024-12-19 19:26:25.4965 INFO::Creating boxplot for categorical data, diagnosis vs F527
## 2024-12-19 19:26:25.695835 INFO::Creating boxplot for categorical data, diagnosis vs F624
## 2024-12-19 19:26:25.903321 INFO::Creating boxplot for categorical data, diagnosis vs F426
## 2024-12-19 19:26:26.155858 INFO::Creating boxplot for categorical data, diagnosis vs F880
## 2024-12-19 19:26:26.44308 INFO::Creating boxplot for categorical data, diagnosis vs F549
## 2024-12-19 19:26:26.754784 INFO::Creating boxplot for categorical data, diagnosis vs F49
## 2024-12-19 19:26:27.048192 INFO::Creating boxplot for categorical data, diagnosis vs F67
## 2024-12-19 19:26:27.331487 INFO::Creating boxplot for categorical data, diagnosis vs F491
## 2024-12-19 19:26:27.621473 INFO::Creating boxplot for categorical data, diagnosis vs F174
## 2024-12-19 19:26:27.818971 INFO::Creating boxplot for categorical data, diagnosis vs F254
## 2024-12-19 19:26:28.027805 INFO::Creating boxplot for categorical data, diagnosis vs F112
## 2024-12-19 19:26:28.221373 INFO::Creating boxplot for categorical data, diagnosis vs F235
## 2024-12-19 19:26:28.459047 INFO::Creating boxplot for categorical data, diagnosis vs F833
## 2024-12-19 19:26:28.643328 INFO::Creating boxplot for categorical data, diagnosis vs F752
## 2024-12-19 19:26:28.88614 INFO::Creating boxplot for categorical data, diagnosis vs F792
## 2024-12-19 19:26:29.156801 INFO::Creating boxplot for categorical data, diagnosis vs F422
## 2024-12-19 19:26:29.40818 INFO::Creating boxplot for categorical data, diagnosis vs F6
## 2024-12-19 19:26:29.626325 INFO::Creating boxplot for categorical data, diagnosis vs F463
## 2024-12-19 19:26:29.832245 INFO::Creating boxplot for categorical data, diagnosis vs F706
## 2024-12-19 19:26:30.041518 INFO::Creating boxplot for categorical data, diagnosis vs F642
## 2024-12-19 19:26:30.287051 INFO::Creating boxplot for categorical data, diagnosis vs F65
## 2024-12-19 19:26:30.514875 INFO::Creating boxplot for categorical data, diagnosis vs F102
## 2024-12-19 19:26:30.775114 INFO::Creating boxplot for categorical data, diagnosis vs F783
## 2024-12-19 19:26:31.057474 INFO::Creating boxplot for categorical data, diagnosis vs F478
## 2024-12-19 19:26:31.278637 INFO::Creating boxplot for categorical data, diagnosis vs F889
## 2024-12-19 19:26:31.456216 INFO::Creating boxplot for categorical data, diagnosis vs F350
## 2024-12-19 19:26:31.652305 INFO::Creating boxplot for categorical data, diagnosis vs F681
## 2024-12-19 19:26:31.826718 INFO::Creating boxplot for categorical data, diagnosis vs F748
## 2024-12-19 19:26:32.014835 INFO::Creating boxplot for categorical data, diagnosis vs F762
## 2024-12-19 19:26:32.206839 INFO::Creating boxplot for categorical data, diagnosis vs F852
## 2024-12-19 19:26:32.378606 INFO::Creating boxplot for categorical data, diagnosis vs F180
## 2024-12-19 19:26:32.576424 INFO::Creating boxplot for categorical data, diagnosis vs F248
## 2024-12-19 19:26:32.756994 INFO::Creating boxplot for categorical data, diagnosis vs F759
## 2024-12-19 19:26:32.937785 INFO::Creating boxplot for categorical data, diagnosis vs F824
## 2024-12-19 19:26:33.111222 INFO::Creating boxplot for categorical data, diagnosis vs F145
## 2024-12-19 19:26:33.285311 INFO::Creating boxplot for categorical data, diagnosis vs F16
## 2024-12-19 19:26:33.48234 INFO::Creating boxplot for categorical data, diagnosis vs F169
## 2024-12-19 19:26:33.658953 INFO::Creating boxplot for categorical data, diagnosis vs F392
## 2024-12-19 19:26:33.831583 INFO::Creating boxplot for categorical data, diagnosis vs F468
## 2024-12-19 19:26:34.002603 INFO::Creating boxplot for categorical data, diagnosis vs F476
## 2024-12-19 19:26:34.173401 INFO::Creating boxplot for categorical data, diagnosis vs F699
## 2024-12-19 19:26:34.369947 INFO::Creating boxplot for categorical data, diagnosis vs F735
## 2024-12-19 19:26:34.545759 INFO::Creating boxplot for categorical data, diagnosis vs F182
## 2024-12-19 19:26:34.717137 INFO::Creating boxplot for categorical data, diagnosis vs F64
## 2024-12-19 19:26:34.887296 INFO::Creating boxplot for categorical data, diagnosis vs F203
## 2024-12-19 19:26:35.074527 INFO::Creating boxplot for categorical data, diagnosis vs F877
## 2024-12-19 19:26:35.299849 INFO::Creating boxplot for categorical data, diagnosis vs F433
## 2024-12-19 19:26:35.491505 INFO::Creating boxplot for categorical data, diagnosis vs F739
## 2024-12-19 19:26:35.670146 INFO::Creating boxplot for categorical data, diagnosis vs F749
## 2024-12-19 19:26:35.854795 INFO::Creating boxplot for categorical data, diagnosis vs F382
## 2024-12-19 19:26:36.02223 INFO::Creating boxplot for categorical data, diagnosis vs F162
## 2024-12-19 19:26:36.221175 INFO::Creating boxplot for categorical data, diagnosis vs F438
## 2024-12-19 19:26:36.40243 INFO::Creating boxplot for categorical data, diagnosis vs F360
## 2024-12-19 19:26:36.573798 INFO::Creating boxplot for categorical data, diagnosis vs F56
## 2024-12-19 19:26:36.742923 INFO::Creating boxplot for categorical data, diagnosis vs F529
## 2024-12-19 19:26:36.927649 INFO::Creating boxplot for categorical data, diagnosis vs F48
## 2024-12-19 19:26:37.177873 INFO::Creating boxplot for categorical data, diagnosis vs F826
## 2024-12-19 19:26:37.352203 INFO::Creating boxplot for categorical data, diagnosis vs F488
## 2024-12-19 19:26:37.52025 INFO::Creating boxplot for categorical data, diagnosis vs F309
## 2024-12-19 19:26:37.687551 INFO::Creating boxplot for categorical data, diagnosis vs F834
## 2024-12-19 19:26:37.860618 INFO::Creating boxplot for categorical data, diagnosis vs F449
## 2024-12-19 19:26:38.058007 INFO::Creating boxplot for categorical data, diagnosis vs F77
## 2024-12-19 19:26:38.23657 INFO::Creating boxplot for categorical data, diagnosis vs F365
## 2024-12-19 19:26:38.412914 INFO::Creating boxplot for categorical data, diagnosis vs F346
## 2024-12-19 19:26:38.585604 INFO::Creating boxplot for categorical data, diagnosis vs F654
## 2024-12-19 19:26:38.756605 INFO::Creating boxplot for categorical data, diagnosis vs F79
## 2024-12-19 19:26:38.956233 INFO::Creating boxplot for categorical data, diagnosis vs F785
## 2024-12-19 19:26:39.134429 INFO::Creating boxplot for categorical data, diagnosis vs F415
## 2024-12-19 19:26:39.306568 INFO::Creating boxplot for categorical data, diagnosis vs F466
## 2024-12-19 19:26:39.490548 INFO::Creating boxplot for categorical data, diagnosis vs F643
## 2024-12-19 19:26:39.66121 INFO::Creating boxplot for categorical data, diagnosis vs F160
## 2024-12-19 19:26:39.860439 INFO::Creating boxplot for categorical data, diagnosis vs F69
## 2024-12-19 19:26:40.161343 INFO::Creating boxplot for categorical data, diagnosis vs F498
## 2024-12-19 19:26:40.457606 INFO::Creating boxplot for categorical data, diagnosis vs F207
## 2024-12-19 19:26:40.761514 INFO::Creating boxplot for categorical data, diagnosis vs F679
## 2024-12-19 19:26:41.056971 INFO::Creating boxplot for categorical data, diagnosis vs F618
## 2024-12-19 19:26:42.210309 INFO::Creating boxplot for categorical data, diagnosis vs F255
## 2024-12-19 19:26:42.462798 INFO::Creating boxplot for categorical data, diagnosis vs F267
## 2024-12-19 19:26:42.691258 INFO::Creating boxplot for categorical data, diagnosis vs F143
## 2024-12-19 19:26:42.908903 INFO::Creating boxplot for categorical data, diagnosis vs F286
## 2024-12-19 19:26:43.084622 INFO::Creating boxplot for categorical data, diagnosis vs F562
## 2024-12-19 19:26:43.345043 INFO::Creating boxplot for categorical data, diagnosis vs F100
## 2024-12-19 19:26:43.599473 INFO::Creating boxplot for categorical data, diagnosis vs F374
## 2024-12-19 19:26:43.837109 INFO::Creating boxplot for categorical data, diagnosis vs F535
## 2024-12-19 19:26:44.02415 INFO::Creating boxplot for categorical data, diagnosis vs F658
## 2024-12-19 19:26:44.188704 INFO::Creating boxplot for categorical data, diagnosis vs F707
## 2024-12-19 19:26:44.37994 INFO::Creating boxplot for categorical data, diagnosis vs F325
## 2024-12-19 19:26:44.558593 INFO::Creating boxplot for categorical data, diagnosis vs F89
## 2024-12-19 19:26:44.731675 INFO::Creating boxplot for categorical data, diagnosis vs F214
## 2024-12-19 19:26:44.906425 INFO::Creating boxplot for categorical data, diagnosis vs F578
## 2024-12-19 19:26:45.071973 INFO::Creating boxplot for categorical data, diagnosis vs F790
## 2024-12-19 19:26:45.237247 INFO::Creating boxplot for categorical data, diagnosis vs F265
## 2024-12-19 19:26:45.427925 INFO::Creating boxplot for categorical data, diagnosis vs F253
## 2024-12-19 19:26:45.608545 INFO::Creating boxplot for categorical data, diagnosis vs F294
## 2024-12-19 19:26:45.79627 INFO::Creating boxplot for categorical data, diagnosis vs F410
## 2024-12-19 19:26:46.032414 INFO::Creating boxplot for categorical data, diagnosis vs F614
## 2024-12-19 19:26:46.275746 INFO::Creating boxplot for categorical data, diagnosis vs F764
## 2024-12-19 19:26:46.489651 INFO::Creating boxplot for categorical data, diagnosis vs F59
## 2024-12-19 19:26:46.727999 INFO::Creating boxplot for categorical data, diagnosis vs F675
## 2024-12-19 19:26:46.89805 INFO::Creating boxplot for categorical data, diagnosis vs F441
## 2024-12-19 19:26:47.068744 INFO::Creating boxplot for categorical data, diagnosis vs F193
## 2024-12-19 19:26:47.235796 INFO::Creating boxplot for categorical data, diagnosis vs F689
## 2024-12-19 19:26:47.419247 INFO::Creating boxplot for categorical data, diagnosis vs F249
## 2024-12-19 19:26:47.586225 INFO::Creating boxplot for categorical data, diagnosis vs F821
## 2024-12-19 19:26:47.759159 INFO::Creating boxplot for categorical data, diagnosis vs F351
## 2024-12-19 19:26:47.930431 INFO::Creating boxplot for categorical data, diagnosis vs F66
## 2024-12-19 19:26:48.10317 INFO::Creating boxplot for categorical data, diagnosis vs F413
## 2024-12-19 19:26:48.280437 INFO::Creating boxplot for categorical data, diagnosis vs F172
## 2024-12-19 19:26:48.465048 INFO::Creating boxplot for categorical data, diagnosis vs F317
## 2024-12-19 19:26:48.673348 INFO::Creating boxplot for categorical data, diagnosis vs F167
## 2024-12-19 19:26:48.973295 INFO::Creating boxplot for categorical data, diagnosis vs F229
## 2024-12-19 19:26:49.269125 INFO::Creating boxplot for categorical data, diagnosis vs F243
## 2024-12-19 19:26:49.519127 INFO::Creating boxplot for categorical data, diagnosis vs F732
## 2024-12-19 19:26:49.688699 INFO::Creating boxplot for categorical data, diagnosis vs F467
## 2024-12-19 19:26:49.857546 INFO::Creating boxplot for categorical data, diagnosis vs F474
## 2024-12-19 19:26:50.564496 INFO::Creating boxplot for categorical data, diagnosis vs F156
## 2024-12-19 19:26:50.849122 INFO::Creating boxplot for categorical data, diagnosis vs F786
## 2024-12-19 19:26:51.128651 INFO::Creating boxplot for categorical data, diagnosis vs F216
## 2024-12-19 19:26:51.356724 INFO::Creating boxplot for categorical data, diagnosis vs F85
## 2024-12-19 19:26:51.533351 INFO::Creating boxplot for categorical data, diagnosis vs F621
## 2024-12-19 19:26:51.694135 INFO::Creating boxplot for categorical data, diagnosis vs F558
## 2024-12-19 19:26:51.857048 INFO::Creating boxplot for categorical data, diagnosis vs F582
## 2024-12-19 19:26:52.020331 INFO::Creating boxplot for categorical data, diagnosis vs F898
## 2024-12-19 19:26:52.195747 INFO::Creating boxplot for categorical data, diagnosis vs F402
## 2024-12-19 19:26:52.361201 INFO::Creating boxplot for categorical data, diagnosis vs F71
## 2024-12-19 19:26:52.55374 INFO::Creating boxplot for categorical data, diagnosis vs F99
## 2024-12-19 19:26:52.715196 INFO::Creating boxplot for categorical data, diagnosis vs F366
## 2024-12-19 19:26:52.877383 INFO::Creating boxplot for categorical data, diagnosis vs F778
## 2024-12-19 19:26:53.056125 INFO::Creating boxplot for categorical data, diagnosis vs F188
## 2024-12-19 19:26:53.221187 INFO::Creating boxplot for categorical data, diagnosis vs F857
## 2024-12-19 19:26:53.377779 INFO::Creating boxplot for categorical data, diagnosis vs F440
## 2024-12-19 19:26:53.543352 INFO::Creating boxplot for categorical data, diagnosis vs F799
## 2024-12-19 19:26:53.705884 INFO::Creating boxplot for categorical data, diagnosis vs F482
## 2024-12-19 19:26:53.878163 INFO::Creating boxplot for categorical data, diagnosis vs