Simulate dose regimens for pharmacokinetic-pharmacodynamic (PK-PD) models described by differential equation (DE) systems. Simulation using ADVAN-style analytical equations is also supported (Abuhelwa et al. (2015) <doi:10.1016/j.vascn.2015.03.004>).
| Version: | 1.4.1 |
| Depends: | R (≥ 4.0.0) |
| Imports: | Rcpp (≥ 1.0.13), BH, data.table, stringr, MASS, randtoolbox, jsonlite, stats, parallel, magrittr |
| LinkingTo: | BH, Rcpp (≥ 1.0.13) |
| Suggests: | httr, testthat (≥ 3.0.0), mockery, knitr, rmarkdown |
| Published: | 2025-04-17 |
| DOI: | 10.32614/CRAN.package.PKPDsim |
| Author: | Ron Keizer [aut, cre], Jasmine Hughes [aut], Dominic Tong [aut], Kara Woo [aut], Jordan Brooks [aut], InsightRX [cph, fnd] |
| Maintainer: | Ron Keizer <ron at insight-rx.com> |
| License: | MIT + file LICENSE |
| URL: | https://github.com/InsightRX/PKPDsim, https://insightrx.github.io/PKPDsim/ |
| NeedsCompilation: | yes |
| Language: | en-US |
| Materials: | README, NEWS |
| In views: | MixedModels, Pharmacokinetics |
| CRAN checks: | PKPDsim results |
| Reference manual: | PKPDsim.html , PKPDsim.pdf |
| Vignettes: |
Covariates (source, R code) Absorption models (source, R code) Export model (source, R code) Model (source, R code) Output (source, R code) Parameters (source, R code) Regimen (source, R code) Simulation (source, R code) Speed (source) |
| Package source: | PKPDsim_1.4.1.tar.gz |
| Windows binaries: | r-devel: PKPDsim_1.4.1.zip, r-release: PKPDsim_1.4.1.zip, r-oldrel: PKPDsim_1.4.1.zip |
| macOS binaries: | r-release (arm64): PKPDsim_1.4.1.tgz, r-oldrel (arm64): PKPDsim_1.4.1.tgz, r-release (x86_64): PKPDsim_1.4.1.tgz, r-oldrel (x86_64): PKPDsim_1.4.1.tgz |
| Old sources: | PKPDsim archive |
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