## ---- echo=FALSE, message=FALSE----------------------------------------------- library(utils) library(stats) library(LambertW) library(survival) library(km.ci) library(optband) ## ---- echo=TRUE--------------------------------------------------------------- set.seed(1990) N = 200 x1 <- stats::rweibull(N, 1, 1) x2 <- stats::rweibull(N, 2, 1) d <- x1 < x2 x <- pmin(x1,x2) mydata = data.frame(stop = x, event = d) S = survival::survfit(Surv(x, d) ~ 1, type="kaplan-meier") ## ---- fig.show='hold', fig.height=6, fig.width=6, echo=TRUE------------------- opt_S <- optband::opt.ci(S, conf.level = 0.95, fun = "surv", tl = NA, tu = NA) plot(opt_S, xlab="time", ylab="KM", mark.time=FALSE) ## ---- fig.show='hold', fig.height=6, fig.width=6, echo=TRUE------------------- opt_H <- optband::opt.ci(S, conf.level = 0.95, fun = "cumhaz", tl = NA, tu = NA) plot(opt_H, fun="cumhaz", xlab="time", ylab="CH", mark.time=FALSE) ## ---- fig.show='hold', fig.height=6, fig.width=6, echo=TRUE------------------- opt_H <- optband::opt.ci(S, conf.level = 0.90, fun = "cumhaz", tl = .1, tu = .9) plot(opt_H, fun="cumhaz", xlab="time", ylab="CH", mark.time=FALSE) ## ---- fig.height=6, fig.width=6, echo=TRUE------------------------------------ color <- c("grey", "darkblue", "red", "green") plot(S, mark.time=FALSE, xlab="time", ylab="KM", col = "white") lines(opt_S, col=color[2], lty=2, lwd=2, mark.time=F) e <- km.ci::km.ci(S, conf.level = 0.95, method = "epband") h <- km.ci::km.ci(S, conf.level = 0.95, method = "hall-wellner") lines(e, col=color[3], lty=3, lwd=2, mark.time=F) lines(h, col=color[4], lty=4, lwd=2, mark.time=F) lines(S,col="grey", lwd=2, mark.time=F) legend("topright", c("KM", "optband", "epband", "hall-wellner"), lwd=2, lty=1:4, col=color) ## ---- fig.height=6, fig.width=6, echo=TRUE------------------------------------ dat <- bladder[bladder$enum==1,] Hdif = survival::survfit(Surv(stop, event) ~ rx, type="kaplan-meier", data=dat) opt_Hdif <- optband::opt.ci(Hdif, fun="cumhaz", conf.level = 0.95, samples=2) plot(opt_Hdif$difference~opt_Hdif$time, xlab="t", ylim=c(-1.5,1), main=expression(hat(Lambda)(t)[1]-hat(Lambda)(t)[2]), ylab="", col = "white") lines(opt_Hdif$difference~opt_Hdif$time, col = "grey", lty=1, lwd=2) lines(-log(opt_Hdif$upper)~opt_Hdif$time, col=4, lty=3, lwd=2) lines(-log(opt_Hdif$lower)~opt_Hdif$time, col=4, lty=3, lwd=2)