F212
## 2024-12-19 19:26:54.037718 INFO::Creating boxplot for categorical data, diagnosis vs F882
## 2024-12-19 19:26:54.216967 INFO::Creating boxplot for categorical data, diagnosis vs F599
## 2024-12-19 19:26:54.382099 INFO::Creating boxplot for categorical data, diagnosis vs F302
## 2024-12-19 19:26:54.548063 INFO::Creating boxplot for categorical data, diagnosis vs F543
## 2024-12-19 19:26:54.72999 INFO::Creating boxplot for categorical data, diagnosis vs F269
## 2024-12-19 19:26:54.898076 INFO::Creating boxplot for categorical data, diagnosis vs F650
## 2024-12-19 19:26:55.061242 INFO::Creating boxplot for categorical data, diagnosis vs F456
## 2024-12-19 19:26:55.22827 INFO::Creating boxplot for categorical data, diagnosis vs F573
## 2024-12-19 19:26:55.399954 INFO::Creating boxplot for categorical data, diagnosis vs F8
## 2024-12-19 19:26:55.581554 INFO::Creating boxplot for categorical data, diagnosis vs F810
## 2024-12-19 19:26:55.750345 INFO::Creating boxplot for categorical data, diagnosis vs F401
## 2024-12-19 19:26:55.922926 INFO::Creating boxplot for categorical data, diagnosis vs F606
## 2024-12-19 19:26:56.089067 INFO::Creating boxplot for categorical data, diagnosis vs F662
## 2024-12-19 19:26:56.259247 INFO::Creating boxplot for categorical data, diagnosis vs F765
## 2024-12-19 19:26:56.453439 INFO::Creating boxplot for categorical data, diagnosis vs F887
## 2024-12-19 19:26:56.622336 INFO::Creating boxplot for categorical data, diagnosis vs F770
## 2024-12-19 19:26:56.782847 INFO::Creating boxplot for categorical data, diagnosis vs F469
## 2024-12-19 19:26:56.947981 INFO::Creating boxplot for categorical data, diagnosis vs F86
## 2024-12-19 19:26:57.179237 INFO::Creating boxplot for categorical data, diagnosis vs F400
## 2024-12-19 19:26:57.374885 INFO::Creating boxplot for categorical data, diagnosis vs F579
## 2024-12-19 19:26:57.56827 INFO::Creating boxplot for categorical data, diagnosis vs F871
## 2024-12-19 19:26:57.756394 INFO::Creating boxplot for categorical data, diagnosis vs F37
## 2024-12-19 19:26:57.930229 INFO::Creating boxplot for categorical data, diagnosis vs F446
## 2024-12-19 19:26:58.098616 INFO::Creating boxplot for categorical data, diagnosis vs F218
## 2024-12-19 19:26:58.279005 INFO::Creating boxplot for categorical data, diagnosis vs F321
## 2024-12-19 19:26:58.520937 INFO::Creating boxplot for categorical data, diagnosis vs F487
## 2024-12-19 19:26:58.684836 INFO::Creating boxplot for categorical data, diagnosis vs F740
## 2024-12-19 19:26:58.845921 INFO::Creating boxplot for categorical data, diagnosis vs F141
## 2024-12-19 19:26:59.011151 INFO::Creating boxplot for categorical data, diagnosis vs F327
## 2024-12-19 19:26:59.174778 INFO::Creating boxplot for categorical data, diagnosis vs F196
## 2024-12-19 19:26:59.353897 INFO::Creating boxplot for categorical data, diagnosis vs F883
## 2024-12-19 19:26:59.570309 INFO::Creating boxplot for categorical data, diagnosis vs F279
## 2024-12-19 19:26:59.764623 INFO::Creating boxplot for categorical data, diagnosis vs F838
## 2024-12-19 19:26:59.929458 INFO::Creating boxplot for categorical data, diagnosis vs F451
## 2024-12-19 19:27:00.098654 INFO::Creating boxplot for categorical data, diagnosis vs F854
## 2024-12-19 19:27:00.272934 INFO::Creating boxplot for categorical data, diagnosis vs F434
## 2024-12-19 19:27:00.441567 INFO::Creating boxplot for categorical data, diagnosis vs F519
## 2024-12-19 19:27:00.603432 INFO::Creating boxplot for categorical data, diagnosis vs F694
## 2024-12-19 19:27:00.769397 INFO::Creating boxplot for categorical data, diagnosis vs F561
## 2024-12-19 19:27:00.93567 INFO::Creating boxplot for categorical data, diagnosis vs F10
## 2024-12-19 19:27:01.11306 INFO::Creating boxplot for categorical data, diagnosis vs F303
## 2024-12-19 19:27:01.278279 INFO::Creating boxplot for categorical data, diagnosis vs F512
## 2024-12-19 19:27:01.456472 INFO::Creating boxplot for categorical data, diagnosis vs F645
## 2024-12-19 19:27:01.633264 INFO::Creating boxplot for categorical data, diagnosis vs F793
## 2024-12-19 19:27:01.855415 INFO::Creating boxplot for categorical data, diagnosis vs F404
## 2024-12-19 19:27:02.031923 INFO::Creating boxplot for categorical data, diagnosis vs F362
## 2024-12-19 19:27:02.209207 INFO::Creating boxplot for categorical data, diagnosis vs F525
## 2024-12-19 19:27:02.371353 INFO::Creating boxplot for categorical data, diagnosis vs F742
## 2024-12-19 19:27:02.555893 INFO::Creating boxplot for categorical data, diagnosis vs F276
## 2024-12-19 19:27:02.723816 INFO::Creating boxplot for categorical data, diagnosis vs F499
## 2024-12-19 19:27:02.971162 INFO::Creating boxplot for categorical data, diagnosis vs F328
## 2024-12-19 19:27:03.147373 INFO::Creating boxplot for categorical data, diagnosis vs F787
## 2024-12-19 19:27:03.32559 INFO::Creating boxplot for categorical data, diagnosis vs F30
## 2024-12-19 19:27:03.515595 INFO::Creating boxplot for categorical data, diagnosis vs F122
## 2024-12-19 19:27:03.686122 INFO::Creating boxplot for categorical data, diagnosis vs F619
## 2024-12-19 19:27:03.88259 INFO::Creating boxplot for categorical data, diagnosis vs F572
## 2024-12-19 19:27:04.073801 INFO::Creating boxplot for categorical data, diagnosis vs F47
## 2024-12-19 19:27:04.245041 INFO::Creating boxplot for categorical data, diagnosis vs F570
## 2024-12-19 19:27:04.421882 INFO::Creating boxplot for categorical data, diagnosis vs F26
## 2024-12-19 19:27:04.591697 INFO::Creating boxplot for categorical data, diagnosis vs F252
## 2024-12-19 19:27:04.788398 INFO::Creating boxplot for categorical data, diagnosis vs F117
## 2024-12-19 19:27:04.96436 INFO::Creating boxplot for categorical data, diagnosis vs F683
## 2024-12-19 19:27:05.135119 INFO::Creating boxplot for categorical data, diagnosis vs F395
## 2024-12-19 19:27:05.303688 INFO::Creating boxplot for categorical data, diagnosis vs F822
## 2024-12-19 19:27:05.478824 INFO::Creating boxplot for categorical data, diagnosis vs F46
## 2024-12-19 19:27:05.66843 INFO::Creating boxplot for categorical data, diagnosis vs F154
## 2024-12-19 19:27:05.846558 INFO::Creating boxplot for categorical data, diagnosis vs F540
## 2024-12-19 19:27:06.012692 INFO::Creating boxplot for categorical data, diagnosis vs F884
## 2024-12-19 19:27:06.181964 INFO::Creating boxplot for categorical data, diagnosis vs F368
## 2024-12-19 19:27:06.34839 INFO::Creating boxplot for categorical data, diagnosis vs F607
## 2024-12-19 19:27:06.516792 INFO::Creating boxplot for categorical data, diagnosis vs F111
## 2024-12-19 19:27:06.709512 INFO::Creating boxplot for categorical data, diagnosis vs F745
## 2024-12-19 19:27:06.883026 INFO::Creating boxplot for categorical data, diagnosis vs F673
## 2024-12-19 19:27:07.067308 INFO::Creating boxplot for categorical data, diagnosis vs F92
## 2024-12-19 19:27:07.246995 INFO::Creating boxplot for categorical data, diagnosis vs F493
## 2024-12-19 19:27:07.447122 INFO::Creating boxplot for categorical data, diagnosis vs F835
## 2024-12-19 19:27:07.684958 INFO::Creating boxplot for categorical data, diagnosis vs F872
## 2024-12-19 19:27:07.858776 INFO::Creating boxplot for categorical data, diagnosis vs F879
## 2024-12-19 19:27:08.05076 INFO::Creating boxplot for categorical data, diagnosis vs F432
## 2024-12-19 19:27:08.266945 INFO::Creating boxplot for categorical data, diagnosis vs F518
## 2024-12-19 19:27:08.479921 INFO::Creating boxplot for categorical data, diagnosis vs F44
## 2024-12-19 19:27:08.671282 INFO::Creating boxplot for categorical data, diagnosis vs F240
## 2024-12-19 19:27:08.846935 INFO::Creating boxplot for categorical data, diagnosis vs F819
## 2024-12-19 19:27:09.023346 INFO::Creating boxplot for categorical data, diagnosis vs F411
## 2024-12-19 19:27:09.198679 INFO::Creating boxplot for categorical data, diagnosis vs F353
## 2024-12-19 19:27:09.375792 INFO::Creating boxplot for categorical data, diagnosis vs F763
## 2024-12-19 19:27:09.609908 INFO::Creating boxplot for categorical data, diagnosis vs F97
## 2024-12-19 19:27:09.788779 INFO::Creating boxplot for categorical data, diagnosis vs F40
## 2024-12-19 19:27:09.989876 INFO::Creating boxplot for categorical data, diagnosis vs F652
## 2024-12-19 19:27:10.172809 INFO::Creating boxplot for categorical data, diagnosis vs F789
## 2024-12-19 19:27:10.349665 INFO::Creating boxplot for categorical data, diagnosis vs F25
## 2024-12-19 19:27:10.543025 INFO::Creating boxplot for categorical data, diagnosis vs F256
## 2024-12-19 19:27:10.758227 INFO::Creating boxplot for categorical data, diagnosis vs F423
## 2024-12-19 19:27:10.938699 INFO::Creating boxplot for categorical data, diagnosis vs F594
## 2024-12-19 19:27:11.113772 INFO::Creating boxplot for categorical data, diagnosis vs F201
## 2024-12-19 19:27:11.305469 INFO::Creating boxplot for categorical data, diagnosis vs F813
## 2024-12-19 19:27:11.510196 INFO::Creating boxplot for categorical data, diagnosis vs F653
## 2024-12-19 19:27:11.69734 INFO::Creating boxplot for categorical data, diagnosis vs F524
## 2024-12-19 19:27:11.866724 INFO::Creating boxplot for categorical data, diagnosis vs F777
## 2024-12-19 19:27:12.046172 INFO::Creating boxplot for categorical data, diagnosis vs F226
## 2024-12-19 19:27:12.280208 INFO::Creating boxplot for categorical data, diagnosis vs F227
## 2024-12-19 19:27:12.516519 INFO::Creating boxplot for categorical data, diagnosis vs F521
## 2024-12-19 19:27:12.710888 INFO::Creating boxplot for categorical data, diagnosis vs F14
## 2024-12-19 19:27:12.875337 INFO::Creating boxplot for categorical data, diagnosis vs F310
## 2024-12-19 19:27:13.053017 INFO::Creating boxplot for categorical data, diagnosis vs F452
## 2024-12-19 19:27:13.236142 INFO::Creating boxplot for categorical data, diagnosis vs F52
## 2024-12-19 19:27:13.432931 INFO::Creating boxplot for categorical data, diagnosis vs F53
## 2024-12-19 19:27:13.680189 INFO::Creating boxplot for categorical data, diagnosis vs F844
## 2024-12-19 19:27:13.952447 INFO::Creating boxplot for categorical data, diagnosis vs F31
## 2024-12-19 19:27:14.206717 INFO::Creating boxplot for categorical data, diagnosis vs F795
## 2024-12-19 19:27:14.406392 INFO::Creating boxplot for categorical data, diagnosis vs F766
## 2024-12-19 19:27:14.633375 INFO::Creating boxplot for categorical data, diagnosis vs F342
## 2024-12-19 19:27:14.84384 INFO::Creating boxplot for categorical data, diagnosis vs F408
## 2024-12-19 19:27:15.034852 INFO::Creating boxplot for categorical data, diagnosis vs F282
## 2024-12-19 19:27:15.203448 INFO::Creating boxplot for categorical data, diagnosis vs F508
## 2024-12-19 19:27:15.377429 INFO::Creating boxplot for categorical data, diagnosis vs F805
## 2024-12-19 19:27:15.562808 INFO::Creating boxplot for categorical data, diagnosis vs F337
## 2024-12-19 19:27:15.851141 INFO::Creating boxplot for categorical data, diagnosis vs F820
## 2024-12-19 19:27:16.077572 INFO::Creating boxplot for categorical data, diagnosis vs F593
## 2024-12-19 19:27:16.343843 INFO::Creating boxplot for categorical data, diagnosis vs F701
## 2024-12-19 19:27:16.632281 INFO::Creating boxplot for categorical data, diagnosis vs F459
## 2024-12-19 19:27:16.92188 INFO::Creating boxplot for categorical data, diagnosis vs F305
## 2024-12-19 19:27:17.24117 INFO::Creating boxplot for categorical data, diagnosis vs F142
## 2024-12-19 19:27:17.519773 INFO::Creating boxplot for categorical data, diagnosis vs F534
## 2024-12-19 19:27:17.79486 INFO::Creating boxplot for categorical data, diagnosis vs F135
## 2024-12-19 19:27:17.97223 INFO::Creating boxplot for categorical data, diagnosis vs F702
## 2024-12-19 19:27:18.145796 INFO::Creating boxplot for categorical data, diagnosis vs F776
## 2024-12-19 19:27:18.385771 INFO::Creating boxplot for categorical data, diagnosis vs F295
## 2024-12-19 19:27:18.565933 INFO::Creating boxplot for categorical data, diagnosis vs F355
## 2024-12-19 19:27:18.79427 INFO::Creating boxplot for categorical data, diagnosis vs F797
## 2024-12-19 19:27:19.042359 INFO::Creating boxplot for categorical data, diagnosis vs F13
## 2024-12-19 19:27:19.259371 INFO::Creating boxplot for categorical data, diagnosis vs F356
## 2024-12-19 19:27:19.530306 INFO::Creating boxplot for categorical data, diagnosis vs F359
## 2024-12-19 19:27:19.805469 INFO::Creating boxplot for categorical data, diagnosis