* using log directory 'd:/Rcompile/CRANpkg/local/4.6/invitroTKstats.Rcheck'
* using R Under development (unstable) (2025-09-03 r88788 ucrt)
* using platform: x86_64-w64-mingw32
* R was compiled by
    gcc.exe (GCC) 14.2.0
    GNU Fortran (GCC) 14.2.0
* running under: Windows Server 2022 x64 (build 20348)
* using session charset: UTF-8
* checking for file 'invitroTKstats/DESCRIPTION' ... OK
* this is package 'invitroTKstats' version '0.0.13'
* package encoding: UTF-8
* checking package namespace information ... OK
* checking package dependencies ... OK
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking whether package 'invitroTKstats' can be installed ... OK
* checking installed package size ... OK
* checking package directory ... OK
* checking 'build' directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking code files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... [1s] OK
* checking whether the package can be loaded with stated dependencies ... [1s] OK
* checking whether the package can be unloaded cleanly ... [1s] OK
* checking whether the namespace can be loaded with stated dependencies ... [1s] OK
* checking whether the namespace can be unloaded cleanly ... [2s] OK
* checking loading without being on the library search path ... [2s] OK
* checking use of S3 registration ... OK
* checking dependencies in R code ... OK
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... [10s] OK
* checking Rd files ... [4s] OK
* checking Rd metadata ... OK
* checking Rd cross-references ... OK
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking contents of 'data' directory ... OK
* checking data for non-ASCII characters ... [0s] OK
* checking LazyData ... OK
* checking data for ASCII and uncompressed saves ... OK
* checking installed files from 'inst/doc' ... OK
* checking files in 'vignettes' ... OK
* checking examples ... [2s] ERROR
Running examples in 'invitroTKstats-Ex.R' failed
The error most likely occurred in:

> ### Name: calc_clint_point
> ### Title: Calculate a Point Estimate of Intrinsic Hepatic Clearance
> ###   (Clint) (Level-3)
> ### Aliases: calc_clint_point
> 
> ### ** Examples
> 
> ## Load example level-2 data
> level2 <- invitroTKstats::clint_L2
> 
> ## scenario 1: 
> ## input level-2 data from the R session and do not export the result table
> level3 <- calc_clint_point(data.in = level2, output.res = FALSE)
Error in UseMethod("logLik") : 
  no applicable method for 'logLik' applied to an object of class "mle"
Calls: calc_clint_point -> AIC -> AIC -> AIC.default -> ll
Execution halted
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes ... OK
* checking re-building of vignette outputs ... [53s] ERROR
Error(s) in re-building vignettes:
--- re-building 'Appendix_vignette.Rmd' using rmarkdown
--- finished re-building 'Appendix_vignette.Rmd'

--- re-building 'Caco2_vignette.Rmd' using rmarkdown
--- finished re-building 'Caco2_vignette.Rmd'

--- re-building 'Clint_vignette.Rmd' using rmarkdown

Quitting from Clint_vignette.Rmd:405-410 [L3 processing]
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
<error/rlang_error>
Error in `UseMethod()`:
! no applicable method for 'logLik' applied to an object of class "mle"
---
Backtrace:
    ▆
 1. └─invitroTKstats::calc_clint_point(...)
 2.   ├─stats::AIC(this.null)
 3.   ├─stats::AIC(this.null)
 4.   └─stats:::AIC.default(this.null)
 5.     └─stats (local) ll(object)
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

Error: processing vignette 'Clint_vignette.Rmd' failed with diagnostics:
no applicable method for 'logLik' applied to an object of class "mle"
--- failed re-building 'Clint_vignette.Rmd'

--- re-building 'Data-guide-and-L0_vignette.Rmd' using rmarkdown
--- finished re-building 'Data-guide-and-L0_vignette.Rmd'

--- re-building 'FupRED_vignette.Rmd' using rmarkdown
--- finished re-building 'FupRED_vignette.Rmd'

--- re-building 'FupUC_vignette.Rmd' using rmarkdown
--- finished re-building 'FupUC_vignette.Rmd'

--- re-building 'plotting-invitroTKstats.Rmd' using rmarkdown
--- finished re-building 'plotting-invitroTKstats.Rmd'

SUMMARY: processing the following file failed:
  'Clint_vignette.Rmd'

Error: Vignette re-building failed.
Execution halted

* checking PDF version of manual ... [23s] OK
* checking HTML version of manual ... [15s] OK
* DONE
Status: 2 ERRORs