vs F121
## 2024-12-19 19:27:20.082154 INFO::Creating boxplot for categorical data, diagnosis vs F850
## 2024-12-19 19:27:20.379886 INFO::Creating boxplot for categorical data, diagnosis vs F899
## 2024-12-19 19:27:20.636594 INFO::Creating boxplot for categorical data, diagnosis vs F628
## 2024-12-19 19:27:20.863423 INFO::Creating boxplot for categorical data, diagnosis vs F843
## 2024-12-19 19:27:21.044507 INFO::Creating boxplot for categorical data, diagnosis vs F107
## 2024-12-19 19:27:21.320235 INFO::Creating boxplot for categorical data, diagnosis vs F287
## 2024-12-19 19:27:21.517587 INFO::Creating boxplot for categorical data, diagnosis vs F165
## 2024-12-19 19:27:21.763265 INFO::Creating boxplot for categorical data, diagnosis vs F557
## 2024-12-19 19:27:22.080774 INFO::Creating boxplot for categorical data, diagnosis vs F127
## 2024-12-19 19:27:22.302507 INFO::Creating boxplot for categorical data, diagnosis vs F299
## 2024-12-19 19:27:22.521073 INFO::Creating boxplot for categorical data, diagnosis vs F497
## 2024-12-19 19:27:22.697758 INFO::Creating boxplot for categorical data, diagnosis vs F711
## 2024-12-19 19:27:22.882408 INFO::Creating boxplot for categorical data, diagnosis vs F319
## 2024-12-19 19:27:23.144874 INFO::Creating boxplot for categorical data, diagnosis vs F271
## 2024-12-19 19:27:23.373623 INFO::Creating boxplot for categorical data, diagnosis vs F157
## 2024-12-19 19:27:23.628274 INFO::Creating boxplot for categorical data, diagnosis vs F560
## 2024-12-19 19:27:23.885383 INFO::Creating boxplot for categorical data, diagnosis vs F680
## 2024-12-19 19:27:24.182295 INFO::Creating boxplot for categorical data, diagnosis vs F580
## 2024-12-19 19:27:24.472923 INFO::Creating boxplot for categorical data, diagnosis vs F152
## 2024-12-19 19:27:24.719809 INFO::Creating boxplot for categorical data, diagnosis vs F12
## 2024-12-19 19:27:24.889741 INFO::Creating boxplot for categorical data, diagnosis vs F324
## 2024-12-19 19:27:25.082585 INFO::Creating boxplot for categorical data, diagnosis vs F893
## 2024-12-19 19:27:25.278674 INFO::Creating boxplot for categorical data, diagnosis vs F318
## 2024-12-19 19:27:25.585992 INFO::Creating boxplot for categorical data, diagnosis vs F784
## 2024-12-19 19:27:25.840223 INFO::Creating boxplot for categorical data, diagnosis vs F567
## 2024-12-19 19:27:26.053041 INFO::Creating boxplot for categorical data, diagnosis vs F457
## 2024-12-19 19:27:26.256137 INFO::Creating boxplot for categorical data, diagnosis vs F708
## 2024-12-19 19:27:26.521156 INFO::Creating boxplot for categorical data, diagnosis vs F669
## 2024-12-19 19:27:26.851897 INFO::Creating boxplot for categorical data, diagnosis vs F87
## 2024-12-19 19:27:29.584945 INFO::Plotting data for metadata number 2, antibiotics
## 2024-12-19 19:27:29.587918 INFO::Creating boxplot for categorical data, antibiotics vs F663
## 2024-12-19 19:27:29.929744 INFO::Creating boxplot for categorical data, antibiotics vs F838
## 2024-12-19 19:27:30.161841 INFO::Creating boxplot for categorical data, antibiotics vs F764
## 2024-12-19 19:27:30.415682 INFO::Creating boxplot for categorical data, antibiotics vs F880
## 2024-12-19 19:27:30.601367 INFO::Creating boxplot for categorical data, antibiotics vs F751
## 2024-12-19 19:27:30.79774 INFO::Creating boxplot for categorical data, antibiotics vs F288
## 2024-12-19 19:27:31.164522 INFO::Creating boxplot for categorical data, antibiotics vs F65
## 2024-12-19 19:27:31.48558 INFO::Creating boxplot for categorical data, antibiotics vs F742
## 2024-12-19 19:27:31.696105 INFO::Creating boxplot for categorical data, antibiotics vs F528
## 2024-12-19 19:27:31.927735 INFO::Creating boxplot for categorical data, antibiotics vs F790
## 2024-12-19 19:27:32.253411 INFO::Creating boxplot for categorical data, antibiotics vs F777
## 2024-12-19 19:27:32.579627 INFO::Creating boxplot for categorical data, antibiotics vs F178
## 2024-12-19 19:27:32.84653 INFO::Creating boxplot for categorical data, antibiotics vs F139
## 2024-12-19 19:27:33.155572 INFO::Creating boxplot for categorical data, antibiotics vs F202
## 2024-12-19 19:27:33.453412 INFO::Creating boxplot for categorical data, antibiotics vs F220
## 2024-12-19 19:27:33.790133 INFO::Creating boxplot for categorical data, antibiotics vs F397
## 2024-12-19 19:27:34.018144 INFO::Creating boxplot for categorical data, antibiotics vs F882
## 2024-12-19 19:27:34.315735 INFO::Creating boxplot for categorical data, antibiotics vs F446
## 2024-12-19 19:27:34.57743 INFO::Creating boxplot for categorical data, antibiotics vs F418
## 2024-12-19 19:27:34.863844 INFO::Creating boxplot for categorical data, antibiotics vs F133
## 2024-12-19 19:27:35.197638 INFO::Creating boxplot for categorical data, antibiotics vs F696
## 2024-12-19 19:27:35.493956 INFO::Creating boxplot for categorical data, antibiotics vs F548
## 2024-12-19 19:27:35.709418 INFO::Creating boxplot for categorical data, antibiotics vs F536
## 2024-12-19 19:27:35.929676 INFO::Creating boxplot for categorical data, antibiotics vs F194
## 2024-12-19 19:27:36.219584 INFO::Creating boxplot for categorical data, antibiotics vs F34
## 2024-12-19 19:27:36.497578 INFO::Creating boxplot for categorical data, antibiotics vs F153
## 2024-12-19 19:27:36.760966 INFO::Creating boxplot for categorical data, antibiotics vs F400
## 2024-12-19 19:27:37.064789 INFO::Creating boxplot for categorical data, antibiotics vs F794
## 2024-12-19 19:27:37.307742 INFO::Creating boxplot for categorical data, antibiotics vs F396
## 2024-12-19 19:27:37.552561 INFO::Creating boxplot for categorical data, antibiotics vs F182
## 2024-12-19 19:27:37.848385 INFO::Creating boxplot for categorical data, antibiotics vs F719
## 2024-12-19 19:27:38.104264 INFO::Creating boxplot for categorical data, antibiotics vs F109
## 2024-12-19 19:27:38.400651 INFO::Creating boxplot for categorical data, antibiotics vs F180
## 2024-12-19 19:27:38.701935 INFO::Creating boxplot for categorical data, antibiotics vs F552
## 2024-12-19 19:27:39.03449 INFO::Creating boxplot for categorical data, antibiotics vs F789
## 2024-12-19 19:27:39.406939 INFO::Creating boxplot for categorical data, antibiotics vs F893
## 2024-12-19 19:27:39.620584 INFO::Creating boxplot for categorical data, antibiotics vs F834
## 2024-12-19 19:27:39.814335 INFO::Creating boxplot for categorical data, antibiotics vs F889
## 2024-12-19 19:27:39.996162 INFO::Creating boxplot for categorical data, antibiotics vs F143
## 2024-12-19 19:27:40.230274 INFO::Creating boxplot for categorical data, antibiotics vs F224
## 2024-12-19 19:27:40.469285 INFO::Creating boxplot for categorical data, antibiotics vs F5
## 2024-12-19 19:27:40.75765 INFO::Creating boxplot for categorical data, antibiotics vs F873
## 2024-12-19 19:27:41.063033 INFO::Creating boxplot for categorical data, antibiotics vs F452
## 2024-12-19 19:27:41.377756 INFO::Creating boxplot for categorical data, antibiotics vs F681
## 2024-12-19 19:27:41.724917 INFO::Creating boxplot for categorical data, antibiotics vs F468
## 2024-12-19 19:27:41.981327 INFO::Creating boxplot for categorical data, antibiotics vs F731
## 2024-12-19 19:27:42.165245 INFO::Creating boxplot for categorical data, antibiotics vs F479
## 2024-12-19 19:27:42.347333 INFO::Creating boxplot for categorical data, antibiotics vs F520
## 2024-12-19 19:27:42.533214 INFO::Creating boxplot for categorical data, antibiotics vs F649
## 2024-12-19 19:27:42.77458 INFO::Creating boxplot for categorical data, antibiotics vs F259
## 2024-12-19 19:27:43.067067 INFO::Creating boxplot for categorical data, antibiotics vs F186
## 2024-12-19 19:27:43.26535 INFO::Creating boxplot for categorical data, antibiotics vs F312
## 2024-12-19 19:27:43.577923 INFO::Creating boxplot for categorical data, antibiotics vs F477
## 2024-12-19 19:27:43.7713 INFO::Creating boxplot for categorical data, antibiotics vs F4
## 2024-12-19 19:27:44.012751 INFO::Creating boxplot for categorical data, antibiotics vs F632
## 2024-12-19 19:27:44.297031 INFO::Creating boxplot for categorical data, antibiotics vs F31
## 2024-12-19 19:27:44.519385 INFO::Creating boxplot for categorical data, antibiotics vs F184
## 2024-12-19 19:27:44.757718 INFO::Creating boxplot for categorical data, antibiotics vs F7
## 2024-12-19 19:27:45.050801 INFO::Creating boxplot for categorical data, antibiotics vs F213
## 2024-12-19 19:27:45.321527 INFO::Creating boxplot for categorical data, antibiotics vs F691
## 2024-12-19 19:27:45.544526 INFO::Creating boxplot for categorical data, antibiotics vs F828
## 2024-12-19 19:27:45.766156 INFO::Creating boxplot for categorical data, antibiotics vs F831
## 2024-12-19 19:27:46.073077 INFO::Creating boxplot for categorical data, antibiotics vs F315
## 2024-12-19 19:27:46.326997 INFO::Creating boxplot for categorical data, antibiotics vs F159
## 2024-12-19 19:27:46.552373 INFO::Creating boxplot for categorical data, antibiotics vs F331
## 2024-12-19 19:27:46.736465 INFO::Creating boxplot for categorical data, antibiotics vs F757
## 2024-12-19 19:27:46.956594 INFO::Creating boxplot for categorical data, antibiotics vs F167
## 2024-12-19 19:27:47.263808 INFO::Creating boxplot for categorical data, antibiotics vs F85
## 2024-12-19 19:27:47.574349 INFO::Creating boxplot for categorical data, antibiotics vs F80
## 2024-12-19 19:27:47.860707 INFO::Creating boxplot for categorical data, antibiotics vs F105
## 2024-12-19 19:27:48.147921 INFO::Creating boxplot for categorical data, antibiotics vs F674
## 2024-12-19 19:27:48.449301 INFO::Creating boxplot for categorical data, antibiotics vs F50
## 2024-12-19 19:27:48.783203 INFO::Creating boxplot for categorical data, antibiotics vs F164
## 2024-12-19 19:27:49.056556 INFO::Creating boxplot for categorical data, antibiotics vs F840
## 2024-12-19 19:27:49.372662 INFO::Creating boxplot for categorical data, antibiotics vs F232
## 2024-12-19 19:27:49.672403 INFO::Creating boxplot for categorical data, antibiotics vs F872
## 2024-12-19 19:27:49.931475 INFO::Creating boxplot for categorical data, antibiotics vs F54
## 2024-12-19 19:27:50.162466 INFO::Creating boxplot for categorical data, antibiotics vs F365
## 2024-12-19 19:27:50.393439 INFO::Creating boxplot for categorical data, antibiotics vs F499
## 2024-12-19 19:27:50.602318 INFO::Creating boxplot for categorical data, antibiotics vs F510
## 2024-12-19 19:27:50.784157 INFO::Creating boxplot for categorical data, antibiotics vs F716
## 2024-12-19 19:27:51.023485 INFO::Creating boxplot for categorical data, antibiotics vs F454
## 2024-12-19 19:27:51.343312 INFO::Creating boxplot for categorical data, antibiotics vs F52
## 2024-12-19 19:27:51.648486 INFO::Creating boxplot for categorical data, antibiotics vs F273
## 2024-12-19 19:27:51.967734 INFO::Creating boxplot for categorical data, antibiotics vs F474
## 2024-12-19 19:27:52.272915 INFO::Creating boxplot for categorical data, antibiotics vs F267
## 2024-12-19 19:27:52.586149 INFO::Creating boxplot for categorical data, antibiotics vs F253
## 2024-12-19 19:27:52.780852 INFO::Creating boxplot for categorical data, antibiotics vs F247
## 2024-12-19 19:27:52.971355 INFO::Creating boxplot for categorical data, antibiotics vs F708
## 2024-12-19 19:27:53.154593 INFO::Creating boxplot for categorical data, antibiotics vs F438
## 2024-12-19 19:27:53.38284 INFO::Creating boxplot for categorical data, antibiotics vs F450
## 2024-12-19 19:27:53.668134 INFO::Creating boxplot for categorical data, antibiotics vs F666
## 2024-12-19 19:27:53.905601 INFO::Creating boxplot for categorical data, antibiotics vs F720
## 2024-12-19 19:27:54.200337 INFO::Creating boxplot for categorical data, antibiotics vs F48
## 2024-12-19 19:27:54.501654 INFO::Creating boxplot for categorical data, antibiotics vs F371
## 2024-12-19 19:27:54.722424 INFO::Creating boxplot for categorical data, antibiotics vs F423
## 2024-12-19 19:27:54.941995 INFO::Creating boxplot for categorical data, antibiotics vs F190
## 2024-12-19 19:27:55.132545 INFO::Creating boxplot for categorical data, antibiotics vs F351
## 2024-12-19 19:27:55.339883 INFO::Creating boxplot for categorical data, antibiotics vs F394
## 2024-12-19 19:27:55.55629 INFO::Creating boxplot for categorical data, antibiotics vs F581
## 2024-12-19 19:27:55.799391 INFO::Creating boxplot for categorical data, antibiotics vs F276
## 2024-12-19 19:27:56.136679 INFO::Creating boxplot for categorical data, antibiotics vs F608
## 2024-12-19 19:27:56.439196 INFO::Creating boxplot for categorical data, antibiotics vs F28
## 2024-12-19 19:27:56.733035 INFO::Creating boxplot for categorical data, antibiotics vs F805
## 2024-12-19 19:27:56.911344 INFO::Creating boxplot for categorical data, antibiotics vs F249
## 2024-12-19 19:27:57.12504 INFO::Creating boxplot for categorical data, antibiotics vs F776
## 2024-12-19 19:27:57.314879 INFO::Creating boxplot for categorical data, antibiotics vs F755
## 2024-12-19 19:27:57.508995 INFO::Creating boxplot for categorical data, antibiotics vs F68
## 2024-12-19 19:27:57.812419 INFO::Creating boxplot for categorical data, antibiotics vs F78
## 2024-12-19 19:27:58.129093 INFO::Creating boxplot for categorical data, antibiotics vs F381
## 2024-12-19 19:27:58.497761 INFO::Creating boxplot for categorical data, antibiotics vs F644
## 2024-12-19 19:27:58.826318 INFO::Creating boxplot for categorical data, antibiotics vs F358
## 2024-12-19 19:27:59.157643 INFO::Creating boxplot for categorical data, antibiotics vs F344
## 2024-12-19 19:27:59.471854 INFO::Creating boxplot for categorical data, antibiotics vs F209
## 2024-12-19 19:27:59.791262 INFO::Creating boxplot for categorical data, antibiotics vs F898
## 2024-12-19 19:28:00.12167 INFO::Creating boxplot for categorical data, antibiotics vs F51
## 2024-12-19 19:28:00.342548 INFO::Creating boxplot for categorical data, antibiotics vs F149
## 2024-12-19 19:28:00.537583 INFO::Creating boxplot for categorical data, antibiotics vs F108
## 2024-12-19 19:28:00.827894 INFO::Creating boxplot for categorical data, antibiotics vs F255
## 2024-12-19 19:28:01.126574 INFO::Creating boxplot for categorical data, antibiotics vs F823
## 2024-12-19 19:28:01.472121 INFO::Creating boxplot for categorical data, antibiotics vs F864
## 2024-12-19 19:28:01.771988 INFO::Creating boxplot for categorical data, antibiotics vs F214
## 2024-12-19 19:28:01.97645 INFO::Creating boxplot for categorical data, antibiotics vs F76
## 2024-12-19 19:28:02.157297 INFO::Creating boxplot for categorical data, antibiotics vs F575
## 2024-12-19 19:28:02.369091 INFO::Creating boxplot for categorical data, antibiotics vs F13
## 2024-12-19 19:28:02.599522 INFO::Creating boxplot for categorical data, antibiotics vs F389
## 2024-12-19 19:28:02.793369 INFO::Creating boxplot for categorical data, antibiotics vs F556
## 2024-12-19 19:28:02.976595 INFO::Creating boxplot for categorical data, antibiotics vs F49
## 2024-12-19 19:28:03.169347 INFO::Creating boxplot for categorical data, antibiotics vs F436
## 2024-12-19 19:28:03.470612 INFO::Creating boxplot for categorical data, antibiotics vs F378
## 2024-12-19 19:28:03.671987 INFO::Creating boxplot for categorical data, antibiotics vs F682
## 2024-12-19 19:28:03.888143 INFO::Creating boxplot for categorical data, antibiotics vs F47
## 2024-12-19 19:28:04.081235 INFO::Creating boxplot for categorical data, antibiotics vs F429
## 2024-12-19 19:28:04.260631 INFO::Creating boxplot for categorical data, antibiotics vs F588
## 2024-12-19 19:28:04.492344 INFO::Creating boxplot for categorical data, antibiotics vs F616
## 2024-12-19 19:28:04.727566 INFO::Creating boxplot for categorical data, antibiotics vs F323
## 2024-12-19 19:28:04.985706 INFO::Creating boxplot for categorical data, antibiotics vs F409
## 2024-12-19 19:28:05.193868 INFO::Creating boxplot for categorical data, antibiotics vs F326
## 2024-12-19 19:28:05.378944 INFO::Creating boxplot for categorical data, antibiotics vs F698
## 2024-12-19 19:28:05.669028 INFO::Creating boxplot for categorical data, antibiotics vs F567
## 2024-12-19 19:28:05.860888 INFO::Creating boxplot for categorical data, antibiotics vs F179
## 2024-12-19 19:28:06.059074 INFO::Creating boxplot for categorical data, antibiotics vs F787
## 2024-12-19 19:28:06.270027 INFO::Creating boxplot for categorical data, antibiotics vs F79
## 2024-12-19 19:28:06.477406 INFO::Creating boxplot for categorical data, antibiotics vs F335
## 2024-12-19 19:28:06.699945 INFO::Creating boxplot for categorical data, antibiotics vs F576
## 2024-12-19 19:28:06.888799 INFO::Creating boxplot for categorical data, antibiotics vs F667
## 2024-12-19 19:28:07.103083 INFO::Creating boxplot for categorical data, antibiotics vs F694
## 2024-12-19 19:28:07.280334 INFO::Creating boxplot for categorical data, antibiotics vs F297
## 2024-12-19 19:28:07.536605 INFO::Creating boxplot for categorical data, antibiotics vs F569
## 2024-12-19 19:28:07.839 INFO::Creating boxplot for categorical data, antibiotics vs F138
## 2024-12-19 19:28:08.157529 INFO::Creating boxplot for categorical data, antibiotics vs F611
## 2024-12-19 19:28:08.371499 INFO::Creating boxplot for categorical data, antibiotics vs F810
## 2024-12-19 19:28:08.578139 INFO::Creating boxplot for categorical data, antibiotics vs F746
## 2024-12-19 19:28:08.887408 INFO::Creating boxplot for categorical data, antibiotics vs F23
## 2024-12-19 19:28:09.202604 INFO::Creating boxplot for categorical data, antibiotics vs F135
## 2024-12-19 19:28:09.506289 INFO::Creating boxplot for categorical data, antibiotics vs F411
## 2024-12-19 19:28:09.799861 INFO::Creating boxplot for categorical data, antibiotics vs F489
## 2024-12-19 19:28:10.126064 INFO::Creating boxplot for categorical data, antibiotics vs F492
## 2024-12-19 19:28:10.418809 INFO::Creating boxplot for categorical data, antibiotics vs F844
## 2024-12-19 19:28:10.718069 INFO::Creating boxplot for categorical data, antibiotics vs F586
## 2024-12-19 19:28:10.954152 INFO::Creating boxplot for categorical data, antibiotics vs F11
## 2024-12-19 19:28:11.212326 INFO::Creating boxplot for categorical data, antibiotics vs F900
## 2024-12-19 19:28:11.511721 INFO::Creating boxplot for categorical data, antibiotics vs F21
## 2024-12-19 19:28:11.773373 INFO::Creating boxplot for categorical data, antibiotics vs F736
## 2024-12-19 19:28:11.987444 INFO::Creating boxplot for categorical data, antibiotics vs F408
## 2024-12-19 19:28:12.194907 INFO::Creating boxplot for categorical data, antibiotics vs F788
## 2024-12-19 19:28:12.481842 INFO::Creating boxplot for categorical data, antibiotics vs F66
## 2024-12-19 19:28:12.819764 INFO::Creating boxplot for categorical data, antibiotics vs F493
## 2024-12-19 19:28:13.064431 INFO::Creating boxplot for categorical data, antibiotics vs F343
## 2024-12-19 19:28:13.246249 INFO::Creating boxplot for categorical data, antibiotics vs F352
## 2024-12-19 19:28:13.43011 INFO::Creating boxplot for categorical data, antibiotics vs F677
## 2024-12-19 19:28:13.640239 INFO::Creating boxplot for categorical data, antibiotics vs F816
## 2024-12-19 19:28:13.826776 INFO::Creating boxplot for categorical data, antibiotics vs F457
## 2024-12-19 19:28:14.011322 INFO::Creating boxplot for categorical data, antibiotics vs F330
## 2024-12-19 19:28:14.187574 INFO::Creating boxplot for categorical data, antibiotics vs F293
## 2024-12-19 19:28:14.372436 INFO::Creating boxplot for categorical data, antibiotics vs F725
## 2024-12-19 19:28:14.61098 INFO::Creating boxplot for categorical data, antibiotics vs F813
## 2024-12-19 19:28:14.799104 INFO::Creating boxplot for categorical data, antibiotics vs F295
## 2024-12-19 19:28:14.988623 INFO::Creating boxplot for categorical data, antibiotics vs F656
## 2024-12-19 19:28:15.199697 INFO::Creating boxplot for categorical data, antibiotics vs F669
## 2024-12-19 19:28:15.383637 INFO::Creating boxplot for categorical data, antibiotics vs F15
## 2024-12-19 19:28:15.604117 INFO::Creating boxplot for categorical data, antibiotics vs F419
## 2024-12-19 19:28:15.8035 INFO::Creating boxplot for categorical data, antibiotics vs F701
## 2024-12-19 19:28:16.082185 INFO::Creating boxplot for categorical data, antibiotics vs F176
## 2024-12-19 19:28:16.289484 INFO::Creating boxplot for categorical data, antibiotics vs F203
## 2024-12-19 19:28:16.546677 INFO::Creating boxplot for categorical data, antibiotics vs F501
## 2024-12-19 19:28:16.737884 INFO::Creating boxplot for categorical data, antibiotics vs F772
## 2024-12-19 19:28:16.946797 INFO::Creating boxplot for categorical data, antibiotics vs F488
## 2024-12-19 19:28:17.156391 INFO::Creating boxplot for categorical data, antibiotics vs F600
## 2024-12-19 19:28:17.357834 INFO::Creating boxplot for categorical data, antibiotics vs F768
## 2024-12-19 19:28:17.597757 INFO::Creating boxplot for categorical data, antibiotics vs F432
## 2024-12-19 19:28:17.817985 INFO::Creating boxplot for categorical data, antibiotics vs F26
## 2024-12-19 19:28:18.107466 INFO::Creating boxplot for categorical data, antibiotics vs F189
## 2024-12-19 19:28:18.31665 INFO::Creating boxplot for categorical data, antibiotics vs F200
## 2024-12-19 19:28:18.509903 INFO::Creating boxplot for categorical data, antibiotics vs F121
## 2024-12-19 19:28:18.77906 INFO::Creating boxplot for categorical data, antibiotics vs F624
## 2024-12-19 19:28:19.025734 INFO::Creating boxplot for categorical data, antibiotics vs F855
## 2024-12-19 19:28:19.287158 INFO::Creating boxplot for categorical data, antibiotics vs F380
## 2024-12-19 19:28:19.562486 INFO::Creating boxplot for categorical data, antibiotics vs F734
## 2024-12-19 19:28:19.843986 INFO::Creating boxplot for categorical data, antibiotics vs F16
## 2024-12-19 19:28:20.156117 INFO::Creating boxplot for categorical data, antibiotics vs F602
## 2024-12-19 19:28:20.386444 INFO::Creating boxplot for categorical data, antibiotics vs F210
## 2024-12-19 19:28:20.710304 INFO::Creating boxplot for categorical data, antibiotics vs F217
## 2024-12-19 19:28:21.041615 INFO::Creating boxplot for categorical data, antibiotics vs F640
## 2024-12-19 19:28:21.35122 INFO::Creating boxplot for categorical data, antibiotics vs F631
## 2024-12-19 19:28:21.580629 INFO::Creating boxplot for categorical data, antibiotics vs F32
## 2024-12-19 19:28:21.869549 INFO::Creating boxplot for categorical data, antibiotics vs F322
## 2024-12-19 19:28:22.136687 INFO::Creating boxplot for categorical data, antibiotics vs F476
## 2024-12-19 19:28:22.378433 INFO::Creating boxplot for categorical data, antibiotics vs F265
## 2024-12-19 19:28:22.69771 INFO::Creating boxplot for categorical data, antibiotics vs F283
## 2024-12-19 19:28:23.000888 INFO::Creating boxplot for categorical data, antibiotics vs F316
## 2024-12-19 19:28:23.258335 INFO::Creating boxplot for categorical data, antibiotics vs F465
## 2024-12-19 19:28:23.450816 INFO::Creating boxplot for categorical data, antibiotics vs F24
## 2024-12-19 19:28:23.647992 INFO::Creating boxplot for categorical data, antibiotics vs F38
## 2024-12-19 19:28:23.88401 INFO::Creating boxplot for categorical data, antibiotics vs F82
## 2024-12-19 19:28:24.158046 INFO::Creating boxplot for categorical data, antibiotics vs F86
## 2024-12-19 19:28:24.367039 INFO::Creating boxplot for categorical data, antibiotics vs F270
## 2024-12-19 19:28:24.960139 INFO::Creating boxplot for categorical data, antibiotics vs F485
## 2024-12-19 19:28:25.209681 INFO::Creating boxplot for categorical data, antibiotics vs F486
## 2024-12-19 19:28:25.500829 INFO::Creating boxplot for categorical data, antibiotics vs F399
## 2024-12-19 19:28:25.774933 INFO::Creating boxplot for categorical data, antibiotics vs F573
## 2024-12-19 19:28:26.045323 INFO::Creating boxplot for categorical data, antibiotics vs F877
## 2024-12-19 19:28:26.282938 INFO::Creating boxplot for categorical data, antibiotics vs F709
## 2024-12-19 19:28:26.494373 INFO::Creating boxplot for categorical data, antibiotics vs F227
## 2024-12-19 19:28:26.745733 INFO::Creating boxplot for categorical data, antibiotics vs F553
## 2024-12-19 19:28:27.024879 INFO::Creating boxplot for categorical data, antibiotics vs F123
## 2024-12-19 19:28:27.325423 INFO::Creating boxplot for categorical data, antibiotics vs F118
## 2024-12-19 19:28:27.619334 INFO::Creating boxplot for categorical data, antibiotics vs F605
## 2024-12-19 19:28:27.961593 INFO::Creating boxplot for categorical data, antibiotics vs F619
## 2024-12-19 19:28:28.290917 INFO::Creating boxplot for categorical data, antibiotics vs F830
## 2024-12-19 19:28:28.614054 INFO::Creating boxplot for categorical data, antibiotics vs F837
## 2024-12-19 19:28:28.872267 INFO::Creating boxplot for categorical data, antibiotics vs F12
## 2024-12-19 19:28:29.068907 INFO::Creating boxplot for categorical data, antibiotics vs F623
## 2024-12-19 19:28:29.300632 INFO::Creating boxplot for categorical data, antibiotics vs F806
## 2024-12-19 19:28:29.570996 INFO::Creating boxplot for categorical data, antibiotics vs F353
## 2024-12-19 19:28:29.890366 INFO::Creating boxplot for categorical data, antibiotics vs F829
## 2024-12-19 19:28:30.212709 INFO::Creating boxplot for categorical data, antibiotics vs F289
## 2024-12-19 19:28:30.519979 INFO::Creating boxplot for categorical data, antibiotics vs F93
## 2024-12-19 19:28:30.869597 INFO::Creating boxplot for categorical data, antibiotics vs F379
## 2024-12-19 19:28:31.190116 INFO::Creating boxplot for categorical data, antibiotics vs F370
## 2024-12-19 19:28:31.474232 INFO::Creating boxplot for categorical data, antibiotics vs F360
## 2024-12-19 19:28:31.884082 INFO::Creating boxplot for categorical data, antibiotics vs F710
## 2024-12-19 19:28:32.232566 INFO::Creating boxplot for categorical data, antibiotics vs F388
## 2024-12-19 19:28:32.5601 INFO::Creating boxplot for categorical data, antibiotics vs F796
## 2024-12-19 19:28:32.861979 INFO::Creating boxplot for categorical data, antibiotics vs F174
## 2024-12-19 19:28:33.173731 INFO::Creating boxplot for categorical data, antibiotics vs F601
## 2024-12-19 19:28:33.364433 INFO::Creating boxplot for categorical data, antibiotics vs F775
## 2024-12-19 19:28:33.703934 INFO::Creating boxplot for categorical data, antibiotics vs F836
## 2024-12-19 19:28:34.020329 INFO::Creating boxplot for categorical data, antibiotics vs F192
## 2024-12-19 19:28:34.319576 INFO::Creating boxplot for categorical data, antibiotics vs F463
## 2024-12-19 19:28:34.64535 INFO::Creating boxplot for categorical data, antibiotics vs F57
## 2024-12-19 19:28:34.949267 INFO::Creating boxplot for categorical data, antibiotics vs F658
## 2024-12-19 19:28:35.304318 INFO::Creating boxplot for categorical data, antibiotics vs F596
## 2024-12-19 19:28:35.593761 INFO::Creating boxplot for categorical data, antibiotics vs F218
## 2024-12-19 19:28:35.938717 INFO::Creating boxplot for categorical data, antibiotics vs F104
## 2024-12-19 19:28:36.282024 INFO::Creating boxplot for categorical data, antibiotics vs F466
## 2024-12-19 19:28:36.62667 INFO::Creating boxplot for categorical data, antibiotics vs F737
## 2024-12-19 19:28:36.952695 INFO::Creating boxplot for categorical data, antibiotics vs F487
## 2024-12-19 19:28:37.228375 INFO::Creating boxplot for categorical data, antibiotics vs F369
## 2024-12-19 19:28:37.423267 INFO::Creating boxplot for categorical data, antibiotics vs F584
## 2024-12-19 19:28:37.610304 INFO::Creating boxplot for categorical data, antibiotics vs F166
## 2024-12-19 19:28:37.840082 INFO::Creating boxplot for categorical data, antibiotics vs F822
## 2024-12-19 19:28:38.278569 INFO::Creating boxplot for categorical data, antibiotics vs F416
## 2024-12-19 19:28:38.588768 INFO::Creating boxplot for categorical data, antibiotics vs F70
## 2024-12-19 19:28:38.900334 INFO::Creating boxplot for categorical data, antibiotics vs F243
## 2024-12-19 19:28:39.12733 INFO::Creating boxplot for categorical data, antibiotics vs F498
## 2024-12-19 19:28:39.439749 INFO::Creating boxplot for categorical data, antibiotics vs F272
## 2024-12-19 19:28:39.630961 INFO::Creating boxplot for categorical data, antibiotics vs F846
## 2024-12-19 19:28:39.826809 INFO::Creating boxplot for categorical data, antibiotics vs F881
## 2024-12-19 19:28:40.015694 INFO::Creating boxplot for categorical data, antibiotics vs F280
## 2024-12-19 19:28:40.333371 INFO::Creating boxplot for categorical data, antibiotics vs F761
## 2024-12-19 19:28:40.546468 INFO::Creating boxplot for categorical data, antibiotics vs F781
## 2024-12-19 19:28:40.736638 INFO::Creating boxplot for categorical data, antibiotics vs F697
## 2024-12-19 19:28:40.965137 INFO::Creating boxplot for categorical data, antibiotics vs F890
## 2024-12-19 19:28:41.245901 INFO::Creating boxplot for categorical data, antibiotics vs F197
## 2024-12-19 19:28:41.611677 INFO::Creating boxplot for categorical data, antibiotics vs F826
## 2024-12-19 19:28:41.91559 INFO::Creating boxplot for categorical data, antibiotics vs F641
## 2024-12-19 19:28:42.150094 INFO::Creating boxplot for categorical data, antibiotics vs F700
## 2024-12-19 19:28:42.332243 INFO::Creating boxplot for categorical data, antibiotics vs F531
## 2024-12-19 19:28:42.519265 INFO::Creating boxplot for categorical data, antibiotics vs F660
## 2024-12-19 19:28:42.746108 INFO::Creating boxplot for categorical data, antibiotics vs F257
## 2024-12-19 19:28:42.93326 INFO::Creating boxplot for categorical data, antibiotics vs F136
## 2024-12-19 19:28:43.126112 INFO::Creating boxplot for categorical data, antibiotics vs F875
## 2024-12-19 19:28:43.367913 INFO::Creating boxplot for categorical data, antibiotics vs F160
## 2024-12-19 19:28:43.767178 INFO::Creating boxplot for categorical data, antibiotics vs F782
## 2024-12-19 19:28:44.083606 INFO::Creating boxplot for categorical data, antibiotics vs F642
## 2024-12-19 19:28:44.402592 INFO::Creating boxplot for categorical data, antibiotics vs F730
## 2024-12-19 19:28:44.714319 INFO::Creating boxplot for categorical data, antibiotics vs F679
## 2024-12-19 19:28:45.00558 INFO::Creating boxplot for categorical data, antibiotics vs F713
## 2024-12-19 19:28:45.286922 INFO::Creating boxplot for categorical data, antibiotics vs F821
## 2024-12-19 19:28:45.576503 INFO::Creating boxplot for categorical data, antibiotics vs F443
## 2024-12-19 19:28:45.875104 INFO::Creating boxplot for categorical data, antibiotics vs F729
## 2024-12-19 19:28:46.122147 INFO::Creating boxplot for categorical data, antibiotics vs F25
## 2024-12-19 19:28:46.411174 INFO::Creating boxplot for categorical data, antibiotics vs F338
## 2024-12-19 19:28:46.750904 INFO::Creating boxplot for categorical data, antibiotics vs F647
## 2024-12-19 19:28:47.022125 INFO::Creating boxplot for categorical data, antibiotics vs F817
## 2024-12-19 19:28:47.21422 INFO::Creating boxplot for categorical data, antibiotics vs F535
## 2024-12-19 19:28:47.414256 INFO::Creating boxplot for categorical data, antibiotics vs F634
## 2024-12-19 19:28:47.618289 INFO::Creating boxplot for categorical data, antibiotics vs F533
## 2024-12-19 19:28:47.834647 INFO::Creating boxplot for categorical data, antibiotics vs F808
## 2024-12-19 19:28:48.03097 INFO::Creating boxplot for categorical data, antibiotics vs F571
## 2024-12-19 19:28:48.226351 INFO::Creating boxplot for categorical data, antibiotics vs F529
## 2024-12-19 19:28:48.435099 INFO::Creating boxplot for categorical data, antibiotics vs F827
## 2024-12-19 19:28:48.640379 INFO::Creating boxplot for categorical data, antibiotics vs F107
## 2024-12-19 19:28:48.836422 INFO::Creating boxplot for categorical data, antibiotics vs F515
## 2024-12-19 19:28:49.028708 INFO::Creating boxplot for categorical data, antibiotics vs F305
## 2024-12-19 19:28:49.222994 INFO::Creating boxplot for categorical data, antibiotics vs F662
## 2024-12-19 19:28:49.406447 INFO::Creating boxplot for categorical data, antibiotics vs F310
## 2024-12-19 19:28:49.627528 INFO::Creating boxplot for categorical data, antibiotics vs F430
## 2024-12-19 19:28:49.824224 INFO::Creating boxplot for categorical data, antibiotics vs F173
## 2024-12-19 19:28:50.022766 INFO::Creating boxplot for categorical data, antibiotics vs F820
## 2024-12-19 19:28:50.214269 INFO::Creating boxplot for categorical data, antibiotics vs F743
## 2024-12-19 19:28:50.396874 INFO::Creating boxplot for categorical data, antibiotics vs F63
## 2024-12-19 19:28:50.615995 INFO::Creating boxplot for categorical data, antibiotics vs F215
## 2024-12-19 19:28:50.802638 INFO::Creating boxplot for categorical data, antibiotics vs F216
## 2024-12-19 19:28:51.017103 INFO::Creating boxplot for categorical data, antibiotics vs F245
## 2024-12-19 19:28:51.220098 INFO::Creating boxplot for categorical data, antibiotics vs F862
## 2024-12-19 19:28:51.409986 INFO::Creating boxplot for categorical data, antibiotics vs F541
## 2024-12-19 19:28:51.743815 INFO::Creating boxplot for categorical data, antibiotics vs F558
## 2024-12-19 19:28:52.033809 INFO::Creating boxplot for categorical data, antibiotics vs F633
## 2024-12-19 19:28:52.271376 INFO::Creating boxplot for categorical data, antibiotics vs F94
## 2024-12-19 19:28:52.482141 INFO::Creating boxplot for categorical data, antibiotics vs F574
## 2024-12-19 19:28:52.716186 INFO::Creating boxplot for categorical data, antibiotics vs F238
## 2024-12-19 19:28:52.939755 INFO::Creating boxplot for categorical data, antibiotics vs F815
## 2024-12-19 19:28:53.140508 INFO::Creating boxplot for categorical data, antibiotics vs F587
## 2024-12-19 19:28:53.336475 INFO::Creating boxplot for categorical data, antibiotics vs F464
## 2024-12-19 19:28:53.543222 INFO::Creating boxplot for categorical data, antibiotics vs F590
## 2024-12-19 19:28:53.767184 INFO::Creating boxplot for categorical data, antibiotics vs F124
## 2024-12-19 19:28:53.965968 INFO::Creating boxplot for categorical data, antibiotics vs F664
## 2024-12-19 19:28:54.160154 INFO::Creating boxplot for categorical data, antibiotics vs F100
## 2024-12-19 19:28:54.357065 INFO::Creating boxplot for categorical data, antibiotics vs F744
## 2024-12-19 19:28:54.546317 INFO::Creating boxplot for categorical data, antibiotics vs F444
## 2024-12-19 19:28:54.774934 INFO::Creating boxplot for categorical data, antibiotics vs F597
## 2024-12-19 19:28:54.991718 INFO::Creating boxplot for categorical data, antibiotics vs F650
## 2024-12-19 19:28:55.18715 INFO::Creating boxplot for categorical data, antibiotics vs F147
## 2024-12-19 19:28:55.39366 INFO::Creating boxplot for categorical data, antibiotics vs F363
## 2024-12-19 19:28:55.593359 INFO::Creating boxplot for categorical data, antibiotics vs F521
## 2024-12-19 19:28:55.823628 INFO::Creating boxplot for categorical data, antibiotics vs F412
## 2024-12-19 19:28:56.025739 INFO::Creating boxplot for categorical data, antibiotics vs F279
## 2024-12-19 19:28:56.219638 INFO::Creating boxplot for categorical data, antibiotics vs F225
## 2024-12-19 19:28:56.408912 INFO::Creating boxplot for categorical data, antibiotics vs F10
## 2024-12-19 19:28:56.658994 INFO::Creating boxplot for categorical data, antibiotics vs F481
## 2024-12-19 19:28:56.866844 INFO::Creating boxplot for categorical data, antibiotics vs F861
## 2024-12-19 19:28:57.143589 INFO::Creating boxplot for categorical data, antibiotics vs F888
## 2024-12-19 19:28:57.336656 INFO::Creating boxplot for categorical data, antibiotics vs F156
## 2024-12-19 19:28:57.517044 INFO::Creating boxplot for categorical data, antibiotics vs F857
## 2024-12-19 19:28:57.733306 INFO::Creating boxplot for categorical data, antibiotics vs F509
## 2024-12-19 19:28:57.928791 INFO::Creating boxplot for categorical data, antibiotics vs F244
## 2024-12-19 19:28:58.118574 INFO::Creating boxplot for categorical data, antibiotics vs F514
## 2024-12-19 19:28:58.303106 INFO::Creating boxplot for categorical data, antibiotics vs F196
## 2024-12-19 19:28:58.507075 INFO::Creating boxplot for categorical data, antibiotics vs F304
## 2024-12-19 19:28:58.771969 INFO::Creating boxplot for categorical data, antibiotics vs F833
## 2024-12-19 19:28:58.968837 INFO::Creating boxplot for categorical data, antibiotics vs F294
## 2024-12-19 19:28:59.17855 INFO::Creating boxplot for categorical data, antibiotics vs F550
## 2024-12-19 19:28:59.376741 INFO::Creating boxplot for categorical data, antibiotics vs F869
## 2024-12-19 19:28:59.589477 INFO::Creating boxplot for categorical data, antibiotics vs F364
## 2024-12-19 19:28:59.793615 INFO::Creating boxplot for categorical data, antibiotics vs F583
## 2024-12-19 19:29:00.005633 INFO::Creating boxplot for categorical data, antibiotics vs F441
## 2024-12-19 19:29:00.205525 INFO::Creating boxplot for categorical data, antibiotics vs F595
## 2024-12-19 19:29:00.414435 INFO::Creating boxplot for categorical data, antibiotics vs F35
## 2024-12-19 19:29:00.705802 INFO::Creating boxplot for categorical data, antibiotics vs F630
## 2024-12-19 19:29:00.893014 INFO::Creating boxplot for categorical data, antibiotics vs F401
## 2024-12-19 19:29:01.082886 INFO::Creating boxplot for categorical data, antibiotics vs F287
## 2024-12-19 19:29:01.270928 INFO::Creating boxplot for categorical data, antibiotics vs F250
## 2024-12-19 19:29:01.458416 INFO::Creating boxplot for categorical data, antibiotics vs F239
## 2024-12-19 19:29:01.682048 INFO::Creating boxplot for categorical data, antibiotics vs F88
## 2024-12-19 19:29:01.881543 INFO::Creating boxplot for categorical data, antibiotics vs F752
## 2024-12-19 19:29:02.083703 INFO::Creating boxplot for categorical data, antibiotics vs F539
## 2024-12-19 19:29:02.266536 INFO::Creating boxplot for categorical data, antibiotics vs F69
## 2024-12-19 19:29:02.51963 INFO::Creating boxplot for categorical data, antibiotics vs F126
## 2024-12-19 19:29:02.70916 INFO::Creating boxplot for categorical data, antibiotics vs F362
## 2024-12-19 19:29:02.92469 INFO::Creating boxplot for categorical data, antibiotics vs F753
## 2024-12-19 19:29:03.209648 INFO::Creating boxplot for categorical data, antibiotics vs F469
## 2024-12-19 19:29:03.482113 INFO::Creating boxplot for categorical data, antibiotics vs F14
## 2024-12-19 19:29:03.701696 INFO::Creating boxplot for categorical data, antibiotics vs F803
## 2024-12-19 19:29:03.899885 INFO::Creating boxplot for categorical data, antibiotics vs F814
## 2024-12-19 19:29:04.108211 INFO::Creating boxplot for categorical data, antibiotics vs F449
## 2024-12-19 19:29:04.298022 INFO::Creating boxplot for categorical data, antibiotics vs F494
## 2024-12-19 19:29:04.512934 INFO::Creating boxplot for categorical data, antibiotics vs F439
## 2024-12-19 19:29:04.726083 INFO::Creating boxplot for categorical data, antibiotics vs F686
## 2024-12-19 19:29:04.935478 INFO::Creating boxplot for categorical data, antibiotics vs F591
## 2024-12-19 19:29:05.128944 INFO::Creating boxplot for categorical data, antibiotics vs F735
## 2024-12-19 19:29:05.328235 INFO::Creating boxplot for categorical data, antibiotics vs F111
## 2024-12-19 19:29:06.296644 INFO::Creating boxplot for categorical data, antibiotics vs F346
## 2024-12-19 19:29:06.473715 INFO::Creating boxplot for categorical data, antibiotics vs F29
## 2024-12-19 19:29:06.653984 INFO::Creating boxplot for categorical data, antibiotics vs F376
## 2024-12-19 19:29:06.829313 INFO::Creating boxplot for categorical data, antibiotics vs F414
## 2024-12-19 19:29:07.010869 INFO::Creating boxplot for categorical data, antibiotics vs F555
## 2024-12-19 19:29:07.198542 INFO::Creating boxplot for categorical data, antibiotics vs F517
## 2024-12-19 19:29:07.370455 INFO::Creating boxplot for categorical data, antibiotics vs F544
## 2024-12-19 19:29:07.542904 INFO::Creating boxplot for categorical data, antibiotics vs F339
## 2024-12-19 19:29:07.725713 INFO::Creating boxplot for categorical data, antibiotics vs F689
## 2024-12-19 19:29:07.904191 INFO::Creating boxplot for categorical data, antibiotics vs F391
## 2024-12-19 19:29:08.094061 INFO::Creating boxplot for categorical data, antibiotics vs F502
## 2024-12-19 19:29:08.282244 INFO::Creating boxplot for categorical data, antibiotics vs F298
## 2024-12-19 19:29:08.483988 INFO::Creating boxplot for categorical data, antibiotics vs F337
## 2024-12-19 19:29:08.660853 INFO::Creating boxplot for categorical data, antibiotics vs F773
## 2024-12-19 19:29:08.83891 INFO::Creating boxplot for categorical data, antibiotics vs F592
## 2024-12-19 19:29:09.030146 INFO::Creating boxplot for categorical data, antibiotics vs F307
## 2024-12-19 19:29:09.21692 INFO::Creating boxplot for categorical data, antibiotics vs F115
## 2024-12-19 19:29:09.448288 INFO::Creating boxplot for categorical data, antibiotics vs F739
## 2024-12-19 19:29:09.654355 INFO::Creating boxplot for categorical data, antibiotics vs F433
## 2024-12-19 19:29:09.838553 INFO::Creating boxplot for categorical data, antibiotics vs F384
## 2024-12-19 19:29:10.136501 INFO::Creating boxplot for categorical data, antibiotics vs F750
## 2024-12-19 19:29:10.405778 INFO::Creating boxplot for categorical data, antibiotics vs F762
## 2024-12-19 19:29:10.585654 INFO::Creating boxplot for categorical data, antibiotics vs F277
## 2024-12-19 19:29:10.762992 INFO::Creating boxplot for categorical data, antibiotics vs F871
## 2024-12-19 19:29:10.961474 INFO::Creating boxplot for categorical data, antibiotics vs F839
## 2024-12-19 19:29:11.15968 INFO::Creating boxplot for categorical data, antibiotics vs F127
## 2024-12-19 19:29:11.448622 INFO::Creating boxplot for categorical data, antibiotics vs F554
## 2024-12-19 19:29:11.631137 INFO::Creating boxplot for categorical data, antibiotics vs F676
## 2024-12-19 19:29:11.810472 INFO::Creating boxplot for categorical data, antibiotics vs F568
## 2024-12-19 19:29:11.998426 INFO::Creating boxplot for categorical data, antibiotics vs F137
## 2024-12-19 19:29:12.184634 INFO::Creating boxplot for categorical data, antibiotics vs F131
## 2024-12-19 19:29:12.407451 INFO::Creating boxplot for categorical data, antibiotics vs F60
## 2024-12-19 19:29:12.606654 INFO::Creating boxplot for categorical data, antibiotics vs F98
## 2024-12-19 19:29:12.895283 INFO::Creating boxplot for categorical data, antibiotics vs F672
## 2024-12-19 19:29:13.167479 INFO::Creating boxplot for categorical data, antibiotics vs F530
## 2024-12-19 19:29:13.368647 INFO::Creating boxplot for categorical data, antibiotics vs F809
## 2024-12-19 19:29:13.565532 INFO::Creating boxplot for categorical data, antibiotics vs F894
## 2024-12-19 19:29:13.784422 INFO::Creating boxplot for categorical data, antibiotics vs F22
## 2024-12-19 19:29:14.027063 INFO::Creating boxplot for categorical data, antibiotics vs F818
## 2024-12-19 19:29:14.266306 INFO::Creating boxplot for categorical data, antibiotics vs F559
## 2024-12-19 19:29:14.478289 INFO::Creating boxplot for categorical data, antibiotics vs F741
## 2024-12-19 19:29:14.651821 INFO::Creating boxplot for categorical data, antibiotics vs F398
## 2024-12-19 19:29:14.853581 INFO::Creating boxplot for categorical data, antibiotics vs F357
## 2024-12-19 19:29:15.061306 INFO::Creating boxplot for categorical data, antibiotics vs F119
## 2024-12-19 19:29:15.259432 INFO::Creating boxplot for categorical data, antibiotics vs F426
## 2024-12-19 19:29:15.445142 INFO::Creating boxplot for categorical data, antibiotics vs F204
## 2024-12-19 19:29:15.647895 INFO::Creating boxplot for categorical data, antibiotics vs F851
## 2024-12-19 19:29:15.818982 INFO::Creating boxplot for categorical data, antibiotics vs F657
## 2024-12-19 19:29:16.011907 INFO::Creating boxplot for categorical data, antibiotics vs F801
## 2024-12-19 19:29:16.206886 INFO::Creating boxplot for categorical data, antibiotics vs F754
## 2024-12-19 19:29:16.393352 INFO::Creating boxplot for categorical data, antibiotics vs F859
## 2024-12-19 19:29:16.587393 INFO::Creating boxplot for categorical data, antibiotics vs F480
## 2024-12-19 19:29:16.823162 INFO::Creating boxplot for categorical data, antibiotics vs F507
## 2024-12-19 19:29:17.019668 INFO::Creating boxplot for categorical data, antibiotics vs F207
## 2024-12-19 19:29:19.682473 INFO::Plotting data for metadata number 3, age
## 2024-12-19 19:29:19.685219 INFO::Creating scatter plot for continuous data, age vs F340
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:20.129317 INFO::Creating scatter plot for continuous data, age vs F603
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:20.512216 INFO::Creating scatter plot for continuous data, age vs F356
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:20.819848 INFO::Creating scatter plot for continuous data, age vs F181
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:21.116187 INFO::Creating scatter plot for continuous data, age vs F177
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:21.316406 INFO::Creating scatter plot for continuous data, age vs F390
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:21.539558 INFO::Creating scatter plot for continuous data, age vs F743
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:21.716803 INFO::Creating scatter plot for continuous data, age vs F491
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:21.935102 INFO::Creating scatter plot for continuous data, age vs F436
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:22.115499 INFO::Creating scatter plot for continuous data, age vs F219
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:22.283168 INFO::Creating scatter plot for continuous data, age vs F483
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:22.470037 INFO::Creating scatter plot for continuous data, age vs F878
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:22.675879 INFO::Creating scatter plot for continuous data, age vs F876
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:22.869092 INFO::Creating scatter plot for continuous data, age vs F211
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:23.055177 INFO::Creating scatter plot for continuous data, age vs F732
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:23.247282 INFO::Creating scatter plot for continuous data, age vs F222
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:23.447705 INFO::Creating scatter plot for continuous data, age vs F688
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:23.65109 INFO::Creating scatter plot for continuous data, age vs F170
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:23.843613 INFO::Creating scatter plot for continuous data, age vs F431
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:24.042054 INFO::Creating scatter plot for continuous data, age vs F174
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:24.217289 INFO::Creating scatter plot for continuous data, age vs F17
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:24.447488 INFO::Creating scatter plot for continuous data, age vs F334
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:24.627877 INFO::Creating scatter plot for continuous data, age vs F835
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:24.806071 INFO::Creating scatter plot for continuous data, age vs F223
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:25.002266 INFO::Creating scatter plot for continuous data, age vs F383
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:25.194117 INFO::Creating scatter plot for continuous data, age vs F623
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:25.377747 INFO::Creating scatter plot for continuous data, age vs F329
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:25.573587 INFO::Creating scatter plot for continuous data, age vs F395
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:25.762737 INFO::Creating scatter plot for continuous data, age vs F528
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:25.943688 INFO::Creating scatter plot for continuous data, age vs F13
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:26.117622 INFO::Creating scatter plot for continuous data, age vs F36
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:26.28702 INFO::Creating scatter plot for continuous data, age vs F285
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:26.4693 INFO::Creating scatter plot for continuous data, age vs F404
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:26.722972 INFO::Creating scatter plot for continuous data, age vs F894
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:26.914077 INFO::Creating scatter plot for continuous data, age vs F300
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:27.110436 INFO::Creating scatter plot for continuous data, age vs F32
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:27.306852 INFO::Creating scatter plot for continuous data, age vs F24
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:27.522045 INFO::Creating scatter plot for continuous data, age vs F97
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:27.728294 INFO::Creating scatter plot for continuous data, age vs F849
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:27.920614 INFO::Creating scatter plot for continuous data, age vs F185
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:28.117154 INFO::Creating scatter plot for continuous data, age vs F513
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:28.309351 INFO::Creating scatter plot for continuous data, age vs F296
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:28.519706 INFO::Creating scatter plot for continuous data, age vs F471
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:28.708392 INFO::Creating scatter plot for continuous data, age vs F793
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:28.891526 INFO::Creating scatter plot for continuous data, age vs F402
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:29.07618 INFO::Creating scatter plot for continuous data, age vs F541
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:29.292391 INFO::Creating scatter plot for continuous data, age vs F496
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:29.477028 INFO::Creating scatter plot for continuous data, age vs F386
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:29.666525 INFO::Creating scatter plot for continuous data, age vs F594
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:29.868311 INFO::Creating scatter plot for continuous data, age vs F704
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:30.044985 INFO::Creating scatter plot for continuous data, age vs F330
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:30.262381 INFO::Creating scatter plot for continuous data, age vs F197
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:30.447313 INFO::Creating scatter plot for continuous data, age vs F735
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:30.631184 INFO::Creating scatter plot for continuous data, age vs F481
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:30.801936 INFO::Creating scatter plot for continuous data, age vs F635
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:31.011972 INFO::Creating scatter plot for continuous data, age vs F687
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:31.259558 INFO::Creating scatter plot for continuous data, age vs F652
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:31.571349 INFO::Creating scatter plot for continuous data, age vs F651
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:31.786882 INFO::Creating scatter plot for continuous data, age vs F82
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:32.001906 INFO::Creating scatter plot for continuous data, age vs F7
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:32.220084 INFO::Creating scatter plot for continuous data, age vs F866
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:32.519311 INFO::Creating scatter plot for continuous data, age vs F593
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:32.800579 INFO::Creating scatter plot for continuous data, age vs F733
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:33.080491 INFO::Creating scatter plot for continuous data, age vs F684
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:33.37891 INFO::Creating scatter plot for continuous data, age vs F410
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:33.663265 INFO::Creating scatter plot for continuous data, age vs F224
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:33.937473 INFO::Creating scatter plot for continuous data, age vs F722
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:34.162008 INFO::Creating scatter plot for continuous data, age vs F856
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:34.39621 INFO::Creating scatter plot for continuous data, age vs F680
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:34.576678 INFO::Creating scatter plot for continuous data, age vs F19
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:34.766405 INFO::Creating scatter plot for continuous data, age vs F860
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:34.936523 INFO::Creating scatter plot for continuous data, age vs F859
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:35.153473 INFO::Creating scatter plot for continuous data, age vs F522
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:35.354847 INFO::Creating scatter plot for continuous data, age vs F372
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:35.573795 INFO::Creating scatter plot for continuous data, age vs F899
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:35.863695 INFO::Creating scatter plot for continuous data, age vs F782
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:36.14843 INFO::Creating scatter plot for continuous data, age vs F839
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:36.384559 INFO::Creating scatter plot for continuous data, age vs F827
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:36.639092 INFO::Creating scatter plot for continuous data, age vs F817
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:36.946698 INFO::Creating scatter plot for continuous data, age vs F345
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:37.218642 INFO::Creating scatter plot for continuous data, age vs F127
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:37.551234 INFO::Creating scatter plot for continuous data, age vs F749
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:37.82007 INFO::Creating scatter plot for continuous data, age vs F877
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:38.103524 INFO::Creating scatter plot for continuous data, age vs F150
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:38.394867 INFO::Creating scatter plot for continuous data, age vs F752
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:38.704831 INFO::Creating scatter plot for continuous data, age vs F848
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:38.987162 INFO::Creating scatter plot for continuous data, age vs F809
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:39.29181 INFO::Creating scatter plot for continuous data, age vs F751
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:39.572414 INFO::Creating scatter plot for continuous data, age vs F15
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:39.871701 INFO::Creating scatter plot for continuous data, age vs F521
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:40.163357 INFO::Creating scatter plot for continuous data, age vs F842
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:40.364332 INFO::Creating scatter plot for continuous data, age vs F319
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:40.564289 INFO::Creating scatter plot for continuous data, age vs F96
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:40.768931 INFO::Creating scatter plot for continuous data, age vs F171
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:40.995334 INFO::Creating scatter plot for continuous data, age vs F241
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:41.176273 INFO::Creating scatter plot for continuous data, age vs F582
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:41.353257 INFO::Creating scatter plot for continuous data, age vs F822
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:41.535488 INFO::Creating scatter plot for continuous data, age vs F748
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:41.737526 INFO::Creating scatter plot for continuous data, age vs F147
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:41.961045 INFO::Creating scatter plot for continuous data, age vs F16
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:42.2605 INFO::Creating scatter plot for continuous data, age vs F212
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:42.5778 INFO::Creating scatter plot for continuous data, age vs F718
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:42.928017 INFO::Creating scatter plot for continuous data, age vs F663
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:43.179032 INFO::Creating scatter plot for continuous data, age vs F690
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:43.484246 INFO::Creating scatter plot for continuous data, age vs F865
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:43.730163 INFO::Creating scatter plot for continuous data, age vs F421
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:43.923604 INFO::Creating scatter plot for continuous data, age vs F110
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:44.122373 INFO::Creating scatter plot for continuous data, age vs F857
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:44.309797 INFO::Creating scatter plot for continuous data, age vs F84
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:44.574823 INFO::Creating scatter plot for continuous data, age vs F123
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:44.842065 INFO::Creating scatter plot for continuous data, age vs F566
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:45.158834 INFO::Creating scatter plot for continuous data, age vs F370
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:45.360016 INFO::Creating scatter plot for continuous data, age vs F65
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:45.549183 INFO::Creating scatter plot for continuous data, age vs F119
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:45.725365 INFO::Creating scatter plot for continuous data, age vs F263
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:45.923804 INFO::Creating scatter plot for continuous data, age vs F630
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:46.121229 INFO::Creating scatter plot for continuous data, age vs F628
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:46.305466 INFO::Creating scatter plot for continuous data, age vs F711
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:46.50126 INFO::Creating scatter plot for continuous data, age vs F152
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:46.82097 INFO::Creating scatter plot for continuous data, age vs F324
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:47.120298 INFO::Creating scatter plot for continuous data, age vs F575
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:47.416141 INFO::Creating scatter plot for continuous data, age vs F699
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:47.739543 INFO::Creating scatter plot for continuous data, age vs F846
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:48.026686 INFO::Creating scatter plot for continuous data, age vs F380
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:48.307054 INFO::Creating scatter plot for continuous data, age vs F172
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:48.633329 INFO::Creating scatter plot for continuous data, age vs F504
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:48.843057 INFO::Creating scatter plot for continuous data, age vs F34
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:49.055923 INFO::Creating scatter plot for continuous data, age vs F199
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:49.300394 INFO::Creating scatter plot for continuous data, age vs F198
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:49.516939 INFO::Creating scatter plot for continuous data, age vs F479
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:49.749072 INFO::Creating scatter plot for continuous data, age vs F673
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:49.937098 INFO::Creating scatter plot for continuous data, age vs F508
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:50.260308 INFO::Creating scatter plot for continuous data, age vs F337
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:50.478121 INFO::Creating scatter plot for continuous data, age vs F737
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:50.672068 INFO::Creating scatter plot for continuous data, age vs F609
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:50.862493 INFO::Creating scatter plot for continuous data, age vs F40
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:51.077968 INFO::Creating scatter plot for continuous data, age vs F821
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:51.279789 INFO::Creating scatter plot for continuous data, age vs F643
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:51.526416 INFO::Creating scatter plot for continuous data, age vs F759
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:51.758673 INFO::Creating scatter plot for continuous data, age vs F417
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:51.961721 INFO::Creating scatter plot for continuous data, age vs F58
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:52.204978 INFO::Creating scatter plot for continuous data, age vs F267
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:52.39667 INFO::Creating scatter plot for continuous data, age vs F101
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:52.57475 INFO::Creating scatter plot for continuous data, age vs F890
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:52.76679 INFO::Creating scatter plot for continuous data, age vs F655
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:52.995675 INFO::Creating scatter plot for continuous data, age vs F95
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:53.173916 INFO::Creating scatter plot for continuous data, age vs F775
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:53.354471 INFO::Creating scatter plot for continuous data, age vs F93
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:53.568237 INFO::Creating scatter plot for continuous data, age vs F353
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:53.794525 INFO::Creating scatter plot for continuous data, age vs F480
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:53.987518 INFO::Creating scatter plot for continuous data, age vs F567
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:54.181126 INFO::Creating scatter plot for continuous data, age vs F871
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:54.367641 INFO::Creating scatter plot for continuous data, age vs F295
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:54.566761 INFO::Creating scatter plot for continuous data, age vs F459
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:54.826978 INFO::Creating scatter plot for continuous data, age vs F812
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:55.043506 INFO::Creating scatter plot for continuous data, age vs F146
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:55.223473 INFO::Creating scatter plot for continuous data, age vs F239
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:55.424835 INFO::Creating scatter plot for continuous data, age vs F754
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:55.713797 INFO::Creating scatter plot for continuous data, age vs F443
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:55.891181 INFO::Creating scatter plot for continuous data, age vs F5
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:56.079489 INFO::Creating scatter plot for continuous data, age vs F864
## `geom_smooth()` using formula = 'y ~ x'
## 2024-12-19 19:29:56.255609 INFO::Creating scatter plot for continuous data, age vs F477
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:56.479036 INFO::Creating scatter plot for continuous data, age vs F571
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## 2024-12-19 19:29:56.68708 INFO::Creating scatter plot for continuous data, age vs F715
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## Initiating effect size calculations
##
## Calculating mean abundance in: IBD
##
## Calculating mean abundance in: Control
##
## Calculating effect size in: IBD
##
## Initiating prioritization
##
## Calculating meta-rank and prioritizing metabolic features
## 2024-12-19 19:29:59.876719 INFO::Writing all prioritized metabolites to file: Macarron_output/prioritized_metabolites_all.csv
## 2024-12-19 19:29:59.902657 INFO::Writing characterizable prioritized metabolites to file: Macarron_output/prioritized_metabolites_characterizable.csv
## 2024-12-19 19:29:59.932931 INFO::Writing highly prioritized metabolites in IBD to file: Macarron_output/highly_prioritized_per_module_in_IBD.csv
abundances_df = read.csv(file = prism_abundances, row.names = 1) # setting features as rownames
annotations_df = read.csv(file = prism_annotations, row.names = 1) # setting features as rownames
metadata_df = read.csv(file = prism_metadata, row.names = 1) # setting samples as rownames
taxonomy_df = read.csv(file = mets_taxonomy)
# Running Macarron
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df)
The Macarron::Macarron()
function is a wrapper for the Macarron framework. Users can also apply individual functions on the input dataframes to achieve same results as the wrapper with the added benefit of storing output from each function for other analyses. There are seven steps:
# Step 1: Storing input data in a summarized experiment object
prism_mbx <- prepInput(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df)
# Step 2: Creating a distance matrix from pairwise correlations in abundances of metabolic features
prism_w <- makeDisMat(se = prism_mbx)
# Step 3: Finding covariance modules
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
# The output is a list containing two dataframes- module assignments and measures of success
# if evaluateMOS=TRUE. To write modules to a separate dataframe, do:
prism_module_assignments <- prism_modules[[1]]
prism_modules_mos <- prism_modules[[2]]
# Step 4: Calculating AVA
prism_ava <- calAVA(se = prism_mbx,
mod.assn = prism_modules)
# Step 5: Calculating q-value
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules)
# Step 6: Calculating effect size
prism_es <- calES(se = prism_mbx,
mac.qval = prism_qval)
# Step 7: Prioritizing metabolic features
prism_prioritized <- prioritize(se = prism_mbx,
mod.assn = prism_modules,
mac.ava = prism_ava,
mac.qval = prism_qval,
mac.es = prism_es)
# The output is a list containing two dataframes- all prioritized metabolic features and
# only characterizable metabolic features.
all_prioritized <- prism_prioritized[[1]]
char_prioritized <- prism_prioritized[[2]]
# Step 8 (optional): View only the highly prioritized metabolic features in each module
prism_highly_prioritized <- showBest(prism_prioritized)
Session info from running the demo in R can be displayed with the following command.
sessionInfo()
## R Under development (unstable) (2024-10-26 r87273 ucrt)
## Platform: x86_64-w64-mingw32/x64
## Running under: Windows Server 2022 x64 (build 20348)
##
## Matrix products: default
##
##
## locale:
## [1] LC_COLLATE=C
## [2] LC_CTYPE=English_United States.utf8
## [3] LC_MONETARY=English_United States.utf8
## [4] LC_NUMERIC=C
## [5] LC_TIME=English_United States.utf8
##
## time zone: America/New_York
## tzcode source: internal
##
## attached base packages:
## [1] stats4 stats graphics grDevices utils datasets methods
## [8] base
##
## other attached packages:
## [1] Macarron_1.11.0 SummarizedExperiment_1.37.0
## [3] Biobase_2.67.0 GenomicRanges_1.59.1
## [5] GenomeInfoDb_1.43.2 IRanges_2.41.2
## [7] S4Vectors_0.45.2 BiocGenerics_0.53.3
## [9] generics_0.1.3 MatrixGenerics_1.19.0
## [11] matrixStats_1.4.1 BiocStyle_2.35.0
##
## loaded via a namespace (and not attached):
## [1] mnormt_2.1.1 DBI_1.2.3 pbapply_1.7-2
## [4] gridExtra_2.3 rlang_1.1.4 magrittr_2.0.3
## [7] compiler_4.5.0 RSQLite_2.3.9 mgcv_1.9-1
## [10] png_0.1-8 vctrs_0.6.5 stringr_1.5.1
## [13] pkgconfig_2.0.3 crayon_1.5.3 fastmap_1.2.0
## [16] backports_1.5.0 XVector_0.47.0 labeling_0.4.3
## [19] rmarkdown_2.29 preprocessCore_1.69.0 UCSC.utils_1.3.0
## [22] bit_4.5.0.1 xfun_0.49 zlibbioc_1.53.0
## [25] cachem_1.1.0 jsonlite_1.8.9 blob_1.2.4
## [28] DelayedArray_0.33.3 BiocParallel_1.41.0 psych_2.4.6.26
## [31] Maaslin2_1.21.0 parallel_4.5.0 cluster_2.1.8
## [34] biglm_0.9-3 R6_2.5.1 RColorBrewer_1.1-3
## [37] bslib_0.8.0 stringi_1.8.4 rpart_4.1.23
## [40] jquerylib_0.1.4 Rcpp_1.0.13-1 bookdown_0.41
## [43] iterators_1.0.14 knitr_1.49 WGCNA_1.73
## [46] base64enc_0.1-3 Matrix_1.7-1 splines_4.5.0
## [49] nnet_7.3-19 tidyselect_1.2.1 rstudioapi_0.17.1
## [52] abind_1.4-8 yaml_2.3.10 doParallel_1.0.17
## [55] codetools_0.2-20 plyr_1.8.9 lattice_0.22-6
## [58] tibble_3.2.1 withr_3.0.2 KEGGREST_1.47.0
## [61] evaluate_1.0.1 foreign_0.8-87 survival_3.8-3
## [64] getopt_1.20.4 Biostrings_2.75.3 pillar_1.10.0
## [67] BiocManager_1.30.25 checkmate_2.3.2 foreach_1.5.2
## [70] pcaPP_2.0-5 ggplot2_3.5.1 munsell_0.5.1
## [73] scales_1.3.0 glue_1.8.0 Hmisc_5.2-1
## [76] tools_4.5.0 robustbase_0.99-4-1 data.table_1.16.4
## [79] mvtnorm_1.3-2 fastcluster_1.2.6 grid_4.5.0
## [82] optparse_1.7.5 impute_1.81.0 AnnotationDbi_1.69.0
## [85] colorspace_2.1-1 nlme_3.1-166 GenomeInfoDbData_1.2.13
## [88] htmlTable_2.4.3 Formula_1.2-5 cli_3.6.3
## [91] S4Arrays_1.7.1 dplyr_1.1.4 DEoptimR_1.1-3-1
## [94] gtable_0.3.6 hash_2.2.6.3 logging_0.10-108
## [97] dynamicTreeCut_1.63-1 sass_0.4.9 digest_0.6.37
## [100] SparseArray_1.7.2 farver_2.1.2 htmlwidgets_1.6.4
## [103] memoise_2.0.1 htmltools_0.5.8.1 lifecycle_1.0.4
## [106] httr_1.4.7 GO.db_3.20.0 bit64_4.5.2
The input taxonomy dataframe can be generated using the input metabolic features annotation dataframe using Macarron::decorateID()
. This function annotates an HMDB ID or a PubChem CID with the chemical class and subclass of the metabolite.
taxonomy_df <- decorateID(input_annotations = annotations_df)
write.csv(taxonomy_df, file="demo_taxonomy.csv", row.names = FALSE)
A record of all chosen parameters and steps that were followed during execution.
This file provides information about the properties of covariance modules used in the analysis. By default, modules are generated using a minimum module size (MMS) (argument: min_module_size
) equal to cube root of the total number of prevalent metabolic features. Macarron evaluates 9 measures of success (MOS) that collectively capture the “correctness” and chemical homogeneity of the modules. The MOS are as follows:
This folder contains the Maaslin2 log file (maaslin2.log), significant associations found by Maaslin2 (significant_results.tsv) and the linear model residuals file (residuals.rds). For more information, see Maaslin2.
Ideally, at least 50% metabolic features must be retained after prevalence filtering. By default, Macarron uses the union of metabolic features observed (non-zero abundance) in at least 70% samples of any phenotype for further analysis. This prevalence threshold may be high for some metabolomics datasets and can be changed using the min_prevalence
argument.
prism_prioritized <- Macarron::Macarron(input_abundances = abundances_df,
input_annotations = annotations_df,
input_metadata = metadata_df,
input_taxonomy = taxonomy_df,
min_prevalence = 0.5)
# or
prism_w <- makeDisMat(se = prism_mbx,
min_prevalence = 0.5)
By default, cube root of the total number of prevalent features is used as the minimum module size (MMS) (argument: min_module_size
) for module detection and generation. We expect this to work for most real world datasets. To determine if the modules are optimal for further analysis, Macarron evaluates several measures of success (MOS) as described above. In addition to evaluating MOS for modules generated using the default MMS, Macarron also evaluates MOS for MMS values that are larger (MMS+5, MMS+10) and smaller (MMS-5, MMS-10) than the default MMS. If you find that the MOS improve with larger or smaller MMS, you may change the default accordingly. For more details about module detection, please see WGCNA
and dynamicTreeCut
.
# See MOS of modules generated using default
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df)
prism_modules_mos <- prism_modules[[2]]
View(prism_modules_mos)
# Change MMS
prism_modules <- findMacMod(se = prism_mbx,
w = prism_w,
input_taxonomy = taxonomy_df,
min_module_size = 10)
Macarron uses Maaslin2 for determining the q-value of differential abundance in a phenotype of interest. For default execution, the phenotype of interest must be a category in column 1 of the metadata dataframe e.g. IBD in diagnosis in the demo. This is also the column that is picked by the metadata_variable
argument for identifying the main phenotypes/conditions in any dataset (see Macarron.log file). Further, in the default execution, all columns in the metadata table are considered as fixed effects and the alphabetically first categorical variable in each covariate with two categories is considered as the reference. Maaslin2 requires reference categories to be explicitly defined for all categorical metadata with more than two categories.
Defaults can be changed with the arguments fixed_effects
, random_effects
and reference
. In the demo example, fixed effects
and reference
can be defined as follows:
prism_qval <- calQval(se = prism_mbx,
mod.assn = prism_modules,
metadata_variable = "diagnosis",
fixed_effects = c("diagnosis","age","antibiotics"),
reference = c("diagnosis,Control";"antibiotics,No"))
The package source contains a script MacarronCMD.R
in inst/scripts
to invoke Macarron in the command line using Rscript.
The inst/scripts
folder also contains a README file that comprehensively documents the usage of the script.